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  1. Article ; Online: Evaluation of a Less Invasive Cochlear Implant Surgery in

    Tekin, Ahmet M / Baelen, Hermine / Heuninck, Emilie / Bayazıt, Yıldırım A / Mertens, Griet / Rompaey, Vincent van / Heyning, Paul van de / Topsakal, Vedat

    Genes

    2023  Volume 14, Issue 3

    Abstract: Cochlear implantation (CI) for deafblindness may have more impact than for non-syndromic hearing loss. Deafblind patients have a double handicap in a society that is more and more empowered by fast communication. CI is a remedy for deafness, but requires ...

    Abstract Cochlear implantation (CI) for deafblindness may have more impact than for non-syndromic hearing loss. Deafblind patients have a double handicap in a society that is more and more empowered by fast communication. CI is a remedy for deafness, but requires revision surgery every 20 to 25 years, and thus placement should be minimally invasive. Furthermore, failed reimplantation surgery will have more impact on a deafblind person. In this context, we assessed the safety of minimally invasive robotically assisted cochlear implant surgery (RACIS) for the first time in a deafblind patient. Standard pure tone audiometry and speech audiometry were performed in a patient with deafblindness as part of this robotic-assisted CI study before and after surgery. This patient, with an optic atrophy 1 (
    MeSH term(s) Female ; Humans ; Cochlear Implantation/methods ; Cochlear Implants ; Deaf-Blind Disorders/genetics ; Deaf-Blind Disorders/surgery ; Deafness/genetics ; Deafness/surgery ; GTP Phosphohydrolases/genetics ; Mutation
    Chemical Substances GTP Phosphohydrolases (EC 3.6.1.-) ; OPA1 protein, human (EC 3.6.1.-)
    Language English
    Publishing date 2023-03-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14030627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Global Research on Hereditary Hearing Impairment Over the Last 40 Years: A Bibliometric Study.

    Tekin, Ahmet M / Bahşi, İlhan / Bayazit, Yıldırım A / Topsakal, Vedat

    The journal of international advanced otology

    2022  Volume 17, Issue 6, Page(s) 482–491

    Abstract: Background: Research on hereditary hearing impairment has had several boosts to identify deafness-causing genes. The number of studies regarding the diagnosis and treatment modalities of hereditary hearing impairment is enormous and increasing; however, ...

    Abstract Background: Research on hereditary hearing impairment has had several boosts to identify deafness-causing genes. The number of studies regarding the diagnosis and treatment modalities of hereditary hearing impairment is enormous and increasing; however, little or no research has been conducted for evaluating the development of scientific output and trends in the field. Here, we provide a comprehensive overview of centers that focus their research on hereditary hearing impairment and their scientific output.
    Methods: Bibliometric analysis of the publications related to hereditary hearing impairment published between 1980 and 2019 were used in this study, which were also indexed in Web of Science database.
    Results: The highest number of scientific articles on hereditary hearing impairment came from the United States, and it was also the most cited country. The University of Iowa is a leading center in the domain of hereditary hearing impairment in the world over the last 40 years. Fudan University, Central South University, and Harvard Medical School are also institutions that have had a focus on hereditary hearing impairment.
    Conclusions: There is a progressive increase in scientific papers on hereditary hearing impairment over the last 40 years that we have found in our bibliometric study. We identified key centers in the scientific research on hereditary hearing impairment in the world and also key journals that focus on hereditary hearing impairment. This information can facilitate new researchers in this field to seek collaboration with experienced partners, better synthesize the orientation and boundaries of the subject, and find target journals. Ultimately, we provided a certain benchmark value for key centers that perhaps should have a more prominent role in constructing experimental research or even clinical guidelines.
    MeSH term(s) Bibliometrics ; Databases, Factual ; Deafness ; Hearing Loss/genetics ; Humans ; Publications ; United States
    Language English
    Publishing date 2022-02-11
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 2561231-1
    ISSN 2148-3817 ; 1308-7649 ; 2148-3817
    ISSN (online) 2148-3817
    ISSN 1308-7649 ; 2148-3817
    DOI 10.5152/iao.2021.21276
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  3. Article ; Online: Does MESNA application make sense in chronic otitis media surgery?

    Kalcioglu, M Tayyar / Bayazit, Yildirim A

    American journal of otolaryngology

    2014  Volume 35, Issue 5, Page(s) 687–688

    MeSH term(s) Cholesteatoma/surgery ; Female ; Humans ; Male ; Mesna/therapeutic use ; Protective Agents/therapeutic use
    Chemical Substances Protective Agents ; Mesna (NR7O1405Q9)
    Language English
    Publishing date 2014-09
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2014.06.008
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  4. Article ; Online: Comprehensive evaluation of patients with primary hyperoxaluria type 1: A nationwide study.

    Bakkaloğlu, Sevcan A / Büyükkaragöz, Bahar / Pınarbaşı, Ayşe Seda / Leventoğlu, Emre / Saygılı, Seha / Çomak, Elif / Yıldırım, Zeynep Y / Akıncı, Nurver / Dursun, İsmail / Karabay Bayazıt, Aysun / Kavaz Tufan, Aslı / Akman, Sema / Yılmaz, Alev / Noyan, Aytül / Ağbaş, Ayşe / Serdaroğlu, Erkin / Delibaş, Ali / Elmacı, Ahmet Midhat / Taşdemir, Mehmet /
    Ezgü, Fatih S / Sever, Lale

    Nephrology (Carlton, Vic.)

    2024  Volume 29, Issue 4, Page(s) 201–213

    Abstract: Background: Primary hyperoxaluria type 1 (PH1) is characterized by increased endogenous oxalate production and deposition as calcium oxalate crystals. The main manifestations are nephrocalcinosis/nephrolithiasis, causing impaired kidney function. We ... ...

    Abstract Background: Primary hyperoxaluria type 1 (PH1) is characterized by increased endogenous oxalate production and deposition as calcium oxalate crystals. The main manifestations are nephrocalcinosis/nephrolithiasis, causing impaired kidney function. We aimed to evaluate the clinical characteristics and overall outcomes of paediatric PH1 patients in Turkey.
    Methods: This is a nationwide, multicentre, retrospective study evaluating all available paediatric PH1 patients from 15 different paediatric nephrology centres in Turkey. Detailed patient data was collected which included demographic, clinical and laboratory features. Patients were classified according to their age and characteristics at presentation: patients presenting in the first year of life with nephrocalcinosis/nephrolithiasis (infantile oxalosis, Group 1), cases with recurrent nephrolithiasis diagnosed during childhood (childhood-onset PH1, Group 2), and asymptomatic children diagnosed with family screening (Group 3).
    Results: Forty-eight patients had a mutation consistent with PH1. The most common mutation was c.971_972delTG (25%). Infantile oxalosis patients had more advanced chronic kidney disease (CKD) or kidney failure necessitating dialysis (76.9% vs. 45.5%). These patients had much worse clinical course and mortality rates seemed to be higher (23.1% vs. 13.6%). Patients with fatal outcomes were the ones with significant comorbidities, especially with cardiovascular involvement. Patients in Group 3 were followed with better outcomes, with no kidney failure or mortality.
    Conclusion: PH1 is not an isolated kidney disease but a systemic disease. Family screening helps to preserve kidney function and prevent systemic complications. Despite all efforts made with traditional treatment methods including transplantation, our results show devastating outcomes or mortality.
    MeSH term(s) Humans ; Child ; Nephrocalcinosis/diagnosis ; Nephrocalcinosis/epidemiology ; Nephrocalcinosis/etiology ; Retrospective Studies ; Kidney Failure, Chronic/complications ; Renal Dialysis/adverse effects ; Hyperoxaluria, Primary/complications ; Hyperoxaluria, Primary/diagnosis ; Hyperoxaluria, Primary/genetics ; Nephrolithiasis/complications ; Nephrolithiasis/diagnosis ; Nephrolithiasis/genetics ; Hyperoxaluria/complications ; Renal Insufficiency
    Language English
    Publishing date 2024-01-30
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1303661-0
    ISSN 1440-1797 ; 1320-5358
    ISSN (online) 1440-1797
    ISSN 1320-5358
    DOI 10.1111/nep.14273
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    Zs.A 4822: Show issues Location:
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  5. Article ; Online: Evaluation of the Claria sharesource system from the perspectives of patient/caregiver, physician, and nurse in children undergoing automated peritoneal dialysis.

    Uzun Kenan, Bahriye / Demircioglu Kilic, Beltinge / Akbalık Kara, Mehtap / Taktak, Aysel / Karabay Bayazit, Aysun / Yuruk Yildirim, Zeynep Nagehan / Delibas, Ali / Aytac, Mehmet Baha / Conkar, Secil / Kaya Aksoy, Gulsah / Donmez, Osman / Yel, Sibel / Saygili, Seha / Akaci, Okan / Buyukkaragoz, Bahar / Alpay, Harika / Bakkaloglu, Sevcan A

    Pediatric nephrology (Berlin, Germany)

    2022  

    Abstract: Background: Automated peritoneal dialysis (APD) is increasingly preferred worldwide. By using a software application (Homechoice with Claria sharesource system (CSS)) with a mod-M added to the APD device, details of the home dialysis treatment become ... ...

    Abstract Background: Automated peritoneal dialysis (APD) is increasingly preferred worldwide. By using a software application (Homechoice with Claria sharesource system (CSS)) with a mod-M added to the APD device, details of the home dialysis treatment become visible for PD nurses and physicians, allowing for close supervision. We aimed to evaluate the perceptions of patients/caregivers, PD nurses, and physicians about the advantages and disadvantages of CSS.
    Methods: Three different web-based questionnaires for patients/caregivers, nurses, and physicians were sent to 15 pediatric nephrology centers with more than 1 year of experience with CSS.
    Results: Respective questionnaires were answered by 30 patients/caregivers, 22 pediatric nephrologists, and 15 PD nurses. Most of the nurses and physicians (87% and 73%) reported that CSS improved patient monitoring. A total of 73% of nurses suggested that CCS is not well known by physicians, while half of them reported reviewing CSS data for all patients every morning. Sixty-eight percent of physicians thought that CSS helps save time for both patients/caregivers and healthcare providers by reducing visits. However, only 20% of patients/caregivers reported reduced hospital visits. A total of 90% of patients/caregivers reported that being under constant monitoring made them feel safe, and 83% stated that the patient's sleep quality improved.
    Conclusions: A remote monitoring APD system, CSS, can be successfully applied with children for increased adherence to dialysis prescription by giving shared responsibility and may help increase the patient's quality of life. This platform is more commonly used by nurses than physicians. Its potential benefits should be evaluated in further well-designed clinical studies with larger patient groups. A higher resolution version of the Graphical abstract is available as Supplementary information.
    Language English
    Publishing date 2022-05-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-022-05563-9
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  6. Article ; Online: Repeated Atmospheric Pressure Alteration Effect on the Cochlea in Rats: Experimental Animal Study.

    Eroglu, Sinan / Dizdar, Handan Turan / Cevizci, Rasit / Cengiz, Abdurrahman Bugra / Ogreden, Sahin / Bulut, Erdogan / Ilgezdi, Savas / Dilci, Alper / Ustun, Selin / Sirvanci, Serap / Cilingir-Kaya, Ozlem Tugce / Bayazit, Dilara / Cakir, Burak Omur / Oktay, Mehmet Faruk / Bayazit, Yildirim

    Aerospace medicine and human performance

    2021  Volume 92, Issue 7, Page(s) 550–555

    Abstract: OBJECTIVE: ...

    Abstract OBJECTIVE:
    MeSH term(s) Animals ; Atmospheric Pressure ; Cochlea ; Evoked Potentials, Auditory, Brain Stem ; Hearing Loss, Noise-Induced ; Rats ; Rats, Wistar
    Language English
    Publishing date 2021-08-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2809085-8
    ISSN 2375-6322 ; 2375-6314
    ISSN (online) 2375-6322
    ISSN 2375-6314
    DOI 10.3357/AMHP.5732.2021
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  7. Article: Genetics of headache and catechol-O-methyltransferase gene polymorphism.

    Bayazit, Yildirim A

    The journal of headache and pain

    2006  Volume 7, Issue 2, Page(s) 60

    MeSH term(s) Catechol O-Methyltransferase/genetics ; Headache/genetics ; Humans ; Polymorphism, Genetic
    Chemical Substances Catechol O-Methyltransferase (EC 2.1.1.6)
    Language English
    Publishing date 2006-05-11
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 2036768-5
    ISSN 1129-2377 ; 1129-2369
    ISSN (online) 1129-2377
    ISSN 1129-2369
    DOI 10.1007/s10194-006-0286-2
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    Zs.A 5464: Show issues Location:
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  8. Article ; Online: Association of Conductive Hearing Loss with the Structural Changes in the Organ of Corti.

    Eroglu, Sinan / Cevizci, Rasit / Turan Dizdar, Handan / Tansuker, Hasan Deniz / Bulut, Erdogan / Dilci, Alper / Ustun, Selin / Sirvanci, Serap / Kaya, Ozlem Tugce / Bayazit, Dilara / Cakir, Burak Omur / Oktay, Mehmet Faruk / Bayazit, Yildirim Ahmet

    ORL; journal for oto-rhino-laryngology and its related specialties

    2021  Volume 83, Issue 4, Page(s) 272–279

    Abstract: Objective: The aim of the study was to evaluate the association of conductive hearing loss (CHL) with the structural changes in the organ of Corti.: Methods: Twenty ears of 10 healthy adult Wistar albino rats were included in the study. The right ... ...

    Abstract Objective: The aim of the study was to evaluate the association of conductive hearing loss (CHL) with the structural changes in the organ of Corti.
    Methods: Twenty ears of 10 healthy adult Wistar albino rats were included in the study. The right ears (n = 10) of the animals served as controls (group 1), and no surgical intervention was performed in these ears. A tympanic membrane perforation without annulus removal was performed under operative microscope on the left ears (n = 5) in 5 of 10 animals (group 2). A tympanic membrane perforation with annulus removal was performed under operative microscope on the left ears (n = 5) of the remaining 5 animals (group 3). Auditory brainstem response testing was performed in the animals before the interventions. After 3 months, the animals were sacrificed, their temporal bones were removed, and inner ears were investigated using scanning electron microscopy (SEM). The organ of Corti was evaluated from the cochlear base to apex in the modiolar axis, and the parameters were scored semiquantitatively.
    Results: In group 1, the pre- and post-intervention hearing thresholds were similar (p > 0.05). In group 2, a hearing decrease of at least 5 dB was encountered in all test frequencies (p > 0.05). In group 3, at the frequency range of 2-32 kHz, there was a significant hearing loss after 3 months (p < 0.01). After 3 months, the hearing thresholds in group 2 and 3 were higher than group 1 (p < 0.01). The hearing threshold in group 3 was higher than group 2 (p < 0.01). On SEM evaluation, the general cell morphology and stereocilia of the outer hair cells were preserved in all segments of the cochlea in group 1 with a mean SEM score of 0.2. There was segmental degeneration in the general cell morphology and outer hair cells in group 2 with a mean SEM score of 2.2. There was widespread degeneration in the general cell morphology and outer hair cells in group 3 with a mean SEM score of 3.2. The SEM scores of group 2 and 3 were significantly higher than group 1 (p < 0.05). The SEM scores of group 3 were significantly higher than group 2 (p < 0.05).
    Conclusion: CHL may be associated with an inner ear damage. The severity of damage appears to be associated with severity and duration of CHL. Early correction of CHL is advocated in order to reverse or prevent progression of the inner ear damage, which will enhance the success rates of hearing restoration surgeries. Subjective differences and compliance of the hearing aid users may be due to the impact of CHL on inner ear structures.
    MeSH term(s) Animals ; Auditory Threshold ; Cochlea ; Evoked Potentials, Auditory, Brain Stem ; Hair Cells, Auditory, Outer ; Hearing ; Hearing Loss, Conductive/etiology ; Rats
    Language English
    Publishing date 2021-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 121482-2
    ISSN 1423-0275 ; 0301-1569
    ISSN (online) 1423-0275
    ISSN 0301-1569
    DOI 10.1159/000513871
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  9. Article: Evaluation of pd-1, pd-l1, and cytotoxic T-lymphocyteassociated protein 4 expressions together with clinicopathological findings in clear cell, papillary, and chromophobe types of renal cell carcinoma.

    Inceman, Merve / Toyran, Tugba / Bayazit, Yildirim / Izol, Volkan / Erdogan, Seyda

    Polish journal of pathology : official journal of the Polish Society of Pathologists

    2023  Volume 73, Issue 3, Page(s) 181–190

    Abstract: Our study aimed to determine the expressions of programmed death protein 1 (PD-1), programmed death ligand protein 1 (PD-L1), and cytotoxic T-lymphocyte- associated protein 4 (CTLA-4) to investigate and compare the differences between early and advanced ... ...

    Title translation Evaluation of pd-1, pd-l1, and cytotoxic T-lymphocyte associated protein 4 expressions together with clinicopathological findings in clear cell, papillary, and chromophobe types of renal cell carcinoma.
    Abstract Our study aimed to determine the expressions of programmed death protein 1 (PD-1), programmed death ligand protein 1 (PD-L1), and cytotoxic T-lymphocyte- associated protein 4 (CTLA-4) to investigate and compare the differences between early and advanced cases in the 3 most common types of renal cell carcinoma (RCC) and reveal their correlations with prognosis and survival. A total of 166 RCC cases diagnosed between 2010 and 2019 in our hospital were included. PD-1, PD-L1, and CTLA-4 markers were applied to the paraffin blocks of the cases using an immunohistochemical method, and their expression status was evaluated by distinguishing subtypes in advanced- and early-stage RCCs. It was observed that PD-L1 positivity in the tumour cells, in clear cell RCC, was statistically significantly more frequent in advanced-stage cases compared to early-stage cases. It was concluded that cases with PD-L1 positivity in tumour- infiltrating mononuclear cells (TIMC) in clear cell and chromophobe RCC had a shorter survival. The frequency of perinephritic fat invasion and necrosis was higher in cases with PD-L1 expression in TIMC. We think that PD-1, PD-L1, and CTLA-4 must be considered together in advanced stage RCC for the treatment of both pathway inhibitors. Further large studies will shed light on the immunotherapy options at the advanced stage of all RCC types even in the absence of metastasis.
    MeSH term(s) Humans ; Carcinoma, Renal Cell/pathology ; CTLA-4 Antigen/therapeutic use ; Programmed Cell Death 1 Receptor/metabolism ; B7-H1 Antigen/metabolism ; Biomarkers, Tumor/metabolism ; Prognosis ; Antineoplastic Agents/therapeutic use ; Kidney Neoplasms/pathology
    Chemical Substances CTLA-4 Antigen ; Programmed Cell Death 1 Receptor ; B7-H1 Antigen ; Biomarkers, Tumor ; Antineoplastic Agents
    Language English
    Publishing date 2023-02-03
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 1283064-1
    ISSN 1233-9687 ; 0031-3114
    ISSN 1233-9687 ; 0031-3114
    DOI 10.5114/pjp.2022.122613
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  10. Article ; Online: Evaluation of a Less Invasive Cochlear Implant Surgery in OPA1 Mutations Provoking Deafblindness

    Tekin, Ahmet M. / Baelen, Hermine / Heuninck, Emilie / Bayazıt, Yıldırım A. / Mertens, Griet / Rompaey, Vincent van / Heyning, Paul van de / Topsakal, Vedat

    Genes (Basel). 2023 Mar. 02, v. 14, no. 3

    2023  

    Abstract: Cochlear implantation (CI) for deafblindness may have more impact than for non-syndromic hearing loss. Deafblind patients have a double handicap in a society that is more and more empowered by fast communication. CI is a remedy for deafness, but requires ...

    Abstract Cochlear implantation (CI) for deafblindness may have more impact than for non-syndromic hearing loss. Deafblind patients have a double handicap in a society that is more and more empowered by fast communication. CI is a remedy for deafness, but requires revision surgery every 20 to 25 years, and thus placement should be minimally invasive. Furthermore, failed reimplantation surgery will have more impact on a deafblind person. In this context, we assessed the safety of minimally invasive robotically assisted cochlear implant surgery (RACIS) for the first time in a deafblind patient. Standard pure tone audiometry and speech audiometry were performed in a patient with deafblindness as part of this robotic-assisted CI study before and after surgery. This patient, with an optic atrophy 1 (OPA1) (OMIM#165500) mutation consented to RACIS for the second (contralateral) CI. The applicability and safety of RACIS were evaluated as well as her subjective opinion on her disability. RACIS was uneventful with successful surgical and auditory outcomes in this case of deafblindness due to the OPA1 mutation. RACIS appears to be a safe and beneficial intervention to increase communication skills in the cases of deafblindness due to an OPA1 mutation. The use of RACIS use should be widespread in deafblindness as it minimizes surgical trauma and possible failures.
    Keywords atrophy ; audiometry ; deafness ; mutation ; patients ; society ; speech ; surgery
    Language English
    Dates of publication 2023-0302
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14030627
    Database NAL-Catalogue (AGRICOLA)

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