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Article ; Online: H4H - hydration for health.

Lafontan, Max

2014 Volume 7 Suppl 2, Page(s) 1–5

MeSH term(s)	Drinking ; Fluid Therapy ; Humans ; Kidney Diseases/prevention & control ; Obesity/prevention & control
Language	English
Publishing date	2014-04-04
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2417831-7
ISSN	1662-4033 ; 1662-4025
ISSN (online)	1662-4033
ISSN	1662-4025
DOI	10.1159/000360666
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Article: Le tissu adipeux : un organe aux ressources insoupçonnées

Lafontan, Max

Société Française de Nutrition Cahiers de nutrition et de diététique. 2015 Dec., v. 50, no. 6

2015

Abstract: The research on adipose tissue (AT) and its major constituent, the adipocyte, reveals that AT, the major energy reservoir of the body, also possesses diversifi ed functions. The adipocyte secretes hormones and various paracrine factors which assure him ... ...

Abstract	The research on adipose tissue (AT) and its major constituent, the adipocyte, reveals that AT, the major energy reservoir of the body, also possesses diversifi ed functions. The adipocyte secretes hormones and various paracrine factors which assure him unsuspected capacities of dialogue with the other organs and tissues. The redefi ning of the links between white AT and brown AT has reintroduced a refl ection on their respective physiological functions. The nature of fat cell progenitors and their role in the control of the renewal rate of AT in initiation of functional pathologies related to disturbances in the expandability of AT have been specifi ed with a special attention for the infi ltration of immune cells. The study of progenitors revealed that the AT is also a reservoir of regenerative cells particularly promising. Moreover, the TA captures and sequesters many persistent organic pollutants and is likely to play a buffer role in the exposure to environmental agents.
Keywords	adipocytes ; adipose tissue ; energy ; hormones ; nutrition ; persistent organic pollutants
Language	English
Dates of publication	2015-12
Size	p. 6S15-6S21.
Publishing place	Elsevier Masson SAS
Document type	Article
ZDB-ID	840946-8
ISSN	0007-9960
ISSN	0007-9960
DOI	10.1016/S0007-9960(15)30013-4
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Article ; Online: Rein, tissu adipeux, adipocytes--quelles nouveautés?

Lafontan, Max

Nephrologie & therapeutique

2011 Volume 7, Issue 2, Page(s) 69–79

Abstract: Increased evidence suggests that obesity-related glomerulopathy and chronic kidney diseases should be identified as isolated complications of obesity. It is questioned if the numerous adipose tissue productions could play a role in the initiation/ ... ...

Title translation	Kidney, adipose tissue, adipocytes--what's new?.
Abstract	Increased evidence suggests that obesity-related glomerulopathy and chronic kidney diseases should be identified as isolated complications of obesity. It is questioned if the numerous adipose tissue productions could play a role in the initiation/maintenance of such kidney diseases. This review will provide a sum-up of recent advances on fat cell metabolism and adipose tissue physiology. The adipose tissue behaves as an endocrine organ with multiple activities. It is secreting hormones (leptin, adiponectin, apelin) and numerous factors with autocrine, paracrine and systemic effects. These secretions are coming from adipocytes themselves or from cells present in the stroma-vascular fraction of the adipose tissue. When expanding, the adipose tissue of the obese is infiltrated by immune cells such as macrophages and lymphocytes; the role of which is not fully clarified. An attempt will be done to delineate if alterations of lipid storage/fatty acid release or of the secretion potencies of adipose tissue could contribute to kidney lipotoxicity and other chronic kidney diseases described in the obese.
MeSH term(s)	Adipocytes/immunology ; Adipocytes/metabolism ; Adiponectin/metabolism ; Adipose Tissue, White/immunology ; Adipose Tissue, White/metabolism ; Apelin ; Biomarkers/metabolism ; Body Mass Index ; Cytokines/secretion ; Evidence-Based Medicine ; Glomerulonephritis/etiology ; Glomerulonephritis/immunology ; Glomerulonephritis/metabolism ; Humans ; Intercellular Signaling Peptides and Proteins/metabolism ; Leptin/metabolism ; Metabolic Syndrome/metabolism ; Obesity/complications ; Obesity/immunology ; Obesity/metabolism ; Renal Insufficiency, Chronic/etiology ; Renal Insufficiency, Chronic/immunology ; Renal Insufficiency, Chronic/metabolism
Chemical Substances	APLN protein, human ; Adiponectin ; Apelin ; Biomarkers ; Cytokines ; Intercellular Signaling Peptides and Proteins ; Leptin
Language	French
Publishing date	2011-04
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	2229575-6
ISSN	1872-9177 ; 1769-7255
ISSN (online)	1872-9177
ISSN	1769-7255
DOI	10.1016/j.nephro.2010.11.004
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Article ; Online: Historical perspectives in fat cell biology: the fat cell as a model for the investigation of hormonal and metabolic pathways.

Lafontan, Max

American journal of physiology. Cell physiology

2011 Volume 302, Issue 2, Page(s) C327–59

Abstract: For many years, there was little interest in the biochemistry or physiology of adipose tissue. It is now well recognized that adipocytes play an important dynamic role in metabolic regulation. They are able to sense metabolic states via their ability to ... ...

Abstract	For many years, there was little interest in the biochemistry or physiology of adipose tissue. It is now well recognized that adipocytes play an important dynamic role in metabolic regulation. They are able to sense metabolic states via their ability to perceive a large number of nervous and hormonal signals. They are also able to produce hormones, called adipokines, that affect nutrient intake, metabolism and energy expenditure. The report by Rodbell in 1964 that intact fat cells can be obtained by collagenase digestion of adipose tissue revolutionized studies on the hormonal regulation and metabolism of the fat cell. In the context of the advent of systems biology in the field of cell biology, the present seems an appropriate time to look back at the global contribution of the fat cell to cell biology knowledge. This review focuses on the very early approaches that used the fat cell as a tool to discover and understand various cellular mechanisms. Attention essentially focuses on the early investigations revealing the major contribution of mature fat cells and also fat cells originating from adipose cell lines to the discovery of major events related to hormone action (hormone receptors and transduction pathways involved in hormonal signaling) and mechanisms involved in metabolite processing (hexose uptake and uptake, storage, and efflux of fatty acids). Dormant preadipocytes exist in the stroma-vascular fraction of the adipose tissue of rodents and humans; cell culture systems have proven to be valuable models for the study of the processes involved in the formation of new fat cells. Finally, more recent insights into adipocyte secretion, a completely new role with major metabolic impact, are also briefly summarized.
MeSH term(s)	Adipocytes/cytology ; Adipocytes/physiology ; Adipogenesis/physiology ; Adipokines/metabolism ; Adipose Tissue/cytology ; Adipose Tissue/physiology ; Animals ; Cell Differentiation ; Cell Line ; Cells, Cultured ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/physiology ; Energy Metabolism/physiology ; Fatty Acids/metabolism ; History, 20th Century ; History, 21st Century ; Humans ; Metabolic Networks and Pathways
Chemical Substances	Adipokines ; Fatty Acids
Language	English
Publishing date	2011-09-07
Publishing country	United States
Document type	Historical Article ; Journal Article ; Review
ZDB-ID	392098-7
ISSN	1522-1563 ; 0363-6143
ISSN (online)	1522-1563
ISSN	0363-6143
DOI	10.1152/ajpcell.00168.2011
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Article: H4H - Hydration for Health

Lafontan, Max

Obesity Facts

2014 Volume 7, Issue 2, Page(s) 1–5

Institution	Inserm/UPS UMR 1048 - Institut des Maladies Métaboliques et Cardiovasculaires, BP84225, 31432 Toulouse Cedex 4, France
Language	English
Publishing date	2014-04-04
Publisher	S. Karger GmbH
Publishing place	Freiburg, Germany
Document type	Article
ZDB-ID	2417831-7
ISBN	978-3-318-02588-0 ; 978-3-318-02589-7 ; 3-318-02588-7 ; 3-318-02589-5
ISSN	1662-4033 ; 1662-4025
ISSN (online)	1662-4033
ISSN	1662-4025
DOI	10.1159/000360666
Database	Karger publisher's database

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Article: Recommendations for Healthier Hydration From an Expert Working Group Meeting

Lafontan, Max

Nutrition today. 2013 , v. 48, no. 4 Suppl

2013

Abstract: ... Lafontan, was commissioned by the Hydration for Health Initiative from Danone to perform an expertise ...

Abstract	An Expert Working Group Meeting composed of the following experts covering diversified fields of expertise such as kinesiology and nutrition, public health, pediatrics, community nutrition, obesity/type 2 diabetes and metabolic diseases: L.E. Armstrong, S. Barquera, J-F. Duhamel, R. Hardinsyah, D. Haslam, and M. Lafontan, was commissioned by the Hydration for Health Initiative from Danone to perform an expertise of the major recent studies on hydration-related questions and to propose recommendations for healthy hydration. A full review article was written and will be published in the near future in Clinical Obesity journal in 2013; major conclusions of this review paper are summarized here.
Keywords	experts ; human nutrition ; noninsulin-dependent diabetes mellitus ; obesity ; pediatrics ; public health
Language	English
Dates of publication	2013-07
Size	p. S31.
Publishing place	Wolters Kluwer Health \| Lippincott Williams & Wilkins
Document type	Article
Note	Affiliations: Max Lafontan, PhD, DSc, is Inserm Emeritus director of research, Inserm/UPS, UMR1048-I2MC, University Paul Sabatier, Toulouse, France.
ZDB-ID	2053548-X
ISSN	1538-9839 ; 0029-666X
ISSN (online)	1538-9839
ISSN	0029-666X
DOI	10.1097/NT.0b013e318297872e
Database	NAL-Catalogue (AGRICOLA)

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Article: Fat cells: afferent and efferent messages define new approaches to treat obesity.

Lafontan, Max

Annual review of pharmacology and toxicology

2005 Volume 45, Page(s) 119–146

Abstract: For a long time neural and endocrine messages were studied for their impact on adipocyte metabolism and control of storage/release of fatty acids. In fact, bidirectional communication exists between adipocytes and other tissues. Several molecules ... ...

Abstract	For a long time neural and endocrine messages were studied for their impact on adipocyte metabolism and control of storage/release of fatty acids. In fact, bidirectional communication exists between adipocytes and other tissues. Several molecules secreted from adipocytes are involved in fat cell signaling to other tissues. Adipocyte products could initiate antagonistic effects on target tissues. Fat cells produce peptides that can elicit insulin resistance, such as tumor necrosis factor-alpha and resistin, as well as hormones that can improve insulin resistance, such as leptin and adiponectin. Secretion of complement proteins, proinflammatory cytokines, procoagulant, and acute phase reactant proteins have also been observed in adipocytes. There is much to learn about how these signals function. It is unlikely that all the adipocyte's endocrine and paracrine signals have been identified. Putative pharmacological strategies aiming at modulation of afferent and efferent fat cell messages are reviewed and discussed.
MeSH term(s)	Adipocytes/metabolism ; Adipocytes/physiology ; Animals ; Anti-Obesity Agents/metabolism ; Anti-Obesity Agents/therapeutic use ; Cell Communication/physiology ; Humans ; Obesity/drug therapy ; Obesity/metabolism ; Obesity/pathology ; Signal Transduction/physiology
Chemical Substances	Anti-Obesity Agents
Language	English
Publishing date	2005
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	196587-6
ISSN	1545-4304 ; 0362-1642
ISSN (online)	1545-4304
ISSN	0362-1642
DOI	10.1146/annurev.pharmtox.45.120403.095843
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Article: Role of Sugar Intake in Beverages on Overweight and Health

Lafontan, Max

Nutrition today. 2010 , v. 45, no. 6 Suppl

2010

Abstract: Epidemiological data have demonstrated an association between sugar intake in beverages and overweight. Cross-sectional studies are the most common but rather limited, and a lot of points are still a matter of debate. Results of intervention trials are ... ...

Abstract	Epidemiological data have demonstrated an association between sugar intake in beverages and overweight. Cross-sectional studies are the most common but rather limited, and a lot of points are still a matter of debate. Results of intervention trials are more promising, although they remain quite rare; they provide the best arguments to infer causality. This overview is limited to the analysis of the putative impact of sugar inclusion in beverages on health, obesity, and diabetes risk. Mechanisms of action and physiological end points are highlighted to clarify the differences existing in the health impact of various kinds of sugars. When considering weight changes and obesity-related questions related to sugar-sweetened beverages consumption, it is important to take into account population differences and genetic parameters. Lifestyle influences (eg, other components of the diet and physical activity) must also be considered in the studies.
Keywords	cross-sectional studies ; diabetes ; diet ; human nutrition ; lifestyle ; mechanism of action ; nutrition risk assessment ; obesity ; physical activity ; sugar sweetened beverages ; sugars
Language	English
Dates of publication	2010-11
Size	p. S13-S17.
Publishing place	Lippincott Williams & Wilkins
Document type	Article
Note	Affiliations: Max Lafontan, PhD, is director of research, Unité Inserm 858, Institut de Médecine Moléculaire de Rangueil, and Université Paul Sabatier, Toulouse, France.
ZDB-ID	960337-2
ISSN	0029-666X
ISSN	0029-666X
DOI	10.1097/NT.0b013e3181fe419e
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Article ; Online: Natriuretic peptides and cGMP signaling control of energy homeostasis.

Moro, Cedric / Lafontan, Max

American journal of physiology. Heart and circulatory physiology

2012 Volume 304, Issue 3, Page(s) H358–68

Abstract: Since the discovery of natriuretic peptides (NPs) by de Bold et al. in 1981, the cardiovascular community has been well aware that they exert potent effects on vessels, heart remodeling, kidney function, and the regulation of sodium and water balance. ... ...

Abstract	Since the discovery of natriuretic peptides (NPs) by de Bold et al. in 1981, the cardiovascular community has been well aware that they exert potent effects on vessels, heart remodeling, kidney function, and the regulation of sodium and water balance. Who would have thought that NPs are also able to exert metabolic effects and contribute to an original cross talk between heart, adipose tissues, and skeletal muscle? The attention on the metabolic role of NPs was awakened in the year 2000 with the discovery that NPs exert potent lipolytic effects mediated by the NP receptor type A/cGMP pathway in human fat cells and that they contribute to lipid mobilization in vivo. In this review, we will discuss the biological effects of NPs on the main tissues involved in the regulation of energy metabolism (i.e., white and brown adipose tissues, skeletal muscle, liver, and pancreas). These recent results on NPs are opening a new chapter into the physiological properties and therapeutic usefulness of this family of hormones.
MeSH term(s)	Adipokines/metabolism ; Adipose Tissue/drug effects ; Adipose Tissue/metabolism ; Adipose Tissue, Brown/drug effects ; Adipose Tissue, Brown/metabolism ; Animals ; Cyclic GMP/physiology ; Cytokines/metabolism ; Energy Metabolism/physiology ; Homeostasis/physiology ; Humans ; Lipid Metabolism/physiology ; Metabolic Diseases/metabolism ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Natriuretic Peptides/physiology ; Natriuretic Peptides/therapeutic use ; Signal Transduction/physiology ; Vascular Diseases/drug therapy
Chemical Substances	Adipokines ; Cytokines ; Natriuretic Peptides ; Cyclic GMP (H2D2X058MU)
Language	English
Publishing date	2012-11-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00704.2012
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Article ; Online: Opportunities for intervention strategies for weight management: global actions on fluid intake patterns.

Lafontan, Max / Visscher, Tommy L S / Farpour-Lambert, Nathalie / Yumuk, Volkan

Obesity facts

2015 Volume 8, Issue 1, Page(s) 54–76

Abstract: Water is an essential nutrient for all physiological functions and particularly important for thermoregulation. About 60% of our body weight is made of water. Under standard conditions (18-20 °C and moderate activity), water balance is regulated within 0. ...

Abstract	Water is an essential nutrient for all physiological functions and particularly important for thermoregulation. About 60% of our body weight is made of water. Under standard conditions (18-20 °C and moderate activity), water balance is regulated within 0.2 % of body weight over a 24-hour period. Water requirement varies between individuals and according to environmental conditions. Concerning considerations related to obesity, the health impact of fluid intake is commonly overlooked. Fluid intake advices are missing in most of food pyramids offered to the public, and water requirements and hydration challenges remain often neglected. The purpose of this paper is to emphasize and discuss the role of water consumption in the context of other important public health measures for weight management. Attention will be focused on fluid intake patterns and hydration-related questions in the context of global interventions and/or physical activity programs settled in weight management protocols.
MeSH term(s)	Beverages ; Dietary Sucrose/adverse effects ; Drinking ; Exercise ; Global Health ; Humans ; Obesity/etiology ; Obesity/prevention & control ; Water
Chemical Substances	Dietary Sucrose ; Water (059QF0KO0R)
Language	English
Publishing date	2015
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2417831-7
ISSN	1662-4033 ; 1662-4025
ISSN (online)	1662-4033
ISSN	1662-4025
DOI	10.1159/000375103
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