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  1. Article: Acute respiratory distress syndrome-a worldwide economic perspective.

    Chebib, Nader / Kreitmann, Louis / Guérin, Claude

    Journal of thoracic disease

    2018  Volume 10, Issue 2, Page(s) 570–575

    Language English
    Publishing date 2018-02-27
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2018.01.72
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Thoracic manifestations of segmental neurofibromatosis.

    Chebib, Nader / Combemale, Patrick / Jullien, Denis / Cottin, Vincent

    BMJ case reports

    2017  Volume 2017

    MeSH term(s) Female ; Humans ; Magnetic Resonance Imaging ; Mediastinal Neoplasms/diagnostic imaging ; Mediastinal Neoplasms/genetics ; Middle Aged ; Mutation ; Neurofibromatosis 1/diagnostic imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2017-09-25
    Publishing country England
    Document type Case Reports
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2017-221253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Interstitial Lung Disease Associated with Adult Niemann-Pick Disease Type B.

    Chebib, Nader / Thivolet-Bejui, Françoise / Cottin, Vincent

    Respiration; international review of thoracic diseases

    2017  Volume 94, Issue 2, Page(s) 237–238

    MeSH term(s) Aged ; Bronchoalveolar Lavage Fluid/cytology ; Female ; Humans ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/etiology ; Lung Diseases, Interstitial/physiopathology ; Macrophages, Alveolar/pathology ; Niemann-Pick Disease, Type B/blood ; Niemann-Pick Disease, Type B/complications ; Niemann-Pick Disease, Type B/diagnostic imaging ; Niemann-Pick Disease, Type B/genetics ; Sphingomyelin Phosphodiesterase/blood ; Sphingomyelin Phosphodiesterase/genetics ; Tomography, X-Ray Computed
    Chemical Substances SMPD1 protein, human (EC 3.1.4.12) ; Sphingomyelin Phosphodiesterase (EC 3.1.4.12)
    Language English
    Publishing date 2017-06-10
    Publishing country Switzerland
    Document type Case Reports ; Journal Article
    ZDB-ID 206674-9
    ISSN 1423-0356 ; 0025-7931
    ISSN (online) 1423-0356
    ISSN 0025-7931
    DOI 10.1159/000477465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pulmonary alveolar proteinosis following cryptococcal meningitis: a possible cause?

    Demir, Sarah / Chebib, Nader / Thivolet-Bejui, Francoise / Cottin, Vincent

    BMJ case reports

    2018  Volume 2018

    Abstract: Autoimmune pulmonary alveolar proteinosis (PAP) is a rare interstitial lung disease characterised by the presence of granulocyte macrophage colony-stimulating factor (GM-CSF) autoantibodies. A man with no history of infection developed cryptococcal ... ...

    Abstract Autoimmune pulmonary alveolar proteinosis (PAP) is a rare interstitial lung disease characterised by the presence of granulocyte macrophage colony-stimulating factor (GM-CSF) autoantibodies. A man with no history of infection developed cryptococcal meningitis and a right parahilar cryptococcal mass. Antifungal treatment led to infection control, although there was presence of neurological sequelae. After 3 years, thoracic CT revealed bilateral ground glass opacities and a crazy paving pattern. Transparietal needle biopsy showed proteinaceous alveolar deposits, confirming the diagnosis of PAP. A high titre of serum anti-GM-CSF autoantibodies was found. No specific treatment was started, and radiological lesions decreased progressively. Cryptococcal infection may occur in PAP and in patients with anti-GM-CSF antibodies without PAP. These antibodies dysregulate phagocytosis in monocytes and macrophages, possibly leading to opportunistic infections in previously healthy subjects.
    MeSH term(s) Adult ; Antifungal Agents/therapeutic use ; Autoimmune Diseases/complications ; Autoimmune Diseases/diagnostic imaging ; Autoimmune Diseases/pathology ; Biopsy ; Diagnosis, Differential ; Humans ; Lung/diagnostic imaging ; Lung/pathology ; Male ; Meningitis, Cryptococcal/complications ; Meningitis, Cryptococcal/drug therapy ; Pulmonary Alveolar Proteinosis/complications ; Pulmonary Alveolar Proteinosis/diagnostic imaging ; Pulmonary Alveolar Proteinosis/pathology ; Tomography, X-Ray Computed/methods
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2018-03-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2017-222940
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Subclinical venous access infection and clinical worsening in pulmonary arterial hypertension.

    Chebib, Nader / Mornex, Jean-François / Cottin, Vincent

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2016  Volume 36, Issue 3, Page(s) 369–370

    MeSH term(s) Aged ; Antihypertensive Agents/administration & dosage ; Catheter-Related Infections/etiology ; Central Venous Catheters/adverse effects ; Epoprostenol/administration & dosage ; Female ; Humans ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/physiopathology ; Infusions, Intravenous ; Male ; Middle Aged ; Pulmonary Wedge Pressure/drug effects
    Chemical Substances Antihypertensive Agents ; Epoprostenol (DCR9Z582X0)
    Language English
    Publishing date 2016-10-21
    Publishing country United States
    Document type Letter
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2016.10.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2056: Show issues Location:
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  6. Article: Epoprostenol discontinuation in patients with pulmonary arterial hypertension: a complex medical and social problem.

    Chebib, Nader / Cottin, Vincent / Taharo-Ag-Ralissoum, Martine / Chuzeville, Michel / Mornex, Jean-François

    Pulmonary circulation

    2017  Volume 8, Issue 1, Page(s) 2045893217753352

    Language English
    Publishing date 2017-12-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2638089-4
    ISSN 2045-8940 ; 2045-8932
    ISSN (online) 2045-8940
    ISSN 2045-8932
    DOI 10.1177/2045893217753352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dysregulation of the endothelin pathway in lymphangioleiomyomatosis with no direct effect on cell proliferation and migration.

    Chebib, Nader / Archer, Fabienne / Bobet-Erny, Alexandra / Leroux, Caroline / Cottin, Vincent

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 14698

    Abstract: LAM is a rare low-grade metastasizing lung neoplasm. Inhibitors of mTOR improve clinical outcome of LAM patients by preventing loss of lung function. Nevertheless, other cell targets may be of interest for drug development. Therefore, we explored the ... ...

    Abstract LAM is a rare low-grade metastasizing lung neoplasm. Inhibitors of mTOR improve clinical outcome of LAM patients by preventing loss of lung function. Nevertheless, other cell targets may be of interest for drug development. Therefore, we explored the potential role of EDN1 (endothelin) in LAM. We report an increased endothelin blood level in LAM patients as well as EDN1 overexpression and EDN1 receptor downregulation in LAM-derived primary cells and in TSC2
    MeSH term(s) Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Endothelin A Receptor Antagonists/pharmacology ; Endothelin-1/blood ; Endothelin-1/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lung/pathology ; Lung Neoplasms/blood ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Lymphangioleiomyomatosis/blood ; Lymphangioleiomyomatosis/genetics ; Lymphangioleiomyomatosis/pathology ; Primary Cell Culture ; Receptor, Endothelin A/metabolism ; Receptor, Endothelin B/metabolism ; Signal Transduction/drug effects ; Sirolimus/pharmacology ; Spheroids, Cellular ; Tuberous Sclerosis/genetics ; Tuberous Sclerosis/pathology ; Tuberous Sclerosis Complex 2 Protein/genetics ; beta-Arrestin 1/metabolism
    Chemical Substances ARRB1 protein, human ; EDNRA protein, human ; EDNRB protein, human ; Endothelin A Receptor Antagonists ; Endothelin-1 ; Receptor, Endothelin A ; Receptor, Endothelin B ; TSC2 protein, human ; Tuberous Sclerosis Complex 2 Protein ; beta-Arrestin 1 ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2018-10-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-32795-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Interstitial Lung Disease Associated with Adult Niemann-Pick Disease Type B

    Chebib, Nader / Thivolet-Bejui, Françoise / Cottin, Vincent

    Respiration

    2017  Volume 94, Issue 2, Page(s) 237–238

    Institution Department of Pneumology, National Reference Center for Rare Pulmonary Diseases and Department of Pathology, Louis Pradel Hospital, Hospices Civils de Lyon, and Claude Bernard Lyon 1 University, University of Lyon, INRA, UMR754, Lyon, France
    Language English
    Publishing date 2017-06-10
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note The Eye Catcher
    ZDB-ID 206674-9
    ISSN 1423-0356 ; 0025-7931
    ISSN (online) 1423-0356
    ISSN 0025-7931
    DOI 10.1159/000477465
    Database Karger publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.138: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  9. Article: Low-pressure support vs automatic tube compensation during spontaneous breathing trial for weaning.

    Guérin, Claude / Terzi, Nicolas / Mezidi, Mehdi / Baboi, Loredana / Chebib, Nader / Yonis, Hodane / Argaud, Laurent / Heunks, Leo / Louis, Bruno

    Annals of intensive care

    2019  Volume 9, Issue 1, Page(s) 137

    Abstract: Background: During spontaneous breathing trial, low-pressure support is thought to compensate for endotracheal tube resistance, but it actually should provide overassistance. Automatic tube compensation is an option available in the ventilator to ... ...

    Abstract Background: During spontaneous breathing trial, low-pressure support is thought to compensate for endotracheal tube resistance, but it actually should provide overassistance. Automatic tube compensation is an option available in the ventilator to compensate for flow-resistance of endotracheal tube. Its effects on patient effort have been poorly investigated. We aimed to compare the effects of low-pressure support and automatic tube compensation during spontaneous breathing trial on breathing power and lung ventilation distribution.
    Results: We performed a randomized crossover study in 20 patients ready to wean. Each patient received both methods for 30 min separated by baseline ventilation: pressure support 0 cmH
    Conclusions: We found that ATC was associated with higher breathing power than low PS during SBT without altering the distribution of lung ventilation.
    Language English
    Publishing date 2019-12-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-019-0611-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Prevalence and risk factors of hemodynamic instability associated with preload-dependence during continuous renal replacement therapy in a prospective observational cohort of critically ill patients.

    Chazot, Guillaume / Bitker, Laurent / Mezidi, Mehdi / Chebib, Nader / Chabert, Paul / Chauvelot, Louis / Folliet, Laure / David, Guillaume / Provoost, Judith / Yonis, Hodane / Richard, Jean-Christophe

    Annals of intensive care

    2021  Volume 11, Issue 1, Page(s) 95

    Abstract: Background: Hemodynamic instability is a frequent complication of continuous renal replacement therapy (CRRT). Postural tests (i.e., passive leg raising in the supine position or Trendelenburg maneuver in the prone position) combined with measurement of ...

    Abstract Background: Hemodynamic instability is a frequent complication of continuous renal replacement therapy (CRRT). Postural tests (i.e., passive leg raising in the supine position or Trendelenburg maneuver in the prone position) combined with measurement of cardiac output are highly reliable to identify preload-dependence and may provide new insights into the mechanisms involved in hemodynamic instability related to CRRT (HIRRT). We aimed to assess the prevalence and risk factors of HIRRT associated with preload-dependence in ICU patients. We conducted a single-center prospective observational cohort study in ICU patients with acute kidney injury KDIGO 3, started on CRRT in the last 24 h, and monitored with a PiCCO® device. The primary endpoint was the rate of HIRRT episodes associated with preload-dependence during the first 7 days after inclusion. HIRRT was defined as the occurrence of a mean arterial pressure below 65 mmHg requiring therapeutic intervention. Preload-dependence was assessed by postural tests every 4 h, and during each HIRRT episode. Data are expressed in median [1st quartile-3rd quartile], unless stated otherwise.
    Results: 42 patients (62% male, age 69 [59-77] year, SAPS-2 65 [49-76]) were included 6 [1-16] h after CRRT initiation and studied continuously for 121 [60-147] h. A median of 5 [3-8] HIRRT episodes occurred per patient, for a pooled total of 243 episodes. 131 episodes (54% [CI
    Conclusions: In this single-center study, HIRRT associated with preload-dependence was slightly more frequent than HIRRT without preload-dependence in ICU patients undergoing CRRT. Testing for preload-dependence could help avoiding unnecessary decrease of fluid removal in preload-independent HIRRT during CRRT.
    Language English
    Publishing date 2021-06-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-021-00883-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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