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Article: Regulation of the Muscarinic M

Liu, Li / Rippe, Catarina / Hansson, Ola / Kryvokhyzha, Dmytro / Fisher, Steven / Ekman, Mari / Swärd, Karl

2021 Volume 12, Page(s) 710968

Abstract: Myocardin-related transcription factors (MRTFs: myocardin/ ...

Abstract	Myocardin-related transcription factors (MRTFs: myocardin/
Language	English
Publishing date	2021-09-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2021.710968
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Article ; Online: Clinical and Preclinical Evidence for M

Smith, Mackenzie / Arthur, Bright / Cikowski, Jakub / Holt, Calista / Gonzalez, Sonia / Fisher, Nicole M / Vermudez, Sheryl Anne D / Lindsley, Craig W / Niswender, Colleen M / Gogliotti, Rocco G

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

2022 Volume 19, Issue 4, Page(s) 1340–1352

Abstract: ... from individuals with RTT and quantified significantly decreased levels of the M ...

Abstract	Rett syndrome (RTT) is a neurodevelopmental disorder that is characterized by developmental regression, loss of communicative ability, stereotyped hand wringing, cognitive impairment, and central apneas, among many other symptoms. RTT is caused by loss-of-function mutations in a methyl-reader known as methyl-CpG-binding protein 2 (MeCP2), a protein that links epigenetic changes on DNA to larger chromatin structure. Historically, target identification for RTT has relied heavily on Mecp2 knockout mice; however, we recently adopted the alternative approach of performing transcriptional profiling in autopsy samples from RTT patients. Through this mechanism, we identified muscarinic acetylcholine receptors (mAChRs) as potential therapeutic targets. Here, we characterized a cohort of 40 temporal cortex samples from individuals with RTT and quantified significantly decreased levels of the M
MeSH term(s)	Mice ; Animals ; Rett Syndrome/drug therapy ; Rett Syndrome/genetics ; Rett Syndrome/metabolism ; Methyl-CpG-Binding Protein 2/genetics ; Methyl-CpG-Binding Protein 2/metabolism ; Apnea ; Receptors, N-Methyl-D-Aspartate ; Glycogen Synthase Kinase 3 beta/genetics ; Glycogen Synthase Kinase 3 beta/metabolism ; Mice, Knockout ; Receptors, Muscarinic/genetics ; Receptors, Muscarinic/metabolism ; Chromatin
Chemical Substances	Methyl-CpG-Binding Protein 2 ; Receptors, N-Methyl-D-Aspartate ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; Receptors, Muscarinic ; Chromatin
Language	English
Publishing date	2022-06-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2316693-9
ISSN	1878-7479 ; 1933-7213
ISSN (online)	1878-7479
ISSN	1933-7213
DOI	10.1007/s13311-022-01254-3
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Article ; Online: Biased M

Moran, Sean P / Xiang, Zixiu / Doyle, Catherine A / Maksymetz, James / Lv, Xiaohui / Faltin, Sehr / Fisher, Nicole M / Niswender, Colleen M / Rook, Jerri M / Lindsley, Craig W / Conn, P Jeffrey

Science signaling

2019 Volume 12, Issue 610

Abstract: Highly selective, positive allosteric modulators (PAMs) of the M ...

Abstract	Highly selective, positive allosteric modulators (PAMs) of the M
MeSH term(s)	Allosteric Site ; Animals ; CHO Cells ; Calcium/chemistry ; Cerebral Cortex/enzymology ; Cognition ; Cricetinae ; Cricetulus ; Electrophysiology ; Female ; Humans ; Long-Term Synaptic Depression ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neuronal Plasticity ; Phospholipase D/genetics ; Phospholipase D/metabolism ; Prefrontal Cortex/enzymology ; Receptor, Muscarinic M1/genetics ; Receptor, Muscarinic M1/metabolism ; Signal Transduction ; Type C Phospholipases/metabolism
Chemical Substances	Receptor, Muscarinic M1 ; Type C Phospholipases (EC 3.1.4.-) ; Phospholipase D (EC 3.1.4.4) ; phospholipase D1 (EC 3.1.4.4) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2019-12-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2417226-1
ISSN	1937-9145 ; 1945-0877
ISSN (online)	1937-9145
ISSN	1945-0877
DOI	10.1126/scisignal.aax2057
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Article ; Online: Structure, dynamics, and molecular inhibition of the Staphylococcus aureus m

Sweeney, Pamela / Galliford, Ashleigh / Kumar, Abhishek / Raju, Dinesh / Krishna, Naveen B / Sutherland, Emmajay / Leo, Caitlin J / Fisher, Gemma / Lalitha, Roopa / Muthuraj, Likith / Sigamani, Gladstone / Oehler, Verena / Synowsky, Silvia / Shirran, Sally L / Gloster, Tracey M / Czekster, Clarissa M / Kumar, Pravin / da Silva, Rafael G

The Journal of biological chemistry

2022 Volume 298, Issue 6, Page(s) 102040

Abstract: The enzyme m ...

Abstract	The enzyme m
MeSH term(s)	Adenine ; Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; Crystallography, X-Ray ; Protein Conformation ; RNA, Transfer/metabolism ; S-Adenosylmethionine/metabolism ; Staphylococcus aureus/enzymology ; tRNA Methyltransferases/chemistry ; tRNA Methyltransferases/metabolism
Chemical Substances	Bacterial Proteins ; S-Adenosylmethionine (7LP2MPO46S) ; RNA, Transfer (9014-25-9) ; tRNA Methyltransferases (EC 2.1.1.-) ; Adenine (JAC85A2161)
Language	English
Publishing date	2022-05-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2022.102040
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Article ; Online: In vivo cardiopulmonary impact of skeletal M

Vincent, Sandra G / Fisher, John T

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology

2021 Volume 191, Issue 6, Page(s) 1059–1070

Abstract: The muscarinic M ...

Abstract	The muscarinic M
MeSH term(s)	Animals ; Locomotion ; Mice ; Pilot Projects ; Receptors, G-Protein-Coupled ; Signal Transduction
Chemical Substances	Receptors, G-Protein-Coupled
Language	English
Publishing date	2021-07-16
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	231245-1
ISSN	1432-136X ; 0174-1578
ISSN (online)	1432-136X
ISSN	0174-1578
DOI	10.1007/s00360-021-01387-5
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Article ; Online: Characterisation of the temperature-dependent M

Miao, Lei / Peng, Ying / Wang, Dianhui / Liang, Jihui / Hu, Chaohao / Nishibori, Eiji / Sun, Lixian / Fisher, Craig A J / Tanemura, Sakae

Physical chemistry chemical physics : PCCP

2020 Volume 22, Issue 15, Page(s) 7984–7994

Abstract: Understanding the mechanism of the insulator-metal transition (IMT) in VO2 is a necessary step in optimising this material's properties for a range of functional applications. Here, Rietveld refinement of synchrotron X-ray powder diffraction patterns is ... ...

Abstract	Understanding the mechanism of the insulator-metal transition (IMT) in VO2 is a necessary step in optimising this material's properties for a range of functional applications. Here, Rietveld refinement of synchrotron X-ray powder diffraction patterns is performed on thermochromic V1-xWxO2 (0.0 ≤ x ≤ 0.02) nanorod aggregates over the temperature range 100 ≤ T ≤ 400 K to examine the effect of doping on the structure and properties of the insulating monoclinic (M1) phase and metallic rutile (R) phase. Precise measurement of the lattice constants of the M1 and R phases enabled the onset (Ton) and endset (Tend) temperatures of the IMT to be determined accurately for different dopant levels. First-principles calculations reveal that the observed decrease in both Ton and Tend with increasing W content is a result of Peierls type V-O-V dimers being replaced by linear W-O-V dimers with a narrowing of the band gap. The results are interpreted in terms of the bandwidth-controlled Mott-Hubbard IMT model, providing a more detailed understanding of the underlying physical mechanisms driving the IMT as well as a guide to optimising properties of VO2-based materials for specific applications.
Language	English
Publishing date	2020-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d0cp01058h
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Article ; Online: Reply to M. Sorigue et al.

MacManus, Michael / Fisher, Richard / McClure, Bev / Seymour, John F

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2018 Volume 37, Issue 3, Page(s) 257–258

MeSH term(s)	Humans ; Lymphoma, Follicular
Language	English
Publishing date	2018-11-26
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.2018.18.01309
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Article ; Online: GW190521: A Binary Black Hole Merger with a Total Mass of 150 M_{⊙}.

Abbott, R / Abbott, T D / Abraham, S / Acernese, F / Ackley, K / Adams, C / Adhikari, R X / Adya, V B / Affeldt, C / Agathos, M / Agatsuma, K / Aggarwal, N / Aguiar, O D / Aich, A / Aiello, L / Ain, A / Ajith, P / Akcay, S / Allen, G /

Allocca, A / Altin, P A / Amato, A / Anand, S / Ananyeva, A / Anderson, S B / Anderson, W G / Angelova, S V / Ansoldi, S / Antier, S / Appert, S / Arai, K / Araya, M C / Areeda, J S / Arène, M / Arnaud, N / Aronson, S M / Arun, K G / Asali, Y / Ascenzi, S / Ashton, G / Aston, S M / Astone, P / Aubin, F / Aufmuth, P / AultONeal, K / Austin, C / Avendano, V / Babak, S / Bacon, P / Badaracco, F / Bader, M K M / Bae, S / Baer, A M / Baird, J / Baldaccini, F / Ballardin, G / Ballmer, S W / Bals, A / Balsamo, A / Baltus, G / Banagiri, S / Bankar, D / Bankar, R S / Barayoga, J C / Barbieri, C / Barish, B C / Barker, D / Barkett, K / Barneo, P / Barone, F / Barr, B / Barsotti, L / Barsuglia, M / Barta, D / Bartlett, J / Bartos, I / Bassiri, R / Basti, A / Bawaj, M / Bayley, J C / Bazzan, M / Bécsy, B / Bejger, M / Belahcene, I / Bell, A S / Beniwal, D / Benjamin, M G / Bentley, J D / Bergamin, F / Berger, B K / Bergmann, G / Bernuzzi, S / Berry, C P L / Bersanetti, D / Bertolini, A / Betzwieser, J / Bhandare, R / Bhandari, A V / Bidler, J / Biggs, E / Bilenko, I A / Billingsley, G / Birney, R / Birnholtz, O / Biscans, S / Bischi, M / Biscoveanu, S / Bisht, A / Bissenbayeva, G / Bitossi, M / Bizouard, M A / Blackburn, J K / Blackman, J / Blair, C D / Blair, D G / Blair, R M / Bobba, F / Bode, N / Boer, M / Boetzel, Y / Bogaert, G / Bondu, F / Bonilla, E / Bonnand, R / Booker, P / Boom, B A / Bork, R / Boschi, V / Bose, S / Bossilkov, V / Bosveld, J / Bouffanais, Y / Bozzi, A / Bradaschia, C / Brady, P R / Bramley, A / Branchesi, M / Brau, J E / Breschi, M / Briant, T / Briggs, J H / Brighenti, F / Brillet, A / Brinkmann, M / Brockill, P / Brooks, A F / Brooks, J / Brown, D D / Brunett, S / Bruno, G / Bruntz, R / Buikema, A / Bulik, T / Bulten, H J / Buonanno, A / Buscicchio, R / Buskulic, D / Byer, R L / Cabero, M / Cadonati, L / Cagnoli, G / Cahillane, C / Calderón Bustillo, J / Callaghan, J D / Callister, T A / Calloni, E / Camp, J B / Canepa, M / Cannon, K C / Cao, H / Cao, J / Carapella, G / Carbognani, F / Caride, S / Carney, M F / Carullo, G / Casanueva Diaz, J / Casentini, C / Castañeda, J / Caudill, S / Cavaglià, M / Cavalier, F / Cavalieri, R / Cella, G / Cerdá-Durán, P / Cesarini, E / Chaibi, O / Chakravarti, K / Chan, C / Chan, M / Chandra, K / Chao, S / Charlton, P / Chase, E A / Chassande-Mottin, E / Chatterjee, D / Chaturvedi, M / Chatziioannou, K / Chen, H Y / Chen, X / Chen, Y / Cheng, H-P / Cheong, C K / Chia, H Y / Chiadini, F / Chierici, R / Chincarini, A / Chiummo, A / Cho, G / Cho, H S / Cho, M / Christensen, N / Chu, Q / Chua, S / Chung, K W / Chung, S / Ciani, G / Ciecielag, P / Cieślar, M / Ciobanu, A A / Ciolfi, R / Cipriano, F / Cirone, A / Clara, F / Clark, J A / Clearwater, P / Clesse, S / Cleva, F / Coccia, E / Cohadon, P-F / Cohen, D / Colleoni, M / Collette, C G / Collins, C / Colpi, M / Constancio, M / Conti, L / Cooper, S J / Corban, P / Corbitt, T R / Cordero-Carrión, I / Corezzi, S / Corley, K R / Cornish, N / Corre, D / Corsi, A / Cortese, S / Costa, C A / Cotesta, R / Coughlin, M W / Coughlin, S B / Coulon, J-P / Countryman, S T / Couvares, P / Covas, P B / Coward, D M / Cowart, M J / Coyne, D C / Coyne, R / Creighton, J D E / Creighton, T D / Cripe, J / Croquette, M / Crowder, S G / Cudell, J-R / Cullen, T J / Cumming, A / Cummings, R / Cunningham, L / Cuoco, E / Curylo, M / Canton, T Dal / Dálya, G / Dana, A / Daneshgaran-Bajastani, L M / D'Angelo, B / Danilishin, S L / D'Antonio, S / Danzmann, K / Darsow-Fromm, C / Dasgupta, A / Datrier, L E H / Dattilo, V / Dave, I / Davier, M / Davies, G S / Davis, D / Daw, E J / DeBra, D / Deenadayalan, M / Degallaix, J / De Laurentis, M / Deléglise, S / Delfavero, M / De Lillo, N / Del Pozzo, W / DeMarchi, L M / D'Emilio, V / Demos, N / Dent, T / De Pietri, R / De Rosa, R / De Rossi, C / DeSalvo, R / de Varona, O / Dhurandhar, S / Díaz, M C / Diaz-Ortiz, M / Dietrich, T / Di Fiore, L / Di Fronzo, C / Di Giorgio, C / Di Giovanni, F / Di Giovanni, M / Di Girolamo, T / Di Lieto, A / Ding, B / Di Pace, S / Di Palma, I / Di Renzo, F / Divakarla, A K / Dmitriev, A / Doctor, Z / Donovan, F / Dooley, K L / Doravari, S / Dorrington, I / Downes, T P / Drago, M / Driggers, J C / Du, Z / Ducoin, J-G / Dupej, P / Durante, O / D'Urso, D / Dwyer, S E / Easter, P J / Eddolls, G / Edelman, B / Edo, T B / Edy, O / Effler, A / Ehrens, P / Eichholz, J / Eikenberry, S S / Eisenmann, M / Eisenstein, R A / Ejlli, A / Errico, L / Essick, R C / Estelles, H / Estevez, D / Etienne, Z B / Etzel, T / Evans, M / Evans, T M / Ewing, B E / Fafone, V / Fairhurst, S / Fan, X / Farinon, S / Farr, B / Farr, W M / Fauchon-Jones, E J / Favata, M / Fays, M / Fazio, M / Feicht, J / Fejer, M M / Feng, F / Fenyvesi, E / Ferguson, D L / Fernandez-Galiana, A / Ferrante, I / Ferreira, E C / Ferreira, T A / Fidecaro, F / Fiori, I / Fiorucci, D / Fishbach, M / Fisher, R P / Fittipaldi, R / Fitz-Axen, M / Fiumara, V / Flaminio, R / Floden, E / Flynn, E / Fong, H / Font, J A / Forsyth, P W F / Fournier, J-D / Frasca, S / Frasconi, F / Frei, Z / Freise, A / Frey, R / Frey, V / Fritschel, P / Frolov, V V / Fronzè, G / Fulda, P / Fyffe, M / Gabbard, H A / Gadre, B U / Gaebel, S M / Gair, J R / Galaudage, S / Ganapathy, D / Ganguly, A / Gaonkar, S G / García-Quirós, C / Garufi, F / Gateley, B / Gaudio, S / Gayathri, V / Gemme, G / Genin, E / Gennai, A / George, D / George, J / Gergely, L / Ghonge, S / Ghosh, Abhirup / Ghosh, Archisman / Ghosh, S / Giacomazzo, B / Giaime, J A / Giardina, K D / Gibson, D R / Gier, C / Gill, K / Glanzer, J / Gniesmer, J / Godwin, P / Goetz, E / Goetz, R / Gohlke, N / Goncharov, B / González, G / Gopakumar, A / Gossan, S E / Gosselin, M / Gouaty, R / Grace, B / Grado, A / Granata, M / Grant, A / Gras, S / Grassia, P / Gray, C / Gray, R / Greco, G / Green, A C / Green, R / Gretarsson, E M / Griggs, H L / Grignani, G / Grimaldi, A / Grimm, S J / Grote, H / Grunewald, S / Gruning, P / Guidi, G M / Guimaraes, A R / Guixé, G / Gulati, H K / Guo, Y / Gupta, A / Gupta, Anchal / Gupta, P / Gustafson, E K / Gustafson, R / Haegel, L / Halim, O / Hall, E D / Hamilton, E Z / Hammond, G / Haney, M / Hanke, M M / Hanks, J / Hanna, C / Hannam, M D / Hannuksela, O A / Hansen, T J / Hanson, J / Harder, T / Hardwick, T / Haris, K / Harms, J / Harry, G M / Harry, I W / Hasskew, R K / Haster, C-J / Haughian, K / Hayes, F J / Healy, J / Heidmann, A / Heintze, M C / Heinze, J / Heitmann, H / Hellman, F / Hello, P / Hemming, G / Hendry, M / Heng, I S / Hennes, E / Hennig, J / Heurs, M / Hild, S / Hinderer, T / Hoback, S Y / Hochheim, S / Hofgard, E / Hofman, D / Holgado, A M / Holland, N A / Holt, K / Holz, D E / Hopkins, P / Horst, C / Hough, J / Howell, E J / Hoy, C G / Huang, Y / Hübner, M T / Huerta, E A / Huet, D / Hughey, B / Hui, V / Husa, S / Huttner, S H / Huxford, R / Huynh-Dinh, T / Idzkowski, B / Iess, A / Inchauspe, H / Ingram, C / Intini, G / Isac, J-M / Isi, M / Iyer, B R / Jacqmin, T / Jadhav, S J / Jadhav, S P / James, A L / Jani, K / Janthalur, N N / Jaranowski, P / Jariwala, D / Jaume, R / Jenkins, A C / Jiang, J / Johns, G R / Johnson-McDaniel, N K / Jones, A W / Jones, D I / Jones, J D / Jones, P / Jones, R / Jonker, R J G / Ju, L / Junker, J / Kalaghatgi, C V / Kalogera, V / Kamai, B / Kandhasamy, S / Kang, G / Kanner, J B / Kapadia, S J / Karki, S / Kashyap, R / Kasprzack, M / Kastaun, W / Katsanevas, S / Katsavounidis, E / Katzman, W / Kaufer, S / Kawabe, K / Kéfélian, F / Keitel, D / Keivani, A / Kennedy, R / Key, J S / Khadka, S / Khalili, F Y / Khan, I / Khan, S / Khan, Z A / Khazanov, E A / Khetan, N / Khursheed, M / Kijbunchoo, N / Kim, Chunglee / Kim, G J / Kim, J C / Kim, K / Kim, W / Kim, W S / Kim, Y-M / Kimball, C / King, P J / Kinley-Hanlon, M / Kirchhoff, R / Kissel, J S / Kleybolte, L / Klimenko, S / Knowles, T D / Knyazev, E / Koch, P / Koehlenbeck, S M / Koekoek, G / Koley, S / Kondrashov, V / Kontos, A / Koper, N / Korobko, M / Korth, W Z / Kovalam, M / Kozak, D B / Kringel, V / Krishnendu, N V / Królak, A / Krupinski, N / Kuehn, G / Kumar, A / Kumar, P / Kumar, Rahul / Kumar, Rakesh / Kumar, S / Kuo, L / Kutynia, A / Lackey, B D / Laghi, D / Lalande, E / Lam, T L / Lamberts, A / Landry, M / Lane, B B / Lang, R N / Lange, J / Lantz, B / Lanza, R K / La Rosa, I / Lartaux-Vollard, A / Lasky, P D / Laxen, M / Lazzarini, A / Lazzaro, C / Leaci, P / Leavey, S / Lecoeuche, Y K / Lee, C H / Lee, H M / Lee, H W / Lee, J / Lee, K / Lehmann, J / Leroy, N / Letendre, N / Levin, Y / Li, A K Y / Li, J / Li, K / Li, T G F / Li, X / Linde, F / Linker, S D / Linley, J N / Littenberg, T B / Liu, J / Liu, X / Llorens-Monteagudo, M / Lo, R K L / Lockwood, A / London, L T / Longo, A / Lorenzini, M / Loriette, V / Lormand, M / Losurdo, G / Lough, J D / Lousto, C O / Lovelace, G / Lück, H / Lumaca, D / Lundgren, A P / Ma, Y / Macas, R / Macfoy, S / MacInnis, M / Macleod, D M / MacMillan, I A O / Macquet, A / Magaña Hernandez, I / Magaña-Sandoval, F / Magee, R M / Majorana, E / Maksimovic, I / Malik, A / Man, N / Mandic, V / Mangano, V / Mansell, G L / Manske, M / Mantovani, M / Mapelli, M / Marchesoni, F / Marion, F / Márka, S / Márka, Z / Markakis, C / Markosyan, A S / Markowitz, A / Maros, E / Marquina, A / Marsat, S / Martelli, F / Martin, I W / Martin, R M / Martinez, V / Martynov, D V / Masalehdan, H / Mason, K / Massera, E / Masserot, A / Massinger, T J / Masso-Reid, M / Mastrogiovanni, S / Matas, A / Matichard, F / Mavalvala, N / Maynard, E / McCann, J J / McCarthy, R / McClelland, D E / McCormick, S / McCuller, L / McGuire, S C / McIsaac, C / McIver, J / McManus, D J / McRae, T / McWilliams, S T / Meacher, D / Meadors, G D / Mehmet, M / Mehta, A K / Mejuto Villa, E / Melatos, A / Mendell, G / Mercer, R A / Mereni, L / Merfeld, K / Merilh, E L / Merritt, J D / Merzougui, M / Meshkov, S / Messenger, C / Messick, C / Metzdorff, R / Meyers, P M / Meylahn, F / Mhaske, A / Miani, A / Miao, H / Michaloliakos, I / Michel, C / Middleton, H / Milano, L / 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Physical review letters

2021 Volume 125, Issue 10, Page(s) 101102

Abstract: ... with masses of 85_{-14}^{+21} M_{⊙} and 66_{-18}^{+17} M_{⊙} (90% credible intervals). We infer ... with only a 0.32% probability of being below 65 M_{⊙}. We calculate the mass of the remnant to be 142_{-16 ... 28} M_{⊙}, which can be considered an intermediate mass black hole (IMBH). The luminosity distance ...

Abstract	On May 21, 2019 at 03:02:29 UTC Advanced LIGO and Advanced Virgo observed a short duration gravitational-wave signal, GW190521, with a three-detector network signal-to-noise ratio of 14.7, and an estimated false-alarm rate of 1 in 4900 yr using a search sensitive to generic transients. If GW190521 is from a quasicircular binary inspiral, then the detected signal is consistent with the merger of two black holes with masses of 85_{-14}^{+21} M_{⊙} and 66_{-18}^{+17} M_{⊙} (90% credible intervals). We infer that the primary black hole mass lies within the gap produced by (pulsational) pair-instability supernova processes, with only a 0.32% probability of being below 65 M_{⊙}. We calculate the mass of the remnant to be 142_{-16}^{+28} M_{⊙}, which can be considered an intermediate mass black hole (IMBH). The luminosity distance of the source is 5.3_{-2.6}^{+2.4} Gpc, corresponding to a redshift of 0.82_{-0.34}^{+0.28}. The inferred rate of mergers similar to GW190521 is 0.13_{-0.11}^{+0.30} Gpc^{-3} yr^{-1}.
Language	English
Publishing date	2021-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.125.101102
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Article ; Online: BCG-mediated protection against M. tuberculosis is sustained post-malaria infection independent of parasite virulence.

Tangie, Emily / Walters, Avril / Hsu, Nai-Jen / Fisher, Michelle / Magez, Stefan / Jacobs, Muazzam / Keeton, Roanne

Immunology

2021 Volume 165, Issue 2, Page(s) 219–233

Abstract: ... on B cells, effector and memory T cells, and the outcome on BCG-induced efficacy against M. tuberculosis ... not significantly alter the ability of the BCG vaccine to inhibit the growth of M. tuberculosis ...

Abstract	Tuberculosis (TB) and malaria remain serious threats to global health. Bacillus Calmette-Guerin (BCG), the only licensed vaccine against TB protects against severe disseminated forms of TB in infants but shows poor efficacy against pulmonary TB in adults. Co-infections have been reported as one of the factors implicated in vaccine inefficacy. Given the geographical overlap of malaria and TB in areas where BCG vaccination is routinely administered, we hypothesized that virulence-dependent co-infection with Plasmodium species could alter the BCG-specific immune responses thus resulting in failure to protect against Mycobacterium tuberculosis. We compared virulent Plasmodium berghei and non-virulent Plasmodium chabaudi, their effects on B cells, effector and memory T cells, and the outcome on BCG-induced efficacy against M. tuberculosis infection. We demonstrate that malaria co-infection modulates both B- and T-cell immune responses but does not significantly alter the ability of the BCG vaccine to inhibit the growth of M. tuberculosis irrespective of parasite virulence. This malaria-driven immune regulation may have serious consequences in the early clinical trials of novel vaccines, which rely on vaccine-specific T-cell responses to screen novel vaccines for progression to the more costly vaccine efficacy trials.
MeSH term(s)	Animals ; Apoptosis ; BCG Vaccine/immunology ; CD4 Lymphocyte Count ; Disease Models, Animal ; Female ; Host-Parasite Interactions/immunology ; Host-Pathogen Interactions/immunology ; Humans ; Immunogenicity, Vaccine ; Malaria/immunology ; Malaria/parasitology ; Memory T Cells/immunology ; Memory T Cells/metabolism ; Mice ; Mycobacterium tuberculosis/immunology ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Tuberculosis/prevention & control ; Tuberculosis Vaccines/immunology ; Tuberculosis, Pulmonary/prevention & control ; Vaccination
Chemical Substances	BCG Vaccine ; Tuberculosis Vaccines
Language	English
Publishing date	2021-12-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80124-0
ISSN	1365-2567 ; 0019-2805 ; 0953-4954
ISSN (online)	1365-2567
ISSN	0019-2805 ; 0953-4954
DOI	10.1111/imm.13431
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Article ; Online: Carcinogen 4-Nitroquinoline Oxide (4-NQO) Induces Oncostatin-M (OSM) in Esophageal Cells.

Mukherjee, Amitava / Epperly, Michael W / Fisher, Renee / Shields, Donna / Hou, Wen / Pennathur, Arjun / Luketich, James / Wang, Hong / Greenberger, Joel S

In vivo (Athens, Greece)

2023 Volume 37, Issue 2, Page(s) 506–518

Abstract: ... by luciferase imaging of p16: Results: A significant increase in the levels of RNA for oncostatin-M was found ...

Abstract	Background/aim: The earliest cellular and molecular biologic changes in the esophagus that lead to esophageal cancer were evaluated in a mouse model. We correlated numbers of senescent cells with the levels of expression of potentially carcinogenic genes in sorted side population (SP) cells containing esophageal stem cells and non-stem cells in the non-side population cells in the 4-nitroquinolone oxide (NQO)-treated esophagus. Materials and methods: We compared stem cells with non-stem cells from the esophagus of mice treated with the chemical carcinogen 4-NQO (100 μg/ml) in drinking water. We also compared gene expression in human esophagus samples treated with 4-NQO (100 μg/ml media) to non-treated samples. We separated and quantitated the relative levels of expression of RNA using RNAseq analysis. We identified senescent cells by luciferase imaging of p16 Results: A significant increase in the levels of RNA for oncostatin-M was found in senescent cells of the esophagus from 4-NQO-treated mice and human esophagus in vitro. Conclusion: Induction of OSM in chemically-induced esophageal cancer in mice correlates with the appearance of senescent cells.
MeSH term(s)	Humans ; Animals ; Mice ; Carcinogens ; Oxides ; Mutagens ; Esophageal Neoplasms/chemically induced ; Esophageal Neoplasms/genetics ; Nitroquinolines ; RNA ; Oncostatin M
Chemical Substances	Carcinogens ; Oxides ; Mutagens ; Nitroquinolines ; RNA (63231-63-0) ; OSM protein, human ; Oncostatin M (106956-32-5)
Language	English
Publishing date	2023-03-07
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.13108
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