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  1. Article ; Online: Enniatin B1 induces damage to Leydig cells via inhibition of the Nrf2/HO-1 and JAK/STAT3 signaling pathways.

    Shen, Hongping / Cai, Yili / Zhu, Keqi / Wang, Dong / Yu, Rui / Chen, Xueqin

    Ecotoxicology and environmental safety

    2024  Volume 273, Page(s) 116116

    Abstract: Enniatin B1 (ENN B1) is a mycotoxin that can be found in various foods. However, whether ENN B1 is hazardous to the reproductive system is still elusive. Leydig cells are testosterone-generating cells that reside in the interstitial compartment between ... ...

    Abstract Enniatin B1 (ENN B1) is a mycotoxin that can be found in various foods. However, whether ENN B1 is hazardous to the reproductive system is still elusive. Leydig cells are testosterone-generating cells that reside in the interstitial compartment between seminiferous tubules. Dysfunction of Leydig cells could result in male infertility. This study aimed to examine the toxicological effects of ENN B1 against TM3 Leydig cells. ENN B1 significantly inhibited cell viability in a dose-dependent manner. ENN B1 treatment also decreased the expression of functional genes in Leydig cells. Moreover, ENN B1 induced Leydig cells apoptosis and oxidative stress. Mechanistically, ENN B1 leads to the upregulation of Bax and downregulation of Bcl-2 in Leydig cells. In addition, ENN B1 inhibited the Nrf2/HO-1 pathway, which is critical for the induction of oxidative stress. Additionally, ENN B1 treatment repressed the JAK/STAT3 signaling pathway in Leydig cells. Rescue experiments showed that activation of STAT3 resulted in alleviation of ENN B1-induced damage in Leydig cells. Collectively, our study demonstrated that ENN B1 induced Leydig cell dysfunction via multiple mechanisms.
    MeSH term(s) Male ; Humans ; Leydig Cells ; NF-E2-Related Factor 2/genetics ; Mycotoxins/pharmacology ; Oxidative Stress ; Apoptosis ; Signal Transduction ; Depsipeptides
    Chemical Substances NF-E2-Related Factor 2 ; enniatins ; Mycotoxins ; Depsipeptides
    Language English
    Publishing date 2024-02-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2024.116116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1418: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Safety Risks of Primary and Secondary Schools in China

    Jincang Yang / Xueqin Dong / Sishi Liu

    Sustainability, Vol 14, Iss 8214, p

    A Systematic Analysis Using AHP–EWM Method

    2022  Volume 8214

    Abstract: Owing to the frequent accidents in primary and secondary schools (PSS) in China in the past decades, a systematic analysis of indicators influencing safety risks in PSS is critical to identifying preventive measures. A two-hierarchy structure of ... ...

    Abstract Owing to the frequent accidents in primary and secondary schools (PSS) in China in the past decades, a systematic analysis of indicators influencing safety risks in PSS is critical to identifying preventive measures. A two-hierarchy structure of indicators was identified by analyzing various cases, intensive interviews, and related previous literature. A combination of the analytic hierarchy process and the entropy weight method was developed to synthetically assess the primary and secondary risk indicators through a case study of Ma Shan School in China. The results are as follows: (1) the primary risk indicators, namely, natural disasters, public health, facility safety, accidental injury, public security, school bullying, and individual health constitute the evaluation framework of the safety risks in PSS. (2) Public health risks and accidental injury risks are the most critical factors that should be prioritized. In addition to providing academic implications, several managerial implications are proposed for these stakeholders to reduce the safety risks in PSS.
    Keywords primary and secondary schools (PSS) ; safety risks ; campus safety ; influencing factors ; preventive measures ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 650
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: A SNARE Protein Identification Method Based on iLearnPlus to Efficiently Solve the Data Imbalance Problem.

    Ma, Dong / Chen, Zhihua / He, Zhanpeng / Huang, Xueqin

    Frontiers in genetics

    2022  Volume 12, Page(s) 818841

    Abstract: Machine learning has been widely used to solve complex problems in engineering applications and scientific fields, and many machine learning-based methods have achieved good results in different fields. SNAREs are key elements of membrane fusion and ... ...

    Abstract Machine learning has been widely used to solve complex problems in engineering applications and scientific fields, and many machine learning-based methods have achieved good results in different fields. SNAREs are key elements of membrane fusion and required for the fusion process of stable intermediates. They are also associated with the formation of some psychiatric disorders. This study processes the original sequence data with the synthetic minority oversampling technique (SMOTE) to solve the problem of data imbalance and produces the most suitable machine learning model with the iLearnPlus platform for the identification of SNARE proteins. Ultimately, a sensitivity of 66.67%, specificity of 93.63%, accuracy of 91.33%, and MCC of 0.528 were obtained in the cross-validation dataset, and a sensitivity of 66.67%, specificity of 93.63%, accuracy of 91.33%, and MCC of 0.528 were obtained in the independent dataset (the adaptive skip dipeptide composition descriptor was used for feature extraction, and LightGBM with proper parameters was used as the classifier). These results demonstrate that this combination can perform well in the classification of SNARE proteins and is superior to other methods.
    Language English
    Publishing date 2022-01-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2021.818841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pavement crack detection based on point cloud data and data fusion.

    Dong, Qiao / Wang, Sike / Chen, Xueqin / Jiang, Wanqi / Li, Ruiqi / Gu, Xingyu

    Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

    2023  Volume 381, Issue 2254, Page(s) 20220165

    Abstract: The three-dimensional detection in point cloud data for pavement cracks has drawn the attention of many researchers recently. In the field of pavement surface point cloud detection, the key tasks include the identification of pavement cracks and the ... ...

    Abstract The three-dimensional detection in point cloud data for pavement cracks has drawn the attention of many researchers recently. In the field of pavement surface point cloud detection, the key tasks include the identification of pavement cracks and the extraction of the location and size information of pavement cracks. Based on the point cloud data of pavement surface, we developed two methods to directly extract and detect cracks, respectively. The first method is based on the improved sliding window algorithm by combining the random sample consensus (RANSAC) technique to directly extract the crack information from point clouds. The second method is developed based on YOLOv5 to process the two-dimensional images transformed from point cloud data for automatic pavement crack detection. We also attempted to fuse the point cloud images with greyscale images as input for the YOLOv5. Analysis results show that the improved sliding window algorithm efficiently extracts pavement cracks with less noise, and the YOLOv5-based method obtains a good detection of pavement cracks. This article is part of the theme issue 'Artificial intelligence in failure analysis of transportation infrastructure and materials'.
    Language English
    Publishing date 2023-07-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 208381-4
    ISSN 1471-2962 ; 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
    ISSN (online) 1471-2962
    ISSN 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
    DOI 10.1098/rsta.2022.0165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  5. Article ; Online: Late-onset paraneoplastic encephalitis originates from dopamine 2 receptor autoimmunity associated with prostate adenocarcinoma.

    Cai, Hanlin / Gao, Hui / Chen, Xueqin / Qin, Linyuan / Wang, Ruihan / Yuan, Qiang / Hong, Zhen / Li, Jinmei / Zhou, Dong / Wang, Minjin / Chen, Qin

    Asian journal of psychiatry

    2024  Volume 93, Page(s) 103910

    MeSH term(s) Male ; Humans ; Autoimmunity ; Dopamine ; Prostate ; Encephalitis ; Adenocarcinoma/complications
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2024-01-03
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2024.103910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Chitosan-Functionalized Poly(β-Amino Ester) Hybrid System for Gene Delivery in Vaginal Mucosal Epithelial Cells.

    Gao, Xueqin / Dong, Dirong / Zhang, Chong / Deng, Yuxing / Ding, Jiahui / Niu, Shiqi / Tan, Songwei / Sun, Lili

    Pharmaceutics

    2024  Volume 16, Issue 1

    Abstract: Gene therapy displays great promise in the treatment of cervical cancer. The occurrence of cervical cancer is highly related to persistent human papilloma virus (HPV) infection. The HPV oncogene can be cleaved via gene editing technology to eliminate ... ...

    Abstract Gene therapy displays great promise in the treatment of cervical cancer. The occurrence of cervical cancer is highly related to persistent human papilloma virus (HPV) infection. The HPV oncogene can be cleaved via gene editing technology to eliminate carcinogenic elements. However, the successful application of the gene therapy method depends on effective gene delivery into the vagina. To improve mucosal penetration and adhesion ability, quaternized chitosan was introduced into the poly(β-amino ester) (PBAE) gene-delivery system in the form of quaternized chitosan-g-PBAE (QCP). At a mass ratio of PBAE:QCP of 2:1, the polymers exhibited the highest green fluorescent protein (GFP) transfection efficiency in HEK293T and ME180 cells, which was 1.1 and 5.4 times higher than that of PEI 25 kD. At this mass ratio, PBAE-QCP effectively compressed the GFP into spherical polyplex nanoparticles (PQ-GFP NPs) with a diameter of 255.5 nm. In vivo results indicated that owing to the mucopenetration and adhesion capability of quaternized CS, the GFP transfection efficiency of the PBAE-QCP hybrid system was considerably higher than those of PBAE and PEI 25 kD in the vaginal epithelial cells of Sprague-Dawley rats. Furthermore, the new system demonstrated low toxicity and good safety, laying an effective foundation for its further application in gene therapy.
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16010154
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  7. Article ; Online: [Functional analysis of functional membrane microdomains in the biosynthesis of menaquinone-7].

    Dong, Yajun / Cui, Shixiu / Liu, Yanfeng / Li, Jianghua / DU, Guocheng / Lü, Xueqin / Liu, Long

    Sheng wu gong cheng xue bao = Chinese journal of biotechnology

    2023  Volume 39, Issue 6, Page(s) 2215–2230

    Abstract: Functional membrane microdomains (FMMs) that are mainly composed of scaffold proteins and polyisoprenoids play important roles in diverse cellular physiological processes in bacteria. The aim of this study was to identify the correlation between MK-7 and ...

    Abstract Functional membrane microdomains (FMMs) that are mainly composed of scaffold proteins and polyisoprenoids play important roles in diverse cellular physiological processes in bacteria. The aim of this study was to identify the correlation between MK-7 and FMMs and then regulate the MK-7 biosynthesis through FMMs. Firstly, the relationship between FMMs and MK-7 on the cell membrane was determined by fluorescent labeling. Secondly, we demonstrated that MK-7 is a key polyisoprenoid component of FMMs by analyzing the changes in the content of MK-7 on cell membrane and the changes in the membrane order before and after destroying the integrity of FMMs. Subsequently, the subcellular localization of some key enzymes in MK-7 synthesis was explored by visual analysis, and the intracellular free pathway enzymes Fni, IspA, HepT and YuxO were localized to FMMs through FloA to achieve the compartmentalization of MK-7 synthesis pathway. Finally, a high MK-7 production strain BS3AT was successfully obtained. The production of MK-7 reached 300.3 mg/L in shake flask and 464.2 mg/L in 3 L fermenter.
    MeSH term(s) Bacillus subtilis/metabolism ; Vitamin K 2/metabolism ; Bioreactors/microbiology ; Membrane Microdomains/metabolism
    Chemical Substances Vitamin K 2 (11032-49-8)
    Language Chinese
    Publishing date 2023-06-25
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1042206-7
    ISSN 1872-2075 ; 1042-749X
    ISSN (online) 1872-2075
    ISSN 1042-749X
    DOI 10.13345/j.cjb.230111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3505: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Complete genome analysis of

    Chen, Benhao / Zhou, Yi / Duan, Lixiao / Gong, Xuemei / Liu, Xingmei / Pan, Kangcheng / Zeng, Dong / Ni, Xueqin / Zeng, Yan

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1322910

    Abstract: Introduction: In recent years, a large number of studies have shown that : Methods: In this study, Illumina NovaSeq PE150 and Oxford Nanopore ONT sequencing platforms were used to sequence the genome of : Results: The complete genome sequencing ... ...

    Abstract Introduction: In recent years, a large number of studies have shown that
    Methods: In this study, Illumina NovaSeq PE150 and Oxford Nanopore ONT sequencing platforms were used to sequence the genome of
    Results: The complete genome sequencing results of
    Conclusion: These findings confirmed the probiotic effects of
    Language English
    Publishing date 2023-12-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1322910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Design of High-Capacity MoS

    Zhou, Yanli / Li, Qiming / Han, Qi / Zhao, Lanling / Liu, Yan / Wang, Yifei / Li, Zhiqi / Dong, Caifu / Sun, Xueqin / Yang, Jian / Zhang, Xiaoyu / Jiang, Fuyi

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 19, Issue 40, Page(s) e2303742

    Abstract: The hierarchical ... ...

    Abstract The hierarchical Cu
    Language English
    Publishing date 2023-06-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202303742
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Evidence-based nursing reduces complications and negative emotions and improves limb function in patients undergoing hip arthroplasty.

    Dong, Lu / Sun, Yindi / Hu, Jing / Xiang, Jie / Liu, Na / Zhu, Hanghang / Zeng, Xueqin

    American journal of translational research

    2023  Volume 15, Issue 3, Page(s) 1779–1788

    Abstract: Objective: This retrospective study primarily analyzed the influence of evidence-based nursing (EBN) on postoperative complications (POCs), negative emotions (NEs) and limb function of patients undergoing hip arthroplasty (HA).: Methods: The research ...

    Abstract Objective: This retrospective study primarily analyzed the influence of evidence-based nursing (EBN) on postoperative complications (POCs), negative emotions (NEs) and limb function of patients undergoing hip arthroplasty (HA).
    Methods: The research participants were 109 patients undergoing HA in Honghui Hospital, Xi'an Jiaotong University from September 2019 to September 2021. Among them, 52 patients who received routine nursing intervention were set as a control group, and 57 patients that received EBN were set as the research group. The POCs (infection; pressure sores, PS; lower extremity deep venous thrombosis, LEDVT), NEs (Hamilton Anxiety/Depression Scale, HAMA/HAMD), limb function (Harris Hip Score, HHS), pain intensity (Visual Analogue Scale, VAS), quality of life (QoL; Short-Form 36 Item Health Survey, SF-36) and sleep quality (Pittsburgh Sleep Quality Index, PSQI) were compared. Finally, the risk factors of complications in patients undergoing HA were identified by Logistic regression.
    Results: The incidence of POCs such as infection, PS and LEDVT was markedly lower in the research group than that in the control group. The postinterventional HAMA and HAMD scores of the research group were obviously lower than the baseline (before intervention) and those of the control group. The research group also exhibited obviously higher scores in various dimensions of the HHS and SF-36 than the baseline and control group. Moreover, the post-interventional VAS and PSQI scores of the research group were markedly reduced compared with the baseline and those of the control group. Factors including drinking history, place of residence and nursing modality were found to be not associated with an increased risk of complications in patients undergoing HA.
    Conclusion: EBN can lower the incidence of POCs, mitigate NEs and pain perception, and enhance limb function, QoL and sleep quality in patients undergoing HA, so it is worth popularizing.
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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