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  1. Article: Neurobiology of Coughing in Children.

    Mazzone, Stuart B

    Journal of clinical medicine

    2023  Volume 12, Issue 23

    Abstract: A cough is one of several defensive responses that protect and clear the airways of inhaled, aspirated or locally produced chemicals and matter. The neural components needed to initiate a cough begin to develop in utero, and at birth the airways and ... ...

    Abstract A cough is one of several defensive responses that protect and clear the airways of inhaled, aspirated or locally produced chemicals and matter. The neural components needed to initiate a cough begin to develop in utero, and at birth the airways and lungs already have a rich supply of sensory and motor-neural innervation. However, a cough is not always the primary defensive response to airway challenge in very young infants, but instead develops in the first postnatal months and matures further into puberty. Consequently, the clinical presentation of a troublesome cough in children may not be the same as in adults, exemplified by important differences in cough sensitivity and hypersensitivity between children and adults. This review will summarise key anatomical and functional concepts in airway neurobiology that may improve understanding of coughs in children.
    Language English
    Publishing date 2023-11-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12237285
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  2. Article ; Online: Neurobiology of Coughing in Children

    Stuart B. Mazzone

    Journal of Clinical Medicine, Vol 12, Iss 23, p

    2023  Volume 7285

    Abstract: A cough is one of several defensive responses that protect and clear the airways of inhaled, aspirated or locally produced chemicals and matter. The neural components needed to initiate a cough begin to develop in utero, and at birth the airways and ... ...

    Abstract A cough is one of several defensive responses that protect and clear the airways of inhaled, aspirated or locally produced chemicals and matter. The neural components needed to initiate a cough begin to develop in utero, and at birth the airways and lungs already have a rich supply of sensory and motor-neural innervation. However, a cough is not always the primary defensive response to airway challenge in very young infants, but instead develops in the first postnatal months and matures further into puberty. Consequently, the clinical presentation of a troublesome cough in children may not be the same as in adults, exemplified by important differences in cough sensitivity and hypersensitivity between children and adults. This review will summarise key anatomical and functional concepts in airway neurobiology that may improve understanding of coughs in children.
    Keywords vagal ; hypersensitivity ; airway innervation ; development ; sensory ; children ; Medicine ; R
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Chronic cough: a disorder of response inhibition?

    Mazzone, Stuart B

    The European respiratory journal

    2019  Volume 53, Issue 5

    MeSH term(s) Chronic Disease ; Cough ; Humans
    Language English
    Publishing date 2019-05-02
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00254-2019
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  4. Article ; Online: Neuroimmune pathways regulating airway inflammation.

    Trevizan-Bau, Pedro / Mazzone, Stuart B

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2023  Volume 131, Issue 5, Page(s) 550–560

    Abstract: Airways diseases are typically accompanied by inflammation, which has long been known to contribute to obstruction, mucus hypersecretion, dyspnea, cough, and other characteristic symptoms displayed in patients. Clinical interventions, therefore, often ... ...

    Abstract Airways diseases are typically accompanied by inflammation, which has long been known to contribute to obstruction, mucus hypersecretion, dyspnea, cough, and other characteristic symptoms displayed in patients. Clinical interventions, therefore, often target inflammation to reverse lung pathology and reduce morbidity. The airways and lungs are densely innervated by subsets of nerve fibers, which are not only impacted by pulmonary inflammation but, in addition, likely serve as important regulators of immune cell function. This bidirectional neuroimmune crosstalk is supported by close spatial relationships between immune cells and airway nerve fibers, complementary neural and immune signaling pathways, local specialized airway chemosensory cells, and dedicated reflex circuits. In this article, we review the recent literature on this topic and present state-of-the-art evidence supporting the role of neuroimmune interactions in airway inflammation. In addition, we extend this evidence to synthesize considerations for the clinical translation of these discoveries to improve the management of patients with airway disease.
    MeSH term(s) Humans ; Inflammation/pathology ; Pneumonia ; Lung ; Cough/metabolism ; Signal Transduction ; Mucus/metabolism
    Language English
    Publishing date 2023-07-29
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2023.07.020
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  5. Article ; Online: Old drug, new tricks: reducing cough in IPF.

    Mazzone, Stuart B

    The Lancet. Respiratory medicine

    2017  Volume 5, Issue 10, Page(s) 766–767

    Language English
    Publishing date 2017-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(17)30341-7
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  6. Article ; Online: Infectious and Inflammatory Pathways to Cough.

    Naqvi, Kubra F / Mazzone, Stuart B / Shiloh, Michael U

    Annual review of physiology

    2022  Volume 85, Page(s) 71–91

    Abstract: Coughing is a dynamic physiological process resulting from input of vagal sensory neurons innervating the airways and perceived airway irritation. Although cough serves to protect and clear the airways, it can also be exploited by respiratory pathogens ... ...

    Abstract Coughing is a dynamic physiological process resulting from input of vagal sensory neurons innervating the airways and perceived airway irritation. Although cough serves to protect and clear the airways, it can also be exploited by respiratory pathogens to facilitate disease transmission. Microbial components or infection-induced inflammatory mediators can directly interact with sensory nerve receptors to induce a cough response. Analysis of cough-generated aerosols and transmission studies have further demonstrated how infectious disease is spread through coughing. This review summarizes the neurophysiology of cough, cough induction by respiratory pathogens and inflammation, and cough-mediated disease transmission.
    MeSH term(s) Humans ; Cough ; Respiratory System/innervation ; Vagus Nerve/physiology ; Sensory Receptor Cells ; Communicable Diseases
    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 207933-1
    ISSN 1545-1585 ; 0066-4278
    ISSN (online) 1545-1585
    ISSN 0066-4278
    DOI 10.1146/annurev-physiol-031422-092315
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  7. Article ; Online: Nonsteroidal anti-inflammatory drugs and pharyngitis.

    Mazzone, Stuart B / Kulasekaran, Anuradha / Shea, Tim / Adegoke, Oluwajoba

    Immunity, inflammation and disease

    2022  Volume 10, Issue 12, Page(s) e738

    MeSH term(s) Humans ; Pharyngitis/drug therapy ; Anti-Inflammatory Agents/therapeutic use
    Chemical Substances Anti-Inflammatory Agents
    Language English
    Publishing date 2022-11-01
    Publishing country England
    Document type Letter
    ZDB-ID 2740382-8
    ISSN 2050-4527 ; 2050-4527
    ISSN (online) 2050-4527
    ISSN 2050-4527
    DOI 10.1002/iid3.738
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  8. Article ; Online: A Cough Is a Cough, Is It Not? Neurophenotypes Define Patients with Chronic Cough.

    Mazzone, Stuart B

    American journal of respiratory and critical care medicine

    2016  Volume 193, Issue 12, Page(s) 1324–1326

    Language English
    Publishing date 2016-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201601-0100ED
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  9. Article ; Online: Regulation of vagally-evoked respiratory responses by the lateral parabrachial nucleus in the mouse.

    Behrens, Robert / Dutschmann, Mathias / Trewella, Matthew / Mazzone, Stuart B / Moe, Aung Aung Kywe

    Respiratory physiology & neurobiology

    2023  Volume 316, Page(s) 104141

    Abstract: Vagal sensory inputs to the brainstem can alter breathing through the modulation of pontomedullary respiratory circuits. In this study, we set out to investigate the localised effects of modulating lateral parabrachial nucleus (LPB) activity on vagally- ... ...

    Abstract Vagal sensory inputs to the brainstem can alter breathing through the modulation of pontomedullary respiratory circuits. In this study, we set out to investigate the localised effects of modulating lateral parabrachial nucleus (LPB) activity on vagally-evoked changes in breathing pattern. In isoflurane-anaesthetised and instrumented mice, electrical stimulation of the vagus nerve (eVNS) produced stimulation frequency-dependent changes in diaphragm electromyograph (dEMG) activity with an evoked tachypnoea and apnoea at low and high stimulation frequencies, respectively. Muscimol microinjections into the LPB significantly attenuated eVNS-evoked respiratory rate responses. Notably, muscimol injections reaching the caudal LPB, previously unrecognised for respiratory modulation, potently modulated eVNS-evoked apnoea, whilst muscimol injections reaching the intermediate LPB selectively modulated the eVNS-evoked tachypnoea. The effects of muscimol on eVNS-evoked breathing rate changes occurred without altering basal eupneic breathing. These results highlight novel roles for the LPB in regulating vagally-evoked respiratory reflexes.
    MeSH term(s) Animals ; Mice ; Respiratory Rate ; Apnea ; Muscimol/pharmacology ; Parabrachial Nucleus ; Tachypnea
    Chemical Substances Muscimol (2763-96-4)
    Language English
    Publishing date 2023-08-18
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2077867-3
    ISSN 1878-1519 ; 1569-9048
    ISSN (online) 1878-1519
    ISSN 1569-9048
    DOI 10.1016/j.resp.2023.104141
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    Zs.A 519: Show issues Location:
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  10. Article ; Online: Comparative localization of colorectal sensory afferent central projections in the mouse spinal cord dorsal horn and caudal medulla dorsal vagal complex.

    Wang, QingQing / Caraballo, Sonia Garcia / Rychkov, Grigori / McGovern, Alice E / Mazzone, Stuart B / Brierley, Stuart M / Harrington, Andrea M

    The Journal of comparative neurology

    2023  Volume 532, Issue 2, Page(s) e25546

    Abstract: The distal colon and rectum (colorectum) are innervated by spinal and vagal afferent pathways. The central circuits into which vagal and spinal afferents relay colorectal nociceptive information remain to be comparatively assessed. To address this, ... ...

    Abstract The distal colon and rectum (colorectum) are innervated by spinal and vagal afferent pathways. The central circuits into which vagal and spinal afferents relay colorectal nociceptive information remain to be comparatively assessed. To address this, regional colorectal retrograde tracing and colorectal distension (CRD)-evoked neuronal activation were used to compare the circuits within the dorsal vagal complex (DVC) and dorsal horn (thoracolumbar [TL] and lumbosacral [LS] spinal levels) into which vagal and spinal colorectal afferents project. Vagal afferent projections were observed in the nucleus tractus solitarius (NTS), area postrema (AP), and dorsal motor nucleus of the vagus (DMV), labeled from the rostral colorectum. In the NTS, projections were opposed to catecholamine and pontine parabrachial nuclei (PbN)-projecting neurons. Spinal afferent projections were labeled from rostral through to caudal aspects of the colorectum. In the dorsal horn, the number of neurons activated by CRD was linked to pressure intensity, unlike in the DVC. In the NTS, 13% ± 0.6% of CRD-activated neurons projected to the PbN. In the dorsal horn, at the TL spinal level, afferent input was associated with PbN-projecting neurons in lamina I (LI), with 63% ± 3.15% of CRD-activated neurons in LI projecting to the PbN. On the other hand, at the LS spinal level, only 18% ± 0.6% of CRD-activated neurons in LI projected to the PbN. The collective data identify differences in the central neuroanatomy that support the disparate roles of vagal and spinal afferent signaling in the facilitation and modulation of colorectal nociceptive responses.
    MeSH term(s) Mice ; Animals ; Vagus Nerve ; Afferent Pathways/physiology ; Neurons ; Spinal Cord Dorsal Horn ; Colorectal Neoplasms/metabolism ; Spinal Cord/metabolism ; Neurons, Afferent/physiology
    Language English
    Publishing date 2023-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3086-7
    ISSN 1096-9861 ; 0021-9967 ; 0092-7317
    ISSN (online) 1096-9861
    ISSN 0021-9967 ; 0092-7317
    DOI 10.1002/cne.25546
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