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  1. Article ; Online: An unusual variant of atrophic dermatofibrosarcoma protuberans.

    Aragão, Simone Silva da Costa / Leite, Everson José Dos Santos / Cardoso, Alberto Eduardo Cox / Houly, Ricardo Luiz Simões

    Anais brasileiros de dermatologia

    2018  Volume 93, Issue 2, Page(s) 282–284

    Abstract: Dermatofibrosarcoma protuberans is an uncommon neoplasm that is most often seen in young adults. The most common clinical presentation is the protruding form; however, other subtypes are known, such as the atrophic. In 2012 there were only 33 reports of ... ...

    Abstract Dermatofibrosarcoma protuberans is an uncommon neoplasm that is most often seen in young adults. The most common clinical presentation is the protruding form; however, other subtypes are known, such as the atrophic. In 2012 there were only 33 reports of this variant in the literature. Many cases of Dermatofibrosarcoma protuberans in children are only discovered in adulthood because they were not diagnosed early. Due the high morbidity, we raise the need for attention from the dermatologist to recognize uncommon neoplasms in the clinical practice. We report a case of a 15-year-old patient diagnosed with atrophic Dermatofibrosarcoma protuberans on the back.
    MeSH term(s) Adolescent ; Biopsy ; Dermatofibrosarcoma/pathology ; Dermatofibrosarcoma/surgery ; Humans ; Immunohistochemistry ; Male ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery ; Treatment Outcome
    Language English
    Publishing date 2018-05-09
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 433655-0
    ISSN 1806-4841 ; 0365-0596
    ISSN (online) 1806-4841
    ISSN 0365-0596
    DOI 10.1590/abd1806-4841.20187049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Basin-wide variation in tree hydraulic safety margins predicts the carbon balance of Amazon forests.

    Tavares, Julia Valentim / Oliveira, Rafael S / Mencuccini, Maurizio / Signori-Müller, Caroline / Pereira, Luciano / Diniz, Francisco Carvalho / Gilpin, Martin / Marca Zevallos, Manuel J / Salas Yupayccana, Carlos A / Acosta, Martin / Pérez Mullisaca, Flor M / Barros, Fernanda de V / Bittencourt, Paulo / Jancoski, Halina / Scalon, Marina Corrêa / Marimon, Beatriz S / Oliveras Menor, Imma / Marimon, Ben Hur / Fancourt, Max /
    Chambers-Ostler, Alexander / Esquivel-Muelbert, Adriane / Rowland, Lucy / Meir, Patrick / Lola da Costa, Antonio Carlos / Nina, Alex / Sanchez, Jesus M B / Tintaya, Jose S / Chino, Rudi S C / Baca, Jean / Fernandes, Leticia / Cumapa, Edwin R M / Santos, João Antônio R / Teixeira, Renata / Tello, Ligia / Ugarteche, Maira T M / Cuellar, Gina A / Martinez, Franklin / Araujo-Murakami, Alejandro / Almeida, Everton / da Cruz, Wesley Jonatar Alves / Del Aguila Pasquel, Jhon / Aragāo, Luís / Baker, Timothy R / de Camargo, Plinio Barbosa / Brienen, Roel / Castro, Wendeson / Ribeiro, Sabina Cerruto / Coelho de Souza, Fernanda / Cosio, Eric G / Davila Cardozo, Nallaret / da Costa Silva, Richarlly / Disney, Mathias / Espejo, Javier Silva / Feldpausch, Ted R / Ferreira, Leandro / Giacomin, Leandro / Higuchi, Niro / Hirota, Marina / Honorio, Euridice / Huaraca Huasco, Walter / Lewis, Simon / Flores Llampazo, Gerardo / Malhi, Yadvinder / Monteagudo Mendoza, Abel / Morandi, Paulo / Chama Moscoso, Victor / Muscarella, Robert / Penha, Deliane / Rocha, Mayda Cecília / Rodrigues, Gleicy / Ruschel, Ademir R / Salinas, Norma / Schlickmann, Monique / Silveira, Marcos / Talbot, Joey / Vásquez, Rodolfo / Vedovato, Laura / Vieira, Simone Aparecida / Phillips, Oliver L / Gloor, Emanuel / Galbraith, David R

    Nature

    2023  Volume 617, Issue 7959, Page(s) 111–117

    Abstract: Tropical forests face increasing climate ... ...

    Abstract Tropical forests face increasing climate risk
    MeSH term(s) Biomass ; Carbon/metabolism ; Droughts ; Forests ; Trees/growth & development ; Trees/metabolism ; Tropical Climate ; Xylem/metabolism ; Rain ; Climate Change ; Carbon Sequestration ; Stress, Physiological ; Dehydration
    Chemical Substances Carbon (7440-44-0)
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-05971-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sensitivity of South American tropical forests to an extreme climate anomaly

    Bennett, Amy / Rodrigues de sousa, Thaiane / Monteagudo-Mendoza, Abel / Esquivel-Muelbert, Adriane / Morandi, Paulo / Coelho de souza, Fernanda / Castro, Wendeson / Duque, Luisa / Flores llampazo, Gerardo / Manoel dos santos, Rubens / Ramos, Eliana / Vilanova torre, Emilio / Alvarez-Davila, Esteban / Baker, Timothy / Costa, Flávia / Lewis, Simon / Marimon, Beatriz / Schietti, Juliana / Burban, Benoît /
    Berenguer, Erika / Araujo-Murakami, Alejandro / Restrepo correa, Zorayda / Lopez, Wilmar / Delgado santana, Flávia / Viscarra, Laura Jessica / Elias, Fernando / Vasquez martinez, Rodolfo / Marimon-Junior, Ben / Galbraith, David / Sullivan, Martin / Emilio, Thaise / Prestes, Nayane / Barlow, Jos / Alencar Fagundes, Nathalle / Almeida de Oliveira, Edmar / Alvarez Loayza, Patricia / Alves, Luciana / Aparecida Vieira, Simone / Andrade Maia, Vinícius / Aragão, Luiz / Arets, Eric / Arroyo, Luzmila / Bánki, Olaf / Baraloto, Christopher / Barbosa Camargo, Plínio / Barroso, Jorcely / Bento da Silva, Wilder / Bonal, Damien / Maës dos santos, Flavio / Brienen, Roel / Brown, Foster / Castilho, Carolina / Cerruto ribeiro, Sabina / Chama moscoso, Victor / Chavez, Ezequiel / Comiskey, James / Cornejo valverde, Fernando / Dávila cardozo, Nállarett / De aguiar-Campos, Natália / De oliveira melo, Lia / Del aguila pasquel, Jhon / Derroire, Géraldine / Disney, Mathias / Do Socorro, Maria / Dourdain, Aurélie / Feldpausch, Ted / Ferreira, Joice / Forni martins, Valeria / Gardner, Toby / Gloor, Emanuel / Gutierrez sibauty, Gloria / Guillen, René / Hase, Eduardo / Hérault, Bruno / Honorio coronado, Eurídice / Huaraca huasco, Walter / Janovec, John / Jimenez-Rojas, Eliana / Joly, Carlos / Kalamandeen, Michelle / Killeen, Timothy / Lais farrapo, Camila / Levesley, Aurora / Lizon romano, Leon / Lopez gonzalez, Gabriela / Magnusson, William / Malhi, Yadvinder / Matias de almeida reis, Simone / Melgaço, Karina / Melo cruz, Omar / Mendoza polo, Irina / Montañez, Tatiana / Morel, Jean / Núñez vargas, Percy / Oliveira de araújo, Raimunda / Pallqui camacho, Nadir / Parada gutierrez, Alexander / Pennington, Toby / Pickavance, Georgia / Pipoly, John / Pitman, Nigel / Quesada, Carlos / Ramirez arevalo, Freddy / Ramírez‐angulo, Hirma / Flora ramos, Rafael / Rodrigo de souza, Cléber / Roopsind, Anand / Schwartz, Gustavo / Silva, Richarlly / Silva espejo, Javier / Silveira, Marcos / Singh, James / Soto shareva, Yhan / Steininger, Marc / Stropp, Juliana / Talbot, Joey / Ter steege, Hans / Terborgh, John / Thomas, Raquel / Valenzuela gamarra, Luis / Van der heijden, Geertje / Van der hout, Peter / Zagt, Roderick / Phillips, Oliver

    Nature Climate Change

    2023  Volume 13, Issue 9

    Abstract: The tropical forest carbon sink is known to be drought sensitive, but it is unclear which forests are the most vulnerable to extreme events. Forests with hotter and drier baseline conditions may be protected by prior adaptation, or more vulnerable ... ...

    Abstract The tropical forest carbon sink is known to be drought sensitive, but it is unclear which forests are the most vulnerable to extreme events. Forests with hotter and drier baseline conditions may be protected by prior adaptation, or more vulnerable because they operate closer to physiological limits. Here we report that forests in drier South American climates experienced the greatest impacts of the 2015–2016 El Niño, indicating greater vulnerability to extreme temperatures and drought. The long-term, ground-measured tree-by-tree responses of 123 forest plots across tropical South America show that the biomass carbon sink ceased during the event with carbon balance becoming indistinguishable from zero (−0.02 ± 0.37 Mg C ha−1 per year). However, intact tropical South American forests overall were no more sensitive to the extreme 2015–2016 El Niño than to previous less intense events, remaining a key defence against climate change as long as they are protected.
    Keywords Life Science
    Subject code 333
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 2614383-5
    ISSN 1758-6798 ; 1758-678X
    ISSN (online) 1758-6798
    ISSN 1758-678X
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book ; Online: Data package for ‘Sensitivity of South American tropical forests to an extreme climate anomaly’.

    Bennett, Amy / Rodrigues de sousa, Thaiane / Monteagudo-Mendoza, Abel / Esquivel-Muelbert, Adriane / Morandi, Paulo / Coelho de souza, Fernanda / Castro, Wendeson / Duque, Luisa / Flores llampazo, Gerardo / Manoel dos santos, Rubens / Ramos, Eliana / Vilanova torre, Emilio / Alvarez-Davila, Esteban / Baker, Timothy / Costa, Flávia / Lewis, Simon / Marimon, Beatriz / Schietti, Juliana / Burban, Benoît /
    Berenguer, Erika / Araujo-Murakami, Alejandro / Restrepo correa, Zorayda / Lopez, Wilmar / Delgado santana, Flávia / Viscarra, Laura Jessica / Elias, Fernando / Vasquez martinez, Rodolfo / Marimon-Junior, Ben / Galbraith, David / Sullivan, Martin / Emilio, Thaise / Prestes, Nayane / Barlow, Jos / Alencar Fagundes, Nathalle / Almeida de Oliveira, Edmar / Alvarez Loayza, Patricia / Alves, Luciana / Aparecida Vieira, Simone / Andrade Maia, Vinícius / Aragão, Luiz / Arets, Eric / Arroyo, Luzmila / Bánki, Olaf / Baraloto, Christopher / Barbosa Camargo, Plínio / Barroso, Jorcely / Bento da Silva, Wilder / Bonal, Damien / Maës dos santos, Flavio / Brienen, Roel / Brown, Foster / Castilho, Carolina / Cerruto ribeiro, Sabina / Chama moscoso, Victor / Chavez, Ezequiel / Comiskey, James / Cornejo valverde, Fernando / Dávila cardozo, Nállarett / De aguiar-Campos, Natália / De oliveira melo, Lia / Del aguila pasquel, Jhon / Derroire, Géraldine / Disney, Mathias / Do Socorro, Maria / Dourdain, Aurélie / Feldpausch, Ted / Ferreira, Joice / Forni martins, Valeria / Gardner, Toby / Gloor, Emanuel / Gutierrez sibauty, Gloria / Guillen, René / Hase, Eduardo / Hérault, Bruno / Honorio coronado, Eurídice / Huaraca huasco, Walter / Janovec, John / Jimenez-Rojas, Eliana / Joly, Carlos / Kalamandeen, Michelle / Killeen, Timothy / Lais farrapo, Camila / Levesley, Aurora / Lizon romano, Leon / Lopez gonzalez, Gabriela / Magnusson, William / Malhi, Yadvinder / Matias de almeida reis, Simone / Melgaço, Karina / Melo cruz, Omar / Mendoza polo, Irina / Montañez, Tatiana / Morel, Jean / Núñez vargas, Percy / Oliveira de araújo, Raimunda / Pallqui camacho, Nadir / Parada gutierrez, Alexander / Pennington, Toby / Pickavance, Georgia / Pipoly, John / Pitman, Nigel / Quesada, Carlos / Ramirez arevalo, Freddy / Ramírez‐angulo, Hirma / Flora ramos, Rafael / Rodrigo de souza, Cléber / Roopsind, Anand / Schwartz, Gustavo / Silva, Richarlly / Silva espejo, Javier / Silveira, Marcos / Singh, James / Soto shareva, Yhan / Steininger, Marc / Stropp, Juliana / Talbot, Joey / Ter steege, Hans / Terborgh, John / Thomas, Raquel / Valenzuela gamarra, Luis / Van der heijden, Geertje / Van der hout, Peter / Zagt, Roderick / Phillips, Oliver

    2023  

    Abstract: The tropical forest carbon sink is known to be drought sensitive, but it is unclear which forests are the most vulnerable to extreme events. Forests with hotter and drier baseline conditions may be protected by prior adaptation, or more vulnerable ... ...

    Abstract The tropical forest carbon sink is known to be drought sensitive, but it is unclear which forests are the most vulnerable to extreme events. Forests with hotter and drier baseline conditions may be protected by prior adaptation, or more vulnerable because they operate closer to physiological limits. Here we report that forests in drier South American climates experienced the greatest impacts of the 2015–2016 El Niño, indicating greater vulnerability to extreme temperatures and drought. The long-term, ground-measured tree-by-tree responses of 123 forest plots across tropical South America show that the biomass carbon sink ceased during the event with carbon balance becoming indistinguishable from zero (−0.02±0.37 Mg C ha−1 per year). However, intact tropical South American forests overall were no more sensitive to the extreme 2015–2016 El Niño than to previous less intense events, remaining a key defence against climate change as long as they are protected.
    Keywords Life Science
    Subject code 333
    Publisher University of Leeds
    Publishing country nl
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Author Correction: Tree mode of death and mortality risk factors across Amazon forests.

    Esquivel-Muelbert, Adriane / Phillips, Oliver L / Brienen, Roel J W / Fauset, Sophie / Sullivan, Martin J P / Baker, Timothy R / Chao, Kuo-Jung / Feldpausch, Ted R / Gloor, Emanuel / Higuchi, Niro / Houwing-Duistermaat, Jeanne / Lloyd, Jon / Liu, Haiyan / Malhi, Yadvinder / Marimon, Beatriz / Marimon Junior, Ben Hur / Monteagudo-Mendoza, Abel / Poorter, Lourens / Silveira, Marcos /
    Torre, Emilio Vilanova / Dávila, Esteban Alvarez / Del Aguila Pasquel, Jhon / Almeida, Everton / Loayza, Patricia Alvarez / Andrade, Ana / Aragão, Luiz E O C / Araujo-Murakami, Alejandro / Arets, Eric / Arroyo, Luzmila / Aymard C, Gerardo A / Baisie, Michel / Baraloto, Christopher / Camargo, Plínio Barbosa / Barroso, Jorcely / Blanc, Lilian / Bonal, Damien / Bongers, Frans / Boot, René / Brown, Foster / Burban, Benoit / Camargo, José Luís / Castro, Wendeson / Moscoso, Victor Chama / Chave, Jerome / Comiskey, James / Valverde, Fernando Cornejo / da Costa, Antonio Lola / Cardozo, Nallaret Davila / Di Fiore, Anthony / Dourdain, Aurélie / Erwin, Terry / Llampazo, Gerardo Flores / Vieira, Ima Célia Guimarães / Herrera, Rafael / Honorio Coronado, Eurídice / Huamantupa-Chuquimaco, Isau / Jimenez-Rojas, Eliana / Killeen, Timothy / Laurance, Susan / Laurance, William / Levesley, Aurora / Lewis, Simon L / Ladvocat, Karina Liana Lisboa Melgaço / Lopez-Gonzalez, Gabriela / Lovejoy, Thomas / Meir, Patrick / Mendoza, Casimiro / Morandi, Paulo / Neill, David / Nogueira Lima, Adriano José / Vargas, Percy Nuñez / de Oliveira, Edmar Almeida / Camacho, Nadir Pallqui / Pardo, Guido / Peacock, Julie / Peña-Claros, Marielos / Peñuela-Mora, Maria Cristina / Pickavance, Georgia / Pipoly, John / Pitman, Nigel / Prieto, Adriana / Pugh, Thomas A M / Quesada, Carlos / Ramirez-Angulo, Hirma / de Almeida Reis, Simone Matias / Rejou-Machain, Maxime / Correa, Zorayda Restrepo / Bayona, Lily Rodriguez / Rudas, Agustín / Salomão, Rafael / Serrano, Julio / Espejo, Javier Silva / Silva, Natalino / Singh, James / Stahl, Clement / Stropp, Juliana / Swamy, Varun / Talbot, Joey / Ter Steege, Hans / Terborgh, John / Thomas, Raquel / Toledo, Marisol / Torres-Lezama, Armando / Gamarra, Luis Valenzuela / van der Heijden, Geertje / van der Meer, Peter / van der Hout, Peter / Martinez, Rodolfo Vasquez / Vieira, Simone Aparecida / Cayo, Jeanneth Villalobos / Vos, Vincent / Zagt, Roderick / Zuidema, Pieter / Galbraith, David

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 209

    Language English
    Publishing date 2021-01-04
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-020-20537-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Water table depth modulates productivity and biomass across Amazonian forests

    Sousa, Thaiane R. / Schietti, Juliana / Ribeiro, Igor O. / Emílio, Thaise / Fernández, Rafael Herrera / ter Steege, Hans / Castilho, Carolina V. / Esquivel-Muelbert, Adriane / Baker, Timothy / Pontes-Lopes, Aline / Silva, Camila V.J. / Silveira, Juliana M. / Derroire, Géraldine / Castro, Wendeson / Mendoza, Abel Monteagudo / Ruschel, Ademir / Prieto, Adriana / Lima, Adriano José Nogueira / Rudas, Agustín /
    Araujo-Murakami, Alejandro / Gutierrez, Alexander Parada / Andrade, Ana / Roopsind, Anand / Manzatto, Angelo Gilberto / Di Fiore, Anthony / Torres-Lezama, Armando / Dourdain, Aurélie / Marimon, Beatriz / Marimon, Ben Hur / Burban, Benoit / van Ulft, Bert / Herault, Bruno / Quesada, Carlos / Mendoza, Casimiro / Stahl, Clement / Bonal, Damien / Galbraith, David / Neill, David / de Oliveira, Edmar A. / Hase, Eduardo / Jimenez-Rojas, Eliana / Vilanova, Emilio / Arets, Eric / Berenguer, Erika / Alvarez-Davila, Esteban / Honorio Coronado, Eurídice N. / Almeida, Everton / Coelho, Fernanda / Valverde, Fernando Cornejo / Elias, Fernando / Brown, Foster / Bongers, Frans / Arevalo, Freddy Ramirez / Lopez-Gonzalez, Gabriela / van der Heijden, Geertje / Aymard C., Gerardo A. / Llampazo, Gerardo Flores / Pardo, Guido / Ramírez-Angulo, Hirma / do Amaral, Iêda Leão / Vieira, Ima Célia Guimarães / Huamantupa-Chuquimaco, Isau / Comiskey, James A. / Singh, James / Espejo, Javier Silva / del Aguila-Pasquel, Jhon / Zwerts, Joeri Alexander / Talbot, Joey / Terborgh, John / Ferreira, Joice / Barroso, Jorcely G. / Barlow, Jos / Camargo, José Luís / Stropp, Juliana / Peacock, Julie / Serrano, Julio / Melgaço, Karina / Ferreira, Leandro V. / Blanc, Lilian / Poorter, Lourens / Gamarra, Luis Valenzuela / Aragão, Luiz / Arroyo, Luzmila / Silveira, Marcos / Peñuela-Mora, Maria Cristina / Vargas, Mario Percy Núñez / Toledo, Marisol / Disney, Mat / Réjou-Méchain, Maxime / Baisie, Michel / Kalamandeen, Michelle / Camacho, Nadir Pallqui / Cardozo, Nállarett Dávila / Silva, Natalino / Pitman, Nigel / Higuchi, Niro / Banki, Olaf / Loayza, Patricia Alvarez / Graça, Paulo M.L.A. / Morandi, Paulo S. / van der Meer, Peter J. / van der Hout, Peter / Naisso, Pétrus / Camargo, Plínio Barbosa / Salomão, Rafael / Thomas, Raquel / Boot, Rene / Umetsu, Ricardo Keichi / da Costa Silva, Richarlly / Burnham, Robyn / Zagt, Roderick / Martinez, Rodolfo Vasquez / Brienen, Roel / Ribeiro, Sabina Cerruto / Lewis, Simon L. / Vieira, Simone Aparecida / de Almeida Reis, Simone Matias / Fauset, Sophie / Laurance, Susan / Feldpausch, Ted / Erwin, Terry / Killeen, Timothy / Wortel, Verginia / Moscoso, Victor Chama / Vos, Vincent / Huasco, Walter Huaraca / Laurance, William / Malhi, Yadvinder / Magnusson, William E. / Phillips, Oliver L. / Costa, Flávia R.C.

    Global Ecology and Biogeography

    2022  Volume 31, Issue 8

    Abstract: Aim: Water availability is the major driver of tropical forest structure and dynamics. Most research has focused on the impacts of climatic water availability, whereas remarkably little is known about the influence of water table depth and excess soil ... ...

    Abstract Aim: Water availability is the major driver of tropical forest structure and dynamics. Most research has focused on the impacts of climatic water availability, whereas remarkably little is known about the influence of water table depth and excess soil water on forest processes. Nevertheless, given that plants take up water from the soil, the impacts of climatic water supply on plants are likely to be modulated by soil water conditions. Location: Lowland Amazonian forests. Time period: 1971–2019. Methods: We used 344 long-term inventory plots distributed across Amazonia to analyse the effects of long-term climatic and edaphic water supply on forest functioning. We modelled forest structure and dynamics as a function of climatic, soil-water and edaphic properties. Results: Water supplied by both precipitation and groundwater affects forest structure and dynamics, but in different ways. Forests with a shallow water table (depth <5 m) had 18% less above-ground woody productivity and 23% less biomass stock than forests with a deep water table. Forests in drier climates (maximum cumulative water deficit < −160 mm) had 21% less productivity and 24% less biomass than those in wetter climates. Productivity was affected by the interaction between climatic water deficit and water table depth. On average, in drier climates the forests with a shallow water table had lower productivity than those with a deep water table, with this difference decreasing within wet climates, where lower productivity was confined to a very shallow water table. Main conclusions: We show that the two extremes of water availability (excess and deficit) both reduce productivity in Amazon upland (terra-firme) forests. Biomass and productivity across Amazonia respond not simply to regional climate, but rather to its interaction with water table conditions, exhibiting high local differentiation. Our study disentangles the relative contribution of those factors, helping to improve understanding of the functioning of tropical ecosystems and how ...
    Keywords above-ground biomass ; carbon ; forest dynamics ; groundwater ; seasonality ; tropical ecology
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 2021283-5
    ISSN 1466-8238 ; 1466-822X ; 0960-7447
    ISSN (online) 1466-8238
    ISSN 1466-822X ; 0960-7447
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice.

    Rocha, Viviane Costa Junqueira / França, Luciana Souza de Aragão / de Araújo, Cintia Figueiredo / Ng, Ayling Martins / de Andrade, Candace Machado / Andrade, André Cronemberger / Santos, Emanuelle de Souza / Borges-Silva, Mariana da Cruz / Macambira, Simone Garcia / Noronha-Dutra, Alberto Augusto / Pontes-de-Carvalho, Lain Carlos

    Cancer chemotherapy and pharmacology

    2016  Volume 77, Issue 3, Page(s) 659–662

    Abstract: Purpose: Doxorubicin (DOX) is a chemotherapeutic that is widely used for the treatment of many human tumors. However, the development of cardiotoxicity has limited its use. The aim of the present study was to evaluate the possible efficacy of mito-TEMPO ...

    Abstract Purpose: Doxorubicin (DOX) is a chemotherapeutic that is widely used for the treatment of many human tumors. However, the development of cardiotoxicity has limited its use. The aim of the present study was to evaluate the possible efficacy of mito-TEMPO (mito-T) as a protective agent against DOX-induced cardiotoxicity in mice.
    Methods: C57BL/6 mice were treated twice with mito-T at low (5 mg/kg body weight) or high (20 mg/kg body weight) dose and once with DOX (24 mg/kg body weight) or saline (0.1 mL/20 g body weight) by means of intraperitoneal injections. The levels of malondialdehyde (MLDA), a marker of lipid peroxidation, and serum levels of creatine kinase were evaluated 48 h after the injection of DOX.
    Results: DOX induced lipid peroxidation in heart mitochondria (p < 0.001), and DOX-treated mice receiving mito-T at low dose had levels of MLDA significantly lower than the mice that received only DOX (p < 0.01). Furthermore, administration of mito-T alone did not cause any significant changes from control values. Additionally, DOX-treated mice treated with mito-T at high dose showed decrease in serum levels of total CK compared to mice treated with DOX alone (p < 0.05).
    Conclusion: Our results indicate that mito-T protects mice against DOX-induced cardiotoxicity.
    MeSH term(s) Animals ; Antibiotics, Antineoplastic/administration & dosage ; Antibiotics, Antineoplastic/toxicity ; Cardiotonic Agents/administration & dosage ; Cardiotonic Agents/pharmacology ; Cardiotoxicity/etiology ; Cardiotoxicity/prevention & control ; Creatine Kinase/blood ; Dose-Response Relationship, Drug ; Doxorubicin/administration & dosage ; Doxorubicin/toxicity ; Female ; Injections, Intraperitoneal ; Lipid Peroxidation/drug effects ; Malondialdehyde/metabolism ; Mice ; Mice, Inbred C57BL ; Mitochondria, Heart/drug effects ; Mitochondria, Heart/pathology ; Organophosphorus Compounds/administration & dosage ; Organophosphorus Compounds/pharmacology ; Piperidines/administration & dosage ; Piperidines/pharmacology
    Chemical Substances Antibiotics, Antineoplastic ; Cardiotonic Agents ; MitoTEMPO ; Organophosphorus Compounds ; Piperidines ; Malondialdehyde (4Y8F71G49Q) ; Doxorubicin (80168379AG) ; Creatine Kinase (EC 2.7.3.2)
    Language English
    Publishing date 2016-03
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 6820-2
    ISSN 1432-0843 ; 0344-5704 ; 0943-9404
    ISSN (online) 1432-0843
    ISSN 0344-5704 ; 0943-9404
    DOI 10.1007/s00280-015-2949-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Water table depth modulates productivity and biomass across Amazonian forests

    Sousa, Thaiane R. / Schietti, Juliana / Ribeiro, Igor O. / Emílio, Thaise / Fernández, Rafael Herrera / ter Steege, Hans / Castilho, Carolina V. / Esquivel‐Muelbert, Adriane / Baker, Timothy / Pontes‐Lopes, Aline / Silva, Camila V. J. / Silveira, Juliana M. / Derroire, Géraldine / Castro, Wendeson / Mendoza, Abel Monteagudo / Ruschel, Ademir / Prieto, Adriana / Lima, Adriano José Nogueira / Rudas, Agustín /
    Araujo‐Murakami, Alejandro / Gutierrez, Alexander Parada / Andrade, Ana / Roopsind, Anand / Manzatto, Angelo Gilberto / Di Fiore, Anthony / Torres‐Lezama, Armando / Dourdain, Aurélie / Marimon, Beatriz / Marimon, Ben Hur / Burban, Benoit / van Ulft, Bert / Herault, Bruno / Quesada, Carlos / Mendoza, Casimiro / Stahl, Clement / Bonal, Damien / Galbraith, David / Neill, David / de Oliveira, Edmar A. / Hase, Eduardo / Jimenez‐Rojas, Eliana / Vilanova, Emilio / Arets, Eric / Berenguer, Erika / Alvarez‐Davila, Esteban / Honorio Coronado, Eurídice N. / Almeida, Everton / Coelho, Fernanda / Valverde, Fernando Cornejo / Elias, Fernando / Brown, Foster / Bongers, Frans / Arevalo, Freddy Ramirez / Lopez‐Gonzalez, Gabriela / van der Heijden, Geertje / Aymard C., Gerardo A. / Llampazo, Gerardo Flores / Pardo, Guido / Ramírez‐Angulo, Hirma / do Amaral, Iêda Leão / Vieira, Ima Célia Guimarães / Huamantupa‐Chuquimaco, Isau / Comiskey, James A. / Singh, James / Espejo, Javier Silva / del Aguila‐Pasquel, Jhon / Zwerts, Joeri Alexander / Talbot, Joey / Terborgh, John / Ferreira, Joice / Barroso, Jorcely G. / Barlow, Jos / Camargo, José Luís / Stropp, Juliana / Peacock, Julie / Serrano, Julio / Melgaço, Karina / Ferreira, Leandro V. / Blanc, Lilian / Poorter, Lourens / Gamarra, Luis Valenzuela / Aragão, Luiz / Arroyo, Luzmila / Silveira, Marcos / Peñuela‐Mora, Maria Cristina / Vargas, Mario Percy Núñez / Toledo, Marisol / Disney, Mat / Réjou‐Méchain, Maxime / Baisie, Michel / Kalamandeen, Michelle / Camacho, Nadir Pallqui / Cardozo, Nállarett Dávila / Silva, Natalino / Pitman, Nigel / Higuchi, Niro / Banki, Olaf / Loayza, Patricia Alvarez / Graça, Paulo M. L. A. / Morandi, Paulo S. / van der Meer, Peter J. / van der Hout, Peter / Naisso, Pétrus / Camargo, Plínio Barbosa / Salomão, Rafael / Thomas, Raquel / Boot, Rene / Umetsu, Ricardo Keichi / da Costa Silva, Richarlly / Burnham, Robyn / Zagt, Roderick / Martinez, Rodolfo Vasquez / Brienen, Roel / Ribeiro, Sabina Cerruto / Lewis, Simon L. / Vieira, Simone Aparecida / de Almeida Reis, Simone Matias / Fauset, Sophie / Laurance, Susan / Feldpausch, Ted / Erwin, Terry / Killeen, Timothy / Wortel, Verginia / Moscoso, Victor Chama / Vos, Vincent / Huasco, Walter Huaraca / Laurance, William / Malhi, Yadvinder / Magnusson, William E. / Phillips, Oliver L. / Costa, Flávia R. C.

    Global ecology and biogeography. 2022 Aug., v. 31, no. 8

    2022  

    Abstract: AIM: Water availability is the major driver of tropical forest structure and dynamics. Most research has focused on the impacts of climatic water availability, whereas remarkably little is known about the influence of water table depth and excess soil ... ...

    Abstract AIM: Water availability is the major driver of tropical forest structure and dynamics. Most research has focused on the impacts of climatic water availability, whereas remarkably little is known about the influence of water table depth and excess soil water on forest processes. Nevertheless, given that plants take up water from the soil, the impacts of climatic water supply on plants are likely to be modulated by soil water conditions. LOCATION: Lowland Amazonian forests. TIME PERIOD: 1971–2019. METHODS: We used 344 long‐term inventory plots distributed across Amazonia to analyse the effects of long‐term climatic and edaphic water supply on forest functioning. We modelled forest structure and dynamics as a function of climatic, soil‐water and edaphic properties. RESULTS: Water supplied by both precipitation and groundwater affects forest structure and dynamics, but in different ways. Forests with a shallow water table (depth <5 m) had 18% less above‐ground woody productivity and 23% less biomass stock than forests with a deep water table. Forests in drier climates (maximum cumulative water deficit < −160 mm) had 21% less productivity and 24% less biomass than those in wetter climates. Productivity was affected by the interaction between climatic water deficit and water table depth. On average, in drier climates the forests with a shallow water table had lower productivity than those with a deep water table, with this difference decreasing within wet climates, where lower productivity was confined to a very shallow water table. MAIN CONCLUSIONS: We show that the two extremes of water availability (excess and deficit) both reduce productivity in Amazon upland (terra‐firme) forests. Biomass and productivity across Amazonia respond not simply to regional climate, but rather to its interaction with water table conditions, exhibiting high local differentiation. Our study disentangles the relative contribution of those factors, helping to improve understanding of the functioning of tropical ecosystems and how they are likely to respond to climate change.
    Keywords biogeography ; biomass ; climate ; climate change ; groundwater ; highlands ; inventories ; soil water ; tropical forests ; water supply ; water table ; Amazonia
    Language English
    Dates of publication 2022-08
    Size p. 1571-1588.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2021283-5
    ISSN 1466-8238 ; 1466-822X ; 0960-7447
    ISSN (online) 1466-8238
    ISSN 1466-822X ; 0960-7447
    DOI 10.1111/geb.13531
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Recurrent Aggressive Angiomyxoma*

    Alencar, Suelene Suassuna Silvestre de / Corrêa, Romualdo da Silva / Menezes, Emanuela Simone Cunha de / Nascimento, Antonio Luiz do / Costa, Davi Aragão Alves da / Alencar, Marcelo José Carlos

    Journal of Coloproctology

    2013  Volume 33, Issue 04, Page(s) 228–231

    Abstract: Introduction: aggressive angiomyxoma is a highly aggressive, rare neoplasm of the mesenchymal tissue with a high recurrence rate. It represents an important differential diagnosis of pelvic tumors in women of reproductive age. This study aims to ... ...

    Abstract Introduction: aggressive angiomyxoma is a highly aggressive, rare neoplasm of the mesenchymal tissue with a high recurrence rate. It represents an important differential diagnosis of pelvic tumors in women of reproductive age. This study aims to describe a case of aggressive angiomyxoma.
    Case report: woman, 37 years old, complained about a bulge on the right perianal region, and anal itching and burning, bleeding, tenesmus and incontinence. The proctologic examination confirmed the perianal bulge and extrinsic compression of the posterior wall of the rectum. Computed tomography (CT) of the pelvis showed a well-defined pelvic mass extending to the right rectal area. Exploratory laparotomy showed a mass of fibro elastic consistency adjacent to the pelvic organs and closely attached to the distal rectum, and performed a resection of the pelvic tumor afterward. Anatomopathological analysis revealed an aggressive angiomyxoma. Magnetic resonance imaging (MRI) of the pelvis showed signs of recurrence in the pelvic cavity on the right side of the rectum. A surgical procedure was performed to resect the lesion. After an asymptomatic period, the MRI showed solid growths located in the right ischiorectal fossa. A new surgical procedure identified only retention cysts in the pelvis and right ischiorectal fossa, only lysis of adhesions was performed. The patient is currently undergoing follow-up without disease recurrence.
    Keywords Pelvic neoplasms ; Neoplasms of connective tissues and soft tissues ; Angiomyxoma ; Local recurrence of neoplasm Laparotomy ; Neoplasias pélvicas ; Neoplasias de tecido conjuntivo e de tecidos moles ; Angiomixoma ; Recidiva local de neoplasia Laparotomia
    Language English
    Publishing date 2013-12-01
    Publisher Thieme Revinter Publicações Ltda.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2664477-0
    ISSN 2317-6423 ; 2237-9363 ; 2317-6423
    ISSN (online) 2317-6423
    ISSN 2237-9363 ; 2317-6423
    DOI 10.1016/j.jcol.2013.08.009
    Database Thieme publisher's database

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  10. Article ; Online: The surgical treatment of patients with ulcerative colitis from an university hospital at Natal, Brazil

    Suelene Suassuna Silvestre de Alencar / Romualdo da Silva Corrêa / Cátia de França Bezerra / Emanuela Simone Cunha de Menezes / Antonio Luiz do Nascimento / Davi Aragão Alves da Costa / Marcelo José Carlos Alencar

    Journal of Coloproctology , Vol 32, Iss 3, Pp 265-

    2012  Volume 270

    Abstract: ... portadores de RCU. MÉTODOS: Trata-se de estudo retrospectivo realizado por meio da análise de prontuários de ... sintomatologia, manifestações extraintestinais, extensão do acometimento colônico, complicações da doença ... As complicações pós-operatórias ocorreram em 55,5% dos pacientes. CONCLUSÕES: O estudo corrobora com os dados da ...

    Abstract INTRODUCTION: Ulcerative colitis (UC) is a chronic inflammatory disease that affects the rectum and colon, involving periods of exacerbation and remission. A considerable number of patients requires surgery during the course of this disease. OBJECTIVE: The purpose of this study is to analyze the profile and therapeutic approach of patients with UC. METHODS: This is a retrospective study that analyzed medical records of patients diagnosed with UC between 1999 and 2010. We selected 45 patients and analyzed the following variables: age, gender, ethnic group, interval between onset of symptoms and diagnosis, extraintestinal manifestations, extent of colonic involvement, disease complications, pharmacological treatment, indication for surgery, time between diagnosis and indication, surgical procedures, early and late complications and pathological results of surgical specimens. Data were analyzed descriptively and compared with other studies. RESULTS: The clinical profile of the patients was consistent with the literature. Nine patients underwent surgical treatment: seven were submitted to proctocolectomy with anastomosis in the ileo-anal pouch and two were submitted to total colectomy; in addition, eight were submitted to ileostomy. Postoperative complications occurred in 55.5% of patients. CONCLUSIONS: The study confirms data from the literature regarding the profile and therapeutic approach of patients with ulcerative colitis. INTRODUÇÃO: A retocolite ulcerativa (RCU) é uma doença inflamatória crônica que acomete reto e cólon, cursando com períodos de exacerbação e remissão. Uma parcela considerável de pacientes necessita de procedimento cirúrgico ao longo do curso dessa enfermidade. OBJETIVO: Este estudo objetiva analisar perfil e abordagem terapêutica de portadores de RCU. MÉTODOS: Trata-se de estudo retrospectivo realizado por meio da análise de prontuários de pacientes acompanhados com diagnóstico de RCU no período de 1999 a 2010. Foram selecionados 45 pessoas, sendo analisadas as variáveis: idade, sexo, raça, intervalo entre início dos sintomas e diagnóstico, sintomatologia, manifestações extraintestinais, extensão do acometimento colônico, complicações da doença, tratamento medicamentoso, indicação de cirurgia, tempo entre esta e o diagnóstico, procedimentos cirúrgicos, complicações precoces e tardias e resultado anatomopatológico das peças cirúrgicas. Os dados foram analisados de forma descritiva e comparados com outros estudos. RESULTADOS: O perfil clínico dos pacientes foi condizente com a literatura. Nove foram submetidos a tratamento cirúrgico, sendo realizadas sete proctocolectomias com anastomose em bolsa íleo-anal e duas colectomias totais, além de oito ileostomias. As complicações pós-operatórias ocorreram em 55,5% dos pacientes. CONCLUSÕES: O estudo corrobora com os dados da literatura referentes ao perfil e abordagem terapêutica dos pacientes com diagnóstico de RCU.
    Keywords proctocolite ; cirurgia colorretal ; complicações pós-operatórias ; sintomas e sinais digestórios ; bolsas do colo ; proctocolitis ; colorectal surgery ; postoperative complications ; signs and symptoms ; digestive ; colonic pouches ; Diseases of the digestive system. Gastroenterology ; RC799-869 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Gastroenterology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2012-09-01T00:00:00Z
    Publisher Sociedade Brasileira de Coloproctologia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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