LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 618

Search options

  1. Article ; Online: An important legacy in public health nutrition: Ruth English AO PhD (1929-2015).

    Wood, Beverley

    Nutrition & dietetics: the journal of the Dietitians Association of Australia

    2020  Volume 77, Issue 4, Page(s) 479–480

    MeSH term(s) History, 20th Century ; History, 21st Century ; Humans ; Nutritional Status ; Public Health
    Language English
    Publishing date 2020-06-04
    Publishing country Australia
    Document type Biography ; Historical Article ; Letter
    ZDB-ID 2082047-1
    ISSN 1747-0080 ; 1446-6368
    ISSN (online) 1747-0080
    ISSN 1446-6368
    DOI 10.1111/1747-0080.12618
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Developmental exposure to 17-α-hydroxyprogesterone caproate disrupts decision-making in adult female rats: A potential role for a dopaminergic mechanism.

    Graney, Paige L / Chen, Michael Y / Wood, Ruth I / Wagner, Christine K

    Hormones and behavior

    2024  Volume 163, Page(s) 105550

    Abstract: The synthetic progestin, 17α-hydroxyprogesterone caproate (17-OHPC), is administered to pregnant individuals at risk for preterm birth and is likely transferred from mother to fetus. Yet, there is little information regarding the potential effects of 17- ... ...

    Abstract The synthetic progestin, 17α-hydroxyprogesterone caproate (17-OHPC), is administered to pregnant individuals at risk for preterm birth and is likely transferred from mother to fetus. Yet, there is little information regarding the potential effects of 17-OHPC administration on behavioral and neural development in offspring. In rats, neonatal 17-OHPC exposure altered dopaminergic fiber distribution and density in the prelimbic medial prefrontal cortex (mPFC) in neonates and adolescents, respectively. Additionally, neonatal 17-OHPC exposure in male rats increased response omissions in a delay discounting task of impulsive decision-making. Because developmental 17-OHPC exposure has differential effects in males and females, investigating the effects of 17-OHPC on impulsive decision-making in female rats is necessary. The present study tested the effects of developmental 17-OHPC exposure (P1-P14) in a delay discounting task in which female rats chose between a small immediate reward and a larger delayed (0, 15 30, or 45 s) reward. 17-OHPC-exposed females made more omissions than controls. There was no effect of 17-OHPC on large reward preference nor on response time, and omissions were similar during both free- and forced-choice trials. The present study also aimed to investigate the neural mechanisms underlying omissions in 17-OHPC-exposed female rats. The dopamine transporter inhibitor, methylphenidate (MPH), was administered prior to delay discounting testing. MPH treatment did not reduce omissions in 17-OHPC-exposed females. If anything, MPH increased omissions in control females nearly fourfold during the longest delays. These results suggest that developmental 17-OHPC exposure increased omissions without affecting impulsivity or slowing decision-making. Furthermore, omissions may be regulated, at least in part, by dopaminergic mechanisms.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 214409-8
    ISSN 1095-6867 ; 0018-506X
    ISSN (online) 1095-6867
    ISSN 0018-506X
    DOI 10.1016/j.yhbeh.2024.105550
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Effort-based decision making in response to high-dose androgens: role of dopamine receptors.

    Donovan, Alexandra / Wood, Ruth I

    Behavioural pharmacology

    2022  Volume 33, Issue 7, Page(s) 435–441

    Abstract: Introduction: Anabolic-androgenic steroids (AAS) are performance-enhancing drugs used by both world-class and rank-and-file athletes. AAS abuse has been linked with risky decision-making, ranging from drunk driving to abusing multiple drugs. Our lab ... ...

    Abstract Introduction: Anabolic-androgenic steroids (AAS) are performance-enhancing drugs used by both world-class and rank-and-file athletes. AAS abuse has been linked with risky decision-making, ranging from drunk driving to abusing multiple drugs. Our lab uses operant behavior in rats to test the effects of AAS (testosterone) on decision making. In our previous study, testosterone caused rats to work harder for food reward during an effort discounting (ED) task. ED is sensitive to dopamine in the nucleus accumbens, and AAS alter accumbens dopamine receptor expression. Accordingly, we determined if testosterone increases response to dopamine receptor antagonists during ED.
    Methods: Rats were treated chronically with high-dose testosterone (7.5 mg/kg; n = 9) or vehicle (n = 9). We measured baseline preference for the large reward in an ED task, where rats choose between a small easy reward (one lever press for one sugar pellet) and a large difficult reward (2, 5, 10, or 15 presses for three pellets). Preference for the large reward was measured after administration of D1-like (SCH23390, 0.01 mg/kg) or D2-like (eticlopride, 0.06 mg/kg) receptor antagonists.
    Results: At baseline, testosterone- and vehicle-treated rats showed similar preference for the large reward lever (FR5, testosterone: 68.6 ± 9.7% and vehicle: 85.7 ± 2.5%). SCH23390 reduced large reward preference significantly in both groups (FR5, testosterone: 41.3 ± 9.2%; vehicle: 49.1 ± 8.2%; F(1,16) = 17.7; P < 0.05). Eticlopride decreased large reward preference in both groups, but more strongly in testosterone-treated rats (FR5: testosterone: 37.0 ± 9.7%; vehicle: 56.3 ± 7.8%; F(1,16) = 35.3; P < 0.05).
    Conclusion: Testosterone increases response to dopamine D2-like receptor blockade, and this contributes to previously observed changes in decision-making behaviors.
    MeSH term(s) Androgens/metabolism ; Androgens/pharmacology ; Animals ; Conditioning, Operant ; Decision Making ; Dopamine/metabolism ; Dopamine Antagonists/metabolism ; Dopamine Antagonists/pharmacology ; Humans ; Nucleus Accumbens/metabolism ; Performance-Enhancing Substances/metabolism ; Performance-Enhancing Substances/pharmacology ; Rats ; Rats, Long-Evans ; Receptors, Dopamine D1/metabolism ; Reward ; Salicylamides ; Sugars/metabolism ; Sugars/pharmacology ; Testosterone/pharmacology
    Chemical Substances Androgens ; Dopamine Antagonists ; Performance-Enhancing Substances ; Receptors, Dopamine D1 ; Salicylamides ; Sugars ; Testosterone (3XMK78S47O) ; eticlopride (J8M468HBH4) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2022-09-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1027374-8
    ISSN 1473-5849 ; 0955-8810
    ISSN (online) 1473-5849
    ISSN 0955-8810
    DOI 10.1097/FBP.0000000000000687
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Book: A stereotaxic atlas of the golden hamster brain

    Morin, Lawrence P. / Wood, Ruth I.

    2001  

    Title variant The golden hamster brain
    Author's details Lawrence P. Morin ; Ruth I. Wood
    Language English
    Size XV, 146 S. : überw. Ill.
    Publisher Acad. Press
    Publishing place San Diego u.a.
    Publishing country United States
    Document type Book
    Accompanying material 1 CD-ROM (12 cm)
    HBZ-ID HT013002050
    ISBN 0-12-507040-3 ; 978-0-12-507040-9
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

  5. Article ; Online: Anabolic-androgenic steroid abuse and cognitive impairment: Testosterone IMPAIRS biconditional task performance in male rats.

    Wood, Ruth I / Serpa, Rebecka O

    Behavioural brain research

    2019  Volume 379, Page(s) 112339

    Abstract: Our goal is to understand the consequences of anabolic-androgenic steroid (AAS) abuse on cognitive function, using rats as a model. There is relatively little research on how AAS abuse impacts cognition. In the present study, rats were tested for their ... ...

    Abstract Our goal is to understand the consequences of anabolic-androgenic steroid (AAS) abuse on cognitive function, using rats as a model. There is relatively little research on how AAS abuse impacts cognition. In the present study, rats were tested for their ability to use contextual information to guide decision-making in biconditional discrimination. The Stroop task is a classic human test for contextual decision-making. In rodents, biconditional discrimination challenges subjects to use contextual cues in the operant chamber to resolve the correct lever response when auditory and visual cues are incongruent. The hypothesis is that chronic high-dose testosterone impairs biconditional discrimination. Rats were trained in 24 trials/day over 14 days, in alternating sessions with each environment. On a flat floor with houselight illuminated, auditory cues (clicker vs tone) signified the active lever. On a barred floor with no light, visual cues from 2 stimulus lights (constant vs blinking) identified the active lever. Rats treated chronically with testosterone (7.5 mg/kg) were unimpaired in task acquisition, and all rats learned to select the correct lever in response to auditory or visual cues. During extinction, controls made significantly more correct than incorrect responses in congruent trials (p < 0.05 by paired t-test), but testosterone-treated rats failed to show a similar preference. This was reflected by significant interactions of drug x cue agreement (F
    MeSH term(s) Anabolic Agents/administration & dosage ; Anabolic Agents/adverse effects ; Androgens/administration & dosage ; Androgens/adverse effects ; Animals ; Behavior, Animal/drug effects ; Cognitive Dysfunction/chemically induced ; Conditioning, Operant/drug effects ; Decision Making/drug effects ; Discrimination Learning/drug effects ; Disease Models, Animal ; Male ; Psychomotor Performance/drug effects ; Rats ; Rats, Long-Evans ; Substance-Related Disorders/physiopathology ; Testosterone/administration & dosage ; Testosterone/adverse effects
    Chemical Substances Anabolic Agents ; Androgens ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2019-11-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 449927-x
    ISSN 1872-7549 ; 0166-4328
    ISSN (online) 1872-7549
    ISSN 0166-4328
    DOI 10.1016/j.bbr.2019.112339
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Developmental exposure to 17α-hydroxyprogesterone caproate impairs adult delayed reinforcement and reversal learning in male and female rats.

    Serpa, Rebecka O / Wagner, Christine K / Wood, Ruth I

    Journal of neuroendocrinology

    2020  Volume 32, Issue 6, Page(s) e12862

    Abstract: Women with a history of unexplained miscarriage are frequently prescribed the synthetic progestin, 17α-hydroxyprogesterone caproate (17-OHPC) during the middle trimester of pregnancy. However, little is known about the long-term behavioural effects of 17- ...

    Abstract Women with a history of unexplained miscarriage are frequently prescribed the synthetic progestin, 17α-hydroxyprogesterone caproate (17-OHPC) during the middle trimester of pregnancy. However, little is known about the long-term behavioural effects of 17-OHPC. Work in rodents suggests that the developing brain is sensitive to progestins. Neonatal 17-OHPC impairs adult performance in set-shifting and delay discounting. The present study tested the effects of 17-OHPC (0.5 mg kg
    MeSH term(s) 17 alpha-Hydroxyprogesterone Caproate/pharmacology ; Animals ; Animals, Newborn ; Behavior, Animal/drug effects ; Conditioning, Operant/drug effects ; Delay Discounting/drug effects ; Female ; Male ; Pregnancy ; Prenatal Exposure Delayed Effects/chemically induced ; Prenatal Exposure Delayed Effects/physiopathology ; Prenatal Exposure Delayed Effects/psychology ; Rats ; Rats, Long-Evans ; Reinforcement, Psychology ; Reversal Learning/drug effects
    Chemical Substances 17 alpha-Hydroxyprogesterone Caproate (276F2O42F5)
    Language English
    Publishing date 2020-06-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1007517-3
    ISSN 1365-2826 ; 0953-8194
    ISSN (online) 1365-2826
    ISSN 0953-8194
    DOI 10.1111/jne.12862
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Cooperative responses in rats playing a 2 × 2 game: Effects of opponent strategy, payoff, and oxytocin.

    Donovan, Alexandra / Ryan, Erin / Wood, Ruth I

    Psychoneuroendocrinology

    2020  Volume 121, Page(s) 104803

    Abstract: The present study tested cooperation in rats playing a 2 × 2 game (2 players, 2 responses) in an operant chamber, where players choose to cooperate or defect without knowledge of their partner's choice. We evaluated cooperative responses in rats ( ... ...

    Abstract The present study tested cooperation in rats playing a 2 × 2 game (2 players, 2 responses) in an operant chamber, where players choose to cooperate or defect without knowledge of their partner's choice. We evaluated cooperative responses in rats (Subjects) playing different games [iterated Prisoner's Dilemma (IPD), Stag Hunt] with a Stooge partner utilizing different response strategies [Tit-for-tat (TFT), Win-stay, Lose-shift (WSLS), Random], and we determined the effects of oxytocin (OT). IPD trial outcomes and payoffs included mutual cooperation (reward, R, 3 sugar pellets each), mutual defection (punishment, P, 1 pellet each), or unilateral defection (temptation, T, 5 pellets) and cooperation (sucker, S, 0 pellets). Stag Hunt was similar, except that T = 2 pellets. We hypothesized that Subjects would make more cooperative responses when playing Stag Hunt vs IPD, when playing IPD with a Stooge using TFT vs WSLS or Random, and when treated with OT. At baseline, Subjects' overall likelihood of cooperation was unaffected by the game (IPD vs SH) or by the Stooges' response strategy (TFT, WSLS, Random). Cooperative responses earned Subjects more pellets, except when playing with a Stooge using a random strategy. Trial outcomes (R, T, S or P) also varied by game and strategy, although the mutual defection (P) was the most common. Systemic pretreatment with OT increased Subjects' cooperative responses, resulting in fewer P and more R outcomes. In particular, IPD-Random Subjects were more cooperative, even at the expense of earning fewer pellets. These results demonstrate that OT increases cooperative behavior in rats playing 2 × 2 games.
    MeSH term(s) Animals ; Behavior, Animal/drug effects ; Behavior, Animal/physiology ; Cooperative Behavior ; Game Theory ; Male ; Motivation ; Oxytocin/pharmacology ; Prisoner Dilemma ; Punishment ; Rats ; Rats, Long-Evans ; Reward
    Chemical Substances Oxytocin (50-56-6)
    Language English
    Publishing date 2020-08-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 197636-9
    ISSN 1873-3360 ; 0306-4530
    ISSN (online) 1873-3360
    ISSN 0306-4530
    DOI 10.1016/j.psyneuen.2020.104803
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Performance on a modified signal detection task of attention is impaired in male and female rats following developmental exposure to the synthetic progestin, 17α-hydroxyprogesterone caproate.

    Lolier, Melanie / Miller, Roy O / Wood, Ruth I / Wagner, Christine K

    Hormones and behavior

    2021  Volume 135, Page(s) 105039

    Abstract: Based on evidence that the developing mesocortical dopamine pathway is sensitive to progestins, in the present study we tested the hypothesis that attention, a fundamental component of successful cognitive behavior, is disrupted by developmental exposure ...

    Abstract Based on evidence that the developing mesocortical dopamine pathway is sensitive to progestins, in the present study we tested the hypothesis that attention, a fundamental component of successful cognitive behavior, is disrupted by developmental exposure to the synthetic progestin, 17-α-hydroxyprogesterone caproate (17-OHPC). To assess attentional impairments, a modified signal detection task was utilized with three stimulus modalities: compound (light and tone), light alone, and tone alone, for four stimulus durations (2, 0.5, 0.25, 0.125 s). Adult rats were trained to push one lever if they detected the stimulus, and another lever if the stimulus was not presented. 17-OHPC animals were able to attend to the task, as evidenced by similar correct responses as controls. However, as the task became increasingly difficult at shorter durations, 17-OHPC animals made significantly more omissions compared to controls, suggesting that 17-OHPC treatment may disrupt attentional processes and/or delay response time. These findings add to the current body of literature demonstrating that exposure to 17-OHPC during development produces deficits in cognitive behavior in adulthood. These results may inform potential risks associated with 17-OHPC treatment in pregnant women with a history of preterm delivery who are commonly recipients of such treatment.
    MeSH term(s) 17 alpha-Hydroxyprogesterone Caproate ; Adult ; Animals ; Attention ; Female ; Humans ; Male ; Pregnancy ; Premature Birth ; Progestins/pharmacology ; Rats
    Chemical Substances Progestins ; 17 alpha-Hydroxyprogesterone Caproate (276F2O42F5)
    Language English
    Publishing date 2021-07-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 214409-8
    ISSN 1095-6867 ; 0018-506X
    ISSN (online) 1095-6867
    ISSN 0018-506X
    DOI 10.1016/j.yhbeh.2021.105039
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Developmental exposure to the synthetic progestin, 17α-hydroxyprogesterone caproate, disrupts the mesocortical serotonin pathway and alters impulsive decision-making in rats.

    Fahrenkopf, Allyssa / Li, Grace / Wood, Ruth I / Wagner, Christine K

    Developmental neurobiology

    2021  Volume 81, Issue 6, Page(s) 763–773

    Abstract: The synthetic progestin, 17α-hydroxyprogesterone caproate (17-OHPC), is administered to women at risk for preterm birth during a critical period of fetal development for mesocortical pathways. Yet, little information is available regarding the potential ... ...

    Abstract The synthetic progestin, 17α-hydroxyprogesterone caproate (17-OHPC), is administered to women at risk for preterm birth during a critical period of fetal development for mesocortical pathways. Yet, little information is available regarding the potential effects of 17-OHPC on the developing fetal brain. In rat models, the mesocortical serotonin pathway is sensitive to progestins. Progesterone receptor (PR) is expressed in layer 3 pyramidal neurons of medial prefrontal cortex (mPFC) and in serotonergic neurons of the dorsal raphe. The present study tested the hypothesis that exposure to 17-OHPC during development disrupts serotonergic innervation of the mPFC in adolescence and impairs behavior mediated by this pathway in adulthood. Administration of 17-OHPC from postnatal days 1-14 decreased the density of SERT-ir fibers within superficial and deep layers and decreased the density of synaptophysin-ir boutons in all layers of prelimbic mPFC at postnatal day 28. In addition, rats exposed to 17-OHPC during development were less likely to make impulsive choices in the Delay Discounting task, choosing the larger, delayed reward more often than controls at moderate delay times. Interestingly, 17-OHPC exposed rats were more likely to fail to make any choice (i.e., increased omissions) compared to controls at longer delays, suggesting disruptions in decision-making. These results suggest that further investigation is warranted in the clinical use of 17-OHPC to better inform a risk/benefit analysis of progestin use in pregnancy.
    MeSH term(s) 17 alpha-Hydroxyprogesterone Caproate/pharmacology ; Adult ; Animals ; Female ; Humans ; Infant, Newborn ; Pregnancy ; Premature Birth ; Progestins/pharmacology ; Rats ; Reward ; Serotonin
    Chemical Substances Progestins ; 17 alpha-Hydroxyprogesterone Caproate (276F2O42F5) ; Serotonin (333DO1RDJY)
    Language English
    Publishing date 2021-08-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2256184-5
    ISSN 1932-846X ; 1097-4695 ; 1932-8451 ; 0022-3034
    ISSN (online) 1932-846X ; 1097-4695
    ISSN 1932-8451 ; 0022-3034
    DOI 10.1002/dneu.22847
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Male rats play a repeated donation game.

    Li, Grace / Wood, Ruth I

    Physiology & behavior

    2017  Volume 174, Page(s) 95–103

    Abstract: While previous studies have demonstrated direct and generalized reciprocity in female Norway rats [26], the present study determined if unrelated male laboratory rats respond on behalf of a partner in an iterated sequential game. Pairs of rats worked for ...

    Abstract While previous studies have demonstrated direct and generalized reciprocity in female Norway rats [26], the present study determined if unrelated male laboratory rats respond on behalf of a partner in an iterated sequential game. Pairs of rats worked for food reward in an operant chamber, where participants alternated as Donor and Responder in successive trials. In each trial, the Donor chose between variable and constant reward levers, where the constant reward lever delivered 1 pellet, and the variable reward lever triggered insertion of Responder lever(s); the Donor received 2 pellets when the Responder made any response. In forced-choice constant (FC) trials, the Responder also received 1 pellet for responding on the constant reward lever. In forced-choice variable (FV) trials, the Responder received no pellets for responding on the variable reward lever. In free-choice (FR) trials, the Responder chose between constant (1 pellet) and variable reward levers (0 pellets). With their cagemate, rats earned 61.4±2.0 pellets (64.0±2.1% of 96 possible pellets). As Donor in FC trials, rats preferred the variable reward lever, and the Responder responded frequently. In FV trials, Donor preference for the variable reward lever declined as Responder lever responses decreased. In FR trials, rats alternated responding on variable and constant reward levers as Donor and Responder, respectively. When paired with a new partner, there was no effect on Donor responses, but responses by the Responder decreased in the FV block. Similar effects were observed when paired with a maximally-cooperative stooge. Importantly, rats did not adjust their behavior as Donor to receive more pellets. Results suggest that unrelated male rats will work on behalf of a partner, and that their behavior is sensitive to familiarity, and to cooperative responses by their partner.
    MeSH term(s) Animals ; Choice Behavior/physiology ; Conditioning, Operant/physiology ; Cooperative Behavior ; Male ; Motivation/physiology ; Rats ; Rats, Long-Evans ; Reinforcement (Psychology)
    Language English
    Publishing date 2017-03-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3907-x
    ISSN 1873-507X ; 0031-9384
    ISSN (online) 1873-507X
    ISSN 0031-9384
    DOI 10.1016/j.physbeh.2017.03.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top