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Article ; Online: Correction to: Investigation of Solvent Effect and H-Bonding on Spectroscopic Properties of 1-(3 Amino-6-(2,5-dichlorothiophen-3-yl)-4-phenylfuro[2,3-b]Pyridin-2-yl) Ethenone: Experimental and Computational Study.

Abuflaha, Rasha K / Yousef, Fakhri O / Ghanem, Raed / Al-Sou'od, Khaldoun / Shahdi, Ihsan A / Almashaqbeh, Omar K / Al-Refai, Mahmoud

Journal of fluorescence

2023 Volume 34, Issue 2, Page(s) 961

Language	English
Publishing date	2023-06-14
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	2016892-5
ISSN	1573-4994 ; 1053-0509
ISSN (online)	1573-4994
ISSN	1053-0509
DOI	10.1007/s10895-023-03294-0
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Article ; Online: Investigation of Solvent Effect and H-Bonding on Spectroscopic Properties of 1-(3-Amino-6-(2,5-dichlorothiophen-3-yl)-4-phenylfuro[2,3-b]Pyridin-2-yl) Ethenone: Experimental and Computational Study.

Abuflaha, Rasha K / Yousef, Fakhri O / Ghanem, Raed / Al-Sou'od, Khaldoun / Shahdi, Ihsan A / Almashaqbeh, Omar K / Al-Refai, Mahmoud

Journal of fluorescence

2023 Volume 33, Issue 6, Page(s) 2349–2360

Abstract: The furo[2,3-b]pyridine moiety is an important scaffold for many biologically active compounds ... therefore, the spectral data of the derivative 1-(3-Amino-6-(2,5-dichlorothiophen-3-yl)-4-phenylfuro[2,3-b]pyridin-2-yl ... parameter, α, of the protic solvents indicated efficient intramolecular charge transfer and noticeable H ...

Abstract	The furo[2,3-b]pyridine moiety is an important scaffold for many biologically active compounds, therefore, the spectral data of the derivative 1-(3-Amino-6-(2,5-dichlorothiophen-3-yl)-4-phenylfuro[2,3-b]pyridin-2-yl) ethenone (FP1) were investigated. Analysis of absorption-pH profile and Förster cycle of FP1 revealed that its excited state is more acidic than its ground state ([Formula: see text] < [Formula: see text]). The main fluorescence emission band of FP1 at 480 nm (in hexane) is shifted to longer wavelengths with increasing polarities of solvents. Linear Lippert's plot and linear correlation between bands maxima and Camlet-Taft parameter, α, of the protic solvents indicated efficient intramolecular charge transfer and noticeable H-bonding. Moreover, the disappearance of the absorption band of FP1 at 385 nm in water, along with the noticeable red shift and quenching of the emission band, and the lower lifetime, relative to nonaqueous solvents, indicate the interruption of the furo[2,3-b]pyridine aromatic moiety. In addition, results from the Time Dependent Density Functional Theory (TDDFT) and Molecular Mechanic (MM) calculations were in agreement with experimentally determined spectra of FP1.
Language	English
Publishing date	2023-04-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2016892-5
ISSN	1573-4994 ; 1053-0509
ISSN (online)	1573-4994
ISSN	1053-0509
DOI	10.1007/s10895-023-03243-x
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Article: Generation of an immortal differentiated lung type-II epithelial cell line from the adult H-2K(b)tsA58 transgenic mouse.

deMello, D E / Mahmoud, S / Padfield, P J / Hoffmann, J W

In vitro cellular & developmental biology. Animal

2000 Volume 36, Issue 6, Page(s) 374–382

Abstract: ... derived from transgenic H-2K(b)-tsA58 mice, capable of being passaged as an immortalized cloned cell line ... in culture. H-2K(b)-tsA58 mice harbor a temperature-sensitive (ts) mutant of the simian virus 40 (SV40) large ... major histocompatibility complex H-2Kb promoter. When cultured under permissive conditions (33 degrees C and in the presence ...

Abstract	This paper describes a new fully differentiated Type-II alveolar epithelial cell line designated T7, derived from transgenic H-2K(b)-tsA58 mice, capable of being passaged as an immortalized cloned cell line in culture. H-2K(b)-tsA58 mice harbor a temperature-sensitive (ts) mutant of the simian virus 40 (SV40) large tumor antigen (T antigen) under the control of the gamma-interferon (INF)-inducible mouse major histocompatibility complex H-2Kb promoter. When cultured under permissive conditions (33 degrees C and in the presence of gamma-INF) cells isolated from H-2Kb-tsA58 mice express the large T antigen, which drives the cells to proliferate. However, upon withdrawal of the gamma-INF and transfer of the cells to a higher temperature (39 degrees C), T antigen expression is turned off, the cells stop proliferating and differentiate. The T7 cell line is a clonal cell line originally derived from a Type-II cell-rich fraction isolated from lungs of H-2Kb-tsA58 mice. The T7 cells form confluent monolayers, and have a polarized epithelial cell morphology with tight junctions and apical microvilli. In addition, the T7 cells have distinct cytoplasmic lamellar bodies, which become more numerous and pronounced when the cells are grown under nonpermissive conditions. The T7 cells synthesize and secrete phosphatidylcholine and the three surfactant proteins, SP-A, SP-B, and SP-C. The T7 cell line is unique in that it is the first non-tumor-derived Type-II cell line capable of synthesizing and secreting the major components of surfactant. Based on the criteria studied, the T7 cell line is phenotypically very similar to normal Type-II cells. The T7 cell line, therefore, should prove a valuable experimental system to advance the study of the cell biology/physiology of surfactant metabolism and secretion as well as serve as a model for other studies of Type-II cell physiology.
MeSH term(s)	Animals ; Cell Differentiation ; Cell Line ; Cell Membrane Permeability ; Cell Polarity ; Cell Size ; Clone Cells/cytology ; Clone Cells/metabolism ; Electric Impedance ; Epithelial Cells/cytology ; H-2 Antigens/genetics ; Mice ; Mice, Transgenic ; Organelles/ultrastructure ; Phosphatidylcholines/biosynthesis ; Phosphatidylcholines/metabolism ; Pulmonary Alveoli/cytology ; Pulmonary Alveoli/metabolism ; Pulmonary Surfactants/biosynthesis ; Pulmonary Surfactants/metabolism ; Respiratory Mucosa/cytology ; Respiratory Mucosa/metabolism
Chemical Substances	H-2 Antigens ; H-2Kb protein, mouse ; Phosphatidylcholines ; Pulmonary Surfactants
Keywords	covid19
Language	English
Publishing date	2000-06
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1077810-x
ISSN	1543-706X ; 1071-2690 ; 0883-8364
ISSN (online)	1543-706X
ISSN	1071-2690 ; 0883-8364
DOI	10.1290/1071-2690(2000)036<0374:GOAIDL>2.0.CO;2
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Article ; Online: Blockage slope and ratio effects on box culvert hydraulics

Mahmoud Zayed

Discover Water, Vol 3, Iss 1, Pp 1-

2023 Volume 16

Abstract: ... ΔH/h u increased by 2, 5, 9, and 13 times for B = 0.40, 0.60, 0.80, and 1, respectively ... For Fo = 0.10, d/h o = 0.13 and L/h o = 0.94 for B = 0.20 compared to d/h o = 0.32 and L/h o = 4.34 for B ... increased dramatically with increasing blockage ratio and Froude number. Compared to blockage ratio B = 0.20 ...

Abstract	Abstract Culvert blockage at the inlet can dramatically alter the local hydraulic characteristics that often increase backwater rise, change the flow patterns, and thereby increase the risk of upstream flooding. The impact of culvert blockage is not usually included in the initial hydraulic design, although it can cause significant losses once the culvert becomes blocked. Culvert hydraulics including backwater rise with respect to blockage slope and ratio has been neglected in the studies conducted so far. In this study, we conducted a series of narrow flume tests to investigate the effects of four bottom blockage slope angles and five blockage ratios on the hydraulic characteristics of box culverts, including backwater rise, and upstream mean velocity at various Froude numbers. The results showed that Froude number, blockage ratio, and slope angle were regarded as the controlling variables for culvert backwater rise. Backwater rise increased dramatically with increasing blockage ratio and Froude number. Compared to blockage ratio B = 0.20, ΔH/h u increased by 2, 5, 9, and 13 times for B = 0.40, 0.60, 0.80, and 1, respectively. However, when the blockage slope angle decreased, the backwater rise reduced and upstream mean velocity increased in compared with vertical blockage. The relative backwater rise reduced from 0.32 to 0.29, when blockage slope angle decreased from 90° to 18.44° at B = 1 and Fo = 0.10. In addition, the length and maximum depth of water surface depression inside the culvert itself were larger with increasing blockage ratio and Froude number. For Fo = 0.10, d/h o = 0.13 and L/h o = 0.94 for B = 0.20 compared to d/h o = 0.32 and L/h o = 4.34 for B = 1. The results were also combined to develop an equation to predict backwater rise in the range 0.10 ≤ Fo ≤ 0.25, 0 ≤ B ≤ 1, and 18.44° ≤ α ≤ 90°. To enhance the accuracy, it is recommended to apply the equation for ΔH/h u ˃ 0.10. It is useful and practical in applications to add the probability of backwater rise or losses owing to culvert blockage ...
Keywords	Box culvert ; Hydraulic blockage ; Blockage slope angle ; Scaled physical models ; Backwater rise ; Water surface elevation ; Water supply for domestic and industrial purposes ; TD201-500 ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Springer
Document type	Article ; Online
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Article ; Online: Safety and efficacy of candesartan versus valsartan combined with amlodipine on peripheral and central blood pressure.

Hanna, S M / Rabea, H M / Abdelrahim, M E A / Mahmoud, H B

Hipertension y riesgo vascular

2024 Volume 41, Issue 1, Page(s) 17–25

Abstract: Introduction: "Amlodipine/valsartan" or "amlodipine/candesartan" combinations represent two effective antihypertensive agents with complementary mechanisms of action. Nevertheless, a study has yet to be done to evaluate the effect of amlodipine/ ... ...

Abstract	Introduction: "Amlodipine/valsartan" or "amlodipine/candesartan" combinations represent two effective antihypertensive agents with complementary mechanisms of action. Nevertheless, a study has yet to be done to evaluate the effect of amlodipine/candesartan on central blood pressure and compare it with amlodipine/valsartan combination. To see how "amlodipine plus candesartan combination" reduces peripheral and central blood pressure compared to the most studied combination, "amlodipine plus valsartan". Material and methods: Eighty-six patients were randomized in an open-label, prospective study by 1:1 ratio to two groups. Group I (n=42) received the amlodipine and valsartan combination, and group II (n=44) received the amlodipine and candesartan combination. Peripheral and central blood pressure (CBP) was measured at baseline, at 6 and 12 weeks of follow-up. Discussion: Both treatment groups reduced peripheral systolic, diastolic, and mean blood pressure. There was no significant difference between and within both groups. The amlodipine/candesartan combination showed more reduction in peripheral systolic blood pressure (PSBP) after 12 weeks of treatment (p=<0.001). Both groups decreased CBP without significant differences between groups. The amlodipine/candesartan combination showed additional efficacy in decreasing CSBP after 12 weeks (p=<0.001). The two treatment groups did not exert significant efficacy in lowering heart rate (HR) and augmentation index% (AIx%). Conclusion: To conclude, the amlodipine 10mg/candesartan 16mg combination was non-inferior to the amlodipine 10mg/valsartan 160mg combination in terms of reducing peripheral and CBP over time.
MeSH term(s)	Humans ; Amlodipine/adverse effects ; Valsartan/pharmacology ; Valsartan/therapeutic use ; Blood Pressure ; Hypertension/drug therapy ; Prospective Studies ; Valine/pharmacology ; Valine/therapeutic use ; Antihypertensive Agents/adverse effects ; Tetrazoles/adverse effects ; Drug Therapy, Combination ; Benzimidazoles ; Biphenyl Compounds
Chemical Substances	Amlodipine (1J444QC288) ; Valsartan (80M03YXJ7I) ; candesartan (S8Q36MD2XX) ; Valine (HG18B9YRS7) ; Antihypertensive Agents ; Tetrazoles ; Benzimidazoles ; Biphenyl Compounds
Language	English
Publishing date	2024-02-28
Publishing country	Spain
Document type	Randomized Controlled Trial ; Journal Article
ISSN	1989-4805
ISSN (online)	1989-4805
DOI	10.1016/j.hipert.2023.11.004
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Article ; Online: Correction to: purification, characterization and anticancer activity of L-methionine γ-lyase from thermo-tolerant aspergillus fumigatus.

Hendy, Mahmoud H / Hashem, Amr H / Suleiman, Waleed B / Sultan, Mahmoud H / Abdelraof, Mohamed

Microbial cell factories

2023 Volume 22, Issue 1, Page(s) 58

Language	English
Publishing date	2023-03-25
Publishing country	England
Document type	Published Erratum
ZDB-ID	2091377-1
ISSN	1475-2859 ; 1475-2859
ISSN (online)	1475-2859
ISSN	1475-2859
DOI	10.1186/s12934-023-02062-w
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Article: Airbag injuries of the hand: a case-series and literature review.

Mahmoud, Asmaa Z B / Alhusain, Abdullah M / Alkhadhrawi, Mohammed N H / Vasilescu, Dana C

Journal of surgical case reports

2024 Volume 2024, Issue 2, Page(s) rjae052

Abstract: Motor vehicle accidents are a significant cause of morbidity and mortality worldwide. Airbags aim to reduce the severity of motor vehicle accidents, but their deployment is not without risks. This study presents five cases presenting with diverse forms ... ...

Abstract	Motor vehicle accidents are a significant cause of morbidity and mortality worldwide. Airbags aim to reduce the severity of motor vehicle accidents, but their deployment is not without risks. This study presents five cases presenting with diverse forms of upper extremity injuries following airbag deployment. The presented cases highlight the variety of clinical presentations, the differences in diagnostics in terms of imaging modalities, as well as the spectrum of possible outcomes from complete healing to decreased range of motion to persistent neurological symptoms. Understanding the mechanisms and presentations of such injuries can only help in improving and creating new strategies for the prevention of such injuries, as well as their management.
Language	English
Publishing date	2024-02-13
Publishing country	England
Document type	Case Reports
ZDB-ID	2580919-2
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjae052
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Article ; Online: Purification, Characterization and anticancer activity of L-methionine γ-lyase from thermo-tolerant Aspergillus fumigatus.

Hendy, Mahmoud H / Hashem, Amr H / Suleiman, Waleed B / Sultan, Mahmoud H / Abdelraof, Mohamed

Microbial cell factories

2023 Volume 22, Issue 1, Page(s) 8

Abstract: Purification of L-methionine γ-lyase (MGL) from A. fumigatus was sequentially conducted using heat treatment and gel filtration, resulting in 3.04 of purification fold and 73.9% of enzymatic recovery. The molecular mass of the purified MGL was ... ...

Abstract	Purification of L-methionine γ-lyase (MGL) from A. fumigatus was sequentially conducted using heat treatment and gel filtration, resulting in 3.04 of purification fold and 73.9% of enzymatic recovery. The molecular mass of the purified MGL was approximately apparent at 46 KDa based on SDS-PAGE analysis. The enzymatic biochemical properties showed a maximum activity at pH 7 and exhibited plausible stability within pH range 5.0-7.5; meanwhile the highest catalytic activity of MGL was observed at 30-40 °C and the enzymatic stability was noted up to 40 °C. The enzyme molecule was significantly inhibited in the presence of Cu
MeSH term(s)	Aspergillus fumigatus/metabolism ; Kinetics ; Carbon-Sulfur Lyases/chemistry ; Carbon-Sulfur Lyases/metabolism ; Methionine
Chemical Substances	L-methionine gamma-lyase (EC 4.4.1.11) ; Carbon-Sulfur Lyases (EC 4.4.-) ; Methionine (AE28F7PNPL)
Language	English
Publishing date	2023-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2091377-1
ISSN	1475-2859 ; 1475-2859
ISSN (online)	1475-2859
ISSN	1475-2859
DOI	10.1186/s12934-023-02019-z
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Article ; Online: The effect of silver nanoparticles on biological and corrosion behavior of electrophoretically deposited hydroxyapatite film on Ti6Al4V.

Balaei, Hassan / Ghasemi, H M / Aghdam, Rouhollah Mehdinavaz / Cheraghali, B / Sohi, Mahmoud Heydarzadeh

Journal of materials science. Materials in medicine

2024 Volume 35, Issue 1, Page(s) 18

Abstract: Surface modification of titanium and its alloys has been seriously considered by researchers to improve their biological behaviors, in the past few decades. In present research, hydroxyapatite (HA) based composite coatings with different concentrations ... ...

Abstract	Surface modification of titanium and its alloys has been seriously considered by researchers to improve their biological behaviors, in the past few decades. In present research, hydroxyapatite (HA) based composite coatings with different concentrations of 0, 2, 4, and 6 wt% of silver (Ag) nanoparticles were electrophoretically deposited (EPD) on anodized and non-anodized Ti6Al4V, using a direct current at a voltage of 30 V for 10 min at room temperature. The specimens were then characterized by means of X-ray diffraction (XRD) analysis, Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) equipped with energy dispersive spectroscopy (EDS). The cell adhesion images and cell viability results showed that HA-Ag composite coatings significantly promoted the biocompatibility of samples compared with the non-anodized and anodized Ti6Al4V. The viabilities of Mg-63 cells on HA-4%Ag coating and bi-layer coating (HA-4%Ag on anodized specimen) were approximately 91% and they were considered as the best coatings in term of biocompatibility. On the other hand, the antibacterial assessments demonstrated that HA-6%Ag coating had the best antibacterial performance compared with other samples. Furthermore, Tafel polarization curves indicated that corrosion resistance of the bi-layer coating was higher than those of the other specimens. The polarization resistance of this coating was about 7 times more than that of theTi6Al4V alloy.
MeSH term(s)	Durapatite/chemistry ; Titanium/chemistry ; Silver ; Spectroscopy, Fourier Transform Infrared ; Coated Materials, Biocompatible/chemistry ; Corrosion ; Metal Nanoparticles ; X-Ray Diffraction ; Alloys/chemistry ; Anti-Bacterial Agents
Chemical Substances	Durapatite (91D9GV0Z28) ; titanium alloy (TiAl6V4) (12743-70-3) ; Titanium (D1JT611TNE) ; Silver (3M4G523W1G) ; Coated Materials, Biocompatible ; Alloys ; Anti-Bacterial Agents
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1031752-1
ISSN	1573-4838 ; 0957-4530
ISSN (online)	1573-4838
ISSN	0957-4530
DOI	10.1007/s10856-024-06784-0
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Article ; Online: 3-year randomized clinical trial to evaluate the performance of posterior composite restorations lined with ion-releasing materials.

Ahmed, Basma / Wafaie, Ramy Ahmed / Hamama, Hamdi H / Mahmoud, Salah Hasab

Scientific reports

2024 Volume 14, Issue 1, Page(s) 4942

Abstract: To evaluate the impact of using ion-releasing liners on the 3-year clinical performance of posterior resin composite restorations after selective caries excavation with polymer burs. 20 patients were enrolled in this trial. Each patient had two deep ... ...

Abstract	To evaluate the impact of using ion-releasing liners on the 3-year clinical performance of posterior resin composite restorations after selective caries excavation with polymer burs. 20 patients were enrolled in this trial. Each patient had two deep carious lesions, one on each side of the mouth. After selective caries removal using polymer bur (PolyBur P1, Komet, Brasseler GmbH Co. KG, Lemgo, Germany), cavities were lined with bioactive ionic resin composite (Activa Bioactive Base/Liner, Pulpdent, Watertown, MA, USA) or resin-modified glass ionomer liner (Riva Light Cure, SDI, Bayswater, Victoria, Australia). All cavities were then restored with nanofilled resin composite (Filtek Z350XT, 3M Oral Care, St. Paul, MN, USA). All the tested materials were placed according to the manufacturers' instructions. Clinical evaluation was accomplished using World Dental Federation (FDI) criteria at baseline and after 6 months, 1, 2, and 3 years. Data were analyzed using Mann-whitney U and Friedman tests (p < 0.05). The success rates were 100% for all resin composite restorations either lined with ion-releasing resin composite or resin-modified glass ionomer liner. Mann-whitney U test revealed that there were no statistically significant differences between both ion-releasing lining material groups for all criteria during the follow-up periods (p > 0.05). Resin composite restorations showed acceptable clinical performance over 3 years either lined with bioactive ionic or resin-modified glass ionomer liners after selective caries excavation preserving pulp vitality. After the 3-year follow-up period, Activa Bioactive and Riva Light Cure liners were clinically effective and they exhibited with the overlying composite restorations successful clinical performance.Trial registration number: NCT05470959. Date of registration: 22/7/2022. Retrospectively registered.
MeSH term(s)	Humans ; Resin Cements ; Composite Resins/therapeutic use ; Silicon Dioxide ; Acrylic Resins ; Victoria ; Dental Restoration, Permanent ; Dental Caries/surgery
Chemical Substances	glass ionomer ; Resin Cements ; Composite Resins ; Silicon Dioxide (7631-86-9) ; Acrylic Resins
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55329-6
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