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Article ; Online: Atherotome dislodgement and successful retrieval during cutting balloon pulmonary angioplasty.

DeSena, Holly C / Ramaciotti, Claudio / Nugent, Alan W

Circulation. Cardiovascular interventions

2012 Volume 5, Issue 3, Page(s) e37–8

MeSH term(s)	Alagille Syndrome/complications ; Angioplasty, Balloon/instrumentation ; Arterial Occlusive Diseases/complications ; Arterial Occlusive Diseases/diagnostic imaging ; Arterial Occlusive Diseases/therapy ; Catheters ; Child ; Constriction, Pathologic ; Equipment Design ; Equipment Failure ; Female ; Humans ; Pulmonary Artery/diagnostic imaging ; Radiography, Interventional ; Treatment Outcome
Language	English
Publishing date	2012-06
Publishing country	United States
Document type	Case Reports ; Journal Article ; Video-Audio Media
ZDB-ID	2450797-0
ISSN	1941-7632 ; 1941-7640
ISSN (online)	1941-7632
ISSN	1941-7640
DOI	10.1161/CIRCINTERVENTIONS.112.969899
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Zs.A 6746: Show issues

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Article ; Online: Cardiac intensive care for the neonate and child after cardiac surgery.

DeSena, Holly C / Nelson, David P / Cooper, David S

Current opinion in cardiology

2015 Volume 30, Issue 1, Page(s) 81–88

Abstract: Purpose of review: The focus of postoperative care in the pediatric patient with congenital heart disease has become a reduction in length of stay and morbidity. This review will discuss strategies to achieve this goal and recent studies to support ... ...

Abstract	Purpose of review: The focus of postoperative care in the pediatric patient with congenital heart disease has become a reduction in length of stay and morbidity. This review will discuss strategies to achieve this goal and recent studies to support current practices. Recent findings: Most agree that prolongation of the length of stay following a cardiac surgery contributes to morbidity. Postoperative feeding difficulty, hyperglycemia, acute kidney injury, fluid overload, and prolonged intubation contribute significantly to length of stay. Summary: Postoperative care of the neonate and child following a cardiac surgery remains challenging with limited data to drive our practices. Patients remain at risk for significant morbidity, and future studies should focus on recognizing predictors of morbidity, prevention, and treatment.
MeSH term(s)	Cardiac Surgical Procedures/methods ; Cardiac Surgical Procedures/mortality ; Child, Preschool ; Critical Care/methods ; Cross Infection/prevention & control ; Female ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/mortality ; Heart Defects, Congenital/surgery ; Hospital Mortality/trends ; Humans ; Infant ; Infant, Newborn ; Intensive Care Units, Neonatal ; Length of Stay/trends ; Male ; Postoperative Care/adverse effects ; Postoperative Care/methods ; Prognosis ; Risk Assessment ; Survival Analysis ; Treatment Outcome
Language	English
Publishing date	2015-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645186-x
ISSN	1531-7080 ; 0268-4705
ISSN (online)	1531-7080
ISSN	0268-4705
DOI	10.1097/HCO.0000000000000127
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Zs.A 2556: Show issues

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Article: Useful References in Pediatric Cardiac Intensive Care: The 2017 Update.

Uzark, Karen C / Costello, John M / DeSena, Holly C / Thiagajaran, Ravi / Smith-Parrish, Melissa / Gist, Katja M

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2018 Volume 19, Issue 6, Page(s) 553–563

Abstract: ... articles included in this article. The first (K.C.U.) and last author (K.M.G.) reviewed and developed ...

Abstract	Objectives: Pediatric cardiac intensive care continues to evolve, with rapid advances in knowledge and improvement in clinical outcomes. In the past, the Board of Directors of the Pediatric Cardiac Intensive Care Society created and subsequently updated a list of sentinel references focused on the care of critically ill children with congenital and acquired heart disease. The objective of this article is to provide clinicians with a compilation and brief summary of updated and useful references that have been published since 2012. Data selection: Pediatric Cardiac Intensive Care Society members were solicited via a survey sent out between March 20, 2017, and April 28, 2017, to provide important references that have impacted clinical care. The survey was sent to approximately 523 members. Responses were received from 45 members, of which some included multiple references. Data extraction: Following review of the list of references, and removing editorials, references were compiled by the first and last author. The final list was submitted to members of the society's Research Briefs Committee, who ranked each publication. Data synthesis: Rankings were compiled and the references with the highest scores included. Research Briefs Committee members ranked the articles from 1 to 3, with one being highly relevant and should be included and 3 being less important and should be excluded. Averages were computed, and the top articles included in this article. The first (K.C.U.) and last author (K.M.G.) reviewed and developed summaries of each article. Conclusions: This article contains a compilation of useful references for the critical care of children with congenital and acquired heart disease published in the last 5 years. In conjunction with the prior version of this update in 2012, this article may be used as an educational reference in pediatric cardiac intensive care.
MeSH term(s)	Child ; Critical Care/statistics & numerical data ; Heart Diseases/therapy ; Humans ; Intensive Care Units, Pediatric/statistics & numerical data ; Publications/statistics & numerical data ; Surveys and Questionnaires
Language	English
Publishing date	2018-03-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000001523
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Zs.A 5600: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 472: Show issues

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Article: Central Venous Catheter Utilization and Complications in the Pediatric Cardiac ICU: A Report From the Pediatric Cardiac Critical Care Consortium (PC4).

DiPietro, Lisa M / Gaies, Michael / Banerjee, Mousumi / Donohue, Janet E / Zhang, Wenying / DeSena, Holly C / Graham, Eric M / Sasaki, Jun / Moga, Michael-Alice / Prodhan, Parthak / Goldstein, Stuart L / Tabbutt, Sarah / Cooper, David S

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2020 Volume 21, Issue 8, Page(s) 729–737

Abstract: Objectives: Current central venous catheter utilization in patients within pediatric cardiac ICUs is not well elucidated. We aim to describe current use of central venous catheters in a multi-institutional cohort and to explore the prevalence and risk ... ...

Abstract	Objectives: Current central venous catheter utilization in patients within pediatric cardiac ICUs is not well elucidated. We aim to describe current use of central venous catheters in a multi-institutional cohort and to explore the prevalence and risk factors for central line-associated thrombosis and central line-associated bloodstream infections. Design: Observational analysis. Setting: Pediatric Cardiac Critical Care Consortium hospitals. Patients: Hospitalizations with at least one cardiac ICU admission from October 2013 to July 2016. Interventions: None. Measurements and main results: There were 17,846 hospitalizations and 69% included greater than or equal to one central venous catheter. Central venous catheter use was higher in younger patients (86% neonates). Surgical hospitalizations included at least one central venous catheter 88% of the time compared with 35% of medical hospitalizations. The most common location for central venous catheters was internal jugular (46%). Central venous catheters were in situ a median of 4 days (interquartile range, 2-10). There were 248 hospitalizations (2% overall, 1.8% medical, and 2.1% surgical) with at least one central line-associated thrombosis (271 total thromboses). Thrombosis was diagnosed at a median of 7 days (interquartile range, 4-14) after catheter insertion. There were 127 hospitalizations (1% overall, 1.4% medical, and 1% surgical) with at least one central line-associated bloodstream infection (136 total infections) with no association with catheter type or location. Central line-associated bloodstream infection was diagnosed at a median of 19 days (interquartile range, 8-36) after catheter insertion. Significant risk factors for central line-associated thrombosis and central line-associated bloodstream infection were younger age, greater surgical complexity, and total catheter days. Conclusions: Utilization of central venous catheters in pediatric cardiac ICUs differs according to indication for hospitalization. Although thrombosis and central line-associated bloodstream infection are infrequent complications of central venous catheter use in cardiac ICU patients, these events can have important short- and long-term consequences for patients. Total central venous catheter line days were the only modifiable risk factor identified. Future study must focus on understanding central venous catheter practices in high-risk patient subgroups that reduce the prevalence of thrombosis and central line-associated bloodstream infection.
MeSH term(s)	Catheter-Related Infections/epidemiology ; Catheter-Related Infections/etiology ; Catheterization, Central Venous/adverse effects ; Central Venous Catheters/adverse effects ; Child ; Critical Care ; Humans ; Infant, Newborn ; Intensive Care Units, Pediatric
Language	English
Publishing date	2020-05-26
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000002306
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Zs.A 5600: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 472: Show issues

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Article ; Online: Ventricular fibrillation in a patient with Pompe disease: a cautionary tale.

Desena, Holly C / Brumund, Michael R / Superneau, Duane / Snyder, Christopher S

Congenital heart disease

2011 Volume 6, Issue 4, Page(s) 397–401

Abstract: Pompe disease is a rare genetic disorder resulting from a deficiency of the acid α-glucosidase enzyme. Although arrhythmias occur in these patients undergoing general anesthesia, they have not received sufficient emphasis in pediatric cardiology. We ... ...

Abstract	Pompe disease is a rare genetic disorder resulting from a deficiency of the acid α-glucosidase enzyme. Although arrhythmias occur in these patients undergoing general anesthesia, they have not received sufficient emphasis in pediatric cardiology. We report a case of an infant with Pompe disease who experienced ventricular fibrillation during induction of anesthesia.
MeSH term(s)	Anesthesia, General/adverse effects ; Cardiomegaly/etiology ; Catheterization, Central Venous ; Electrocardiography ; Enzyme Replacement Therapy ; Female ; Glycogen Storage Disease Type II/complications ; Glycogen Storage Disease Type II/diagnosis ; Glycogen Storage Disease Type II/drug therapy ; Humans ; Infant ; Ventricular Fibrillation/diagnosis ; Ventricular Fibrillation/etiology ; Ventricular Fibrillation/therapy
Language	English
Publishing date	2011-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2274321-2
ISSN	1747-0803 ; 1747-079X
ISSN (online)	1747-0803
ISSN	1747-079X
DOI	10.1111/j.1747-0803.2010.00471.x
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Zs.A 6693: Show issues

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Article ; Online: Shock and persistent MRSA bacteremia.

DeSena, Holly C / Steele, Russell W / Young, Thomas W

Clinical pediatrics

2010 Volume 49, Issue 5, Page(s) 509–511

MeSH term(s)	Bacteremia/complications ; Bacteremia/diagnosis ; Bacteremia/therapy ; Biopsy, Needle ; Combined Modality Therapy ; Echocardiography, Doppler ; Endocarditis, Bacterial/complications ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/diagnostic imaging ; Endocarditis, Bacterial/therapy ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Infant ; Methicillin-Resistant Staphylococcus aureus/isolation & purification ; Monitoring, Physiologic/methods ; Recurrence ; Risk Assessment ; Severity of Illness Index ; Shock, Septic/complications ; Shock, Septic/diagnosis ; Shock, Septic/therapy ; Staphylococcal Infections/complications ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/therapy ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/isolation & purification ; Treatment Outcome
Language	English
Publishing date	2010-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207678-0
ISSN	1938-2707 ; 0009-9228
ISSN (online)	1938-2707
ISSN	0009-9228
DOI	10.1177/0009922809351741
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Zs.A 454: Show issues

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Article ; Online: Morphology of interatrial defects created by interventional techniques in a neonatal animal model.

DeSena, Holly C / Veeram Reddy, Surendranath Reddy / Welch, Tre' / Wang, Jian / Forbess, Joseph / Nugent, Alan W

Pediatric cardiology

2013 Volume 35, Issue 3, Page(s) 381–385

Abstract: Pathological details are lacking of various techniques used for interatrial defect (IAD) creation in lesions requiring mixing or with left atrial hypertension. Therefore, the morphology of the IAD created by different interventional techniques is ... ...

Abstract	Pathological details are lacking of various techniques used for interatrial defect (IAD) creation in lesions requiring mixing or with left atrial hypertension. Therefore, the morphology of the IAD created by different interventional techniques is described. The atrial septa of ten euthanized piglets (seven at <3 days and three at 2 weeks of age) were surgically exposed. In pigs of both ages, a needle-created communication was dilated with angioplasty, cutting, and cryoplasty balloons. A stent was also implanted in a newborn pig. By way of a patent foramen ovale (PFO) in newborns, angioplasty and septostomy balloons and a stent created IADs. The morphology of the IAD was directly imaged and the size measured. Newborn piglets had noticeably thinner atrial septa, and a PFO was still present. Static balloon dilation created a circular IAD equivalent to the balloon diameter (3 and 6 mm) in both the created defects of pigs of both ages and the neonatal PFO. A 3-mm cutting balloon (CB) produced a 2-mm triangular IAD (corresponding to atherotomes) in pigs of both ages. Premounted stents, by way of a created defect or PFO, led to circular IADs equivalent to balloon diameter. The 3-mm cryoplasty balloon created a large 5 × 4-mm IAD in the newborn pig; however, the IAD measured only 2 × 1-mm at 2 weeks. By way of a neonatal PFO, a septostomy balloon (inflated to 2 cc) created a 3-mm circular IAD. In neonatal piglet hearts, static balloon angioplasty, CBs, and stents created a predictable IAD. Cryoplasty balloons created highly variable defects.
MeSH term(s)	Angioplasty, Balloon, Coronary ; Animals ; Animals, Newborn ; Cryosurgery ; Disease Models, Animal ; Heart Atria/surgery ; In Vitro Techniques ; Stents ; Swine
Language	English
Publishing date	2013-09-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	800857-7
ISSN	1432-1971 ; 0172-0643
ISSN (online)	1432-1971
ISSN	0172-0643
DOI	10.1007/s00246-013-0786-1
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Zs.A 1528: Show issues

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Article ; Online: Atrial fibrillation induction by transesophageal electrophysiology studies in patients with asymptomatic ventricular preexcitation.

Hoyt, Walter J / Thomas, Patricia E / DeSena, Holly C / Steinberg, Joan S / Harmon, Donald E / Snyder, Christopher S

Congenital heart disease

2013 Volume 8, Issue 1, Page(s) 57–61

Abstract: Objective: Ventricular preexcitation is a conduction abnormality caused by an accessory pathway bridging the atria and ventricles. If the accessory pathway conducts rapidly during atrial fibrillation (AFib), sudden death may result. The purpose of this ... ...

Abstract	Objective: Ventricular preexcitation is a conduction abnormality caused by an accessory pathway bridging the atria and ventricles. If the accessory pathway conducts rapidly during atrial fibrillation (AFib), sudden death may result. The purpose of this study was to determine the ability of transesophageal electrophysiology studies (TEEPS) to induce AFib in pediatric patients with asymptomatic ventricular preexcitation (aVPE). Design: A retrospective review of patients with aVPE who had a TEEPS was conducted. Inclusion criteria were evidence of ventricular preexcitation on electrocardiogram; age <18 years; and no history of tachycardia, palpitations, or syncope. Data gathered included age, weight, height, form of sedation, and TEEPS results. If AFib was induced, patients were classified as at risk of sudden death if the shortest preexcited RR interval during AFib was <250 ms or no risk if ≥ 250 ms. Results: A total of 26 patients met the inclusion criteria, with average age of 11.9 years, weight of 48.9 kg, and height of 149.2 cm. During the procedure, nine patients underwent conscious sedation (34.6%), and 17 underwent general anesthesia (65.4%). AFib was induced in 23 patients (88.5%), of whom 17 (73.9%) had no risk and six (26.1%) had risk. No statistical differences were noted in age, weight, height, or form of sedation when comparisons were made between AFib induction and no AFib induction. Conclusions: TEEPS induced AFib in 88.5% of patients. Age, weight, height, and form of sedation had no effect upon AFib inducibility. TEEPS is an effective modality to induce AFib in pediatric patients with aVPE.
MeSH term(s)	Adolescent ; Atrial Fibrillation/complications ; Atrial Fibrillation/physiopathology ; Child ; Child, Preschool ; Death, Sudden, Cardiac/prevention & control ; Electrophysiologic Techniques, Cardiac/methods ; Female ; Humans ; Male ; Pre-Excitation Syndromes/complications ; Pre-Excitation Syndromes/physiopathology ; Retrospective Studies ; Risk Assessment
Language	English
Publishing date	2013-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2274321-2
ISSN	1747-0803 ; 1747-079X
ISSN (online)	1747-0803
ISSN	1747-079X
DOI	10.1111/j.1747-0803.2012.00689.x
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Article ; Online: An unusual cardiac defect in a patient with clinical features overlapping between cardiofaciocutaneous and Noonan syndromes.

DeSena, Holly C / Niyazov, Dmitriy M / Parrino, P Eugene / Lucas, Victor W / Shah, Sangeeta B / Moodie, Douglas S

Congenital heart disease

2010 Volume 5, Issue 1, Page(s) 70–75

Abstract: It is important to recognize the possibility of a syndromic etiology of cardiac defects when dysmorphic features and other congenital defects are present. We report a patient who presented with atrial fibrillation and was found to have an abnormal mitral ...

Abstract	It is important to recognize the possibility of a syndromic etiology of cardiac defects when dysmorphic features and other congenital defects are present. We report a patient who presented with atrial fibrillation and was found to have an abnormal mitral valve, congenital aneurysm of the left atrial appendage, and features consistent with both Cardiofaciocutaneous syndrome and Noonan syndrome. The congenital aneurysm of the left atrial appendage was a previously unreported cardiac presentation for either syndrome. Diagnostic considerations based upon his genotype and phenotype are discussed, along with his unique cardiac presentation and treatment.
MeSH term(s)	Abnormalities, Multiple/diagnosis ; Abnormalities, Multiple/genetics ; Abnormalities, Multiple/surgery ; Atrial Appendage/abnormalities ; Atrial Appendage/surgery ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/genetics ; Atrial Fibrillation/surgery ; Cardiac Surgical Procedures ; DNA Mutational Analysis ; Electrocardiography ; Genotype ; Heart Aneurysm/congenital ; Heart Aneurysm/diagnosis ; Heart Aneurysm/genetics ; Heart Aneurysm/surgery ; Heart Defects, Congenital/complications ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/genetics ; Heart Defects, Congenital/surgery ; Heart Valve Prosthesis Implantation ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Mitral Valve/abnormalities ; Mitral Valve/surgery ; Noonan Syndrome/complications ; Noonan Syndrome/diagnosis ; Noonan Syndrome/genetics ; Noonan Syndrome/surgery ; Phenotype ; Treatment Outcome
Language	English
Publishing date	2010-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2274321-2
ISSN	1747-0803 ; 1747-079X
ISSN (online)	1747-0803
ISSN	1747-079X
DOI	10.1111/j.1747-0803.2009.00329.x
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