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Article ; Online: Safety pharmacology and subchronic toxicity of jinqing granules in rats.

Zhou, Xuerong / Rong, Qian / Xu, Min / Zhang, Yuanli / Dong, Qi / Xiao, Yuanling / Liu, Qiji / Chen, Helin / Yang, Xiaoyu / Yu, Kaisheng / Li, Yinglun / Zhao, Ling / Ye, Gang / Shi, Fei / Lv, Cheng

BMC veterinary research

2017 Volume 13, Issue 1, Page(s) 179

Abstract: Background: Jinqing granules which are made of a mixture extract that contains Radix Tinosporae ... pharmacology experiments, Jinqing granules had no evident adverse effects on the central nervous ... cardiovascular, or respiratory systems. In subchronic toxicity study, 2-8 g/kg of Jinqing granules induced no ...

Abstract	Background: Jinqing granules which are made of a mixture extract that contains Radix Tinosporae and Canarii fructus in proportions according to a longstanding formula have a good effect on the prevention and treatment of gastric ulcer disease. It has not been through safety through systematic toxicological studies, however. To provide basis for clinical application, we performed safety pharmacology and subchronic toxicity experiments in specific pathogen-free Sprague-Dawley rats. Results: In safety pharmacology experiments, Jinqing granules had no evident adverse effects on the central nervous, cardiovascular, or respiratory systems. In subchronic toxicity study, 2-8 g/kg of Jinqing granules induced no evident adverse effects on Clinical signs, body weight changes, food and water intake, death daily, indicators of urine, hematological assay, serum biochemistry, organ coefficient and histopathological examination. However, the 16 g/kg dose was associated with slightly slowed weight growth, decreased number of sperm in seminiferous tubules and increased values of serum aspartate aminotransferase and bilirubin. During the 30-day feeding test, 3 rats that received the 16 g/kg dose died, but the deaths were most likely due to trauma of oral gavage, not to drug toxicity. Conclusion: Jinqing granules given to Sprague-Dawley rats orally for 30 days at a dose of 8 g/kg or less appears safe, but higher doses were not proven safe. The significance of these observations with respect to animal usage of Jinqing granules deserves thorough investigation.
MeSH term(s)	Animals ; Burseraceae/chemistry ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/toxicity ; Female ; Male ; Rats ; Rats, Sprague-Dawley ; Tinospora/chemistry
Chemical Substances	Drugs, Chinese Herbal ; jinqing
Language	English
Publishing date	2017-06-17
Publishing country	England
Document type	Journal Article
ISSN	1746-6148
ISSN (online)	1746-6148
DOI	10.1186/s12917-017-1095-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Safety pharmacology and subchronic toxicity of jinqing granules in rats

Xuerong Zhou / Qian Rong / Min Xu / Yuanli Zhang / Qi Dong / Yuanling Xiao / Qiji Liu / Helin Chen / Xiaoyu Yang / Kaisheng Yu / Yinglun Li / Ling Zhao / Gang Ye / Fei Shi / Cheng Lv

BMC Veterinary Research, Vol 13, Iss 1, Pp 1-

2017 Volume 11

Abstract: Abstract Background Jinqing granules which are made of a mixture extract that contains Radix ... experiments, Jinqing granules had no evident adverse effects on the central nervous, cardiovascular, or ... respiratory systems. In subchronic toxicity study, 2–8 g/kg of Jinqing granules induced no evident adverse effects ...

Abstract	Abstract Background Jinqing granules which are made of a mixture extract that contains Radix Tinosporae and Canarii fructus in proportions according to a longstanding formula have a good effect on the prevention and treatment of gastric ulcer disease. It has not been through safety through systematic toxicological studies, however. To provide basis for clinical application, we performed safety pharmacology and subchronic toxicity experiments in specific pathogen-free Sprague-Dawley rats. Results In safety pharmacology experiments, Jinqing granules had no evident adverse effects on the central nervous, cardiovascular, or respiratory systems. In subchronic toxicity study, 2–8 g/kg of Jinqing granules induced no evident adverse effects on Clinical signs, body weight changes, food and water intake, death daily, indicators of urine, hematological assay, serum biochemistry, organ coefficient and histopathological examination. However, the 16 g/kg dose was associated with slightly slowed weight growth, decreased number of sperm in seminiferous tubules and increased values of serum aspartate aminotransferase and bilirubin. During the 30-day feeding test, 3 rats that received the 16 g/kg dose died, but the deaths were most likely due to trauma of oral gavage, not to drug toxicity. Conclusion Jinqing granules given to Sprague-Dawley rats orally for 30 days at a dose of 8 g/kg or less appears safe, but higher doses were not proven safe. The significance of these observations with respect to animal usage of Jinqing granules deserves thorough investigation.
Keywords	Jinqing granules ; Rats ; Toxicity ; Safety pharmacology ; Subchronic toxicity ; Veterinary medicine ; SF600-1100
Subject code	590
Language	English
Publishing date	2017-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Safety pharmacology and subchronic toxicity of jinqing granules in rats

Zhou, Xuerong / Chen, Helin / Dong, Qi / Li, Yinglun / Liu, Qiji / Lv, Cheng / Rong, Qian / Shi, Fei / Xiao, Yuanling / Xu, Min / Yang, Xiaoyu / Ye, Gang / Yu, Kaisheng / Zhang, Yuanli / Zhao, Ling

BMC veterinary research. 2017 Dec., v. 13, no. 1

2017

Abstract: BACKGROUND: Jinqing granules which are made of a mixture extract that contains Radix Tinosporae and ... pharmacology experiments, Jinqing granules had no evident adverse effects on the central nervous ... cardiovascular, or respiratory systems. In subchronic toxicity study, 2–8 g/kg of Jinqing granules induced no ...

Abstract	BACKGROUND: Jinqing granules which are made of a mixture extract that contains Radix Tinosporae and Canarii fructus in proportions according to a longstanding formula have a good effect on the prevention and treatment of gastric ulcer disease. It has not been through safety through systematic toxicological studies, however. To provide basis for clinical application, we performed safety pharmacology and subchronic toxicity experiments in specific pathogen-free Sprague-Dawley rats. RESULTS: In safety pharmacology experiments, Jinqing granules had no evident adverse effects on the central nervous, cardiovascular, or respiratory systems. In subchronic toxicity study, 2–8 g/kg of Jinqing granules induced no evident adverse effects on Clinical signs, body weight changes, food and water intake, death daily, indicators of urine, hematological assay, serum biochemistry, organ coefficient and histopathological examination. However, the 16 g/kg dose was associated with slightly slowed weight growth, decreased number of sperm in seminiferous tubules and increased values of serum aspartate aminotransferase and bilirubin. During the 30-day feeding test, 3 rats that received the 16 g/kg dose died, but the deaths were most likely due to trauma of oral gavage, not to drug toxicity. CONCLUSION: Jinqing granules given to Sprague-Dawley rats orally for 30 days at a dose of 8 g/kg or less appears safe, but higher doses were not proven safe. The significance of these observations with respect to animal usage of Jinqing granules deserves thorough investigation.
Keywords	adverse effects ; aspartate transaminase ; bilirubin ; blood serum ; body weight changes ; death ; drug toxicity ; granules ; histopathology ; pharmacology ; rats ; seminiferous tubules ; specific pathogen-free animals ; spermatozoa ; stomach ulcers ; subchronic toxicity ; urine
Language	English
Dates of publication	2017-12
Size	p. 179.
Publishing place	BioMed Central
Document type	Article
ISSN	1746-6148
DOI	10.1186/s12917-017-1095-3
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Article ; Online: A benzothiophene-based fluorescent probe with dual-functional to polarity and cyanide for practical applications in living cells and real water samples.

Peng, Ting / Chen, Jian / Liu, Ruiyuan / Qu, Jinqing

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2024 Volume 314, Page(s) 124198

Abstract: Polarity is a significant intracellular environmental parameter associated with cancer, while cyanide ( ... ...

Abstract	Polarity is a significant intracellular environmental parameter associated with cancer, while cyanide (CN
MeSH term(s)	Humans ; Fluorescent Dyes ; Cyanides/toxicity ; Spectrometry, Fluorescence ; Solvents ; Drinking Water ; Thiophenes
Chemical Substances	Fluorescent Dyes ; Cyanides ; benzothiophene (073790YQ2G) ; Solvents ; Drinking Water ; Thiophenes
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2024.124198
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Article ; Online: Rhein against

Li, Yuyang / Chen, Weiwei / Ma, Jinxin / Huang, Guoying / Li, Guangquan / He, Qiumei / Kong, Xiangyu / Tang, Ling / Chen, Jinqing / Ding, Wenyou / Zhang, Zhongbin / Ding, Wenya

Current research in food science

2024 Volume 8, Page(s) 100718

Abstract: Currently, dairy mastitis caused ... ...

Abstract	Currently, dairy mastitis caused by
Language	English
Publishing date	2024-03-16
Publishing country	Netherlands
Document type	Journal Article
ISSN	2665-9271
ISSN (online)	2665-9271
DOI	10.1016/j.crfs.2024.100718
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Article ; Online: Differential expression profile of circular RNAs in mouse peritoneum with peritoneal fibrosis and the potential regulatory role of novel_circ_0007527

Yingfeng Shi / Yan Hu / Hui Chen / Jinqing Li / Min Tao / Xun Zhou / Qin Zhong / Andong Qiu / Shougang Zhuang / Na Liu

Genes and Diseases, Vol 11, Iss 3, Pp 100991- (2024)

2024

Keywords	Medicine (General) ; R5-920 ; Genetics ; QH426-470
Language	English
Publishing date	2024-05-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The status and childcare management of overweight and obesity among preschool children in Hangzhou.

Hu, Ye / Qian, Xia / Chen, Jinqing / Huang, Dan

Journal of pediatric endocrinology & metabolism : JPEM

2023 Volume 36, Issue 9, Page(s) 859–864

Abstract: Objectives: This study aims to investigate the prevalence of overweight and obesity in preschool children in Hangzhou and assess the impact of childcare management. By examining the characteristics and predicting the trends of overweight and obesity, we ...

Abstract	Objectives: This study aims to investigate the prevalence of overweight and obesity in preschool children in Hangzhou and assess the impact of childcare management. By examining the characteristics and predicting the trends of overweight and obesity, we hope to emphasize the significance of childcare management in primary community health service centers and the use of Electronic Health-care System in kindergartens. This study also seeks to provide evidence for intervention measures and effective prevention and control management of childhood obesity. Methods: From 2020 to 2022, kindergarten children aged 3-6 years old were selected as the research objects in kindergartens in Hangzhou. The Electronic Health-care System will be utilized to facilitate the management of childhood obesity and provide guidance and training to pediatricians and Primary Care Physicians. Results: The overall detection rates of overweight and obesity were 7.27 % and 3.55 %, respectively, among children aged 3-6 years in Hangzhou. The rates of simple obesity in Hangzhou preschool children aged 3-6 years were 4.25 , 3.42, and 3.04 % from 2020 to 2022, respectively; the overweight detection rates of children were 8.27 , 7.28, and 6.34 %, respectively, and the difference was statistically significant (p<0.05). The detection rates of overweight and obesity in 2022 were significantly lower than those in 2020 (p<0.05). The prevalence of obesity in children increased with age. Boys had a significantly higher incidence rate of obesity than girls (p<0.05). The proportion of children with moderate and severe obesity showed a downward trend. Intervention measures for childhood obesity in primary community health service centers and kindergartens are constantly being implemented. Conclusions: The prevalence of obesity in preschool children aged 3-6 years in Hangzhou exhibited a decreasing tendency. This research has identified that child care administration, particularly the implementation of the Electronic Health-care System, demonstrates effectiveness in handling overweight and obesity amongst children.
MeSH term(s)	Child ; Male ; Female ; Humans ; Child, Preschool ; Overweight/epidemiology ; Overweight/therapy ; Pediatric Obesity/diagnosis ; Pediatric Obesity/epidemiology ; Pediatric Obesity/prevention & control ; Child Care ; Obesity, Morbid ; Surveys and Questionnaires ; Prevalence
Language	English
Publishing date	2023-08-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1231070-0
ISSN	2191-0251 ; 0334-018X
ISSN (online)	2191-0251
ISSN	0334-018X
DOI	10.1515/jpem-2023-0248
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Article ; Online: Differential expression profile of circular RNAs in mouse peritoneum with peritoneal fibrosis and the potential regulatory role of novel_circ_0007527.

Shi, Yingfeng / Hu, Yan / Chen, Hui / Li, Jinqing / Tao, Min / Zhou, Xun / Zhong, Qin / Qiu, Andong / Zhuang, Shougang / Liu, Na

Genes & diseases

2023 Volume 11, Issue 3, Page(s) 100991

Language	English
Publishing date	2023-06-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2821806-1
ISSN	2352-3042 ; 2352-3042
ISSN (online)	2352-3042
ISSN	2352-3042
DOI	10.1016/j.gendis.2023.04.025
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Article: Characteristics of the Complete Genome of Ageratum Yellow Vein China Virus Infecting

Mo, Cuiping / Tang, Yafei / Chen, Jinqing / Cui, Lixian / Xie, Huiting / Qin, Bixia / Cai, Jianhe / Li, Zhanbiao

Plant disease

2023 Volume 107, Issue 10, Page(s) 2944–2948

Abstract: Sonchus ( ...

Abstract	Sonchus (
MeSH term(s)	Begomovirus ; Sonchus/genetics ; Phylogeny ; Plant Diseases ; Sequence Analysis, DNA ; China
Language	English
Publishing date	2023-10-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-11-22-2688-SC
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Article ; Online: Genome-wide identification and expression analysis of the Auxin-Response factor (ARF) gene family in Medicago sativa under abiotic stress.

Chen, Fenqi / Zhang, Jinqing / Ha, Xue / Ma, Huiling

BMC genomics

2023 Volume 24, Issue 1, Page(s) 498

Abstract: Background: Alfalfa (Medicago sativa) is the most widely planted legume forage and one of the most economically valuable crops in the world. The periodic changes in its growth and development and abiotic stress determine its yield and economic benefits. ...

Abstract	Background: Alfalfa (Medicago sativa) is the most widely planted legume forage and one of the most economically valuable crops in the world. The periodic changes in its growth and development and abiotic stress determine its yield and economic benefits. Auxin controls many aspects of alfalfa growth by regulating gene expression, including organ differentiation and stress response. Auxin response factors (ARF) are transcription factors that play an essential role in auxin signal transduction and regulate the expression of auxin-responsive genes. However, the function of ARF transcription factors is unclear in autotetraploid-cultivated alfalfa. Result: A total of 81 ARF were identified in the alfalfa genome in this study. Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were analyzed, identifying that ARF genes are mainly involved in transcriptional regulation and plant hormone signal transduction pathways. Phylogenetic analysis showed that MsARF was divided into four clades: I, II, III, and IV, each containing 52, 13, 7, and 9 genes, respectively. The promoter region of the MsARF gene contained stress-related elements, such as ABRE, TC-rich repeats, MBS, LTR. Proteins encoded by 50 ARF genes were localized in the nucleus without guide peptides, signal peptides, or transmembrane structures, indicating that most MsARF genes are not secreted or transported but only function in the nucleus. Protein structure analysis revealed that the secondary and tertiary structures of the 81 MsARF genes varied. Chromosomal localization analysis showed 81 MsARF genes were unevenly distributed on 25 chromosomes, with the highest distribution on chromosome 5. Furthermore, 14 segmental duplications and two sets of tandem repeats were identified. Expression analysis indicated that the MsARF was differentially expressed in different tissues and under various abiotic stressors. The quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis showed that the expression profiles of 23 MsARF genes were specific to abiotic stresses such as drought, salt, high temperature, and low temperature, as well as tissue-specific and closely related to the duration of stress. Conclusion: This study identified MsARF in the cultivated alfalfa genome based on the autotetraploid level, which GO, KEGG analysis, phylogenetic analysis, sequence characteristics, and expression pattern analysis further confirmed. Together, these findings provide clues for further investigation of MsARF functional verification and molecular breeding of alfalfa. This study provides a novel approach to systematically identify and characterize ARF transcription factors in autotetraploid cultivated alfalfa, revealing 23 MsARF genes significantly involved in response to various stresses.
MeSH term(s)	Medicago sativa/genetics ; Indoleacetic Acids ; Phylogeny ; Plant Growth Regulators ; Stress, Physiological/genetics
Chemical Substances	Indoleacetic Acids ; Plant Growth Regulators
Language	English
Publishing date	2023-08-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2041499-7
ISSN	1471-2164 ; 1471-2164
ISSN (online)	1471-2164
ISSN	1471-2164
DOI	10.1186/s12864-023-09610-z
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