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  1. Book: Experimental protocols in biotechnology

    Gupta, Neelima / Gupta, Varsha

    (Springer protocols)

    2020  

    Author's details edited by Neelima Gupta (Chhatrapati Shahu Ji Maharaj University, Kanpur, Uttar Pradesh, India), Varsha Gupta (Department of Biotechnology, Chhatrapati Shahu Ji Maharaj University, Kanpur, Uttar Pradesh, India)
    Series title Springer protocols
    Language English
    Size xv, 246 Seiten, Illustrationen
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT020536188
    ISBN 978-1-0716-0606-3 ; 9781071606070 ; 1-0716-0606-9 ; 1071606077
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2020 A 1095 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Hand hygiene with interventions: an observational study from a tertiary care institute over 2 years.

    Chaudhary, Preeti / Gupta, Varsha

    Journal of preventive medicine and hygiene

    2024  Volume 64, Issue 4, Page(s) E488–E492

    Abstract: Background: Appropriate adherence to hand hygiene (HH) practices by health care workers (HCWs) reduces the transmission of pathogens and subsequently the incidence of hospital acquired infections (HAIs), in health care settings. Strict monitoring and ... ...

    Abstract Background: Appropriate adherence to hand hygiene (HH) practices by health care workers (HCWs) reduces the transmission of pathogens and subsequently the incidence of hospital acquired infections (HAIs), in health care settings. Strict monitoring and auditing of this simple and cost-effective intervention is very important, as it significantly contributes in reducing the HAIs.
    Material and methods: A retrospective observational study, evaluating the HH audits from June 2021 till May 2023 in a tertiary health care facility in North India. HH audits were conducted in the ICUs and wards daily, by the trained infection control nurses (ICNs), using direct observation method based on World health organization (WHO) hand hygiene observational forms. HH total adherence (HHTAR), partial adherence (HHPAR) and complete adherence rate (HHCAR) were analyzed in Microsoft Excel sheet. HHTAR rates were compared among different profession, moments and the month wise trend was also observed over the period.
    Results: A total of 24,740 HH opportunities were observed. The compliance rate for HHCAR, HHPAR and HHTAR were 20.3%, 41.5% and 61.4% respectively. Overall better compliance was reported from the ICUs, profession-specific compliance was highest among nurses (62.8%) and doctors (61.5%). Significant increase in adherence rate was appreciated post intervention 46.1% to 67.3%, (p value < 0.01).
    Conclusions: Continuous monitoring and reinforcement with timely feedback for intervention and regular auditing is a necessity to improve and maintain the appropriate HH practices among the HCWs. Low- and middle-income countries need to focus more on this simple and promising measure to combat the increasing HAI rates.
    MeSH term(s) Humans ; Hand Hygiene ; Tertiary Healthcare ; Guideline Adherence ; Cross Infection/prevention & control ; Cross Infection/epidemiology ; Health Personnel ; Infection Control/methods
    Language English
    Publishing date 2024-01-01
    Publishing country Italy
    Document type Observational Study ; Journal Article
    ZDB-ID 1102926-2
    ISSN 2421-4248 ; 1121-2233
    ISSN (online) 2421-4248
    ISSN 1121-2233
    DOI 10.15167/2421-4248/jpmh2023.64.4.3087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: An Unusual Painless Lesion on the Shin.

    Goel, Aakanksha / Shrivastava, Prabhat / Gupta, Varsha / Tomar, Reena

    Oman medical journal

    2023  Volume 38, Issue 3, Page(s) e518

    Language English
    Publishing date 2023-05-31
    Publishing country Oman
    Document type Journal Article
    ZDB-ID 2571431-4
    ISSN 2070-5204 ; 1999-768X
    ISSN (online) 2070-5204
    ISSN 1999-768X
    DOI 10.5001/omj.2023.24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Salmonella Typhi: A Review of Antibiogram Journey in Developing Countries.

    Singhal, Lipika / Sandhu, Diljot / Gupta, Varsha / Kour, Ivneet

    Infectious disorders drug targets

    2024  

    Abstract: Background: Typhoid fever poses a significant health challenge in low- and middleincome countries (LMiCs), impacting millions of individuals across various age groups. Its prevalence is particularly pronounced in South Asia. Factors contributing to its ... ...

    Abstract Background: Typhoid fever poses a significant health challenge in low- and middleincome countries (LMiCs), impacting millions of individuals across various age groups. Its prevalence is particularly pronounced in South Asia. Factors contributing to its transmission in South Asia include rapid unplanned urbanization, urban-rural disparities, provision of poor water and sanitation facilities, and open defecation. The mortality rate of typhoid fever is up to 1%, and those who survive have a protracted period of poor health and carry an enormous financial burden. The treatment is further complicated by the emerging antibiotic resistance leaving few treatment options in hands. This issue has become more urgent due to the further emergence of extended drug-resistant (XDR) and multidrugresistant (MDR) typhoid strains, as well as their subsequent global spread. Fluoroquinoloneresistant Salmonella spp. is currently classified by the World Health Organization (WHO) as a high (Priority 2) pathogen. As a result, establishing minimum inhibitory concentrations (MIC) according to the latest guidelines may prove effective in treating typhoid fever and minimizing the rising threat of drug resistance.
    Language English
    Publishing date 2024-01-23
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2234298-9
    ISSN 2212-3989 ; 1871-5265
    ISSN (online) 2212-3989
    ISSN 1871-5265
    DOI 10.2174/0118715265255339240102110929
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: XDR

    Singhal, Lipika / Gupta, Varsha / Gautam, Vikas / Kour, Ivneet

    Asia-Pacific journal of public health

    2023  Volume 35, Issue 6-7, Page(s) 463–464

    MeSH term(s) Humans ; Asia ; Asian ; Oceania ; Salmonella typhi ; Typhoid Fever/microbiology ; Typhoid Fever/prevention & control ; Typhoid-Paratyphoid Vaccines/therapeutic use ; Vaccines
    Chemical Substances Typhoid-Paratyphoid Vaccines ; Vaccines
    Language English
    Publishing date 2023-09-04
    Publishing country China
    Document type Letter
    ZDB-ID 1025444-4
    ISSN 1941-2479 ; 1010-5395
    ISSN (online) 1941-2479
    ISSN 1010-5395
    DOI 10.1177/10105395231199159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Langya Virus, a Newly Discovered Henipavirus Capable of "Zoonotic Spillover and Associated Community Health Concerns".

    Kour, Ivneet / Singhal, Lipika / Gupta, Varsha

    Asia-Pacific journal of public health

    2023  Volume 35, Issue 6-7, Page(s) 459–460

    MeSH term(s) Humans ; Animals ; Public Health ; Zoonoses
    Language English
    Publishing date 2023-08-19
    Publishing country China
    Document type Letter
    ZDB-ID 1025444-4
    ISSN 1941-2479 ; 1010-5395
    ISSN (online) 1941-2479
    ISSN 1010-5395
    DOI 10.1177/10105395231193267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Amphid sensory neurons of

    Venkatesh, Siddharth R / Gupta, Anjali / Singh, Varsha

    Life science alliance

    2023  Volume 6, Issue 8

    Abstract: The survival of a host during infection relies on its ability to rapidly sense the invading pathogen and mount an appropriate response. The bacterivorous ... ...

    Abstract The survival of a host during infection relies on its ability to rapidly sense the invading pathogen and mount an appropriate response. The bacterivorous nematode
    MeSH term(s) Animals ; Caenorhabditis elegans ; Sensory Receptor Cells ; Caenorhabditis elegans Proteins/genetics
    Chemical Substances Caenorhabditis elegans Proteins
    Language English
    Publishing date 2023-05-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.202301949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Triple Burden: The Incorrigible Threat of Tuberculosis, HIV, and COVID-19.

    Gupta, Parakriti / Sandhu, Diljot / Gupta, Varsha / Singhal, Lipika

    Infectious disorders drug targets

    2023  

    Abstract: The Coronavirus-19 (COVID-19) hasn't seen the dawn since its emergence, however waxing and waning has resulted in the emergence of deadly variants. The effects of the pandemic have not been limited to its virulence, but have rather conferred multiple ... ...

    Abstract The Coronavirus-19 (COVID-19) hasn't seen the dawn since its emergence, however waxing and waning has resulted in the emergence of deadly variants. The effects of the pandemic have not been limited to its virulence, but have rather conferred multiple collateral effects, especially in developing countries; thereby, designating it as a SYNDEMIC. The same culminated in neglect of non-COVID-19 conditions like tuberculosis (TB) and human immunodeficiency virus-acquired immunodeficiency syndrome (HIV/AIDS). Besides being the prognostic factor for severe COVID-19, these infections in hidden pockets served as a reservoir for the emergence of the deadly Omicron. Another significant impact of this juxtaposition was on the delivery of healthcare services for TB and HIV. The unanticipated COVID-19 pandemic turned the path of ongoing progress of elimination programs. Direct consequences of the COVID-19 pandemic were pronounced on diagnosis, treatment, and services for patients with TB and HIV. Essential TB services were reallocated to the COVID-19 rapid response task force. However, despite escalating the tribulations, this triple burden has simultaneously taught lessons to escalate the progress of halted programs. The pandemic has catalyzed an unusual level of collaboration among scientists, which can be exploited for TB and HIV. Fast-track diagnostics, digitalization, contact tracing, and vaccine development have enabled the world to envision the same for TB/HIV.
    Language English
    Publishing date 2023-11-06
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2234298-9
    ISSN 2212-3989 ; 1871-5265
    ISSN (online) 2212-3989
    ISSN 1871-5265
    DOI 10.2174/0118715265259959231031104820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Risk factor and resistance profile of colistin resistant Acinetobacter baumannii and Klebsiellapneumoniae.

    Vasesi, Dipanshu / Gupta, Varsha / Gupta, Parakriti / Singhal, Lipika

    Indian journal of medical microbiology

    2023  Volume 47, Page(s) 100486

    Abstract: Purpose: Antimicrobial resistance is one of the major global health concerns, which is relentless despite multipronged measures. Carbapenems and colistin, drug of choice for multi drug resistant Klebsiella pneumoniae and Acinetobacter species, have also ...

    Abstract Purpose: Antimicrobial resistance is one of the major global health concerns, which is relentless despite multipronged measures. Carbapenems and colistin, drug of choice for multi drug resistant Klebsiella pneumoniae and Acinetobacter species, have also been rendered of less use. This underlines the need to decipher prevalence of colistin resistance comprehensively for formulation of hospital and country-wise antibiogram. We conducted this study to decipher the prevalence of colistin resistance in our tertiary care centre of North India.
    Materials and methods: This was a prospective, case control study conducted over a period of one and half years. All carbapenem resistant Klebsiella pneumoniae and Acinetobacter isolates were included. Kirby-Bauer method of disc diffusion was used for all antibiotics, except colistin for which broth microdilution was performed and interpreted using CLSI guidelines. Demographic details, risk factors and outcome details were recorded. Genotypic characterization was performed using representative strains, for bla
    Results: Of 103 carbapenem resistant isolates, 7 were found to be colistin resistant. Median age was 43 years, with male:female ratio of 1.1:1. 35% isolates were from pus samples, followed by endotracheal aspirate. Colistin resistance was more in ICUs than wards. Presence of indwelling devices was noted as the most common risk factor, followed by previous antibiotic exposure and use of steroids/immunosuppressants. Indwelling devices, steroids/immunosuppressants usage, length of hospital stay, COPD, prior usage of carbapenems, piperacillin-tazobactam and colistin, usage of ampicillin-sulbactam during hospital stay, were statistically significant. Mortality was noted in 4 cases, with statistical difference between control and case arm. The bla
    Conclusion: The present study unravels incidence, risk factors and resistance encoding genes at our centre. This is of immense help in formulation of antibiotic policies and guidance for infection control measures.
    MeSH term(s) Male ; Humans ; Female ; Adult ; Colistin/pharmacology ; Acinetobacter baumannii/genetics ; Case-Control Studies ; Prospective Studies ; Acinetobacter Infections/epidemiology ; Anti-Bacterial Agents/pharmacology ; Carbapenems/pharmacology ; Microbial Sensitivity Tests ; Immunosuppressive Agents ; Steroids ; beta-Lactamases/genetics
    Chemical Substances Colistin (Z67X93HJG1) ; Anti-Bacterial Agents ; Carbapenems ; Immunosuppressive Agents ; Steroids ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2023-10-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1038798-5
    ISSN 1998-3646 ; 0255-0857
    ISSN (online) 1998-3646
    ISSN 0255-0857
    DOI 10.1016/j.ijmmb.2023.100486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: WITHDRAWN: Salmonella typhi: A Review of Antibiogram Journey in Developing Countries

    Singhal, Lipika / Sandhu, Diljot / Kour, Ivneet / Gupta, Varsha

    Infectious disorders drug targets

    2022  

    Language English
    Publishing date 2022-06-09
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2234298-9
    ISSN 2212-3989 ; 1871-5265
    ISSN (online) 2212-3989
    ISSN 1871-5265
    DOI 10.2174/1871526522666220609100932
    Database MEDical Literature Analysis and Retrieval System OnLINE

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