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  1. Article ; Online: Comparison of outcomes between aortic root replacement and supra-coronary interposition graft for type A aortic dissection: A retrospective case series.

    Hartley, Philip / Salmasi, M Yousuf / Morosin, Marco / Mensah, Kwabena / Asimakopoulos, George

    Journal of cardiac surgery

    2022  

    Abstract: Background: The decision to conserve or replace the native aortic valve following acute type-A aortic dissection (ATAAD) is an area of cardiac surgery without standardized practice. This single-center retrospective study analysed the long-term ... ...

    Abstract Background: The decision to conserve or replace the native aortic valve following acute type-A aortic dissection (ATAAD) is an area of cardiac surgery without standardized practice. This single-center retrospective study analysed the long-term performance of the native aortic valve and root following surgery for ATAAD.
    Methods: Between 2009 and 2018 all cases ATAAD treated at Royal Brompton and Harefield NHS Foundation Trust were analysed. Patients were divided into two groups: (a) ascending aorta (interposition) graft (AAG) without valve replacement and (b) nonvalve-sparing aortic root replacement (ARR). Preoperative covariates were compared, as well as operative characteristics and postoperative complications. Long-term survival and echocardiographic outcomes were analysed using regression analysis.
    Results: In total, 116 patients were included: 63 patients in the AAG group and 53 patients in the ARR group. In patients where the native aortic valve was conserved, nine developed severe aortic regurgitation and two patients developed dilation of the aortic root requiring subsequent replacement during the follow-up period. Aortic regurgitation at presentation was not found to be associated with subsequent risk of developing severe aortic regurgitation or reintervention on the aortic valve. Overall mortality was observed to be significantly lower in patients undergoing AAG (17.5% vs. 41.5%, p = .004).
    Conclusions: With careful patient selection, the native aortic root shows good long-term durability both in terms of valve competence and stable root dimensions after surgery for ATAAD. This study supports the consideration of conservation of the aortic valve during emergency surgery for type-A dissection, in the absence of a definitive indication for root replacement, including in cases where aortic regurgitation complicates the presentation.
    Language English
    Publishing date 2022-10-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.16985
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Advanced Respiratory Failure Requiring Tracheostomy-A Marker of Unfavourable Prognosis after Heart Transplantation.

    Załęska-Kocięcka, Marta / Morosin, Marco / Dutton, Jonathan / Garda, Rita Fernandez / Piotrowska, Katarzyna / Lees, Nicholas / Aw, Tuan-Chen / Saez, Diana Garcia / Doce, Ana Hurtado

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 8

    Abstract: Advanced respiratory failure with tracheostomy requirement is common in heart recipients. The aim of the study is to assess the tracheostomy rate after orthotopic heart transplantation and identify the subgroups of patients with the highest need for ... ...

    Abstract Advanced respiratory failure with tracheostomy requirement is common in heart recipients. The aim of the study is to assess the tracheostomy rate after orthotopic heart transplantation and identify the subgroups of patients with the highest need for tracheostomy and these groups' association with mortality at a single centre through a retrospective analysis of 140 consecutive patients transplanted between December 2012 and July 2018. As many as 28.6% heart recipients suffered from advanced respiratory failure with a need for tracheostomy that was performed after a median time of 11.5 days post-transplant. Tracheostomy was associated with a history of stroke (OR 3.4; 95% CI) 1.32-8.86;
    Language English
    Publishing date 2024-04-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14080851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Safety of tracheostomy during extracorporeal membrane oxygenation support: A single-center experience.

    Morosin, Marco / Azzu, Alessia / Antonopoulos, Alexios / Kuhn, Timothy / Anandanadesan, Rathai / Garfield, Benjamin / Aw, Tuan-Chen / Ledot, Stephane / Bianchi, Paolo

    Artificial organs

    2023  Volume 47, Issue 11, Page(s) 1762–1772

    Abstract: Background: Some patients on extracorporeal membrane oxygenation (ECMO) require prolonged mechanical ventilation. An early tracheostomy strategy while on ECMO has appeared to be beneficial for these patients. This study aims to explore the safety of ... ...

    Abstract Background: Some patients on extracorporeal membrane oxygenation (ECMO) require prolonged mechanical ventilation. An early tracheostomy strategy while on ECMO has appeared to be beneficial for these patients. This study aims to explore the safety of tracheostomy in ECMO patients.
    Methods: This is a retrospective observational single-center study.
    Results: Hundred and nine patients underwent tracheostomy (76 percutaneous and 33 surgical) during V-V ECMO support over an 8-year period. Patients with a percutaneous tracheostomy showed a significantly shorter ECMO duration [25.5 (17.3-40.1) vs 37.2 (26.5-53.2) days, p = 0.013] and a shorter ECMO-to-tracheostomy time [13.3 (8.5-19.7) vs 27.8 (16.3-36.9) days, p < 0.001] compared to those who underwent a surgical approach. There was no difference between the two strategies regarding both major and minor/no bleeding (p = 0.756). There was no difference in survival rate between patients who underwent percutaneous or surgical tracheostomy (p = 0.173). Patients who underwent an early tracheostomy (within 10 days from ECMO insertion) showed a significantly shorter hospital stay (p < 0.001) and a shorter duration of V-V ECMO support (p < 0.001). Our series includes 24 patients affected by COVID-19, who did not show significantly higher rates of major bleeding when compared to non-COVID-19 patients (p = 0.297). Within the COVID-19 subgroup, there was no difference in major bleeding rates between surgical and percutaneous approach (p = 1.0).
    Conclusions: Percutaneous and surgical tracheostomy during ECMO have a similar safety profile in terms of bleeding risk and mortality. Percutaneous tracheostomy may favor a shorter duration of ECMO support and hospital stay and can be considered a safe alternative to surgical tracheostomy, even in COVID-19 patients, if relevant clinical expertise is available.
    MeSH term(s) Humans ; Tracheostomy/adverse effects ; Extracorporeal Membrane Oxygenation/adverse effects ; COVID-19/therapy ; Hemorrhage ; Retrospective Studies
    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 441812-8
    ISSN 1525-1594 ; 0160-564X
    ISSN (online) 1525-1594
    ISSN 0160-564X
    DOI 10.1111/aor.14633
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  4. Article ; Online: Extensive cardiac infiltrative melanoma.

    Morosin, Marco / Azzu, Alessia / Capoccia, Massimo / Rosendahl, Ulrich

    Journal of cardiac surgery

    2019  Volume 34, Issue 9, Page(s) 858–859

    Abstract: We report an unusual clinical case of a 66-year-old patient with cardiac involvement from a metastatic melanoma, causing the formation of a large right atrial mass with extensive infiltration of the right atrial free wall, the interatrial septum, the ... ...

    Abstract We report an unusual clinical case of a 66-year-old patient with cardiac involvement from a metastatic melanoma, causing the formation of a large right atrial mass with extensive infiltration of the right atrial free wall, the interatrial septum, the coronary sinus, and up to the mitral annulus and posterior wall of the right ventricle, unamendable to complete surgical excision. As secondary cardiac tumors are not part of routine daily clinical practice, we thought that this clinical case would be a good educational opportunity for the practicing clinicians, both specialists and nonspecialists.
    MeSH term(s) Aged ; Cardiac Surgical Procedures/methods ; Echocardiography, Transesophageal ; Heart Atria ; Heart Neoplasms/diagnosis ; Heart Neoplasms/surgery ; Humans ; Magnetic Resonance Imaging, Cine ; Melanoma/diagnosis ; Melanoma/secondary ; Melanoma/surgery ; Neoplasm Metastasis
    Language English
    Publishing date 2019-08-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.14184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Supravalvular mitral remnant: The other side of the… valve.

    Dell'Angela, Luca / Gatti, Giuseppe / Morosin, Marco / Lardieri, Gerardina

    Journal of cardiac surgery

    2020  Volume 35, Issue 10, Page(s) 2806–2807

    Abstract: We report a challenging clinical case of an atypical supravalvular mitral remnant in recent mitral and aortic valve replacement with mechanical valve prostheses, associated with postoperative recurrent inflammatory episodes overlapped with difficult ... ...

    Abstract We report a challenging clinical case of an atypical supravalvular mitral remnant in recent mitral and aortic valve replacement with mechanical valve prostheses, associated with postoperative recurrent inflammatory episodes overlapped with difficult anticoagulation. Negative myocardial scintigraphy was associated with persistence of negative blood cultures. Serial echocardiographic evaluation was performed before and after antimicrobial treatment, and at 3 months follow-up a transesophageal echocardiography showed the persistence of the mass. Diagnostic suspect was finally confirmed.
    MeSH term(s) Adult ; Aortic Valve Stenosis/surgery ; Bicuspid Aortic Valve Disease/surgery ; Diagnosis, Differential ; Echocardiography, Transesophageal ; Endocarditis/diagnostic imaging ; Follow-Up Studies ; Heart Valve Prosthesis ; Humans ; Male ; Mitral Valve/surgery ; Mitral Valve Insufficiency/surgery ; Postoperative Complications/diagnostic imaging ; Recurrence ; Severity of Illness Index ; Time Factors
    Language English
    Publishing date 2020-07-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.14899
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cardiac Decompression by Pericardiectomy for Constrictive Pericarditis: Multimodality Imaging to Identify Patients at Risk for Prolonged Inotropic Support.

    Azzu, Alessia / Morosin, Marco / Antonopoulos, Alexios S / Capoccia, Massimo / Rosendahl, Ulrich / Mohiaddin, Raad

    Journal of cardiovascular imaging

    2021  Volume 29, Issue 4, Page(s) 361–372

    Abstract: Background: Post-pericardiectomy right ventricular (RV) failure has been reported but it remains not well-studied. To investigate imaging parameters that could predict RV function and the outcome of patients post-pericardiectomy.: Methods: We ... ...

    Abstract Background: Post-pericardiectomy right ventricular (RV) failure has been reported but it remains not well-studied. To investigate imaging parameters that could predict RV function and the outcome of patients post-pericardiectomy.
    Methods: We analysed data from a total of 53 CP patients undergoing pericardiectomy. Preoperative, early and at 6 months postoperative echocardiographic (echo) imaging datasets were analysed and correlated with preoperative cardiac magnetic resonance (CMR), cardiac computed tomography scans and histology. The primary endpoint of the study was RV functional status early postoperatively and at 6 months. Secondary endpoint was the need for prolonged inotropic support.
    Results: A cause of CP was identified in 26 patients (49%). Inotropic support ≥ 48 hours was required in n = 28 (53%) of patients and was correlated with lower preoperative RV areas by echo or RV volumes by CMR (p < 0.05 for all). A pericardial score based on pericardial thickness/calcification and epicardial fat thickness had good diagnostic accuracy to identify patients requiring prolonged use of inotropes (area under the curve, 0.825; 95% confidence interval, 0.674-0.976). Pericardiectomy resulted in RV decompression and impaired RV function early postoperatively (fractional area change: 40.5% ± 8.8% preoperatively vs. 31.4% ± 10.4% early postoperatively vs. 42.5% ± 10.2% at 6 months, p < 0.001).
    Conclusions: We show that a smaller RV cavity size and a pericardial scoring system are associated with prolonged inotropic support in CP patients undergoing pericardiectomy. RV systolic impairment post decompression is present in most patients, but it is only transient.
    Language English
    Publishing date 2021-05-06
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3020035-0
    ISSN 2586-7296 ; 2586-7210
    ISSN (online) 2586-7296
    ISSN 2586-7210
    DOI 10.4250/jcvi.2020.0223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Apical Ballooning Following Mitral Valve Reoperation.

    Dell'Angela, Luca / Gatti, Giuseppe / Morosin, Marco / Lardieri, Gerardina

    Journal of cardiothoracic and vascular anesthesia

    2019  Volume 34, Issue 1, Page(s) 303–305

    MeSH term(s) Heart Valve Prosthesis ; Humans ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/etiology ; Mitral Valve Insufficiency/surgery ; Reoperation ; Rheumatic Heart Disease/surgery
    Language English
    Publishing date 2019-06-20
    Publishing country United States
    Document type Letter
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2019.06.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Propofol Infusion Syndrome: An Early and Unusual Electrocardiographic Pattern.

    Dell'Angela, Luca / Gatti, Giuseppe / Morosin, Marco / Lardieri, Gerardina

    Journal of cardiothoracic and vascular anesthesia

    2019  Volume 34, Issue 7, Page(s) 2004–2006

    MeSH term(s) Anesthetics, Intravenous/adverse effects ; Electrocardiography ; Humans ; Infusions, Intravenous ; Propofol/adverse effects ; Propofol Infusion Syndrome
    Chemical Substances Anesthetics, Intravenous ; Propofol (YI7VU623SF)
    Language English
    Publishing date 2019-10-24
    Publishing country United States
    Document type Letter
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2019.10.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Reply to: RV dysfunction in Covid-19 ARDS: Is there a difference in the impact of mechanical ventilation and ECMO?

    Bleakley, Caroline / Singh, Suveer / de Marvao, Antonio / Morosin, Marco / Androulakis, Emmanouil / Cannata, Antonio / Price, Susanna

    International journal of cardiology

    2021  Volume 332, Page(s) 239

    MeSH term(s) COVID-19 ; Critical Illness ; Extracorporeal Membrane Oxygenation ; Humans ; Respiration, Artificial ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/therapy ; SARS-CoV-2 ; Ventricular Dysfunction, Right
    Language English
    Publishing date 2021-02-22
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2021.02.053
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  10. Article: An unusual etiology of torsade de pointes-induced syncope.

    Morosin, Marco / Dametto, Ermanno / Bianco, Federica Del / Brieda, Marco / Nicolosi, Gian L

    Archives of medical science : AMS

    2017  Volume 13, Issue 3, Page(s) 686–688

    Language English
    Publishing date 2017-04-20
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2203781-0
    ISSN 1734-1922
    ISSN 1734-1922
    DOI 10.5114/aoms.2017.67287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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