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Article ; Online: Synthesis of cyclopent-1-enecarbonitriles

Moczulski, Marek / Deredas, Dariusz / Kuśmierek, Elżbieta / Albrecht, Łukasz / Albrecht, Anna

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 29, Page(s) 4372–4375

Abstract: In the manuscript, a novel method for the preparation of cyclopent-1- ... ...

Abstract	In the manuscript, a novel method for the preparation of cyclopent-1-enecarbonitriles
Language	English
Publishing date	2023-04-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d2cc06543f
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Article: Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation.

Frydrysiak, Marlena / Pachniak, Paulina / Krysicka, Anna / Moczulski, Dariusz

Clinical case reports

2023 Volume 11, Issue 6, Page(s) e7284

Abstract: Key clinical message: Lupus anticoagulant caused aPTT prolongation in rare case can cause bleeding tendency especially when combined with other hemostasis abnormalities. In such cases, aPTT value can be corrected by immunosuppressants within several ... ...

Abstract	Key clinical message: Lupus anticoagulant caused aPTT prolongation in rare case can cause bleeding tendency especially when combined with other hemostasis abnormalities. In such cases, aPTT value can be corrected by immunosuppressants within several days of treatment. When anticoagulation therapy is needed vitamin K antagonist are a good option for the initial treatment. Abstract: Lupus anticoagulant antibodies despite causing aPTT prolongation are commonly associated with increased risk of thrombosis. We present a rare case of patient when these autoantibodies resulted in dramatic aPTT prolongation and combined with associated thrombocytopenia resulted in minor bleeding events. In presented case treatment with oral steroids resulted in aPTT values correction followed by resolution of bleeding tendency within several days. Later, the patient developed chronic atrial fibrillation and was started on anticoagulation treatment initially with vitamin K antagonist without bleeding complications during follow-up period. Corresponding changes in patient's aPTT time in a course of whole treatment is presented.
Language	English
Publishing date	2023-06-07
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.7284
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Article ; Online: Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation

Marlena Frydrysiak / Paulina Pachniak / Anna Krysicka / Dariusz Moczulski

Clinical Case Reports, Vol 11, Iss 6, Pp n/a-n/a (2023)

2023

Abstract: Key Clinical Message Lupus anticoagulant caused aPTT prolongation in rare case can cause bleeding tendency especially when combined with other hemostasis abnormalities. In such cases, aPTT value can be corrected by immunosuppressants within several days ... ...

Abstract	Key Clinical Message Lupus anticoagulant caused aPTT prolongation in rare case can cause bleeding tendency especially when combined with other hemostasis abnormalities. In such cases, aPTT value can be corrected by immunosuppressants within several days of treatment. When anticoagulation therapy is needed vitamin K antagonist are a good option for the initial treatment. Abstract Lupus anticoagulant antibodies despite causing aPTT prolongation are commonly associated with increased risk of thrombosis. We present a rare case of patient when these autoantibodies resulted in dramatic aPTT prolongation and combined with associated thrombocytopenia resulted in minor bleeding events. In presented case treatment with oral steroids resulted in aPTT values correction followed by resolution of bleeding tendency within several days. Later, the patient developed chronic atrial fibrillation and was started on anticoagulation treatment initially with vitamin K antagonist without bleeding complications during follow‐up period. Corresponding changes in patient's aPTT time in a course of whole treatment is presented.
Keywords	aPTT prolongation ; bleeding ; case report ; lupus anticoagulant ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
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Article ; Online: No evidence for change in expression of

Kępczyński, Łukasz / Wcisło, Szymon / Korzeniewska-Dyl, Irmina / Połatyńska, Katarzyna / Gach, Agnieszka / Moczulski, Dariusz

Adipocyte

2021 Volume 10, Issue 1, Page(s) 153–159

Abstract: TBC1D1 and TBC1D4 proteins play analogous, but not identical role in governing insulin-signalling pathway. Little is known about changes in expression levels ... ...

Abstract	TBC1D1 and TBC1D4 proteins play analogous, but not identical role in governing insulin-signalling pathway. Little is known about changes in expression levels of
MeSH term(s)	Adipocytes/drug effects ; Adipocytes/metabolism ; Adipokines/pharmacology ; Cells, Cultured ; Cytokines/pharmacology ; GTPase-Activating Proteins/genetics ; GTPase-Activating Proteins/metabolism ; Gene Expression Profiling ; Humans
Chemical Substances	Adipokines ; Cytokines ; GTPase-Activating Proteins ; TBC1D1 protein, human ; TBC1D4 protein, human
Language	English
Publishing date	2021-03-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2162-397X
ISSN (online)	2162-397X
DOI	10.1080/21623945.2021.1900497
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Article: Assessment of cardiovascular risk in patients with metabolic syndrome working in the agricultural sector.

Godala, Małgorzata / Moczulski, Dariusz / Maślach, Dominik / Materek-Kuśmierkiewicz, Izabela / Gaszyńska, Ewelina

Przeglad epidemiologiczny

2021 Volume 75, Issue 1, Page(s) 108–118

Abstract: Introduction: Cardiovascular diseases are the main death cause in Poland. Several clinical studies showed association between metabolic syndrome and higher prevalence of diabetes mellitus, cardiac events and mortality. The aim of the study was to ... ...

Abstract	Introduction: Cardiovascular diseases are the main death cause in Poland. Several clinical studies showed association between metabolic syndrome and higher prevalence of diabetes mellitus, cardiac events and mortality. The aim of the study was to estimate cardiovascular complications and death risk in subjects with metabolic syndrome (MS) working in agriculture. Material and methods: The study included 332 people working in agriculture in Lodz voivodeship, 231 with MS and 101 healthy ones. Increased risk of cardiovascular complications was determined for pulse pressure (pp) >63 mmHg. Based on the SCORE index, 10-year death risk due to cardiovascular complications was estimated taking into account sex, age, smoking, systolic blood pressure and total cholesterol concentration. A value ≥5% was accepted as high risk of death within 10 years. Results: Increased risk of cardiovascular complications (pulse pressure >63 mmHg) was found in 31.60% subjects with MS and 6.93% healthy ones. Conclusions: High risk of cardiovascular complications and death occurs statistically more frequently in subjects with MS than in the rest of the population.
MeSH term(s)	Agriculture ; Cardiovascular Diseases/epidemiology ; Heart Disease Risk Factors ; Humans ; Metabolic Syndrome/epidemiology ; Poland/epidemiology ; Risk Assessment ; Risk Factors
Language	English
Publishing date	2021-08-02
Publishing country	Poland
Document type	Journal Article
ZDB-ID	421782-2
ISSN	0033-2100
ISSN	0033-2100
DOI	10.32394/pe.75.11
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Article ; Online: Association of chemotactic cytokine receptor 5 (CCR5) gene polymorphism (59029 A/G, rs1799987) with diabetic kidney disease in patients with type 2 diabetes from Poland.

Pokrzywnicka, Patrycja / Kwiendacz, Hanna / Nabrdalik, Katarzyna / Hajzler, Weronika / Adamczyk, Piotr / Moczulski, Dariusz / Trautsolt, Wanda / Grzeszczak, Władysław / Gumprecht, Janusz

Endokrynologia Polska

2022 Volume 73, Issue 1, Page(s) 103–109

Abstract: Introduction: Diabetic kidney disease (DKD) pathogenesis is multifactorial and is a combination of metabolic, genetic, and environmental factors. Due to a long period of asymptomatic course, it is often diagnosed late when advanced stages of the disease ...

Abstract	Introduction: Diabetic kidney disease (DKD) pathogenesis is multifactorial and is a combination of metabolic, genetic, and environmental factors. Due to a long period of asymptomatic course, it is often diagnosed late when advanced stages of the disease are present. Among patients with diabetes, the presence of chemotactic cytokine receptor 5 (CCR5) gene polymorphism is suspected to be associated with the risk of DKD occurrence; however, the results of the research conducted so far are inconclusive. The aim of this study was to evaluate the CCR5 gene polymorphism (rs1799987, 59029 A/G) association with DKD among patients with type 2 diabetes mellitus (T2DM), who are residents of the Upper Silesia region of Poland. Material and methods: CCR5 gene polymorphism (rs1799987, 59029 A/G) was assessed among consecutive patients with type 2 diabetes mellitus (T2DM) treated in a single outpatient diabetology clinic in Upper Silesia, Poland. Its association with DKD was examined. Additionally, selected clinical and demographic data were included in the analysis. Results: Among 467 eligible study patients, there was no association between examined CCR5 gene polymorphism and the presence of DKD in relation both to the American Diabetes Association definition (p = 0.6) and to the National Kidney Foundation definition (p = 0.3) of this complication. Conclusion: The presented study did not confirm the association between the examined gene polymorphism and the risk of DKD; further studies in this area are needed in order to establish or explicitly exclude this association.
MeSH term(s)	Chemokines ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/genetics ; Diabetic Nephropathies/genetics ; Humans ; Poland ; Polymorphism, Genetic ; Receptors, CCR5/genetics
Chemical Substances	CCR5 protein, human ; Chemokines ; Receptors, CCR5
Language	English
Publishing date	2022-02-04
Publishing country	Poland
Document type	Journal Article
ZDB-ID	419270-9
ISSN	2299-8306 ; 0423-104X
ISSN (online)	2299-8306
ISSN	0423-104X
DOI	10.5603/EP.a2022.0001
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Article ; Online: Interleukin 1

Brzoza, Zenon / Rymarczyk, Barbara / Grzeszczak, Wladyslaw / Trautsolt, Wanda / Pluta-Kubicz, Marzena / Moczulski, Dariusz

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

2020 Volume 40, Issue 10, Page(s) 497–500

Abstract: Recent studies underline a potential role of autoimmune and genetic disturbances in this disorder pathogenesis. Variants in genes related to inflammatory processes may possibly predispose to chronic spontaneous urticaria (CSU) occurrence. The objective ... ...

Abstract	Recent studies underline a potential role of autoimmune and genetic disturbances in this disorder pathogenesis. Variants in genes related to inflammatory processes may possibly predispose to chronic spontaneous urticaria (CSU) occurrence. The objective of this study was to search for an association of
MeSH term(s)	Adult ; Age of Onset ; Alleles ; Chronic Urticaria/genetics ; Female ; Genotype ; Haplotypes ; Humans ; Interleukin-1/genetics ; Male ; Middle Aged ; Polymorphism, Genetic ; Young Adult
Chemical Substances	Interleukin-1
Language	English
Publishing date	2020-10-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1226675-9
ISSN	1557-7465 ; 1079-9907
ISSN (online)	1557-7465
ISSN	1079-9907
DOI	10.1089/jir.2020.0103
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Article ; Online: An assessment of the antioxidant vitamins concentration in people with metabolic syndrome working in agriculture

Małgorzata Godala / Ewelina Gaszyńska / Dariusz Moczulski / Izabela Materek-Kuśmierkiewicz / Michalina Krzyżak

Medycyna Pracy, Vol 72, Iss 2, Pp 123-

2021 Volume 129

Abstract: Background Vitamins A, C and E are important parts of the antioxidant barrier. Polish data on antioxidant vitamins deficiency in the population are rare, especially among physically active people with metabolic disorders. The aim of this study was to ... ...

Abstract	Background Vitamins A, C and E are important parts of the antioxidant barrier. Polish data on antioxidant vitamins deficiency in the population are rare, especially among physically active people with metabolic disorders. The aim of this study was to evaluate the serum concentrations of vitamins A, C and E in people with metabolic syndrome (MS) working in agriculture, the prevalence of their deficiency in these workers, and the correlation between antioxidant vitamins concentration and traditional biomarkers of cardiovascular diseases. Material and Methods The study included 332 residents of the Łódź Voivodeship working in agriculture: 231 people with MS and 101 healthy ones. The serum concentrations of vitamins A, C and E were assessed using the chemiluminescent immunoassay technology. The antioxidant vitamins intake was assessed by means of a 24-h recall questionnaire using Diet 5.0 software. Results The mean serum concentrations of vitamins A, C and E were significantly lower in the MS workers than in the healthy ones No correlation was found between the antioxidant vitamins concentration and the dietary intake but there was a correlation between the antioxidant vitamins concentration and high-density lipoprotein cholesterol (HDL-C). A correlation was found between the serum concentrations of vitamins A and C, and vitamins A and E, in the MS workers. Conclusions The serum concentrations of antioxidant vitamins in the MS workers were significantly lower than in the healthy controls, despite the similar physical activity level. The dietary intake had no impact on the serum concentrations of these vitamins. The HDL-C concentration in the MS workers correlated with the concentrations of all antioxidant vitamins. Med Pr. 2021;72(2):123–9
Keywords	metabolic syndrome ; deficiency ; agriculture ; vitamin a ; vitamin c ; vitamin e ; Public aspects of medicine ; RA1-1270
Subject code	630
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Nofer Institute of Occupational Medicine
Document type	Article ; Online
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Article ; Online: Assessment of 25(OH)D concentration in people with metabolic syndrome working in agriculture

Małgorzata Godala / Ewelina Gaszyńska / Dariusz Moczulski / Izabela Materek-Kuśmierkiewicz / Michalina Krzyżak

Medycyna Pracy, Vol 72, Iss 1, Pp 9-

2021 Volume 18

Abstract: Background Polish data on vitamin D deficiency in the population are incomplete. Vitamin D deficiency seems to be common, but there is a lack of studies concerning the concentration of 25(OH)D in people with high UV exposure. The aim of this study was to ...

Abstract	Background Polish data on vitamin D deficiency in the population are incomplete. Vitamin D deficiency seems to be common, but there is a lack of studies concerning the concentration of 25(OH)D in people with high UV exposure. The aim of this study was to evaluate the plasma concentration of 25(OH)D in people with and without metabolic syndrome (MS), working in agriculture, the prevalence of its deficiency in these workers, and the correlation between the plasma concentration of 25(OH)D and traditional biomarkers of cardiovascular diseases. Material and Methods The study included 332 people working in agriculture in the Łódź voivodeship, including 231 people with MS and 101 healthy ones. The plasma concentration of 25(OH)D was assessed using the chemiluminescent immunoassay technology. The vitamin D intake was assessed using a 24-h recall questionnaire using Diet 5.0 software. Results The mean plasma concentration of 25(OH)D was 13.64±8.01 ng/ml in MS workers, and it was significantly lower than in the healthy ones (26.61±10.12 ng/ml, p < 0.00001); the highest concentration of 25(OH)D was noted in summer months. Deficient plasma concentrations of 25(OH)D were found significantly more often in MS workers than in the controls (81.82% and 20.79%, respectively, p < 0.00001). No correlation was found between the plasma vitamin D concentration and its dietary intake. The plasma concentration of 25(OH)D correlated with age of the examined workers (r = –0.28, p = 0.023), high density lipoprotein concentration (r = 0.19, p = 0.036) and glucose concentration (Rho = –0.24, p = 0.02). A multivariate analysis of variance demonstrated that the body mass index affected significantly the mean value of the 25(OH)D concentration in MS workers. Conclusions The concentration of vitamin D in the plasma of workers with MS was significantly lower than in the healthy controls despite the same high UV exposure; these workers also manifested significantly higher 25(OH)D deficiency than the control subjects. This study indicates the ...
Keywords	vitamin d ; diet ; metabolic syndrome ; deficiency ; agriculture ; 25(oh)d ; Public aspects of medicine ; RA1-1270
Subject code	630
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Nofer Institute of Occupational Medicine
Document type	Article ; Online
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Article: Underlying Kidney Diseases and Complications for COVID-19: A Review.

Dadson, Prince / Tetteh, Comfort Dede / Rebelos, Eleni / Badeau, Robert M / Moczulski, Dariusz

Frontiers in medicine

2020 Volume 7, Page(s) 600144

Abstract: There is mounting evidence supporting that patients with kidney diseases are particularly vulnerable to coronavirus disease-2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The review was conducted to examine ... ...

Abstract	There is mounting evidence supporting that patients with kidney diseases are particularly vulnerable to coronavirus disease-2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The review was conducted to examine the risk and complications of COVID-19 among patients with confirmed cases of underlying kidney disease. A search of Google Scholar, PubMed and Science direct databases to August 2020 was conducted using search terms pertaining to kidney diseases, renal insufficiency, kidney injury, angiotensin receptors, hemodialysis, and kidney transplant. We briefly reviewed COVID-19 in the context of kidney diseases. A significant proportion of hospitalized patients for COVID-19 have acute kidney injury, which further deteriorates their prognosis. COVID-19 increases morbidity and mortality among people already diagnosed with kidney disorders and obesity due to multiple organ injury caused by the SARS-CoV-2. This review supports the need for clinicians to carefully manage and monitor all patients with renal disorders in order to minimize acute kidney injuries. Although some therapeutic drugs have been suggested by some studies, treatment should be administered cautiously not to worsen the condition of the kidney. Further studies are required to highlight the efficient management of patients with underlying kidney diseases, who are infected with SARS-CoV-2. With proactive systematic screening and triaging, close monitoring and prompt management of coexisting other infections, the COVID-19 disease burden among these patients could be reduced.
Language	English
Publishing date	2020-11-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2020.600144
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