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  1. Article ; Online: Behandlung von Psoriasis durch Veränderungen des Lebensstils.

    Makrantonaki, Evgenia

    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete

    2019  Volume 70, Issue 12, Page(s) 993–994

    Title translation Treatment of psoriasis via lifestyle changes.
    MeSH term(s) Humans ; Life Style ; Psoriasis ; Risk Factors
    Language German
    Publishing date 2019-10-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2403-x
    ISSN 1432-1173 ; 0017-8470
    ISSN (online) 1432-1173
    ISSN 0017-8470
    DOI 10.1007/s00105-019-04495-0
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  2. Article: Hormonelle und gynäkologische Risikofaktoren bei frontal fibrosierender Alopezie

    Makrantonaki, Evgenia

    Karger Kompass Dermatologie

    2019  Volume 7, Issue 3, Page(s) 129–130

    Abstract: Introduction: Frontal fibrosing alopecia (FFA) is a condition that likely involves an interplay of autoimmune, hormonal, and environmental factors in its pathogenesis. There is a lack of comparative studies demonstrating the presence of hormonal ... ...

    Institution Derma Zentrum Wildeshausen, Wildeshausen, Deutschland Klinik für Dermatologie und Allergologie, Universitätsklinikum Ulm, Ulm, Deutschland
    Abstract Introduction: Frontal fibrosing alopecia (FFA) is a condition that likely involves an interplay of autoimmune, hormonal, and environmental factors in its pathogenesis. There is a lack of comparative studies demonstrating the presence of hormonal background differences in FFA patients compared to the general population. Materials and Methods: A single-center case-control study was designed, including 104 female FFA patients and 208 controls. Patients and controls were interviewed, and extensive data regarding their gynecological and hormonal background were recorded. Results: One hundred four cases and 208 age-matched controls were included in the study. A significant difference of 2 years in the age of menopause was detected with a consistent mean increase in fertile life for the control group of 1.7 years. After the multivariate analysis, we found previous intake of tamoxifen to be a risk factor for the development of FFA (OR 14.89). The only protective factor identified was the previous use of an intrauterine device (IUD) (OR 0.22). Conclusions: An earlier menopause and tamoxifen intake might promote or maintain FFA, while the use of an IUD might protect from developing FFA. Our results support the previously proposed hypothesis of an underlying hormonal mechanism in the etiopathogenesis of FFA and point out low-estrogen environments as an ideal condition for FFA development.
    Keywords Frontal fibrosing alopecia ; Hormonal background ; Gynecological background ; Menopause ; Tamoxifen ; Intrauterine device
    Language English
    Publishing date 2019-07-08
    Publisher S. Karger GmbH
    Publishing place Freiburg, Germany
    Document type Article
    Note Wissenstransfer
    ZDB-ID 3028561-6
    ISSN 2296-536X ; 2296-5424
    ISSN (online) 2296-536X
    ISSN 2296-5424
    DOI 10.1159/000501220
    Database Karger publisher's database

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  3. Article ; Online: Therapieresistente Immunglobulin-A-Vaskulitis (IgAV) mit systemischer Beteiligung beim Erwachsenen.

    Szmagala, Aleksandra / Zouboulis, Christos C / Baldus, Stephan / Anhuth, Dieter / Makrantonaki, Evgenia

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2023  Volume 21 Suppl 2, Page(s) 28–30

    Language German
    Publishing date 2023-05-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.15098_g
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  4. Article: Skin Mirrors Brain: A Chance for Alzheimer's Disease Research.

    Zouboulis, Christos C / Makrantonaki, Evgenia / Hossini, Amir M

    Advances in experimental medicine and biology

    2022  Volume 1339, Page(s) 371–380

    Abstract: The accessibility of skin and the easy isolation of its cells and matrix components provide a valuable tool for studying the molecular factors involved in human aging. Moreover, increasing evidence corroborates the use of the skin as a model for age- ... ...

    Abstract The accessibility of skin and the easy isolation of its cells and matrix components provide a valuable tool for studying the molecular factors involved in human aging. Moreover, increasing evidence corroborates the use of the skin as a model for age-associated pathological conditions in the entire body. Apparently based on the fact that the nervous system and skin share a common ectodermal origin, certain genes and molecular pathways associated with the pathomechanism of neurodegenerative diseases modify their expression with progressing skin aging. Alzheimer's disease and intrinsic skin aging share a common signalling pathway with major genes been regulated in both tissues. In our studies, functional neuronal cells derived from induced pluripotent stem cells originating from normal human skin fibroblasts of patients with sporadic Alzheimer's disease expressed proteins, which are implicated in Alzheimer's disease pathophysiology. Cumulative data lead to valuable insights regarding the understanding of Alzheimer's disease and its pathogenesis, given that these innovative patient cell models display the Alzheimer's disease phenotype.
    MeSH term(s) Alzheimer Disease/genetics ; Brain ; Humans ; Induced Pluripotent Stem Cells ; Neurons
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-78787-5_45
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Das Cushing-Syndrom im Spiegel der Haut

    Makrantonaki, Evgenia

    Karger Kompass Dermatologie

    2018  Volume 6, Issue 1, Page(s) 28–30

    Abstract: Cushing's syndrome is a rare endocrine disorder that comprises a large group of signs and symptoms resulting from chronic exposure to excess corticosteroids. Most cases of Cushing's syndrome are due to increased adrenocorticotropic hormone production ... ...

    Institution Derma Zentrum, Wildeshausen, Deutschland Klinik für Dermatologie und Allergologie, Universitätsklinikum Ulm, Ulm, Deutschland
    Abstract Cushing's syndrome is a rare endocrine disorder that comprises a large group of signs and symptoms resulting from chronic exposure to excess corticosteroids. Most cases of Cushing's syndrome are due to increased adrenocorticotropic hormone production from a pituitary adenoma, which is referred to as Cushing's disease. Most of the signs and symptoms are nonspecific and common in the general population, making a diagnosis often challenging. However, several dermatological manifestations, such as fragile skin, easy bruising, and reddish purple striae, are more discriminatory. Because uncontrolled Cushing's syndrome of any etiology is associated with substantial morbidity, including increased cardiovascular disease and mortality, it is important to make an early diagnosis. Unfortunately, median delays of 2 years to diagnosis have been reported. We report a case of a woman who had multiple dermatological findings, including facial plethora, easy bruising, violaceous striae, hirsutism, and acne, the latter 2 signs reflecting androgen excess. Of interest, our patient presented with a chief complaint of hair loss, a common complaint in the general population that occurs with a greater frequency in patients with Cushing's disease and is attributed to androgenetic alopecia, but it is rarely the presenting symptom.
    Keywords Cushing’s disease ; Female-pattern hair loss ; Androgenetic alopecia
    Language English
    Publishing date 2018-02-15
    Publisher S. Karger GmbH
    Publishing place Freiburg, Germany
    Document type Article
    Note Wissenstransfer
    ZDB-ID 3028561-6
    ISSN 2296-536X ; 2296-5424
    ISSN (online) 2296-536X
    ISSN 2296-5424
    DOI 10.1159/000485391
    Database Karger publisher's database

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  6. Article: Challenge and promise: Human skin aging.

    Makrantonaki, Evgenia

    Dermato-endocrinology

    2013  Volume 4, Issue 3, Page(s) 225–226

    Language English
    Publishing date 2013-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2540047-2
    ISSN 1938-1980 ; 1938-1972
    ISSN (online) 1938-1980
    ISSN 1938-1972
    DOI 10.4161/derm.23097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dermatoendokrinologie.

    Böhm, Markus / Makrantonaki, Evgenia / Zouboulis, Christos C

    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete

    2020  Volume 71, Issue 10, Page(s) 739–740

    Title translation Dermatoendocrinology.
    MeSH term(s) Dermatology ; Endocrinology ; Humans
    Keywords covid19
    Language German
    Publishing date 2020-09-28
    Publishing country Germany
    Document type Editorial
    ZDB-ID 2403-x
    ISSN 1432-1173 ; 0017-8470
    ISSN (online) 1432-1173
    ISSN 0017-8470
    DOI 10.1007/s00105-020-04683-3
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  8. Article: Hidradenitis suppurativa: Systemische Inflammation als Ursache berücksichtigen

    Makrantonaki, Evgenia

    Karger Kompass Dermatologie

    2017  Volume 5, Issue 3, Page(s) 146–147

    Abstract: Hintergrund: Hidradenitis suppurativa (HS) ist eine chronisch-entzündliche Hauterkrankung. Die Evidenzlage spricht zunehmend dafür, dass dysfunktionelle Immunreaktionen sowohl der adaptiven als auch der angeborenen Immunität an HS beteiligt sind. Die ... ...

    Institution Klinik für Dermatologie und Allergologie, Universität Ulm, Life Science Building N27, Ulm
    Abstract Hintergrund: Hidradenitis suppurativa (HS) ist eine chronisch-entzündliche Hauterkrankung. Die Evidenzlage spricht zunehmend dafür, dass dysfunktionelle Immunreaktionen sowohl der adaptiven als auch der angeborenen Immunität an HS beteiligt sind. Die kürzlich postulierte Assoziation der HS mit dem metabolischen Syndrom könnte zusätzlich zum Entzündungsgeschehen bei HS beitragen. Ziel: Untersuchung des Entzündungsstatus und des Leukozytenprofils im peripheren Blut von HS-Patienten. Material und Methoden: In einer komparativ aufgebauten Querschnittstudie untersuchten wir hochsensitives C-reaktives Protein (hs-CRP) und das Leukozytenprofil in Blutproben von stationär behandelten HS-Patienten (HS-HOSP), laut Selbstauskunft an HS leidenden Patienten aus der Allgemeinbevölkerung (HS-POP) sowie Populationskontrollen. Ergebnisse: Unsere Studie umfasste 32 Personen in der HS-HOSP-Gruppe, 430 in der HS-POP-Gruppe und 20 780 Kontrollen. Der mediane hs-CRP-Wert betrug in der HS-HOSP Gruppe 5,1 mg/l (Quartilsabstand 2,6-8,2), in der HS-POP-Gruppe 2,2 mg/l (1,0-4,3) und bei den Kontrollen 1,3 mg/l (0,7-2,9). Eine nach Lebensalter und Geschlecht adjustierte Analyse ergab ei- nen signifikant höheren hs-CRP-Wert für beide HS-Gruppen im Vergleich zur Kontrollgruppe (p < 0,0001). In der nach Alter und Geschlecht adjustierten Analyse war in beiden HS-Gruppen die Wahrscheinlichkeit einer Leukozytose im Vergleich zur Kontrolle signifikant erhöht; die Odds Ratio lag für die HS-HOSP-Gruppe bei 4,38 (95-%-KI = 2,18-8,80; p < 0,0001) und für die HS-POP-Gruppe bei 1,95 (95-%-KI = 1,58-2,42; p < 0,0001). Das nach Lebensalter und Geschlecht adjustierte Leukozyten-Differentialblutbild ergab signifikant höhere Werte für neutrophile Granulozyten (p < 0,0001) und Monozyten (p = 0,0014; p = 0,0004) in den HS-Gruppen im Vergleich zu den Kontrollen. Schlussfolgerung: Die mit HS assoziierten hs-CRP-Werte scheinen im intermediären Bereich zu liegen (2,2-5,1 mg/l), was eher auf eine systemische Inflammation als auf eine Infektion hindeutet. Bei der Leukozytose im peripheren Blut bei HS standen neutrophile Granulozyten und Monozyten im Mittelpunkt.
    Keywords Epidemiologie ; Hidradenitis suppurativa ; Weiße Blutzellen ; Leukozyten ; Inflammation ; Infektion
    Language German
    Publishing date 2017-07-12
    Publisher S. Karger GmbH
    Publishing place Freiburg, Germany
    Document type Article
    Note Wissenstransfer
    ZDB-ID 3028561-6
    ISSN 2296-536X ; 2296-5424
    ISSN (online) 2296-536X
    ISSN 2296-5424
    DOI 10.1159/000475562
    Database Karger publisher's database

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  9. Article ; Online: Connective Tissue and Fibroblast Senescence in Skin Aging.

    Wlaschek, Meinhard / Maity, Pallab / Makrantonaki, Evgenia / Scharffetter-Kochanek, Karin

    The Journal of investigative dermatology

    2021  Volume 141, Issue 4S, Page(s) 985–992

    Abstract: There is increasing evidence that skin aging is significantly enforced by the accumulation of senescent dermal fibroblasts. Various stressors damaging macromolecules inside and outside fibroblasts are responsible. In addition, NK cells fail to adequately ...

    Abstract There is increasing evidence that skin aging is significantly enforced by the accumulation of senescent dermal fibroblasts. Various stressors damaging macromolecules inside and outside fibroblasts are responsible. In addition, NK cells fail to adequately remove senescent (SEN) fibroblasts from tissues. SEN fibroblasts by the release of the proinflammatory, tissue degrading senescent-associated secretory phenotype factors and vesicles with distinct cargo impact on their endogenous niche and spread senescence and skin aging. In this review, we will further discuss less noticed facets, including the plasticity of distinct dermal fibroblast phenotypes, the underestimated impact of the extracellular matrix itself, and the depletion of fibroblast subsets on skin homeostasis and aging.
    MeSH term(s) Animals ; Cell Communication ; Cellular Senescence ; Connective Tissue/pathology ; Extracellular Matrix/pathology ; Fibroblasts/pathology ; Humans ; Killer Cells, Natural ; Mice ; Models, Animal ; Skin/cytology ; Skin/pathology ; Skin Aging
    Language English
    Publishing date 2021-02-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2020.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Hautalterung – zelluläre Seneszenz : Wohin geht die Reise?

    Scharffetter-Kochanek, Karin / Wang, Yongfang / Makrantonaki, Evgenia / Crisan, Diana / Wlaschek, Meinhard / Geiger, Hartmut / Maity, Pallab

    Dermatologie (Heidelberg, Germany)

    2023  Volume 74, Issue 9, Page(s) 645–656

    Abstract: Background: Cellular senescence is the main cause of skin and organ aging and is associated with a wide range of aging-related diseases.: Objectives: To understand which senolytics, senomorphics, and cell-based therapies have been developed to ... ...

    Title translation Skin aging-cellular senescence : What is the future?
    Abstract Background: Cellular senescence is the main cause of skin and organ aging and is associated with a wide range of aging-related diseases.
    Objectives: To understand which senolytics, senomorphics, and cell-based therapies have been developed to alleviate and even rejuvenate skin aging and reduce cellular senescence.
    Methods: Basic literature for the mode of action of senolytics and senomorphics and their clinical perspectives in daily routine are discussed.
    Results: Various causes lead to mitochondrial dysfunction and the activation of pro-aging signaling pathways, which eventually lead to cellular senescence with degradation of structural proteins of the dermal connective tissue and severe suppression of regenerative stem cell niches of the skin.
    Conclusions: Depletion of senescent cells suppress skin aging and enforce rejuvenation of skin and other organs and their function. The removal of senescent cells by cells of the native immune system is severely disturbed during aging. Selected senolytics and senomorphics are approved and are already on the market.
    MeSH term(s) Skin Aging ; Senotherapeutics ; Cellular Senescence ; Cell- and Tissue-Based Therapy
    Chemical Substances Senotherapeutics
    Language German
    Publishing date 2023-08-28
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-7013
    ISSN (online) 2731-7013
    DOI 10.1007/s00105-023-05201-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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