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Article ; Online: Expression of VEGFR2 Ligand Binding Domain in Pichia pink™ 4 Cells and Evaluation of Its Interactions with VEGF-A

Fathi, Zahra / Boojar, Masoud Mashhadi Akbar / Sajedi, Reza H / Dehnavi, Ehsan / Jahanafrooz, Zohreh

2024

Abstract: Vascular endothelial growth factor ... ...

Abstract	Vascular endothelial growth factor A
Language	English
Publishing date	2024-02-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1193057-3
ISSN	1559-0305 ; 1073-6085
ISSN (online)	1559-0305
ISSN	1073-6085
DOI	10.1007/s12033-024-01057-1
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Article: Evaluation of Silibinin Effect on U-CH2 and MCF-7 Cell Lines through xCELLigence System.

Jahanafrooz, Zohreh / Rinner, Beate

Advanced pharmaceutical bulletin

2021 Volume 13, Issue 1, Page(s) 5–6

Language	English
Publishing date	2021-10-26
Publishing country	Iran
Document type	Journal Article
ZDB-ID	3018440-X
ISSN	2251-7308 ; 2228-5881
ISSN (online)	2251-7308
ISSN	2228-5881
DOI	10.34172/apb.2023.002
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Article: Comparative Evaluation of Lipofectamine and Dendrimer for Transfection of Short RNA Into Human T47D and MCF-10A Cell Lines.

Jahanafrooz, Zohreh / Bakhshandeh, Behnaz / Shirzadi, Erfan

Advanced pharmaceutical bulletin

2022 Volume 13, Issue 2, Page(s) 385–392

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2022-04-30
Publishing country	Iran
Document type	Journal Article
ZDB-ID	3018440-X
ISSN	2251-7308 ; 2228-5881
ISSN (online)	2251-7308
ISSN	2228-5881
DOI	10.34172/apb.2023.022
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Article ; Online: Pore-forming Peptides: A New Treatment Option for Cancer.

Jahanafrooz, Zohreh / Mokhtarzadeh, Ahad

Current medicinal chemistry

2021 Volume 29, Issue 23, Page(s) 4078–4096

Abstract: Cancer, a challenging medical problem, affects millions of people around the world. Cancer cell resistance is one of the main drawbacks in the complete prosperity of even more sophisticated therapies. Pore-forming peptides (PFPs), a group of natural ... ...

Abstract	Cancer, a challenging medical problem, affects millions of people around the world. Cancer cell resistance is one of the main drawbacks in the complete prosperity of even more sophisticated therapies. Pore-forming peptides (PFPs), a group of natural defense system proteins are used by nearly all living organisms as anti-bacterial and anti-- fungal agents, and could also be regarded as novel tumoricidal peptides. PFPs approach entails using soluble peptides by assembling them mainly on the target cell membrane and forming potential death-causing pores. Physical damage induction by natural PFPs or their synthetic derivatives could conquer the resistance mechanisms of tumor cells. Given that peptide drugs involve a significant proportion of the pharmaceutical market primarily because of easy synthesis and safety, evaluating this nature provided a model system as a group of anticancer peptides seems a valuable approach. Here, the mode of action of PFPs and their anticancer mechanism are highlighted, followed by addressing the anticancer studies using PFPs from different sources along with various strategies applied to obtain selective action of PFPs against cancer cells. Challenges and future perspectives of these promising bioactive molecules in cancer treatment are also provided.
MeSH term(s)	Cell Membrane/metabolism ; Humans ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Peptides/analysis ; Peptides/pharmacology ; Peptides/therapeutic use
Chemical Substances	Peptides
Language	English
Publishing date	2021-11-26
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867328666211126150055
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Zs.A 4432: Show issues

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Article ; Online: Anti-breast cancer activity of the essential oil from grapefruit mint (Mentha suaveolens × piperita).

Jahanafrooz, Zohreh / Mousavi, Mir Mohammad Hossein / Akbarzadeh, Soghra / Hemmatzadeh, Maedeh / Maggi, Filippo / Morshedloo, Mohammad Reza

Fitoterapia

2024 Volume 174, Page(s) 105875

Abstract: Grapefruit mint (Mentha suaveolens × piperita) is a hybrid, perennial, and aromatic plant widely cultivated all over the world and used in the food, cosmetics, and pharmaceutical industries mostly for its valuable essential oil. Herein, we evaluated the ... ...

Abstract	Grapefruit mint (Mentha suaveolens × piperita) is a hybrid, perennial, and aromatic plant widely cultivated all over the world and used in the food, cosmetics, and pharmaceutical industries mostly for its valuable essential oil. Herein, we evaluated the anticancer activity of the grapefruit mint essential oil, cultivated in Iran. For the chemical composition analysis of essential oil, GC-MS was used. MTT assay was utilized for assessing the cytotoxic activity of the essential oil. The type of cell death was determined by annexin V/PI staining. Essential oil effect on the expression of maternally expressed gene 3 (MEG3), a regulatory lncRNA involved in cell growth, proliferation, and metastasis, was studied using qRT-PCR. Linalool (43.9%) and linalool acetate (40.1%) were identified as the dominant compounds of essential oil. Compared with MCF-7, the MDA-MB-231 cells were more sensitive to essential oil (IC
MeSH term(s)	Humans ; Female ; Oils, Volatile/pharmacology ; Oils, Volatile/chemistry ; Mentha/chemistry ; Citrus paradisi ; Molecular Structure ; Breast Neoplasms/drug therapy ; Mentha piperita ; Acyclic Monoterpenes
Chemical Substances	Oils, Volatile ; linalool (D81QY6I88E) ; Acyclic Monoterpenes
Language	English
Publishing date	2024-02-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	412385-2
ISSN	1873-6971 ; 0367-326X
ISSN (online)	1873-6971
ISSN	0367-326X
DOI	10.1016/j.fitote.2024.105875
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Article ; Online: Microbial L-asparaginase as a promising enzyme for treatment of various cancers.

Darvishi, Farshad / Jahanafrooz, Zohreh / Mokhtarzadeh, Ahad

Applied microbiology and biotechnology

2022 Volume 106, Issue 17, Page(s) 5335–5347

Abstract: Metabolic differences between normal and cancerous cells have been used as a point of view for developing anticancer drugs. Some degrading enzymes of certain amino acids have been regarded to kill cancerous cells. L-Asparaginase (ASNase) has shown an ... ...

Abstract	Metabolic differences between normal and cancerous cells have been used as a point of view for developing anticancer drugs. Some degrading enzymes of certain amino acids have been regarded to kill cancerous cells. L-Asparaginase (ASNase) has shown an excellent therapeutic response to asparagine-auxotrophic cancers such as acute lymphoblastic leukemia (ALL). Some bacteria, yeasts, molds, plants, and animals produce ASNase. Bacterial ASNases from Escherichia coli and Erwinia chrysanthemi are the FDA-approved drugs for ALL treatment. Here, we review new natural prokaryotic and eukaryotic sources of ASNases, recent advances to introduce improvement strategies for the production of recombinant ASNases as well as their chemical modifications, immobilization, nanoencapsulation, and in silico studies to increase efficiency and decrease side effects. Recent studies for application of ASNases to treatment of asparagine-auxotrophic cancers, especially solid cancers, have been reviewed. Furthermore, challenges and future perspectives are discussed for this promising therapeutic enzyme. KEY POINTS: • Review recent advances to introduce new sources of microbial L-asparaginases. • Review improvement strategies for the development of stable and non-toxic L-asparaginases. • Review microbial L-asparaginase application in various cancers' treatment.
MeSH term(s)	Animals ; Antineoplastic Agents ; Asparaginase ; Asparagine ; Bacteria ; Escherichia coli ; Precursor Cell Lymphoblastic Leukemia-Lymphoma
Chemical Substances	Antineoplastic Agents ; Asparagine (7006-34-0) ; Asparaginase (EC 3.5.1.1)
Language	English
Publishing date	2022-07-25
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-022-12086-8
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Zs.A 2229: Show issues

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Article ; Online: Human amniotic membrane as a multifunctional biomaterial: recent advances and applications.

Jahanafrooz, Zohreh / Bakhshandeh, Behnaz / Behnam Abdollahi, Seyyed / Seyedjafari, Ehsan

Journal of biomaterials applications

2022 Volume 37, Issue 8, Page(s) 1341–1354

Abstract: The developing fetus is wrapped by a human amniotic membrane or amnion. Amnion is a promising human tissue allograft in clinical application because of its chemical composition, collagen-based, and mechanical properties of the extracellular matrix. In ... ...

Abstract	The developing fetus is wrapped by a human amniotic membrane or amnion. Amnion is a promising human tissue allograft in clinical application because of its chemical composition, collagen-based, and mechanical properties of the extracellular matrix. In addition, amnion contains cells and growth factors; therefore, meets the essential parameters of tissue engineering. No donor morbidity, easy processing and storage, fewer ethical issue, anti-inflammatory, antioxidant, antibacterial, and non-immunogenic properties are other advantages of amnion usage. For these reasons, amnion can resolve some bottlenecks in the regenerative medicine issues such as tissue engineering and cell therapy. Over the last decades, biomedical applications of amnion have evolved from a simple sheet for skin or cornea repair to high-technology applications such as amnion nanocomposite, powder, or hydrogel for the regeneration of cartilage, muscle, tendon, and heart. Furthermore, amnion has anticancer as well as drug/cell delivery capacity. This review highlights various ancient and new applications of amnion in research and clinical applications, from regenerative medicine to cancer therapy, focusing on articles published during the last decade that also revealed information regarding amnion-based products. Challenges and future perspectives of the amnion in regenerative medicine are also discussed.
MeSH term(s)	Humans ; Amnion/chemistry ; Regenerative Medicine ; Tissue Engineering ; Skin
Language	English
Publishing date	2022-11-04
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	639283-0
ISSN	1530-8022 ; 0885-3282
ISSN (online)	1530-8022
ISSN	0885-3282
DOI	10.1177/08853282221137609
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Zs.B 3175: Show issues

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Article: Microbial L-asparaginase as a promising enzyme for treatment of various cancers

Darvishi, Farshad / Jahanafrooz, Zohreh / Mokhtarzadeh, Ahad

Applied microbiology and biotechnology. 2022 Sept., v. 106, no. 17

2022

Abstract	Metabolic differences between normal and cancerous cells have been used as a point of view for developing anticancer drugs. Some degrading enzymes of certain amino acids have been regarded to kill cancerous cells. L-Asparaginase (ASNase) has shown an excellent therapeutic response to asparagine-auxotrophic cancers such as acute lymphoblastic leukemia (ALL). Some bacteria, yeasts, molds, plants, and animals produce ASNase. Bacterial ASNases from Escherichia coli and Erwinia chrysanthemi are the FDA-approved drugs for ALL treatment. Here, we review new natural prokaryotic and eukaryotic sources of ASNases, recent advances to introduce improvement strategies for the production of recombinant ASNases as well as their chemical modifications, immobilization, nanoencapsulation, and in silico studies to increase efficiency and decrease side effects. Recent studies for application of ASNases to treatment of asparagine-auxotrophic cancers, especially solid cancers, have been reviewed. Furthermore, challenges and future perspectives are discussed for this promising therapeutic enzyme. KEY POINTS: • Review recent advances to introduce new sources of microbial L-asparaginases. • Review improvement strategies for the development of stable and non-toxic L-asparaginases. • Review microbial L-asparaginase application in various cancers’ treatment.
Keywords	Erwinia chrysanthemi ; Escherichia coli ; asparaginase ; biotechnology ; computer simulation ; lymphocytic leukemia ; microbiology ; nanocapsules ; therapeutics
Language	English
Dates of publication	2022-09
Size	p. 5335-5347.
Publishing place	Springer Berlin Heidelberg
Document type	Article
Note	Review
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-022-12086-8
Database	NAL-Catalogue (AGRICOLA)

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Article: An overview of human proteins and genes involved in SARS-CoV-2 infection

Jahanafrooz, Zohreh / Chen, Zhishan / Bao, Jiandong / Li, Hongzhi / Lipworth, Loren / Guo, Xingyi

Gene. 2022 Jan. 15, v. 808

2022

Abstract: As of July 2021, the outbreak of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has led to more than 200 million infections and more than 4.2 million deaths globally. Complications of severe COVID-19 include acute kidney injury, liver ... ...

Abstract	As of July 2021, the outbreak of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has led to more than 200 million infections and more than 4.2 million deaths globally. Complications of severe COVID-19 include acute kidney injury, liver dysfunction, cardiomyopathy, and coagulation dysfunction. Thus, there is an urgent need to identify proteins and genetic factors associated with COVID-19 susceptibility and outcome. We comprehensively reviewed recent findings of host-SARS-CoV-2 interactome analyses. To identify genetic variants associated with COVID-19, we focused on the findings from genome and transcriptome wide association studies (GWAS and TWAS) and bioinformatics analysis. We described established human proteins including ACE2, TMPRSS2, 40S ribosomal subunit, ApoA1, TOM70, HLA-A, and PALS1 interacting with SARS-CoV-2 based on cryo–electron microscopy results. Furthermore, we described approximately 1000 human proteins showing evidence of interaction with SARS-CoV-2 and highlighted host cellular processes such as innate immune pathways affected by infection. We summarized the evidence on more than 20 identified candidate genes in COVID-19 severity. Predicted deleterious and disruptive genetic variants with possible effects on COVID-19 infectivity have been also summarized. These findings provide novel insights into SARS-CoV-2 biology and infection as well as potential strategies for development of novel COVID therapeutic targets and drug repurposing.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; acute kidney injury ; bioinformatics ; cardiomyopathy ; coagulation ; cryo-electron microscopy ; drugs ; genes ; humans ; liver ; pathogenicity ; therapeutics ; transcriptome
Language	English
Dates of publication	2022-0115
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2021.145963
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Article ; Online: Transcriptomic and in vivo approaches introduced human iPSC-derived microvesicles for skin rejuvenation.

Bakhshandeh, Behnaz / Jahanafrooz, Zohreh / Allahdadi, Shiva / Daryani, Shiva / Dehghani, Zahra / Sadeghi, Mahya / Pedram, Mir Sepehr / Dehghan, Mohammad Mehdi

Scientific reports

2023 Volume 13, Issue 1, Page(s) 9963

Abstract: The skin undergoes the formation of fine lines and wrinkles through the aging process; also, burns, trauma, and other similar circumstances give rise to various forms of skin ulcers. Induced pluripotent stem cells (iPSCs) have become promising candidates ...

Abstract	The skin undergoes the formation of fine lines and wrinkles through the aging process; also, burns, trauma, and other similar circumstances give rise to various forms of skin ulcers. Induced pluripotent stem cells (iPSCs) have become promising candidates for skin healing and rejuvenation due to not stimulating inflammatory responses, low probability of immune rejection, high metabolic activity, good large-scale production capacity and potentials for personalized medicine. iPSCs can secrete microvesicles (MVs) containing RNA and proteins responsible for the normal repairing process of the skin. This study aimed to evaluate the possibility, safety and effectiveness of applying iPSCs-derived MVs for skin tissue engineering and rejuvenation applications. The possibility was assessed using the evaluation of the mRNA content of iPSC-derived MVs and the behavior of fibroblasts after MV treatment. Investigating the effect of microvesicle on stemness potential of mesenchymal stem cells was performed for safety concerns. In vivo evaluation of MVs was done in order to investigate related immune response, re-epithelialization and blood vessel formation to measure effectiveness. Shedding MVs were round in shape distributed in the range from 100 to 1000 nm in diameter and positive for AQP3, COL2A, FGF2, ITGB, and SEPTIN4 mRNAs. After treating dermal fibroblasts with iPSC-derived MVs, the expressions of collagens Iα1 and III transcripts (as the main fibrous extracellular matrix (ECM) proteins) were upregulated. Meanwhile, the survival and proliferation of MV treated fibroblasts did not change significantly. Evaluation of stemness markers in MV treated MSCs showed negligible alteration. In line with in vitro results, histomorphometry and histopathology findings also confirmed the helpful effect of MVs in skin regeneration in the rat burn wound models. Conducting more investigations on hiPSCs-derived MVs may lead to produce more efficient and safer biopharmaceutics for skin regeneration in the pharmaceutical market.
MeSH term(s)	Humans ; Rats ; Animals ; Induced Pluripotent Stem Cells/metabolism ; Transcriptome ; Rejuvenation ; Skin/pathology ; Cell-Derived Microparticles/metabolism
Language	English
Publishing date	2023-06-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-36162-9
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