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  1. Book: Advances in the neuroscience of addiction

    Kuhn, Cynthia M.

    (Frontiers in neuroscience)

    2010  

    Author's details ed. by Cynthia M. Kuhn
    Series title Frontiers in neuroscience
    Keywords Substance-Related Disorders / metabolism ; Behavior, Addictive / metabolism ; Research
    Language English
    Size XVI, 222 S. : Ill., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton, Fla. u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT015535783
    ISBN 978-0-8493-7391-6 ; 0-8493-7391-3
    Database Catalogue ZB MED Medicine, Health

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    2010 A 2269 order for loan Magazin

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  2. Article ; Online: The effects of peri-adolescent alcohol use on the developing hippocampus.

    Walker, C D / Kuhn, Cynthia M / Risher, M-L

    International review of neurobiology

    2021  Volume 160, Page(s) 251–280

    Abstract: Adolescence is a period of continued brain development. Regions of the brain, such as the hippocampus, continue to undergo refinement and maturation throughout adolescence and into early adulthood. Adolescence is also a time of heightened sensitivity to ... ...

    Abstract Adolescence is a period of continued brain development. Regions of the brain, such as the hippocampus, continue to undergo refinement and maturation throughout adolescence and into early adulthood. Adolescence is also a time of heightened sensitivity to novelty and reward, which contribute to an increase in risk-taking behaviors including the use of drugs and alcohol. Importantly, binge drinking is highly prevalent among adolescents and emerging adults. The hippocampus which is important for the integration of emotion, reward, homeostasis, and memory is particularly vulnerable to the neurotoxic effects of alcohol. In this chapter, we cover the fundamentals of hippocampal neuroanatomy and the current state of knowledge of the acute and chronic effects of ethanol in adolescent humans and adolescent rodent models. We focus on the hippocampal-dependent behavioral, structural, and neurochemical changes and identify knowledge gaps in our understanding of age-dependent neurobiological effects of alcohol use.
    MeSH term(s) Adolescent ; Ethanol/toxicity ; Hippocampus/drug effects ; Hippocampus/growth & development ; Humans ; Underage Drinking
    Chemical Substances Ethanol (3K9958V90M)
    Language English
    Publishing date 2021-09-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 209876-3
    ISSN 2162-5514 ; 0074-7742
    ISSN (online) 2162-5514
    ISSN 0074-7742
    DOI 10.1016/bs.irn.2021.08.003
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  3. Article ; Online: Cognitive Deficits in Executive and Language Functions Predict Postoperative Delirium.

    Olotu, Cynthia / Lebherz, Lisa / Ascone, Leonie / Scherwath, Angela / Kühn, Simone / Härter, Martin / Kiefmann, Rainer

    Journal of cardiothoracic and vascular anesthesia

    2023  Volume 37, Issue 12, Page(s) 2552–2560

    Abstract: Objectives: Postoperative delirium (POD) remains the most common complication in older adults, with cognitive impairment being the main risk factor. Patients with mild cognitive impairment, in particular, have much to lose from delirium; despite this, ... ...

    Abstract Objectives: Postoperative delirium (POD) remains the most common complication in older adults, with cognitive impairment being the main risk factor. Patients with mild cognitive impairment, in particular, have much to lose from delirium; despite this, their cognitive impairment might be clinically overlooked. Understanding which cognitive domains are particularly predictive in this regard may improve the sensitivity of preoperative testing and allow for a more targeted application of resource-intensive measures to prevent delirium in the perioperative period. The authors conducted this study with the aim of identifying the most indicative cognitive domains.
    Design: A secondary analysis of a randomized controlled trial.
    Setting: At a single center, the University Medical Centre Hamburg in Hamburg, Germany.
    Participants: Patients ≥60 years without major neurocognitive disorders (dementia, Mini-Mental State Examination score ≤23) scheduled for cardiovascular surgery.
    Measurements and main results: Preoperative neuropsychologic testing and delirium screening were performed twice daily until postoperative day 5. A multiple logistic regression model was applied to determine the predictive ability of test performances for the development of delirium.
    Results: A total of 541 patients were included in the analysis; the delirium rate was 15.6%. After controlling for confounders, only low performance within the Trail Making Test B/A (odds ratio [OR] = 1.32; 95% CI: 1.05-1.66) and letter fluency (OR = 0.66; 95% CI: 0.45-0.96) predicted a particularly high risk for delirium development. The discriminative ability of the final multiple logistic regression model to predict POD had an area under the curve of 0.786.
    Conclusions: Impairment in the cognitive domains of executive function and language skills associated with memory, inhibition, and access speed seem to be particularly associated with the development of delirium after surgery in adults ≥65 years of age without apparent preoperative neurocognitive impairment.
    MeSH term(s) Humans ; Aged ; Emergence Delirium/diagnosis ; Emergence Delirium/epidemiology ; Emergence Delirium/etiology ; Delirium/diagnosis ; Delirium/epidemiology ; Delirium/etiology ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Prospective Studies ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/etiology ; Cognition/physiology ; Risk Factors
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2023.08.154
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  4. Article ; Online: A SSTDR Methodology, Implementations, and Challenges.

    Kingston, Samuel / Benoit, Evan / Edun, Ayobami S / Elyasichamazkoti, Farhad / E Sweeney, Dawn / Harley, Joel B / Kuhn, Paul K / Furse, Cynthia M

    Sensors (Basel, Switzerland)

    2021  Volume 21, Issue 16

    Abstract: Sequence time-domain reflectometry (STDR) and spread spectrum time-domain reflectometry (SSTDR) detect, locate, and diagnose faults in live (energized) electrical systems. In this paper, we survey the present SSTDR literature for discussions on theory, ... ...

    Abstract Sequence time-domain reflectometry (STDR) and spread spectrum time-domain reflectometry (SSTDR) detect, locate, and diagnose faults in live (energized) electrical systems. In this paper, we survey the present SSTDR literature for discussions on theory, algorithms used in its analysis, and its more prominent implementations and applications. Our review includes both scientific litera-ture and selected patents. We also discuss future applications of SSTDR.
    MeSH term(s) Algorithms ; Electricity
    Language English
    Publishing date 2021-08-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s21165268
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  5. Article ; Online: Corrigendum to "Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress" [Psychoneuroendocrinology 79 (2017) (May) 13-19].

    Jiang, Rong / Babyak, Michael A / Brummett, Beverly H / Siegler, Ilene C / Kuhn, Cynthia M / Williams, Redford B

    Psychoneuroendocrinology

    2020  Volume 121, Page(s) 104861

    Language English
    Publishing date 2020-09-12
    Publishing country England
    Document type Published Erratum
    ZDB-ID 197636-9
    ISSN 1873-3360 ; 0306-4530
    ISSN (online) 1873-3360
    ISSN 0306-4530
    DOI 10.1016/j.psyneuen.2020.104861
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  6. Article ; Online: Glb1 knockout mouse model shares natural history with type II GM1 gangliosidosis patients.

    Nicoli, Elena-Raluca / Huebecker, Mylene / Han, Sangwoo T / Garcia, Karolyn / Munasinghe, Jeeva / Lizak, Martin / Latour, Yvonne / Yoon, Robin / Glase, Brianna / Tyrlik, Michal / Peiravi, Morteza / Springer, Danielle / Baker, Eva H / Priestman, David / Sidhu, Rohini / Kell, Pamela / Jiang, Xuntian / Kolstad, Josephine / Kuhn, Anna Luisa /
    Shazeeb, Mohammed Salman / Acosta, Maria T / Proia, Richard L / Platt, Frances M / Tifft, Cynthia J

    Molecular genetics and metabolism

    2023  Volume 138, Issue 2, Page(s) 107508

    Abstract: GM1 gangliosidosis is a rare lysosomal storage disorder affecting multiple organ systems, primarily the central nervous system, and is caused by functional deficiency of β-galactosidase (GLB1). Using CRISPR/Cas9 genome editing, we generated a mouse model ...

    Abstract GM1 gangliosidosis is a rare lysosomal storage disorder affecting multiple organ systems, primarily the central nervous system, and is caused by functional deficiency of β-galactosidase (GLB1). Using CRISPR/Cas9 genome editing, we generated a mouse model to evaluate characteristics of the disease in comparison to GM1 gangliosidosis patients. Our Glb1
    MeSH term(s) Male ; Female ; Animals ; Mice ; Gangliosidosis, GM1/genetics ; Mice, Knockout ; beta-Galactosidase/genetics ; Lysosomal Storage Diseases/genetics ; Exons
    Chemical Substances beta-Galactosidase (EC 3.2.1.23)
    Language English
    Publishing date 2023-01-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1418518-0
    ISSN 1096-7206 ; 1096-7192
    ISSN (online) 1096-7206
    ISSN 1096-7192
    DOI 10.1016/j.ymgme.2023.107508
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  7. Article ; Online: Correction to: Sex and race differences of cerebrospinal fluid metabolites in healthy individuals.

    Reavis, Zackery W / Mirjankar, Nikhil / Sarangi, Srikant / Boyle, Stephen H / Kuhn, Cynthia M / Matson, Wayne R / Babyak, Michael A / Matson, Samantha A / Siegler, Ilene C / Kaddurah-Daouk, Rima / Suarez, Edward C / Williams, Redford B / Grichnik, Katherine / Stafford-Smith, Mark / Georgiades, Anastasia

    Metabolomics : Official journal of the Metabolomic Society

    2021  Volume 17, Issue 6, Page(s) 56

    Language English
    Publishing date 2021-06-09
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2250617-2
    ISSN 1573-3890 ; 1573-3882
    ISSN (online) 1573-3890
    ISSN 1573-3882
    DOI 10.1007/s11306-021-01809-z
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  8. Article ; Online: Novel mucosal adjuvant, mastoparan-7, improves cocaine vaccine efficacy.

    St John, Ashley L / Choi, Hae Woong / Walker, Q David / Blough, Bruce / Kuhn, Cynthia M / Abraham, Soman N / Staats, Herman F

    NPJ vaccines

    2020  Volume 5, Issue 1, Page(s) 12

    Abstract: Cocaine is one of the most potent and addictive psychostimulants known and there are no available pharmacotherapies to treat cocaine addiction. Here we describe a novel cocaine vaccine employing the mucosal adjuvant and mast cell-activating oligopeptide, ...

    Abstract Cocaine is one of the most potent and addictive psychostimulants known and there are no available pharmacotherapies to treat cocaine addiction. Here we describe a novel cocaine vaccine employing the mucosal adjuvant and mast cell-activating oligopeptide, mastoparan-7 (M7), to achieve optimal IgA antibody responses in mucosal secretions and effective induction of humoral immunity using a short immunization protocol. This formulation, using a hapten-carrier system to deliver cocaine as antigen, also reduced cocaine penetration of the blood brain barrier and protected mice from its psychoactive effects by reducing cocaine-induced locomotion. Surprisingly, the magnitude of cocaine-specific antibody titers induced by each adjuvant was not the major determinant of functional protection from cocaine challenge. A side-by-side comparison of the two haptens, cocaine and its analog GNC demonstrated that cocaine haptenation resulted in superior functional protection when used in combination with the novel mucosal adjuvant, M7. These results provide a new potential strategy for combatting cocaine addiction through mucosal vaccination.
    Language English
    Publishing date 2020-02-05
    Publishing country England
    Document type Journal Article
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-020-0161-1
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  9. Article ; Online: Correction to: Effects of Environmental Stress and Gender on Associations among Symptoms of Depression and the Serotonin Transporter Gene Linked Polymorphic Region (5-HTTLPR).

    Brummett, Beverly H / Boyle, Stephen H / Siegler, Ilene C / Kuhn, Cynthia M / Ashley-Koch, Allison / Jonassaint, Charles R / Züchner, Stephan / Collins, Ann / Suarez, Edward C / Williams, Redford B

    Behavior genetics

    2020  Volume 51, Issue 2, Page(s) 162

    Language English
    Publishing date 2020-12-21
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 280238-7
    ISSN 1573-3297 ; 0005-7851 ; 0001-8244
    ISSN (online) 1573-3297
    ISSN 0005-7851 ; 0001-8244
    DOI 10.1007/s10519-020-10029-5
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  10. Article ; Online: Correction to: 5-HTTLPR and Gender Moderate Changes in Negative Affect Responses to Tryptophan Infusion.

    Brummett, Beverly H / Muller, Christopher L / Collins, Ann L / Boyle, Stephen H / Kuhn, Cynthia M / Siegler, Ilene C / Williams, Redford B / Suarez, Edward C / Ashley-Koch, Allison

    Behavior genetics

    2020  Volume 51, Issue 2, Page(s) 163

    Language English
    Publishing date 2020-12-16
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 280238-7
    ISSN 1573-3297 ; 0005-7851 ; 0001-8244
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    DOI 10.1007/s10519-020-10030-y
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