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Article ; Online: Rickettsiosis in Denmark: A nation-wide survey.

Jensen, Bo Bødker / Andersen, Nanna Skaarup / Wölfel, Silke / Chen, Ming / Paarup, Helene M / Olesen, Carsten Riis / Fournier, Pierre Edouard / Jensen, Per Moestrup / Skarphedinsson, Sigurdur

Ticks and tick-borne diseases

2023 Volume 14, Issue 6, Page(s) 102236

Abstract: Rickettsia helvetica has been reported at varying prevalences in Danish and other European Ixodes ricinus populations. Though apparently widespread and with reported cases of human infection, the significance of the bacteria as a threat to public health ... ...

Abstract	Rickettsia helvetica has been reported at varying prevalences in Danish and other European Ixodes ricinus populations. Though apparently widespread and with reported cases of human infection, the significance of the bacteria as a threat to public health remains unclear. We present a nation-wide survey of rickettsia in ticks, roe deer and humans in Denmark. Ticks were collected by flagging and screened for presence of rickettsial DNA by polymerase chain reaction. Sera from roe deer, hunters, neuroborreliosis patients and blood donors were analyzed for presence of anti-R. helvetica and Rickettsia felis antibodies by immunofluorescence microscopy. The Rickettsia minimum infection rate in ticks was 4.9 % (367/973 pools positive, 7510 ticks in total), with 3.9 % in nymphs and 9.3 % in adults. Rickettsia helvetica accounted for 4.17 % and Rickettsia monacensis for 0.03 %, 0.6 % comprised non-differentiable rickettsial DNA. The prevalence of antibodies against R. helvetica was 2.8 % (9/319) in roe deer, while no hunters (n = 536) or blood donors (n = 181) were positive. The prevalence of anti-R. helvetica antibodies among Lyme neuroborreliosis patients was 6 % (3/47), where it co-occurred with Anaplasma phagocytophilum. Based on our study autochthonous rickettsiosis is of limited concern to the public health in Denmark, but our finding of R. monacensis for the first time in Denmark illustrates the dynamic nature of tick-borne pathogens, emphasizing that continuous surveillance is necessary.
MeSH term(s)	Animals ; Adult ; Humans ; Deer ; Rickettsia Infections/epidemiology ; Rickettsia Infections/veterinary ; Ixodes ; Denmark/epidemiology
Language	English
Publishing date	2023-09-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2541872-5
ISSN	1877-9603 ; 1877-959X
ISSN (online)	1877-9603
ISSN	1877-959X
DOI	10.1016/j.ttbdis.2023.102236
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Article: Immediate inflammatory response to mechanical circulatory support in a porcine model of severe cardiogenic shock.

Gregers, Emilie / Frederiksen, Peter H / Udesen, Nanna L J / Linde, Louise / Banke, Ann / Povlsen, Amalie L / Larsen, Jeppe P / Hassager, Christian / Jensen, Lisette O / Lassen, Jens F / Schmidt, Henrik / Ravn, Hanne B / Heegaard, Peter M H / Møller, Jacob E

Intensive care medicine experimental

2024 Volume 12, Issue 1, Page(s) 39

Abstract: Background: In selected cases of cardiogenic shock, veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is combined with trans valvular micro axial flow pumps (ECMELLA). Observational studies indicate that ECMELLA may reduce mortality but ... ...

Abstract	Background: In selected cases of cardiogenic shock, veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is combined with trans valvular micro axial flow pumps (ECMELLA). Observational studies indicate that ECMELLA may reduce mortality but exposing the patient to two advanced mechanical support devices may affect the early inflammatory response. We aimed to explore inflammatory biomarkers in a porcine cardiogenic shock model managed with V-A ECMO or ECMELLA. Methods: Fourteen landrace pigs had acute myocardial infarction-induced cardiogenic shock with minimal arterial pulsatility by microsphere embolization and were afterwards managed 1:1 with either V-A ECMO or ECMELLA for 4 h. Serial blood samples were drawn hourly and analyzed for serum concentrations of interleukin 6 (IL-6), IL-8, tumor necrosis factor alpha, and serum amyloid A (SAA). Results: An increase in IL-6, IL-8, and SAA levels was observed during the experiment for both groups. At 2-4 h of support, IL-6 levels were higher in ECMELLA compared to V-A ECMO animals (difference: 1416 pg/ml, 1278 pg/ml, and 1030 pg/ml). SAA levels were higher in ECMELLA animals after 3 and 4 h of support (difference: 401 ng/ml and 524 ng/ml) and a significant treatment-by-time effect of ECMELLA on SAA was identified (p = 0.04). No statistical significant between-group differences were observed in carotid artery blood flow, urine output, and lactate levels. Conclusions: Left ventricular unloading with Impella during V-A ECMO resulted in a more extensive inflammatory reaction despite similar end-organ perfusion.
Language	English
Publishing date	2024-04-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2740385-3
ISSN	2197-425X
ISSN	2197-425X
DOI	10.1186/s40635-024-00625-8
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Article ; Online: Optimized Multi-Attribute Method Workflow Addressing Missed Cleavages and Chromatographic Tailing/Carry-Over of Hydrophobic Peptides.

Kristensen, Dan B / Ørgaard, Martin / Sloth, Trine M / Christoffersen, Nanna S / Leth-Espensen, Katrine Z / Jensen, Pernille F

Analytical chemistry

2022 Volume 94, Issue 49, Page(s) 17195–17204

Abstract: Peptide mapping by liquid chromatography mass spectrometry (LC-MS) and the related multi-attribute method (MAM) are well-established analytical tools for verification of the primary structure and mapping/quantitation of co- and post-translational ... ...

Abstract	Peptide mapping by liquid chromatography mass spectrometry (LC-MS) and the related multi-attribute method (MAM) are well-established analytical tools for verification of the primary structure and mapping/quantitation of co- and post-translational modifications (PTMs) or product quality attributes in biopharmaceutical development. Proteolytic digestion is a key step in peptide mapping workflows, which traditionally is labor-intensive, involving multiple manual steps. Recently, simple high-temperature workflows with automatic digestion were introduced, which facilitate robustness and reproducibility across laboratories. Here, a modified workflow with an automatic digestion step is presented, which includes a two-step digestion at high and low temperatures, as opposed to the original one-step digestion at a high temperature. The new automatic digestion workflow significantly reduces the number of missed cleavages, obtaining a more complete digestion profile. In addition, we describe how chromatographic peak tailing and carry-over is dramatically reduced for hydrophobic peptides by switching from the traditional C18 reversed-phase (RP) column chemistry used for peptide mapping to a less retentive C4 column chemistry. No negative impact is observed on MS/MS-derived sequence coverage when switching to a C4 column chemistry. Overall, the new peptide mapping workflow significantly reduces the number of missed cleavages, yielding more robust and simple data interpretation, while providing dramatically reduced tailing and carry-over of hydrophobic peptides.
MeSH term(s)	Tandem Mass Spectrometry/methods ; Reproducibility of Results ; Chromatography, Liquid/methods ; Peptide Mapping/methods ; Peptides/chemistry ; Workflow
Chemical Substances	Peptides
Language	English
Publishing date	2022-11-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.2c03820
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Article ; Online: Health promotion intervention among women with recent gestational diabetes mellitus: penetration, participation, and baseline findings from the Face-it randomized controlled trial.

Jensen, Nanna Husted / Kragelund Nielsen, Karoline / Dahl-Petersen, Inger Katrine / Kampmann, Ulla / Damm, Peter / Ovesen, Per / Mathiesen, Elisabeth Reinhardt / Vinter, Christina Anne / Davidsen, Emma / Thøgersen, Maja / Timm, Anne / Andersen, Lise Lotte Torvin / Knorr, Sine / Jensen, Dorte Møller / Maindal, Helle Terkildsen

BMJ open diabetes research & care

2023 Volume 11, Issue 5

Abstract: ... who attended baseline had a mean age of 32.7 (±4.8) years and body mass index (BMI) of 28.1 (±5.4) kg/m ...

Abstract	Introduction: Face-it is a randomized controlled trial for women with recent gestational diabetes mellitus (GDM) and their families designed to evaluate the effect of a health promotion intervention on type 2 diabetes mellitus (T2DM) risk and quality of life. This study examined (1) the penetration and participation rates for the Face-it trial, (2) the characteristics of the participating women and the potential differences in characteristics according to partner participation status, and (3) representativity of the women at baseline. Research design and methods: We identified women with GDM during pregnancy and invited them and their partners to a baseline examination 10-14 weeks after delivery. Representativity was assessed by comparing the baseline participants with non-participating women, the general population of women with GDM delivering in Denmark, and populations from other intervention trials. Results: The penetration rate was 38.0% (867/2279) and the participation rate was 32.9% (285/867). The 285 women who attended baseline had a mean age of 32.7 (±4.8) years and body mass index (BMI) of 28.1 (±5.4) kg/m Conclusions: The penetration and participation rates were acceptable. We found a high rate of partner participation. Overall, women participating with a partner were comparable with those participating without a partner. Participating women were broadly similar to the general national GDM population, however with prepregnancy obesity, multiparity, preterm delivery, and multiple pregnancy being less represented. Trial registration number: NCT03997773.
MeSH term(s)	Pregnancy ; Infant, Newborn ; Humans ; Female ; Adult ; Diabetes, Gestational/epidemiology ; Diabetes, Gestational/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Quality of Life ; Premature Birth ; Obesity/epidemiology ; Health Promotion
Language	English
Publishing date	2023-09-21
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2732918-5
ISSN	2052-4897 ; 2052-4897
ISSN (online)	2052-4897
ISSN	2052-4897
DOI	10.1136/bmjdrc-2023-003529
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Article ; Online: Accelerating ice flow at the onset of the Northeast Greenland Ice Stream.

Grinsted, Aslak / Hvidberg, Christine S / Lilien, David A / Rathmann, Nicholas M / Karlsson, Nanna B / Gerber, Tamara / Kjær, Helle Astrid / Vallelonga, Paul / Dahl-Jensen, Dorthe

Nature communications

2022 Volume 13, Issue 1, Page(s) 5589

Abstract: Mass loss near the ice-sheet margin is evident from remote sensing as frontal retreat and increases in ice velocities. Velocities in the ice sheet interior are orders of magnitude smaller, making it challenging to detect velocity change. Here, we analyze ...

Abstract	Mass loss near the ice-sheet margin is evident from remote sensing as frontal retreat and increases in ice velocities. Velocities in the ice sheet interior are orders of magnitude smaller, making it challenging to detect velocity change. Here, we analyze a 35-year record of remotely sensed velocities, and a 6-year record of repeated GPS observations, at the East Greenland Ice-core Project (EastGRIP), located in the middle of the Northeast-Greenland Ice Stream (NEGIS). We find that the shear margins of NEGIS are accelerating, indicating a widening of the ice stream. We demonstrate that the widening of the ice stream is unlikely to be a response to recent changes at the outlets of NEGIS. Modelling indicates that the observed spatial fingerprint of acceleration is more consistent with a softening of the shear margin, e.g. due to evolving fabric or temperature, than a response to external forcing at the surface or bed.
Language	English
Publishing date	2022-09-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-32999-2
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Article ; Online: Comparison of diabetic and idiopathic sensory polyneuropathies with respect to nerve fibre affection and risk factors.

Itani, Mustapha / Gylfadottir, Sif / Krøigård, Thomas / Gaist, Laura / Holbech, Jakob Vormstrup / Kristensen, Alexander Gramm / Karlsson, Pall / Möller, Sören / Tankisi, Hatice / Gaist, David / Jensen, Troels S / Finnerup, Nanna Brix / Sindrup, Søren Hein

BMJ neurology open

2022 Volume 4, Issue 1, Page(s) e000247

Abstract: ... had greater body mass index (32 vs 27.4 kg/m: Conclusion: DPN and IPN showed clear differences ...

Abstract	Background and purpose: Chronic distal sensory or sensorimotor polyneuropathy is the most common pattern of polyneuropathy. The cause of this pattern is most often diabetes or unknown. This cross-sectional study is one of the first studies to compare the demographics, cardiovascular risk factors and clinical characteristics of diabetic polyneuropathy (DPN) with idiopathic polyneuropathy (IPN). Methods: Patients with DPN were included from a sample of 389 patients with type 2 diabetes mellitus (T2DM) enrolled from a national cohort of patients with recently diagnosed T2DM (Danish Centre for Strategic Research in Type 2 Diabetes cohort). Patients with IPN were included from a regional cohort of patients with symptoms of polyneuropathy referred for workup at a combined secondary and tertiary neurological centre (database cohort). Results: A total of 214 patients with DPN were compared with a total of 88 patients with IPN. Patients with DPN were older (67.4 vs 59 years) and had a longer duration of neuropathy symptoms. Patients with DPN had greater body mass index (32 vs 27.4 kg/m Conclusion: DPN and IPN showed clear differences in neuropathy characteristics, indicating that these two entities are to be regarded as aetiologically and pathogenetically distinct.
Language	English
Publishing date	2022-03-14
Publishing country	England
Document type	Journal Article
ISSN	2632-6140
ISSN (online)	2632-6140
DOI	10.1136/bmjno-2021-000247
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Article ; Online: Characteristics and long-term prognosis of Danish residents with a positive intrathecal antibody index test for herpes simplex virus or varicella-zoster virus compared with individuals with a positive cerebrospinal fluid PCR: a nationwide cohort study.

Platz, Isabella L / Tetens, Malte M / Dessau, Ram / Ellermann-Eriksen, Svend / Andersen, Nanna S / Jensen, Veronika Vorobieva Solholm / Østergaard, Christian / Bodilsen, Jacob / Søgaard, Kirstine Kobberøe / Bangsborg, Jette / Nielsen, Alex Christian Yde / Møller, Jens Kjølseth / Lebech, Anne-Mette / Omland, Lars Haukali / Obel, Niels

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2023 Volume 30, Issue 2, Page(s) 240–246

Abstract: Objectives: We compared characteristics and outcomes of individuals who in the cerebrospinal fluid (CSF) were positive for herpes simplex virus (HSV) or varicella-zoster virus (VZV)-intrathecal antibody index test ([AI]-positive) vs. individuals who ... ...

Abstract	Objectives: We compared characteristics and outcomes of individuals who in the cerebrospinal fluid (CSF) were positive for herpes simplex virus (HSV) or varicella-zoster virus (VZV)-intrathecal antibody index test ([AI]-positive) vs. individuals who were PCR-positive for HSV type 1 (HSV1), type 2 (HSV2), and for VZV. Methods: Nationwide cohort study of all Danish residents with positive CSF-AI or -PCR for HSV or VZV (1995-2021). We calculated short- and long-term risks as age-, sex-, and comorbidity-adjusted odds ratios (aOR), adjusted hazard ratios (aHR), and absolute risk differences with 95% CIs. Results: Compared with individuals with positive PCR for HSV1 (n = 321), HSV2 (n = 497), and VZV (n = 1054), individuals with a positive AI for HSV (n = 177) and VZV (n = 219) had CSF pleocytosis less frequently (leucocyte count >10/μL: HSV-AI: 39%, VZV-AI: 52%, HSV1-PCR: 81%, HSV2-PCR: 92%, VZV-PCR: 83%), and were less frequently diagnosed with central nervous system infection ([aOR {95%CI}]: HSV-AI vs. HSV1-PCR: [0.1 {0.1, 0.2}], HSV-AI vs. HSV2-PCR: [0.1 {0.0, 0.1}], VZV-AI vs. VZV-PCR: [0.2 {0.2, 0.3}]). Individuals with a positive HSV-AI or VZV-AI had increased risk of demyelinating disease ([aOR {95%CI}; aHR {95%CI}]: HSV-AI vs. HSV1-PCR: [4.6 {0.9, 24.5}; aHR not applicable], HSV-AI vs. HSV2-PCR: [10.4 {2.3, 45.9}; 12.4 {2.3, 66.0}], VZV-AI vs. VZV-PCR: [aOR not applicable; 10.3 {1.8, 58.8}]). Disability pension was less frequent among HSV-AI than HSV1-PCR cohort members (5-year risk difference: -23.6%, 95%CI: -35.2, -11.8), and more frequent among VZV-AI than VZV-PCR cohort members (5-year risk difference: 16.8%, 95%CI: 5.0, 28.7). Discussion: AI-positive individuals differ from PCR-positive individuals in several aspects. AI appears unspecific for current central nervous system infections.
MeSH term(s)	Humans ; Herpesvirus 3, Human/genetics ; Cohort Studies ; Herpesvirus 1, Human/genetics ; Prognosis ; Polymerase Chain Reaction ; Denmark/epidemiology
Language	English
Publishing date	2023-11-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2023.11.004
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Article ; Online: Physical constraints and functional plasticity of cellulases

Jeppe Kari / Gustavo A. Molina / Kay S. Schaller / Corinna Schiano-di-Cola / Stefan J. Christensen / Silke F. Badino / Trine H. Sørensen / Nanna S. Røjel / Malene B. Keller / Nanna Rolsted Sørensen / Bartlomiej Kolaczkowski / Johan P. Olsen / Kristian B. R. M. Krogh / Kenneth Jensen / Ana M. Cavaleiro / Günther H. J. Peters / Nikolaj Spodsberg / Kim Borch / Peter Westh

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 10

Abstract: Enzyme reactions at interfaces are common in both Nature and industrial applications but no general kinetic framework exists for interfacial enzymes. Here, the authors kinetically characterize 83 cellulases and identify a scaling relationship between ... ...

Abstract	Enzyme reactions at interfaces are common in both Nature and industrial applications but no general kinetic framework exists for interfacial enzymes. Here, the authors kinetically characterize 83 cellulases and identify a scaling relationship between ligand binding strength and maximal turnover, a so-called linear free energy relationship, which may help rationalize cellulolytic mechanisms and guide the selection of technical enzymes.
Keywords	Science ; Q
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Physical constraints and functional plasticity of cellulases.

Kari, Jeppe / Molina, Gustavo A / Schaller, Kay S / Schiano-di-Cola, Corinna / Christensen, Stefan J / Badino, Silke F / Sørensen, Trine H / Røjel, Nanna S / Keller, Malene B / Sørensen, Nanna Rolsted / Kolaczkowski, Bartlomiej / Olsen, Johan P / Krogh, Kristian B R M / Jensen, Kenneth / Cavaleiro, Ana M / Peters, Günther H J / Spodsberg, Nikolaj / Borch, Kim / Westh, Peter

Nature communications

2021 Volume 12, Issue 1, Page(s) 3847

Abstract: Enzyme reactions, both in Nature and technical applications, commonly occur at the interface of immiscible phases. Nevertheless, stringent descriptions of interfacial enzyme catalysis remain sparse, and this is partly due to a shortage of coherent ... ...

Abstract	Enzyme reactions, both in Nature and technical applications, commonly occur at the interface of immiscible phases. Nevertheless, stringent descriptions of interfacial enzyme catalysis remain sparse, and this is partly due to a shortage of coherent experimental data to guide and assess such work. In this work, we produced and kinetically characterized 83 cellulases, which revealed a conspicuous linear free energy relationship (LFER) between the substrate binding strength and the activation barrier. The scaling occurred despite the investigated enzymes being structurally and mechanistically diverse. We suggest that the scaling reflects basic physical restrictions of the hydrolytic process and that evolutionary selection has condensed cellulase phenotypes near the line. One consequence of the LFER is that the activity of a cellulase can be estimated from its substrate binding strength, irrespectively of structural and mechanistic details, and this appears promising for in silico selection and design within this industrially important group of enzymes.
MeSH term(s)	Algorithms ; Biocatalysis ; Cellulases/chemistry ; Cellulases/metabolism ; Cellulose/metabolism ; Hydrolysis ; Kinetics ; Molecular Dynamics Simulation ; Protein Binding ; Protein Domains ; Substrate Specificity
Chemical Substances	Cellulose (9004-34-6) ; Cellulases (EC 3.2.1.-)
Language	English
Publishing date	2021-06-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-24075-y
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Article ; Online: Pancreatic enzyme treatment in chronic pancreatitis: Quality of management and adherence to guidelines-A cross-sectional observational study.

Erchinger, Friedemann / Tjora, Erling / Nordaas, Ingrid Kvåle / Dimcevski, Georg / Olesen, Søren Schou / Jensen, Nanna / Dahl, Eva Efsen / Borch, Anders / Nøjgaard, Camilla / Novovic, Srdan / Barauskas, Giedrus / Ignatavicius, Povilas / Vujasinovic, Miroslav / Lőhr, Matthias / Laukkarinen, Johanna / Parhiala, Mikael / Drewes, Asbjørn Mohr / Engjom, Trond

United European gastroenterology journal

2022 Volume 10, Issue 8, Page(s) 844–853

Abstract: ... Patients and methods: Patients with definitive or probable CP according to M-ANNHEIM diagnostic criteria ...

Abstract	Objectives: Pancreatic exocrine insufficiency (PEI) is a common complication in patients with chronic pancreatitis (CP), leading to increased morbidity and mortality if not treated adequately. Pancreatic enzyme replacement therapy\|pancreas enzyme replacement therapy (PERT) is the cornerstone in treatment of patients with PEI. In the present study, we use data from the Scandinavian Baltic Pancreatic Club database to examine adherence of PERT according to United European Gastroenterology evidence-based guidelines treatment of CP. Patients and methods: Patients with definitive or probable CP according to M-ANNHEIM diagnostic criteria were included. We collected information on exposures, exocrine function, intake of pancreatic enzymes, and markers of nutrition. Fecal elastase <200 μg/g was defined as a marker for PEI. Enzyme replacement therapy of 100,000 lipase units or more was defined as adequate treatment. Results: We included 1006 patients from 8 centers in five countries. Sixty-four percent of the patients were correctly treated. Twenty-five per cent of PEI patients were not taking enzymes at all, and 20% of PEI patients were undertreated with insufficient PERT doses according to the guidelines. Fourteen percent of patients with sufficient pancreatic function were receiving enzymes despite normal exocrine pancreatic function. There were center differences. Current smoking was associated with lack of treatment and alcohol abuse was associated with under-treatment. There were no associations between "no treatment" or "under-treatment" for underweight or vitamin D deficiency. Conclusion: In our CP expert centers, the adherence to guidelines for enzyme treatment is insufficient. Both patient factors and center differences have influence on treatment adherence.
MeSH term(s)	Enzyme Replacement Therapy ; Exocrine Pancreatic Insufficiency/drug therapy ; Exocrine Pancreatic Insufficiency/etiology ; Humans ; Lipase/therapeutic use ; Pancreatic Elastase ; Pancreatitis, Chronic/complications ; Pancreatitis, Chronic/drug therapy
Chemical Substances	Lipase (EC 3.1.1.3) ; Pancreatic Elastase (EC 3.4.21.36)
Language	English
Publishing date	2022-08-18
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2728585-6
ISSN	2050-6414 ; 2050-6406
ISSN (online)	2050-6414
ISSN	2050-6406
DOI	10.1002/ueg2.12276
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