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  1. Book: Advances in paediatric rheumatology and translation of research to targeted therapies

    Woo, Patricia

    (Best practice & research : Clinical rheumatology ; 28,2)

    2014  

    Author's details Patricia Woo ..., guest ed
    Series title Best practice & research : Clinical rheumatology ; 28,2
    Best practice & research
    Best practice & research ; Clinical rheumatology
    Collection Best practice & research
    Best practice & research ; Clinical rheumatology
    Language English
    Size S. 173 - 350 : Ill.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT018334787
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1036 -28,2- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Eric Bywaters and Barbara Ansell: Founders of Modern Pediatric Rheumatology.

    Woo, Patricia / Petty, Ross E

    Rheumatic diseases clinics of North America

    2023  Volume 50, Issue 1, Page(s) 93–101

    Abstract: Eric Bywaters and Barbara Ansell were, without doubt, two of the giants in the field of Rheumatology. With their keen clinical observations and their visionary development of a dedicated multidisciplinary program focusing on diagnosis, treatment, and ... ...

    Abstract Eric Bywaters and Barbara Ansell were, without doubt, two of the giants in the field of Rheumatology. With their keen clinical observations and their visionary development of a dedicated multidisciplinary program focusing on diagnosis, treatment, and research, they are remembered as the founders of the modern specialty of Pediatric Rheumatology.
    MeSH term(s) History, 20th Century ; Humans ; Rheumatology/history ; Pediatrics
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Biography ; Journal Article
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2023.08.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Type 6 secretion system components hcp and vgrG support mutualistic partnership between Xenorhabdus bovienii symbiont and Steinernema jollieti host.

    Pothula, Ratnasri / Lee, Min-Woo / Patricia Stock, S

    Journal of invertebrate pathology

    2023  Volume 198, Page(s) 107925

    Abstract: Xenorhabdus, like other Gram-negative bacteria, possesses a Type 6 Secretion System (T6SS) which acts as a contact-dependent molecular syringe, delivering diverse proteins (effectors) directly into other cells. The number of T6SS loci encoded in ... ...

    Abstract Xenorhabdus, like other Gram-negative bacteria, possesses a Type 6 Secretion System (T6SS) which acts as a contact-dependent molecular syringe, delivering diverse proteins (effectors) directly into other cells. The number of T6SS loci encoded in Xenorhabdus genomes are variable both at the inter and intraspecific level. Some environmental isolates of Xenorhabdus bovienii, encode at least one T6SS locus while others possess two loci. Previous work conducted by our team demonstrated that X. bovienii [Jollieti strain SS-2004], which has two T6SSs (T6SS-1 and T6SS-2), hcp genes are required for biofilm formation. Additionally, while T6SS-1 hcp gene plays a role in the antibacterial competition, T6SS-2 hcp does not. In this study, we tested the hypothesis that vgrG genes are also involved in mutualistic and pathogenic interactions. For this purpose, targeted mutagenesis together with wet lab experiments including colonization, competition, biofilm, and virulence experiments, were carried out to assess the role of vgrG in the mutualistic and antagonistic interactions in the life cycle of XBJ. Our results revealed that vgrG genes are not required for biofilm formation but play a role in outcompeting other Xenorhabdus bacteria. Additionally, both vgrG and hcp genes are required to fully colonize the nematode host. We also demonstrated that hcp and vgrG genes in both T6SS clusters are needed to support the reproductive fitness of the nematodes. Overall, results from this study revealed that in X. bovieni jollieti strain, the twoT6SS clusters play an important role in the fitness of the nematodes in relation to colonization and reproduction. These results lay a foundation for further investigations on the functional significance of T6SSs in the mutualistic and pathogenic lifecycle of Xenorhabdus spp.
    MeSH term(s) Animals ; Type VI Secretion Systems/genetics ; Type VI Secretion Systems/metabolism ; Xenorhabdus ; Virulence/genetics ; Nematoda/genetics ; Nematoda/microbiology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism
    Chemical Substances Type VI Secretion Systems ; Bacterial Proteins
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390885-9
    ISSN 1096-0805 ; 0022-2011
    ISSN (online) 1096-0805
    ISSN 0022-2011
    DOI 10.1016/j.jip.2023.107925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 958: Show issues Location:
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  4. Book ; Online: Pediatric Rheumatology in Clinical Practice

    Woo, Patricia / Laxer, Ronald M. / Sherry, David D.

    2007  

    Author's details by Patricia Woo, Ronald M. Laxer, David D. Sherry
    Keywords Internal medicine ; Pediatrics ; Rheumatology
    Language English
    Publisher Springer-Verlag London Limited
    Publishing place London
    Document type Book ; Online
    HBZ-ID TT050387238
    ISBN 978-1-8462-8420-5 ; 978-1-8462-8421-2 ; 1-8462-8420-1 ; 1-8462-8421-X
    DOI 10.1007/978-1-84628-421-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Book: Pediatric rheumatology in clinical practice

    Woo, Patricia / Laxer, Ronald M. / Sherry, David D.

    2007  

    Author's details Patricia Woo ; Ronald M. Laxer, and David D. Sherry
    Keywords Rheumatic Diseases ; Inflammation ; Pediatrics / methods ; Child ; Pediatric rheumatology
    Subject code 618.92723
    Language English
    Size VIII, 188 S. : Ill., 21cm
    Publisher Springe
    Publishing place London
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index. - Formerly CIP
    HBZ-ID HT015323092
    ISBN 978-1-8462-8420-5 ; 1-8462-8420-1 ; 184628421X ; 9781846284212
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 3652 order for loan Magazin

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  6. Article ; Online: Type 6 secretion system components hcp and vgrG support mutualistic partnership between Xenorhabdus bovienii symbiont and Steinernema jollieti host

    Pothula, Ratnasri / Lee, Min-Woo / Patricia Stock, S.

    Journal of Invertebrate Pathology. 2023 June, v. 198 p.107925-

    2023  

    Abstract: Xenorhabdus, like other Gram-negative bacteria, possesses a Type 6 Secretion System (T6SS) which acts as a contact-dependent molecular syringe, delivering diverse proteins (effectors) directly into other cells. The number of T6SS loci encoded in ... ...

    Abstract Xenorhabdus, like other Gram-negative bacteria, possesses a Type 6 Secretion System (T6SS) which acts as a contact-dependent molecular syringe, delivering diverse proteins (effectors) directly into other cells. The number of T6SS loci encoded in Xenorhabdus genomes are variable both at the inter and intraspecific level. Some environmental isolates of Xenorhabdus bovienii, encode at least one T6SS locus while others possess two loci. Previous work conducted by our team demonstrated that X. bovienii [Jollieti strain SS-2004], which has two T6SSs (T6SS-1 and T6SS-2), hcp genes are required for biofilm formation. Additionally, while T6SS-1 hcp gene plays a role in the antibacterial competition, T6SS-2 hcp does not. In this study, we tested the hypothesis that vgrG genes are also involved in mutualistic and pathogenic interactions. For this purpose, targeted mutagenesis together with wet lab experiments including colonization, competition, biofilm, and virulence experiments, were carried out to assess the role of vgrG in the mutualistic and antagonistic interactions in the life cycle of XBJ. Our results revealed that vgrG genes are not required for biofilm formation but play a role in outcompeting other Xenorhabdus bacteria. Additionally, both vgrG and hcp genes are required to fully colonize the nematode host. We also demonstrated that hcp and vgrG genes in both T6SS clusters are needed to support the reproductive fitness of the nematodes. Overall, results from this study revealed that in X. bovieni jollieti strain, the twoT6SS clusters play an important role in the fitness of the nematodes in relation to colonization and reproduction. These results lay a foundation for further investigations on the functional significance of T6SSs in the mutualistic and pathogenic lifecycle of Xenorhabdus spp.
    Keywords Steinernema ; Xenorhabdus bovienii ; biofilm ; genes ; invertebrates ; loci ; mutagenesis ; reproductive fitness ; symbionts ; syringes ; type VI secretion system ; virulence ; Xenorhabdus ; Type 6 secretion system ; Mutualism ; Pathogenesis
    Language English
    Dates of publication 2023-06
    Publishing place Elsevier Inc.
    Document type Article ; Online
    Note Pre-press version ; Use and reproduction
    ZDB-ID 390885-9
    ISSN 1096-0805 ; 0022-2011
    ISSN (online) 1096-0805
    ISSN 0022-2011
    DOI 10.1016/j.jip.2023.107925
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 958: Show issues Location:
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  7. Article ; Online: A Shadowed Type-2 Fuzzy Approach for Crossover Parameter Adaptation in Differential Evolution

    Patricia Ochoa / Cinthia Peraza / Oscar Castillo / Zong Woo Geem

    Algorithms, Vol 16, Iss 279, p

    2023  Volume 279

    Abstract: The shadowed type-2 fuzzy systems are used more frequently today as they provide an alternative to classical fuzzy logic. The primary purpose of fuzzy logic is to simulate reasoning in a computer. This work aims to use shadowed type-2 fuzzy systems (ST2- ... ...

    Abstract The shadowed type-2 fuzzy systems are used more frequently today as they provide an alternative to classical fuzzy logic. The primary purpose of fuzzy logic is to simulate reasoning in a computer. This work aims to use shadowed type-2 fuzzy systems (ST2-FS) to dynamically adapt the crossing parameter of differential evolution (DE). To test the performance of the dynamic crossing parameter, the motor position control problem was used, which contains an interval type-2 fuzzy system (IT2-FS) for controlling the motor. A comparison is made between the original DE and the algorithm using shadowed type-2 fuzzy systems (DE-ST2-FS), as well as a comparison with the results of other state-of-the-art metaheuristics.
    Keywords shadowed type-2 fuzzy logic ; interval type-2 fuzzy controller ; differential evolution ; Industrial engineering. Management engineering ; T55.4-60.8 ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 629
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Conference proceedings: Paediatric rheumatology update

    Woo, Patricia

    1990  

    Institution State of the Arts' Symposium on Paediatric Rheumatology
    Author's details [State of the Arts' Symposium on Paediatric Rheumatology ... 22nd and 23rd September, 1988 ... Harrow]. Ed. by Patricia Woo
    Keywords Rheumatic Diseases / in infancy & childhood / congresses ; Rheumatismus ; Kind
    Subject Kindheit ; Kindesalter ; Kindschaft ; Kinder ; Rheuma ; Rheumatische Krankheit
    Size XII, 247 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Pr
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT003573677
    ISBN 0-19-261860-1 ; 978-0-19-261860-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 5113 order for loan Magazin

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  9. Article ; Online: In Vitro Characterization of the Physical Interactions between the Long Noncoding RNA TERRA and the Telomeric Proteins TRF1 and TRF2.

    Abreu, Patricia L / Lee, Yong Woo / Azzalin, Claus M

    International journal of molecular sciences

    2022  Volume 23, Issue 18

    Abstract: RNA-protein interactions drive key cellular pathways such as protein translation, nuclear organization and genome stability maintenance. The human telomeric protein TRF2 binds to the long noncoding RNA TERRA through independent domains, including its N- ... ...

    Abstract RNA-protein interactions drive key cellular pathways such as protein translation, nuclear organization and genome stability maintenance. The human telomeric protein TRF2 binds to the long noncoding RNA TERRA through independent domains, including its N-terminal B domain. We previously demonstrated that TRF2 B domain binding to TERRA supports invasion of TERRA into telomeric double stranded DNA, leading to the formation of telomeric RNA:DNA hybrids. The other telomeric protein TRF1, which also binds to TERRA, suppresses this TRF2-associated activity by preventing TERRA-B domain interactions. Herein, we show that the binding of both TRF1 and TRF2 to TERRA depends on the ability of the latter to form G-quadruplex structures. Moreover, a cluster of arginines within the B domain is largely responsible for its binding to TERRA. On the other side, a patch of glutamates within the N-terminal A domain of TRF1 mainly accounts for the inhibition of TERRA-B domain complex formation. Finally, mouse TRF2 B domain binds to TERRA, similarly to its human counterpart, while mouse TRF1 A domain lacks the inhibitory activity. Our data shed further light on the complex crosstalk between telomeric proteins and RNAs and suggest a lack of functional conservation in mouse.
    MeSH term(s) Animals ; DNA/chemistry ; Glutamates ; Humans ; Mice ; RNA, Long Noncoding/genetics ; Telomere/genetics ; Telomere/metabolism ; Telomeric Repeat Binding Protein 1/chemistry ; Telomeric Repeat Binding Protein 1/genetics ; Telomeric Repeat Binding Protein 1/metabolism ; Telomeric Repeat Binding Protein 2/genetics
    Chemical Substances Glutamates ; RNA, Long Noncoding ; Telomeric Repeat Binding Protein 1 ; Telomeric Repeat Binding Protein 2 ; DNA (9007-49-2)
    Language English
    Publishing date 2022-09-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms231810463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Real-world implementation of 4-component meningococcal serogroup B vaccine (4CMenB): implications for clinical practices.

    Sohn, Woo-Yun / Tahrat, Halima / Novy, Patricia / Bekkat-Berkani, Rafik

    Expert review of vaccines

    2022  Volume 21, Issue 3, Page(s) 325–335

    Abstract: Introduction: Invasive meningococcal disease due to serogroup B (MenB) is an uncommon but life-threatening disease. The 4-component meningococcal serogroup B vaccine (4CMenB) is the only MenB vaccine with real-world evidence supporting a reduction in ... ...

    Abstract Introduction: Invasive meningococcal disease due to serogroup B (MenB) is an uncommon but life-threatening disease. The 4-component meningococcal serogroup B vaccine (4CMenB) is the only MenB vaccine with real-world evidence supporting a reduction in incidence without safety concerns.
    Areas covered: We reviewed recommendations and real-world implementation of 4CMenB in National Immunization Programs (NIPs) and implications for clinical practice through a non-systematic literature search.
    Expert opinion: 4CMenB is registered in 45 countries, 33 of which recommend it clinically: nine for infants, children, adolescents, and high-risk groups; 11 for infants and high-risk groups; the US for individuals aged 16-23 years and high-risk groups; two for infants; 10 for high-risk groups and/or outbreak control. Dosing schedule varies between countries. To date, nine countries include 4CMenB in their NIP: UK, Andorra, Ireland, Italy, San Marino, Lithuania, Malta, Czech Republic, and Portugal. Australia funds it for Aboriginal and Torres Strait Islander children under 2 years, and high-risk individuals. South Australia funds for all infants and adolescents. Many factors influenced introduction into NIPs: disease burden, public awareness, cost-effectiveness, prior meningococcal vaccination programs, efficacy and safety profile. In the future, more countries might consider including 4CMenB in their NIP due to growing evidence on effectiveness and safety.
    MeSH term(s) Adolescent ; Adult ; Child ; Humans ; Infant ; Meningococcal Infections/epidemiology ; Meningococcal Infections/prevention & control ; Meningococcal Vaccines ; Neisseria meningitidis, Serogroup B ; Serogroup ; Vaccination ; Young Adult
    Chemical Substances Meningococcal Vaccines
    Language English
    Publishing date 2022-02-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1080/14760584.2022.2021881
    Database MEDical Literature Analysis and Retrieval System OnLINE

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