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Article ; Online: The D

Wimer, Lauren / Goncharova, Elena / Galkina, Sofiya / Nyangau, Edna / Shankaran, Mahalakshmi / Davis, Asia / Prado, Leandro / Munoz, Maria Castro / Epstein, Sharon / Patterson, Cavan / Shaum, Nicholas / Hellerstein, Mark / Evans, William / Melov, Simon

Aging cell

2023 Volume 22, Issue 8, Page(s) e13897

Abstract: ... Recently, the D ...

Abstract	Developing accurate methods to quantify age-related muscle loss (sarcopenia) could greatly accelerate development of therapies to treat muscle loss in the elderly, as current methods are inaccurate or expensive. The current gold standard method for quantifying sarcopenia is dual-energy X-ray absorptiometry (DXA) but does not measure muscle directly-it is a composite measure quantifying "lean mass" (muscle) excluding fat and bone. In humans, DXA overestimates muscle mass, which has led to erroneous conclusions about the importance of skeletal muscle in human health and disease. In animal models, DXA is a popular method for measuring lean mass. However, instrumentation is expensive and is potentially limited by anesthesia concerns. Recently, the D
MeSH term(s)	Muscle, Skeletal ; Absorptiometry, Photon ; Body Composition ; Animals ; Mice ; Male ; Female ; Mice, Inbred C57BL ; Creatinine/urine ; Body Weights and Measures/methods
Chemical Substances	Creatinine (AYI8EX34EU)
Language	English
Publishing date	2023-06-05
Publishing country	England
Document type	Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2113083-8
ISSN	1474-9726 ; 1474-9718
ISSN (online)	1474-9726
ISSN	1474-9718
DOI	10.1111/acel.13897
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Observation of a Resonant Structure near the D_{s}^{+}D_{s}^{-} Threshold in the B^{+}→D_{s}^{+}D_{s}^{-}K^{+} Decay.

Aaij, R / Abdelmotteleb, A S W / Abellan Beteta, C / Abudinén, F / Ackernley, T / Adeva, B / Adinolfi, M / Afsharnia, H / Agapopoulou, C / Aidala, C A / Aiola, S / Ajaltouni, Z / Akar, S / Akiba, K / Albrecht, J / Alessio, F / Alexander, M / Alfonso Albero, A / Aliouche, Z /

Alvarez Cartelle, P / Amalric, R / Amato, S / Amey, J L / Amhis, Y / An, L / Anderlini, L / Andersson, M / Andreianov, A / Andreotti, M / Andreou, D / Ao, D / Archilli, F / Artamonov, A / Artuso, M / Aslanides, E / Atzeni, M / Audurier, B / Bachmann, S / Bachmayer, M / Back, J J / Bailly-Reyre, A / Baladron Rodriguez, P / Balagura, V / Baldini, W / Baptista de Souza Leite, J / Barbetti, M / Barlow, R J / Barsuk, S / Barter, W / Bartolini, M / Baryshnikov, F / Basels, J M / Bassi, G / Batsukh, B / Battig, A / Bay, A / Beck, A / Becker, M / Bedeschi, F / Bediaga, I B / Beiter, A / Belavin, V / Belin, S / Bellee, V / Belous, K / Belov, I / Belyaev, I / Benane, G / Bencivenni, G / Ben-Haim, E / Berezhnoy, A / Bernet, R / Bernet Andres, S / Berninghoff, D / Bernstein, H C / Bertella, C / Bertolin, A / Betancourt, C / Betti, F / Bezshyiko, Ia / Bhasin, S / Bhom, J / Bian, L / Bieker, M S / Biesuz, N V / Bifani, S / Billoir, P / Biolchini, A / Birch, M / Bishop, F C R / Bitadze, A / Bizzeti, A / Blago, M P / Blake, T / Blanc, F / Blusk, S / Bobulska, D / Boelhauve, J A / Boente Garcia, O / Boettcher, T / Boldyrev, A / Bolognani, C S / Bolzonella, R / Bondar, N / Borgato, F / Borghi, S / Borsato, M / Borsuk, J T / Bouchiba, S A / Bowcock, T J V / Boyer, A / Bozzi, C / Bradley, M J / Braun, S / Brea Rodriguez, A / Brodzicka, J / Brossa Gonzalo, A / Brown, J / Brundu, D / Buonaura, A / Buonincontri, L / Burke, A T / Burr, C / Bursche, A / Butkevich, A / Butter, J S / Buytaert, J / Byczynski, W / Cadeddu, S / Cai, H / Calabrese, R / Calefice, L / Cali, S / Calladine, R / Calvi, M / Calvo Gomez, M / Campana, P / Campora Perez, D H / Campoverde Quezada, A F / Capelli, S / Capriotti, L / Carbone, A / Carboni, G / Cardinale, R / Cardini, A / Carli, I / Carniti, P / Carus, L / Casais Vidal, A / Caspary, R / Casse, G / Cattaneo, M / Cavallero, G / Cavallini, V / Celani, S / Cerasoli, J / Cervenkov, D / Chadwick, A J / Chapman, M G / Charles, M / Charpentier, Ph / Chavez Barajas, C A / Chefdeville, M / Chen, C / Chen, S / Chernov, A / Chernyshenko, S / Chobanova, V / Cholak, S / Chrzaszcz, M / Chubykin, A / Chulikov, V / Ciambrone, P / Cicala, M F / Cid Vidal, X / Ciezarek, G / Ciullo, G / Clarke, P E L / Clemencic, M / Cliff, H V / Closier, J / Cobbledick, J L / Coco, V / Coelho, J A B / Cogan, J / Cogneras, E / Cojocariu, L / Collins, P / Colombo, T / Congedo, L / Contu, A / Cooke, N / Corredoira, I / Corti, G / Couturier, B / Craik, D C / Crkovská, J / Cruz Torres, M / Currie, R / Da Silva, C L / Dadabaev, S / Dai, L / Dai, X / Dall'Occo, E / Dalseno, J / D'Ambrosio, C / Daniel, J / Danilina, A / d'Argent, P / Davies, J E / Davis, A / De Aguiar Francisco, O / de Boer, J / De Bruyn, K / De Capua, S / De Cian, M / De Freitas Carneiro Da Graca, U / De Lucia, E / De Miranda, J M / De Paula, L / De Serio, M / De Simone, D / De Simone, P / De Vellis, F / de Vries, J A / Dean, C T / Debernardis, F / Decamp, D / Dedu, V / Del Buono, L / Delaney, B / Dembinski, H-P / Denysenko, V / Deschamps, O / Dettori, F / Dey, B / Di Cicco, A / Di Nezza, P / Diachkov, I / Didenko, S / Dieste Maronas, L / Ding, S / Dobishuk, V / Dolmatov, A / Dong, C / Donohoe, A M / Dordei, F / Dos Reis, A C / Douglas, L / Downes, A G / Dudek, M W / Dufour, L / Duk, V / Durante, P / Durham, J M / Dutta, D / Dziurda, A / Dzyuba, A / Easo, S / Egede, U / Egorychev, V / Eidelman, S / Eirea Orro, C / Eisenhardt, S / Ejopu, E / Ek-In, S / Eklund, L / Ely, S / Ene, A / Epple, E / Escher, S / Eschle, J / Esen, S / Evans, T / Fabiano, F / Falcao, L N / Fan, Y / Fang, B / Farry, S / Fazzini, D / Feo, M / Fernandez Gomez, M / Fernez, A D / Ferrari, F / Ferreira Lopes, L / Ferreira Rodrigues, F / Ferreres Sole, S / Ferrillo, M / Ferro-Luzzi, M / Filippov, S / Fini, R A / Fiorini, M / Firlej, M / Fischer, K M / Fitzgerald, D S / Fitzpatrick, C / Fiutowski, T / Fleuret, F / Fontana, M / Fontanelli, F / Forty, R / Foulds-Holt, D / Franco Lima, V / Franco Sevilla, M / Frank, M / Franzoso, E / Frau, G / Frei, C / Friday, D A / Fu, J / Fuehring, Q / Fulghesu, T / Gabriel, E / Galati, G / Galati, M D / Gallas Torreira, A / Galli, D / Gambetta, S / Gan, Y / Gandelman, M / Gandini, P / Gao, Y / Garau, M / Garcia Martin, L M / Garcia Moreno, P / García Pardiñas, J / Garcia Plana, B / Garcia Rosales, F A / Garrido, L / Gaspar, C / Geertsema, R E / Gerick, D / Gerken, L L / Gersabeck, E / Gersabeck, M / Gershon, T / Giambastiani, L / Gibson, V / Giemza, H K / Gilman, A L / Giovannetti, M / Gioventù, A / Gironella Gironell, P / Giugliano, C / Giza, M A / Gizdov, K / Gkougkousis, E L / Gligorov, V V / Göbel, C / Golobardes, E / Golubkov, D / Golutvin, A / Gomes, A / Gomez Fernandez, S / Goncalves Abrantes, F / Goncerz, M / Gong, G / Gorelov, I V / Gotti, C / Grabowski, J P / Grammatico, T / Granado Cardoso, L A / Graugés, E / Graverini, E / Graziani, G / Grecu, A T / Greeven, L M / Grieser, N A / Grillo, L / Gromov, S / Gruberg Cazon, B R / Gu, C / Guarise, M / Guittiere, M / Günther, P A / Gushchin, E / Guth, A / Guz, Y / Gys, T / Hadavizadeh, T / Haefeli, G / Haen, C / Haimberger, J / Haines, S C / Halewood-Leagas, T / Halvorsen, M M / Hamilton, P M / Hammerich, J / Han, Q / Han, X / Hansen, E B / Hansmann-Menzemer, S / Hao, L / Harnew, N / Harrison, T / Hasse, C / Hatch, M / He, J / Heijhoff, K / Heinicke, K / Henderson, C / Henderson, R D L / Hennequin, A M / Hennessy, K / Henry, L / Herd, J H / Heuel, J / Hicheur, A / Hill, D / Hilton, M / Hollitt, S E / Horswill, J / Hou, R / Hou, Y / Hu, J / Hu, W / Hu, X / Huang, W / Huang, X / Hulsbergen, W / Hunter, R J / Hushchyn, M / Hutchcroft, D / Ibis, P / Idzik, M / Ilin, D / Ilten, P / Inglessi, A / Iniukhin, A / Ishteev, A / Ivshin, K / Jacobsson, R / Jage, H / Jaimes Elles, S J / Jakobsen, S / Jans, E / Jashal, B K / Jawahery, A / Jevtic, V / Jiang, E / Jiang, X / Jiang, Y / John, M / Johnson, D / Jones, C R / Jones, T P / Jost, B / Jurik, N / Juszczak, I / Kandybei, S / Kang, Y / Karacson, M / Karpenkov, D / Karpov, M / Kautz, J W / Keizer, F / Keller, D M / Kenzie, M / Ketel, T / Khanji, B / Kharisova, A / Kholodenko, S / Khreich, G / Kirn, T / Kirsebom, V S / Kitouni, O / Klaver, S / Kleijne, N / Klimaszewski, K / Kmiec, M R / Koliiev, S / Kondybayeva, A / Konoplyannikov, A / Kopciewicz, P / Kopecna, R / Koppenburg, P / Korolev, M / Kostiuk, I / Kot, O / Kotriakhova, S / Kozachuk, A / Kravchenko, P / Kravchuk, L / Krawczyk, R D / Kreps, M / Kretzschmar, S / Krokovny, P / Krupa, W / Krzemien, W / Kubat, J / Kucewicz, W / Kucharczyk, M / Kudryavtsev, V / Kunde, G J / Kupsc, A / Lacarrere, D / Lafferty, G / Lai, A / Lampis, A / Lancierini, D / Landesa Gomez, C / Lane, J J / Lane, R / Lanfranchi, G / Langenbruch, C / Langer, J / Lantwin, O / Latham, T / Lazzari, F / Lazzaroni, M / Le Gac, R / Lee, S H / Lefèvre, R / Leflat, A / Legotin, S / Lenisa, P / Leroy, O / Lesiak, T / Leverington, B / Li, A / Li, H / Li, K / Li, P / Li, P-R / Li, S / Li, T / Li, Y / Li, Z / Liang, X / Lin, C / Lin, T / Lindner, R / Lisovskyi, V / Litvinov, R / Liu, G / Liu, H / Liu, Q / Liu, S / Lobo Salvia, A / Loi, A / Lollini, R / Lomba Castro, J / Longstaff, I / Lopes, J H / Lopez Huertas, A / López Soliño, S / Lovell, G H / Lu, Y / Lucarelli, C / Lucchesi, D / Luchuk, S / Lucio Martinez, M / Lukashenko, V / Luo, Y / Lupato, A / Luppi, E / Lusiani, A / Lynch, K / Lyu, X-R / Ma, L / Ma, R / Maccolini, S / Machefert, F / Maciuc, F / Mackay, I / Macko, V / Mackowiak, P / Madhan Mohan, L R / Maevskiy, A / Maisuzenko, D / Majewski, M W / Malczewski, J J / Malde, S / Malecki, B / Malinin, A / Maltsev, T / Manca, G / Mancinelli, G / Mancuso, C / Manuzzi, D / Manzari, C A / Marangotto, D / Maratas, J M / Marchand, J F / Marconi, U / Mariani, S / Marin Benito, C / Marks, J / Marshall, A M / Marshall, P J / Martelli, G / Martellotti, G / Martinazzoli, L / Martinelli, M / Martinez Santos, D / Martinez Vidal, F / Massafferri, A / Materok, M / Matev, R / Mathad, A / Matiunin, V / Matteuzzi, C / Mattioli, K R / Mauri, A / Maurice, E / Mauricio, J / Mazurek, M / McCann, M / Mcconnell, L / McGrath, T H / McHugh, N T / McNab, A / McNulty, R / Mead, J V / Meadows, B / Meier, G / Melnychuk, D / Meloni, S / Merk, M / Merli, A / Meyer Garcia, L / Miao, D / Mikhasenko, M / Milanes, D A / Millard, E / Milovanovic, M / Minard, M-N / Minotti, A / Miralles, T / Mitchell, S E / Mitreska, B / Mitzel, D S / Mödden, A / Mohammed, R A / Moise, R D / Mokhnenko, S / Mombächer, T / Monk, M / Monroy, I A / Monteil, S / Morandin, M / Morello, G / Morello, M J / Moron, J / Morris, A B / Morris, A G / Mountain, R / Mu, H / Muhammad, E / Muheim, F / Mulder, M / Müller, K / Murphy, C H / Murray, D / Murta, R / Muzzetto, P / Naik, P / Nakada, T / Nandakumar, R / Nanut, T / Nasteva, I / Needham, M / Neri, N / Neubert, S / Neufeld, N / Neustroev, P / Newcombe, R / Nicolini, J / Niel, E M / Nieswand, S / Nikitin, N / Nolte, N S / Normand, C / Novoa Fernandez, J / Nunez, C / Oblakowska-Mucha, A / Obraztsov, V / Oeser, T / O'Hanlon, D P / Okamura, S / Oldeman, R / Oliva, F / Olivares, M E / Onderwater, C J G / O'Neil, R H / Otalora Goicochea, J M / Ovsiannikova, T / Owen, P / Oyanguren, A / Ozcelik, O / Padeken, K O / Pagare, B / Pais, P R / Pajero, T / Palano, A / Palutan, M / Pan, Y / Panshin, G / Paolucci, L / Papanestis, A / Pappagallo, M / Pappalardo, L L / Pappenheimer, C / Parker, W / Parkes, C / Passalacqua, B / Passaleva, G / Pastore, A / Patel, M / Patrignani, C / Pawley, C J / Pearce, A / Pellegrino, A / Pepe Altarelli, M / Perazzini, S / Pereima, D / Pereiro Castro, A / Perret, P / Petric, M / Petridis, K / Petrolini, A / Petrov, A / Petrucci, S / Petruzzo, M / Pham, H / Philippov, A / Piandani, R / Pica, L / Piccini, M / Pietrzyk, B / Pietrzyk, G / Pili, M / Pinci, D / Pisani, F / Pizzichemi, M / Placinta, V / Plews, J / Plo Casasus, M / Polci, F / Poli Lener, M / Poliakova, M / Poluektov, A / Polukhina, N / Polyakov, I / Polycarpo, E / Ponce, S / Popov, D / Popov, S / Poslavskii, S / Prasanth, K / Promberger, L / Prouve, C / Pugatch, V / Puill, V / Punzi, G / Qi, H R / Qian, W / Qin, N / Qu, S / Quagliani, R / Raab, N V / Rabadan Trejo, R I / Rachwal, B / Rademacker, J H / Rajagopalan, R / Rama, M / Ramos Pernas, M / Rangel, M S / Ratnikov, F / Raven, G / Rebollo De Miguel, M / Redi, F / Reich, J / Reiss, F / Remon Alepuz, C / Ren, Z / Renaudin, V / Resmi, P K / Ribatti, R / Ricci, A M / Ricciardi, S / Richardson, K / Richardson-Slipper, M / Rinnert, K / Robbe, P / Robertson, G / Rodrigues, A B / Rodrigues, E / Rodriguez Fernandez, E / Rodriguez Lopez, J A / Rodriguez Rodriguez, E / Rollings, A / Roloff, P / Romanovskiy, V / Romero Lamas, M / Romero Vidal, A / Roth, J D / Rotondo, M / Rudolph, M S / Ruf, T / Ruiz Fernandez, R A / Ruiz Vidal, J / Ryzhikov, A / Ryzka, J / Saborido Silva, J J / Sagidova, N / Sahoo, N / Saitta, B / Salomoni, M / Sanchez Gras, C / Sanderswood, I / Santacesaria, R / Santamarina Rios, C / Santimaria, M / Santovetti, E / Saranin, D / Sarpis, G / Sarpis, M / Sarti, A / Satriano, C / Satta, A / Saur, M / Savrina, D / Sazak, H / Scantlebury Smead, L G / Scarabotto, A / Schael, S / Scherl, S / Schiller, M / Schindler, H / Schmelling, M / Schmidt, B / Schmitt, S / Schneider, O / Schopper, A / Schubiger, M / Schulte, S / Schune, M H / Schwemmer, R / Sciascia, B / Sciuccati, A / Sellam, S / Semennikov, A / Senghi Soares, M / Sergi, A / Serra, N / Sestini, L / Seuthe, A / Shang, Y / Shangase, D M / Shapkin, M / Shchemerov, I / Shchutska, L / Shears, T / Shekhtman, L / Shen, Z / Sheng, S / Shevchenko, V / Shi, B / Shields, E B / Shimizu, Y / Shmanin, E / Shupperd, J D / Siddi, B G / Silva Coutinho, R / Simi, G / Simone, S / Singla, M / Skidmore, N / Skuza, R / Skwarnicki, T / Slater, M W / Smallwood, J C / Smeaton, J G / Smith, E / Smith, K / Smith, M / Snoch, A / Soares Lavra, L / Sokoloff, M D / Soler, F J P / Solomin, A / Solovev, A / Solovyev, I / Song, R / Souza De Almeida, F L / Souza De Paula, B / Spaan, B / Spadaro Norella, E / Spiridenkov, E / Spradlin, P / Sriskaran, V / Stagni, F / Stahl, M / Stahl, S / Stanislaus, S / Stein, E N / Steinkamp, O / Stenyakin, O / Stevens, H / Stone, S / Strekalina, D / Suljik, F / Sun, J / Sun, L / Sun, Y / Svihra, P / Swallow, P N / Swientek, K / Szabelski, A / Szumlak, T / Szymanski, M / Tan, Y / Taneja, S / Tanner, A R / Tat, M D / Terentev, A / Teubert, F / Thomas, E / Thompson, D J D / Thomson, K A / Tilquin, H / Tisserand, V / T'Jampens, S / Tobin, M / Tomassetti, L / Tonani, G / Tong, X / Torres Machado, D / Tou, D Y / Trifonova, E / Trilov, S M / Trippl, C / Tuci, G / Tully, A / Tuning, N / Ukleja, A / Unverzagt, D J / Ursov, E / Usachov, A / Ustyuzhanin, A / Uwer, U / Vagner, A / Vagnoni, V / Valassi, A / Valenti, G / Valls Canudas, N / van Beuzekom, M / Van Dijk, M / Van Hecke, H / van Herwijnen, E / Van Hulse, C B / van Veghel, M / Vazquez Gomez, R / Vazquez Regueiro, P / Vázquez Sierra, C / Vecchi, S / Velthuis, J J / Veltri, M / Venkateswaran, A / Veronesi, M / Vesterinen, M / Vieira, D / Vieites Diaz, M / Vilasis-Cardona, X / Vilella Figueras, E / Villa, A / Vincent, P / Volle, F C / Vom Bruch, D / Vorobyev, A / Vorobyev, V / Voropaev, N / Vos, K / Vrahas, C / Waldi, R / Walsh, J / Wan, G / Wang, C / Wang, J / Wang, M / Wang, R / Wang, X / Wang, Y / Wang, Z / Ward, J A / Watson, N K / Websdale, D / Wei, Y / Weisser, C / Westhenry, B D C / White, D J / Whitehead, M / Wiederhold, A R / Wiedner, D / Wilkinson, G / Wilkinson, M K / Williams, I / Williams, M / Williams, M R J / Williams, R / Wilson, F F / Wislicki, W / Witek, M / Witola, L / Wong, C P / Wormser, G / Wotton, S A / Wu, H / Wyllie, K / Xiang, Z / Xiao, D / Xie, Y / Xu, A / Xu, J / Xu, L / Xu, M / Xu, Q / Xu, Z / Yang, D / Yang, S / Yang, Y / Yang, Z / Yeomans, L E / Yeroshenko, V / Yeung, H / Yin, H / Yu, J / Yuan, X / Zaffaroni, E / Zavertyaev, M / Zdybal, M / Zenaiev, O / Zeng, M / Zhang, C / Zhang, D / Zhang, L / Zhang, S / Zhang, Y / Zharkova, A / Zhelezov, A / Zheng, Y / Zhou, T / Zhou, X / Zhou, Y / Zhovkovska, V / Zhu, X / Zhu, Z / Zhukov, V / Zou, Q / Zucchelli, S / Zuliani, D / Zunica, G

Physical review letters

2023 Volume 131, Issue 7, Page(s) 71901

Abstract: An amplitude analysis of the B^{+}→D_{s}^{+}D_{s}^{-}K^{+} decay is carried out to study ... referred to as X(3960), is observed in the D_{s}^{+}D_{s}^{-} invariant-mass spectrum with significance ... for an additional structure is found around 4140 MeV in the D_{s}^{+}D_{s}^{-} invariant mass, which might be caused ...

Abstract	An amplitude analysis of the B^{+}→D_{s}^{+}D_{s}^{-}K^{+} decay is carried out to study for the first time its intermediate resonant contributions, using proton-proton collision data collected with the LHCb detector at center-of-mass energies of 7, 8, and 13 TeV. A near-threshold peaking structure, referred to as X(3960), is observed in the D_{s}^{+}D_{s}^{-} invariant-mass spectrum with significance greater than 12 standard deviations. The mass, width, and the quantum numbers of the structure are measured to be 3956±5±10 MeV, 43±13±8 MeV, and J^{PC}=0^{++}, respectively, where the first uncertainties are statistical and the second systematic. The properties of the new structure are consistent with recent theoretical predictions for a state composed of cc[over ¯]ss[over ¯] quarks. Evidence for an additional structure is found around 4140 MeV in the D_{s}^{+}D_{s}^{-} invariant mass, which might be caused either by a new resonance with the 0^{++} assignment or by a J/ψϕ↔D_{s}^{+}D_{s}^{-} coupled-channel effect.
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.071901
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Measurement of the Ratios of Branching Fractions R(D^{*}) and R(D^{0}).

Aaij, R / Abdelmotteleb, A S W / Abellan Beteta, C / Abudinén, F / Ackernley, T / Adeva, B / Adinolfi, M / Adlarson, P / Afsharnia, H / Agapopoulou, C / Aidala, C A / Ajaltouni, Z / Akar, S / Akiba, K / Albicocco, P / Albrecht, J / Alessio, F / Alexander, M / Alfonso Albero, A /

Aliouche, Z / Alvarez Cartelle, P / Amalric, R / Amato, S / Amey, J L / Amhis, Y / An, L / Anderlini, L / Andersson, M / Andreianov, A / Andreotti, M / Andreou, D / Ao, D / Archilli, F / Artamonov, A / Artuso, M / Aslanides, E / Atzeni, M / Audurier, B / Bachiller Perea, I B / Bachmann, S / Bachmayer, M / Back, J J / Bailly-Reyre, A / Baladron Rodriguez, P / Balagura, V / Baldini, W / Baptista de Souza Leite, J / Barbetti, M / Barlow, R J / Barsuk, S / Barter, W / Bartolini, M / Baryshnikov, F / Basels, J M / Bassi, G / Batsukh, B / Battig, A / Bay, A / Beck, A / Becker, M / Bedeschi, F / Bediaga, I B / Beiter, A / Belin, S / Bellee, V / Belous, K / Belov, I / Belyaev, I / Benane, G / Bencivenni, G / Ben-Haim, E / Berezhnoy, A / Bernet, R / Bernet Andres, S / Berninghoff, D / Bernstein, H C / Bertella, C / Bertolin, A / Betancourt, C / Betti, F / Bezshyiko, Ia / Bhasin, S / Bhom, J / Bian, L / Bieker, M S / Biesuz, N V / Billoir, P / Biolchini, A / Birch, M / Bishop, F C R / Bitadze, A 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Zhou, X / Zhou, Y / Zhovkovska, V / Zhu, X / Zhu, Z / Zhukov, V / Zou, Q / Zucchelli, S / Zuliani, D / Zunica, G

Physical review letters

2023 Volume 131, Issue 11, Page(s) 111802

Abstract: The ratios of branching fractions R(D^{*})≡B(B[over ¯]→D^{*}τ^{-}ν[over ¯]_{τ})/B(B[over ¯]→D^{*}μ^ ... ν[over ¯]_{μ}) and R(D^{0})≡B(B^{-}→D^{0}τ^{-}ν[over ¯]_{τ})/B(B^{-}→D^{0}μ^{-}ν[over ¯]_{μ}) are ... is identified in the decay mode τ^{-}→μ^{-}ν_{τ}ν[over ¯]_{μ}. The measured values are R(D^{*})=0 ...

Abstract	The ratios of branching fractions R(D^{})≡B(B[over ¯]→D^{}τ^{-}ν[over ¯]_{τ})/B(B[over ¯]→D^{}μ^{-}ν[over ¯]_{μ}) and R(D^{0})≡B(B^{-}→D^{0}τ^{-}ν[over ¯]_{τ})/B(B^{-}→D^{0}μ^{-}ν[over ¯]_{μ}) are measured, assuming isospin symmetry, using a sample of proton-proton collision data corresponding to 3.0 fb^{-1} of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The tau lepton is identified in the decay mode τ^{-}→μ^{-}ν_{τ}ν[over ¯]_{μ}. The measured values are R(D^{})=0.281±0.018±0.024 and R(D^{0})=0.441±0.060±0.066, where the first uncertainty is statistical and the second is systematic. The correlation between these measurements is ρ=-0.43. The results are consistent with the current average of these quantities and are at a combined 1.9 standard deviations from the predictions based on lepton flavor universality in the standard model.
Language	English
Publishing date	2023-09-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.111802
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Article ; Online: rTg-D

Judianne Davis / Feng Xu / Xiaoyue Zhu / William E. Van Nostrand

Cerebral Circulation - Cognition and Behavior, Vol 3, Iss , Pp 100133- (2022)

A novel transgenic rat model of cerebral amyloid angiopathy Type-2

2022

Abstract: ... A novel transgenic rat model (rTg-D) was generated that produces human familial CAA Dutch E22Q mutant ... rTg-D rats. Results: rTg-D rats begin to accumulate Aβ in brain and develop varying levels of larger ... present mostly in the thalamic region of affected rTg-D rats. In contrast to capillary CAA type-1 ...

Abstract	Background: Cerebral amyloid angiopathy (CAA) is common disorder of the elderly, a prominent comorbidity of Alzheimer's disease, and causes vascular cognitive impairment and dementia. Previously, we generated a transgenic rat model of capillary CAA type-1 that develops many pathological features of human disease. However, a complementary rat model of larger vessel CAA type-2 disease has been lacking. Methods: A novel transgenic rat model (rTg-D) was generated that produces human familial CAA Dutch E22Q mutant amyloid β-protein (Aβ) in brain and develops larger vessel CAA type-2. Quantitative biochemical and pathological analyses were performed to characterize the progression of CAA and associated pathologies in aging rTg-D rats. Results: rTg-D rats begin to accumulate Aβ in brain and develop varying levels of larger vessel CAA type-2, in the absence of capillary CAA type-1, starting around 18 months of age. Larger vessel CAA was mainly composed of the Aβ40 peptide and most prominent in surface leptomeningeal/pial vessels and arterioles of the cortex and thalamus. Cerebral microbleeds and small vessel occlusions were present mostly in the thalamic region of affected rTg-D rats. In contrast to capillary CAA type-1 the amyloid deposited within the walls of larger vessels of rTg-D rats did not promote perivascular astrocyte and microglial responses or accumulate the Aβ chaperone apolipoprotein E. Conclusion: Although variable in severity, the rTg-D rats specifically develop larger vessel CAA type-2 that reflects many of the pathological features of human disease and provide a new model to investigate the pathogenesis of this condition.
Keywords	Cerebral amyloid angiopathy ; Small vessel disease ; Amyloid β protein ; Dutch mutation ; Transgenic rat ; Microbleed ; Specialties of internal medicine ; RC581-951 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Observation of a New Excited D_{s}^{+} Meson in B^{0}→D^{-}D^{+}K^{+}π^{-} Decays.

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M / Kudryavtsev, V / Kuindersma, H S / Kunde, G J / Kvaratskheliya, T / Lacarrere, D / Lafferty, G / Lai, A / Lampis, A / Lancierini, D / Lane, J J / Lane, R / Lanfranchi, G / Langenbruch, C / Langer, J / Lantwin, O / Latham, T / Lazzari, F / Le Gac, R / Lee, S H / Lefèvre, R / Leflat, A / Legotin, S / Leroy, O / Lesiak, T / Leverington, B / Li, H / Li, L / Li, P / Li, X / Li, Y / Li, Z / Liang, X / Lin, T / Lindner, R / Lisovskyi, V / Litvinov, R / Liu, G / Liu, H / Liu, S / Liu, X / Loi, A / Lomba Castro, J / Longstaff, I / Lopes, J H / Loustau, G / Lovell, G H / Lu, Y / Lucchesi, D / Luchuk, S / Lucio Martinez, M / Lukashenko, V / Luo, Y / Lupato, A / Luppi, E / Lupton, O / Lusiani, A / Lyu, X / Ma, L / Maccolini, S / Machefert, F / Maciuc, F / Macko, V / Mackowiak, P / Maddrell-Mander, S / Madejczyk, O / Madhan Mohan, L R / Maev, O / Maevskiy, A / Maisuzenko, D / Majewski, M W / Malde, S / Malecki, B / Malinin, A / Maltsev, T / Malygina, H / Manca, G / Mancinelli, G / Manera 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Murphy, C H / Murray, D / Muzzetto, P / Naik, P / Nakada, T / Nandakumar, R / Nanut, T / Nasteva, I / Needham, M / Neri, I / Neri, N / Neubert, S / Neufeld, N / Newcombe, R / Nguyen, T D / Nguyen-Mau, C / Niel, E M / Nieswand, S / Nikitin, N / Nolte, N S / Nunez, C / Oblakowska-Mucha, A / Obraztsov, V / O'Hanlon, D P / Oldeman, R / Olivares, M E / Onderwater, C J G / Ossowska, A / Otalora Goicochea, J M / Ovsiannikova, T / Owen, P / Oyanguren, A / Pagare, B / Pais, P R / Pajero, T / Palano, A / Palutan, M / Pan, Y / Panshin, G / Papanestis, A / Pappagallo, M / Pappalardo, L L / Pappenheimer, C / Parker, W / Parkes, C / Parkinson, C J / Passalacqua, B / Passaleva, G / Pastore, A / Patel, M / Patrignani, C / Pawley, C J / Pearce, A / Pellegrino, A / Pepe Altarelli, M / Perazzini, S / Pereima, D / Perret, P / Petridis, K / Petrolini, A / Petrov, A / Petrucci, S / Petruzzo, M / Pham, T T H / Philippov, A / Pica, L / Piccini, M / Pietrzyk, B / Pietrzyk, G / Pili, M / Pinci, D / Pisani, F / Piucci, A / P K, Resmi / Placinta, V / Plews, J / Plo Casasus, M / Polci, F / Poli Lener, M / Poliakova, M / Poluektov, A / Polukhina, N / Polyakov, I / Polycarpo, E / Pomery, G J / Ponce, S / Popov, D / Popov, S / Poslavskii, S / Prasanth, K / Promberger, L / Prouve, C / Pugatch, V / Pullen, H / Punzi, G / Qian, W / Qin, J / Quagliani, R / Quintana, B / Raab, N V / Rabadan Trejo, R I / Rachwal, B / Rademacker, J H / Rama, M / Ramos Pernas, M / Rangel, M S / Ratnikov, F / Raven, G / Reboud, M / Redi, F / Reiss, F / Remon Alepuz, C / Ren, Z / Renaudin, V / Ribatti, R / Ricciardi, S / Richards, D S / Rinnert, K / Robbe, P / Robert, A / Robertson, G / Rodrigues, A B / Rodrigues, E / Rodriguez Lopez, J A / Rollings, A / Roloff, P / Romanovskiy, V / Romero Lamas, M / Romero Vidal, A / Roth, J D / Rotondo, M / Rudolph, M S / Ruf, T / Ruiz Vidal, J / Ryzhikov, A / Ryzka, J / Saborido Silva, J J / Sagidova, N / Sahoo, N / Saitta, B / Sanchez Gonzalo, D / Sanchez Gras, C / Santacesaria, R / 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Viemann, H / Vilasis-Cardona, X / Vilella Figueras, E / Vincent, P / Vitali, G / Vollhardt, A / Vom Bruch, D / Vorobyev, A / Vorobyev, V / Voropaev, N / Waldi, R / Walsh, J / Wang, C / Wang, J / Wang, M / Wang, R / Wang, Y / Wang, Z / Wark, H M / Watson, N K / Weber, S G / Websdale, D / Weisser, C / Westhenry, B D C / White, D J / Whitehead, M / Wiedner, D / Wilkinson, G / Wilkinson, M / Williams, I / Williams, M / Williams, M R J / Wilson, F F / Wislicki, W / Witek, M / Witola, L / Wormser, G / Wotton, S A / Wu, H / Wyllie, K / Xiang, Z / Xiao, D / Xie, Y / Xu, A / Xu, J / Xu, L / Xu, M / Xu, Q / Xu, Z / Yang, D / Yang, Y / Yang, Z / Yao, Y / Yeomans, L E / Yin, H / Yu, J / Yuan, X / Yushchenko, O / Zaffaroni, E / Zarebski, K A / Zavertyaev, M / Zdybal, M / Zenaiev, O / Zeng, M / Zhang, D / Zhang, L / Zhang, S / Zhang, Y / Zhelezov, A / Zheng, Y / Zhou, X / Zhou, Y / Zhu, X / Zhukov, V / Zonneveld, J B / Zucchelli, S / Zuliani, D / Zunica, G

Physical review letters

2021 Volume 126, Issue 12, Page(s) 122002

Abstract: ... A new excited D_{s}^{+} meson is observed decaying into the D^{+}K^{+}π^{-} final state with large ... analysis are also reported. The new resonance, denoted as D_{s0}(2590)^{+}, is a strong candidate to be ... the D_{s}(2^{1}S_{0})^{+} state, the radial excitation of the pseudoscalar ground-state D_{s}^{+} meson. ...

Abstract	Using pp collision data corresponding to an integrated luminosity of 5.4 fb^{-1} collected with the LHCb detector at a center-of-mass energy of 13 TeV, the B^{0}→D^{-}D^{+}K^{+}π^{-} decay is studied. A new excited D_{s}^{+} meson is observed decaying into the D^{+}K^{+}π^{-} final state with large statistical significance. The pole mass and width, and the spin parity of the new state are measured with an amplitude analysis to be m_{R}=2591±6±7 MeV, Γ_{R}=89±16±12 MeV, and J^{P}=0^{-}, where the first uncertainty is statistical and the second systematic. Fit fractions for all components in the amplitude analysis are also reported. The new resonance, denoted as D_{s0}(2590)^{+}, is a strong candidate to be the D_{s}(2^{1}S_{0})^{+} state, the radial excitation of the pseudoscalar ground-state D_{s}^{+} meson.
Language	English
Publishing date	2021-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.126.122002
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Article ; Online: Atomic autoionization in the photo-dissociation of super-excited deuterated water molecules fragmenting into D

Iskandar, W / Rescigno, T N / Orel, A E / Larsen, K A / Griffin, B / Call, D / Davis, V / Jochim, B / Severt, T / Williams, J B / Ben-Itzhak, I / Slaughter, D S / Weber, Th

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 32, Page(s) 21562–21572

Abstract: We present the relaxation dynamics of deuterated water ... ...

Abstract	We present the relaxation dynamics of deuterated water molecules
Language	English
Publishing date	2023-08-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp02438e
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Article ; Online: African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A.

Siddappa, Manjunath / Hussain, Shahid / Wani, Sajad A / White, Jason / Tang, Hancong / Gray, Jaimie S / Jafari, Hedieh / Wu, Hsu-Chang / Long, Mark D / Elhussin, Isra / Karanam, Balasubramanyam / Wang, Honghe / Morgan, Rebecca / Hardiman, Gary / Adelani, Isaacson B / Rotimi, Solomon O / Murphy, Adam R / Nonn, Larisa / Davis, Melissa B /

Kittles, Rick A / Hughes Halbert, Chanita / Sucheston-Campbell, Lara E / Yates, Clayton / Campbell, Moray J

Cancer research communications

2023 Volume 3, Issue 4, Page(s) 621–639

Abstract: African American (AA) prostate cancer associates with vitamin D: Significance: Our study ...

Abstract	African American (AA) prostate cancer associates with vitamin D Significance: Our study identified that genomic ancestry drives the VDR complex composition, genomic distribution, and transcriptional function, and is disrupted by BAZ1A and illustrates a novel driver for AA prostate cancer.
MeSH term(s)	Male ; Humans ; Receptors, Calcitriol/genetics ; Transcriptome/genetics ; Black or African American/genetics ; Prostatic Neoplasms/genetics ; Chromatin/genetics ; Chromosomal Proteins, Non-Histone/genetics
Chemical Substances	Receptors, Calcitriol ; Chromatin ; BAZ1A protein, human ; Chromosomal Proteins, Non-Histone
Language	English
Publishing date	2023-04-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2767-9764
ISSN (online)	2767-9764
DOI	10.1158/2767-9764.CRC-22-0389
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Search for Evidence of Baryogenesis and Dark Matter in B^{+}→ψ_{D}+p Decays at BABAR.

Lees, J P / Poireau, V / Tisserand, V / Grauges, E / Palano, A / Eigen, G / Brown, D N / Kolomensky, Yu G / Fritsch, M / Koch, H / Cheaib, R / Hearty, C / Mattison, T S / McKenna, J A / So, R Y / Blinov, V E / Buzykaev, A R / Druzhinin, V P / Kozyrev, E A /

Kravchenko, E A / Serednyakov, S I / Skovpen, Yu I / Solodov, E P / Todyshev, K Yu / Lankford, A J / Dey, B / Gary, J W / Long, O / Eisner, A M / Lockman, W S / Panduro Vazquez, W / Chao, D S / Cheng, C H / Echenard, B / Flood, K T / Hitlin, D G / Li, Y / Lin, D X / Middleton, S / Miyashita, T S / Ongmongkolkul, P / Oyang, J / Porter, F C / Röhrken, M / Meadows, B T / Sokoloff, M D / Smith, J G / Wagner, S R / Bernard, D / Verderi, M / Bettoni, D / Bozzi, C / Calabrese, R / Cibinetto, G / Fioravanti, E / Garzia, I / Luppi, E / Santoro, V / Calcaterra, A / de Sangro, R / Finocchiaro, G / Martellotti, S / Patteri, P / Peruzzi, I M / Piccolo, M / Rotondo, M / Zallo, A / Passaggio, S / Patrignani, C / Shuve, B J / Lacker, H M / Bhuyan, B / Mallik, U / Chen, C / Cochran, J / Prell, S / Gritsan, A V / Arnaud, N / Davier, M / Le Diberder, F / Lutz, A M / Wormser, G / Lange, D J / Wright, D M / Coleman, J P / Hutchcroft, D E / Payne, D J / Touramanis, C / Bevan, A J / Di Lodovico, F / Cowan, G / Banerjee, Sw / Brown, D N / Davis, C L / Denig, A G / Gradl, W / Griessinger, K / Hafner, A / Schubert, K R / Barlow, R J / Lafferty, G D / Cenci, R / Jawahery, A / Roberts, D A / Cowan, R / Robertson, S H / Seddon, R M / Neri, N / Palombo, F / Cremaldi, L / Godang, R / Summers, D J / De Nardo, G / Sciacca, C / Jessop, C P / LoSecco, J M / Honscheid, K / Gaz, A / Margoni, M / Simi, G / Simonetto, F / Stroili, R / Akar, S / Ben-Haim, E / Bomben, M / Bonneaud, G R / Calderini, G / Chauveau, J / Marchiori, G / Ocariz, J / Biasini, M / Manoni, E / Rossi, A / Batignani, G / Bettarini, S / Carpinelli, M / Casarosa, G / Chrzaszcz, M / Forti, F / Giorgi, M A / Lusiani, A / Oberhof, B / Paoloni, E / Rama, M / Rizzo, G / Walsh, J J / Zani, L / Smith, A J S / Anulli, F / Faccini, R / Ferrarotto, F / Ferroni, F / Pilloni, A / Bünger, C / Dittrich, S / Grünberg, O / Leddig, T / Voß, C / Waldi, R / Adye, T / Wilson, F F / Emery, S / Vasseur, G / Aston, D / Cartaro, C / Convery, M R / Dunwoodie, W / Ebert, M / Field, R C / Fulsom, B G / Graham, M T / Hast, C / Kim, P / Luitz, S / MacFarlane, D B / Muller, D R / Neal, H / Ratcliff, B N / Roodman, A / Sullivan, M K / Va'vra, J / Wisniewski, W J / Purohit, M V / Wilson, J R / Sekula, S J / Ahmed, H / Tasneem, N / Bellis, M / Burchat, P R / Puccio, E M T / Ernst, J A / Gorodeisky, R / Guttman, N / Peimer, D R / Soffer, A / Spanier, S M / Ritchie, J L / Izen, J M / Lou, X C / Bianchi, F / De Mori, F / Filippi, A / Lanceri, L / Vitale, L / Martinez-Vidal, F / Oyanguren, A / Albert, J / Beaulieu, A / Bernlochner, F U / King, G J / Kowalewski, R / Lueck, T / Miller, C / Nugent, I M / Roney, J M / Sobie, R J / Gershon, T J / Harrison, P F / Latham, T E / Wu, S L

Physical review letters

2023 Volume 131, Issue 20, Page(s) 201801

Abstract: A new dark sector antibaryon, denoted ψ_{D}, could be produced in decays of B mesons. This Letter ... presents a search for B^{+}→ψ_{D}+p (and the charge conjugate) decays in e^{+}e^{-} annihilations at 10.58 ... in the range from 10^{-7}-10^{-5} are obtained at 90% confidence level for masses of 1.0D}}<4.3 GeV/c^ ...

Abstract	A new dark sector antibaryon, denoted ψ_{D}, could be produced in decays of B mesons. This Letter presents a search for B^{+}→ψ_{D}+p (and the charge conjugate) decays in e^{+}e^{-} annihilations at 10.58 GeV, using data collected in the BABAR experiment. Data corresponding to an integrated luminosity of 398 fb^{-1} are analyzed. No evidence for a signal is observed. Branching fraction upper limits in the range from 10^{-7}-10^{-5} are obtained at 90% confidence level for masses of 1.0<m_{ψ_{<mark>D}}<4.3 GeV/c^{2}. The result is also reinterpreted to provide the first limits on a supersymmetric model with R-parity violation and a light neutralino.
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.201801
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Article: Phenomewide Association Study of Health Outcomes Associated With the Genetic Correlates of 25 Hydroxyvitamin D Concentration and Vitamin D Binding Protein Concentration.

Kresge, Hailey A / Blostein, Freida / Goleva, Slavina / Albiñana, Clara / Revez, Joana A / Wray, Naomi R / Vilhjálmsson, Bjarni J / Zhu, Zhihong / McGrath, John J / Davis, Lea K

Twin research and human genetics : the official journal of the International Society for Twin Studies

2024 , Page(s) 1–11

Abstract: While it is known that vitamin D deficiency is associated with adverse bone outcomes, it remains ... unclear whether low vitamin D status may increase the risk of a wider range of health outcomes. We had ... D (25OHD) and the vitamin D binding protein (DBP, encoded by the ...

Abstract	While it is known that vitamin D deficiency is associated with adverse bone outcomes, it remains unclear whether low vitamin D status may increase the risk of a wider range of health outcomes. We had the opportunity to explore the association between common genetic variants associated with both 25 hydroxyvitamin D (25OHD) and the vitamin D binding protein (DBP, encoded by the
Language	English
Publishing date	2024-04-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2182682-1
ISSN	1839-2628 ; 1832-4274
ISSN (online)	1839-2628
ISSN	1832-4274
DOI	10.1017/thg.2024.19
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Article ; Online: Clinical, metabolic, and immunological characterisation of adult Ugandan patients with new-onset diabetes and low vitamin D status.

Kibirige, Davis / Sekitoleko, Isaac / Balungi, Priscilla / Kyosiimire-Lugemwa, Jacqueline / Lumu, William

BMC endocrine disorders

2022 Volume 22, Issue 1, Page(s) 230

Abstract: Background: Low vitamin D concentrations are associated with metabolic derangements, notably ... of a black Ugandan adult population with recently diagnosed diabetes and hypovitaminosis D.: Methods ... Serum vitamin D concentrations were measured in 327 participants with recently diagnosed diabetes ...

Abstract	Background: Low vitamin D concentrations are associated with metabolic derangements, notably insulin resistance and pancreatic beta-cell dysfunction in Caucasian populations. Studies on its association with the clinical, metabolic, and immunologic characteristics in black African adult populations with new-onset diabetes are limited. This study aimed to describe the clinical, metabolic, and immunologic characteristics of a black Ugandan adult population with recently diagnosed diabetes and hypovitaminosis D. Methods: Serum vitamin D concentrations were measured in 327 participants with recently diagnosed diabetes. Vitamin D deficiency, vitamin D insufficiency, and normal vitamin D status were defined as serum 25 hydroxyvitamin D levels of < 20 ng/ml, 21-29 ng/ml, and ≥ 30 ng/ml, respectively. Results: The median (IQR) age, glycated haemoglobin, and serum vitamin D concentration of the participants were 48 years (39-58), 11% (8-13) or 96 mmol/mol (67-115), and 24 ng/ml (18-30), respectively. Vitamin D deficiency, vitamin D insufficiency, and normal vitamin D status were noted in 105 participants (32.1%), 140 participants (42.8%), and 82 participants (25.1%), respectively. Compared with those having normal serum vitamin D levels, participants with vitamin D deficiency and insufficiency had higher circulating concentrations of interleukin (IL) 6 (29 [16-45] pg/ml, 23 [14-40] pg/ml vs 18 [14-32] pg/ml, p = 0.01), and IL-8 (24 [86-655] pg/ml, 207 [81-853] pg/ml vs 98 [67-224], p = 0.03). No statistically significant differences were noted in the markers of body adiposity, insulin resistance, and pancreatic beta-cell function between both groups. Conclusion: Vitamin D deficiency and insufficiency were highly prevalent in our study population and were associated with increased circulating concentrations of pro-inflammatory cytokines. The absence of an association between pancreatic beta-cell function, insulin resistance, and low vitamin D status may indicate that the latter does not play a significant role in the pathogenesis of type 2 diabetes in our adult Ugandan population.
MeSH term(s)	Adult ; Cytokines ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Glycated Hemoglobin A ; Humans ; Insulin Resistance ; Interleukin-8 ; Middle Aged ; Uganda/epidemiology ; Vitamin D ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology ; Vitamins
Chemical Substances	Cytokines ; Glycated Hemoglobin A ; Interleukin-8 ; Vitamins ; Vitamin D (1406-16-2)
Language	English
Publishing date	2022-09-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2091323-0
ISSN	1472-6823 ; 1472-6823
ISSN (online)	1472-6823
ISSN	1472-6823
DOI	10.1186/s12902-022-01148-7
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