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  1. Article ; Online: The SUMO stress response in transcriptional regulation: Causal relationships or secondary bystander effects?

    Enserink, Jorrit M

    BioEssays : news and reviews in molecular, cellular and developmental biology

    2022  Volume 44, Issue 7, Page(s) e2200065

    MeSH term(s) Bystander Effect ; Gene Expression Regulation ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Transcription, Genetic
    Chemical Substances Small Ubiquitin-Related Modifier Proteins
    Language English
    Publishing date 2022-06-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.202200065
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  2. Article ; Online: Cell Cycle-Dependent Transcription: The Cyclin Dependent Kinase Cdk1 Is a Direct Regulator of Basal Transcription Machineries.

    Enserink, Jorrit M / Chymkowitch, Pierre

    International journal of molecular sciences

    2022  Volume 23, Issue 3

    Abstract: The cyclin-dependent kinase Cdk1 is best known for its function as master regulator of the cell cycle. It phosphorylates several key proteins to control progression through the different phases of the cell cycle. However, studies conducted several ... ...

    Abstract The cyclin-dependent kinase Cdk1 is best known for its function as master regulator of the cell cycle. It phosphorylates several key proteins to control progression through the different phases of the cell cycle. However, studies conducted several decades ago with mammalian cells revealed that Cdk1 also directly regulates the basal transcription machinery, most notably RNA polymerase II. More recent studies in the budding yeast
    MeSH term(s) Animals ; CDC2 Protein Kinase/genetics ; CDC2 Protein Kinase/metabolism ; CDC2 Protein Kinase/physiology ; Cell Cycle/genetics ; Cell Cycle/physiology ; Cell Cycle Proteins/metabolism ; Cyclin-Dependent Kinases/genetics ; Cyclin-Dependent Kinases/metabolism ; Humans ; Phosphorylation ; RNA Polymerase II/metabolism ; Transcription, Genetic/genetics ; Transcription, Genetic/physiology
    Chemical Substances Cell Cycle Proteins ; CDC2 Protein Kinase (EC 2.7.11.22) ; Cyclin-Dependent Kinases (EC 2.7.11.22) ; RNA Polymerase II (EC 2.7.7.-)
    Language English
    Publishing date 2022-01-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23031293
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  3. Article ; Online: Cell Cycle-Dependent Transcription

    Jorrit M. Enserink / Pierre Chymkowitch

    International Journal of Molecular Sciences, Vol 23, Iss 1293, p

    The Cyclin Dependent Kinase Cdk1 Is a Direct Regulator of Basal Transcription Machineries

    2022  Volume 1293

    Abstract: The cyclin-dependent kinase Cdk1 is best known for its function as master regulator of the cell cycle. It phosphorylates several key proteins to control progression through the different phases of the cell cycle. However, studies conducted several ... ...

    Abstract The cyclin-dependent kinase Cdk1 is best known for its function as master regulator of the cell cycle. It phosphorylates several key proteins to control progression through the different phases of the cell cycle. However, studies conducted several decades ago with mammalian cells revealed that Cdk1 also directly regulates the basal transcription machinery, most notably RNA polymerase II. More recent studies in the budding yeast Saccharomyces cerevisiae have revisited this function of Cdk1 and also revealed that Cdk1 directly controls RNA polymerase III activity. These studies have also provided novel insight into the physiological relevance of this process. For instance, cell cycle-stage-dependent activity of these complexes may be important for meeting the increased demand for various proteins involved in housekeeping, metabolism, and protein synthesis. Recent work also indicates that direct regulation of the RNA polymerase II machinery promotes cell cycle entry. Here, we provide an overview of the regulation of basal transcription by Cdk1, and we hypothesize that the original function of the primordial cell-cycle CDK was to regulate RNAPII and that it later evolved into specialized kinases that govern various aspects of the transcription machinery and the cell cycle.
    Keywords cyclin-dependent kinase ; Cdk1 ; RNA polymerase ; transcription ; cell cycle ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 571
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Sumo during stress: When transcription takes a pause (comment on DOI.10.1002/bies.201600263).

    Enserink, Jorrit M

    BioEssays : news and reviews in molecular, cellular and developmental biology

    2017  Volume 39, Issue 6

    Language English
    Publishing date 2017-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.201700065
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2024: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Regulation of Cellular Processes by SUMO: Understudied Topics.

    Enserink, Jorrit M

    Advances in experimental medicine and biology

    2017  Volume 963, Page(s) 89–97

    Abstract: SUMO plays a multiple role in maintenance of cellular homeostasis, both under normal conditions and under cell stress . Considerable effort has been devoted to unraveling the functions of SUMO in regulation of transcription and preservation of genome ... ...

    Abstract SUMO plays a multiple role in maintenance of cellular homeostasis, both under normal conditions and under cell stress . Considerable effort has been devoted to unraveling the functions of SUMO in regulation of transcription and preservation of genome stability. However, it is clear from high-throughput SUMO proteome studies that SUMO likely regulates many more cellular processes. The function of SUMO in these processes has hardly been explored. This review will focus on the emerging function of SUMO in regulation of several of these processes.
    MeSH term(s) Animals ; Genomic Instability ; Homeostasis ; Humans ; Signal Transduction ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Stress, Physiological ; Sumoylation ; Ubiquitin-Protein Ligases/metabolism
    Chemical Substances Small Ubiquitin-Related Modifier Proteins ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-319-50044-7_5
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  6. Article ; Online: Analysis of the pheromone signaling pathway by RT-qPCR in the budding yeast

    Ramos-Alonso, Lucía / Garcia, Ignacio / Enserink, Jorrit M / Chymkowitch, Pierre

    STAR protocols

    2022  Volume 3, Issue 1, Page(s) 101210

    Abstract: ... ...

    Abstract FUS3
    MeSH term(s) Mitogen-Activated Protein Kinases/metabolism ; Pheromones/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics ; Signal Transduction/genetics ; Yeast, Dried
    Chemical Substances Pheromones ; Saccharomyces cerevisiae Proteins ; FUS3 protein, S cerevisiae (EC 2.7.11.24) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2022-03-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101210
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  7. Article ; Online: Pharmacologic Control of CAR T Cells.

    Caulier, Benjamin / Enserink, Jorrit M / Wälchli, Sébastien

    International journal of molecular sciences

    2021  Volume 22, Issue 9

    Abstract: Chimeric antigen receptor (CAR) therapy is a promising modality for the treatment of advanced cancers that are otherwise incurable. During the last decade, different centers worldwide have tested the anti-CD19 CAR T cells and shown clinical benefits in ... ...

    Abstract Chimeric antigen receptor (CAR) therapy is a promising modality for the treatment of advanced cancers that are otherwise incurable. During the last decade, different centers worldwide have tested the anti-CD19 CAR T cells and shown clinical benefits in the treatment of B cell tumors. However, despite these encouraging results, CAR treatment has also been found to lead to serious side effects and capricious response profiles in patients. In addition, the CD19 CAR success has been difficult to reproduce for other types of malignancy. The appearance of resistant tumor variants, the lack of antigen specificity, and the occurrence of severe adverse effects due to over-stimulation of the therapeutic cells have been identified as the major impediments. This has motivated a growing interest in developing strategies to overcome these hurdles through CAR control. Among them, the combination of small molecules and approved drugs with CAR T cells has been investigated. These have been exploited to induce a synergistic anti-cancer effect but also to control the presence of the CAR T cells or tune the therapeutic activity. In the present review, we discuss opportunistic and rational approaches involving drugs featuring anti-cancer efficacy and CAR-adjustable effect.
    MeSH term(s) B-Lymphocytes ; Humans ; Immunotherapy, Adoptive ; Neoplasms/immunology ; Neoplasms/therapy
    Language English
    Publishing date 2021-04-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22094320
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  8. Article ; Online: Analysis of the pheromone signaling pathway by RT-qPCR in the budding yeast Saccharomyces cerevisiae

    Lucía Ramos-Alonso / Ignacio Garcia / Jorrit M. Enserink / Pierre Chymkowitch

    STAR Protocols, Vol 3, Iss 1, Pp 101210- (2022)

    2022  

    Abstract: Summary: FUS3 and STE2 expression levels can be used as reporters for signaling through the pheromone pathway in the budding yeast Saccharomyces cerevisiae. Here, we describe an optimized protocol to measure the expression levels of FUS3 and STE2 using ... ...

    Abstract Summary: FUS3 and STE2 expression levels can be used as reporters for signaling through the pheromone pathway in the budding yeast Saccharomyces cerevisiae. Here, we describe an optimized protocol to measure the expression levels of FUS3 and STE2 using quantitative reverse transcription PCR (RT-qPCR). We describe the steps for comparing untreated and pheromone-treated yeast cells and how to quantify the changes in various deletion strains. The protocol can be applied to determine potential regulators of the pheromone pathway.For complete details on the use and execution of this protocol, please refer to Garcia et al. (2021).
    Keywords Cell Biology ; Model Organisms ; Molecular Biology ; Gene Expression ; Signal Transduction ; Science (General) ; Q1-390
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Sumo and the cellular stress response.

    Enserink, Jorrit M

    Cell division

    2015  Volume 10, Page(s) 4

    Abstract: The ubiquitin family member Sumo has important functions in many cellular processes including DNA repair, transcription and cell division. Numerous studies have shown that Sumo is essential for maintaining cell homeostasis when the cell encounters ... ...

    Abstract The ubiquitin family member Sumo has important functions in many cellular processes including DNA repair, transcription and cell division. Numerous studies have shown that Sumo is essential for maintaining cell homeostasis when the cell encounters endogenous or environmental stress, such as osmotic stress, hypoxia, heat shock, genotoxic stress, and nutrient stress. Regulation of transcription is a key component of the Sumo stress response, and multiple mechanisms have been described by which Sumo can regulate transcription. Although many individual substrates have been described that are sumoylated during the Sumo stress response, an emerging concept is modification of entire complexes or pathways by Sumo. This review focuses on the function and regulation of Sumo during the stress response.
    Language English
    Publishing date 2015-06-20
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1747-1028
    ISSN 1747-1028
    DOI 10.1186/s13008-015-0010-1
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  10. Article ; Online: Pharmacologic Control of CAR T Cells

    Benjamin Caulier / Jorrit M. Enserink / Sébastien Wälchli

    International Journal of Molecular Sciences, Vol 22, Iss 4320, p

    2021  Volume 4320

    Abstract: Chimeric antigen receptor (CAR) therapy is a promising modality for the treatment of advanced cancers that are otherwise incurable. During the last decade, different centers worldwide have tested the anti-CD19 CAR T cells and shown clinical benefits in ... ...

    Abstract Chimeric antigen receptor (CAR) therapy is a promising modality for the treatment of advanced cancers that are otherwise incurable. During the last decade, different centers worldwide have tested the anti-CD19 CAR T cells and shown clinical benefits in the treatment of B cell tumors. However, despite these encouraging results, CAR treatment has also been found to lead to serious side effects and capricious response profiles in patients. In addition, the CD19 CAR success has been difficult to reproduce for other types of malignancy. The appearance of resistant tumor variants, the lack of antigen specificity, and the occurrence of severe adverse effects due to over-stimulation of the therapeutic cells have been identified as the major impediments. This has motivated a growing interest in developing strategies to overcome these hurdles through CAR control. Among them, the combination of small molecules and approved drugs with CAR T cells has been investigated. These have been exploited to induce a synergistic anti-cancer effect but also to control the presence of the CAR T cells or tune the therapeutic activity. In the present review, we discuss opportunistic and rational approaches involving drugs featuring anti-cancer efficacy and CAR-adjustable effect.
    Keywords chimeric antigen receptor ; small molecules ; drugs ; kinase inhibitors ; CAR T cell ; immunotherapy ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 380
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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