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Article ; Online: A modified candy-plug technique to occlude false lumen in aortic dissection.

Palm, Erik / Valtola, Antti / Manninen, Hannu / Saari, Petri

CVIR endovascular

2022 Volume 5, Issue 1, Page(s) 57

Abstract: Purpose: Aim of this technical note article is to introduce a modified, novel way to custom create a candy-plug (CP) device to endovascularly occlude false lumen. The technique is illustrated by a patient case with significant backflow to false lumen ( ... ...

Abstract	Purpose: Aim of this technical note article is to introduce a modified, novel way to custom create a candy-plug (CP) device to endovascularly occlude false lumen. The technique is illustrated by a patient case with significant backflow to false lumen (FL). The patient had already undergone surgical repair of the ascending aorta, aortic arch and subsequent TEVAR procedure down to the ostium of the celiac trunk because of type A aortic dissection, but the descending thoracic aorta continued to dilate due to backflow to the FL from an uncovered tear at the level of the renal arteries. Materials and methods: We modified a Gore Excluder 36-45 mm aortic extender (W. L. Gore & Associates, Inc. Flagstaff, USA) endoprosthesis into a CP device that was subsequently positioned under local anesthesia into the FL of the distal descending thoracic aorta. Results: In 1 month control the backflow to false lumen had ceased and the aorta had decreased in diameter from 69 to 66 mm, FL from 37 to 34 mm, true lumen (TL) remained the same 32 mm. Conclusion: We describe a modified, effective candy-plug technique to occlude retrograde false lumen filling in aortic dissection.
Language	English
Publishing date	2022-10-29
Publishing country	Switzerland
Document type	Journal Article
ISSN	2520-8934
ISSN (online)	2520-8934
DOI	10.1186/s42155-022-00331-0
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Article ; Online: Pretreatment with a dual antiplatelet and anticoagulant (APAC) reduces ischemia-reperfusion injury in a mouse model of temporary middle cerebral artery occlusion-implications for neurovascular procedures.

Denorme, Frederik / Frösen, Juhana / Jouppila, Annukka / Lindgren, Antti / Resendiz-Nieves, Julio C / Manninen, Hannu / De Meyer, Simon F / Lassila, Riitta

Acta neurochirurgica

2024 Volume 166, Issue 1, Page(s) 137

Abstract: ... 01 and p < 0.001, respectively) at 24 h after transient occlusion compared with vehicle-treated mice ... administered 10 min before or 60 min after the start of ischemia. At 24 h later, mice were scored ... functions (p < 0.05 and p < 0.01, respectively) and had significantly reduced cerebral infarct sizes (p < 0 ...

Abstract	Background: Several neurovascular procedures require temporary occlusion of cerebral arteries, leading to ischemia of unpredictable length, occasionally causing brain infarction. Experimental models of cerebral ischemia-reperfusion injury have established that platelet adhesion and coagulation play detrimental roles in reperfusion injury following transient cerebral ischemia. Therefore, in a model of cerebral ischemia-reperfusion injury (IRI), we investigated the therapeutic potential of a dual antiplatelet and anticoagulant (APAC) heparin proteoglycan mimetic which is able to bind to vascular injury sites. Methods: Brain ischemia was induced in mice by transient occlusion of the right middle cerebral artery for 60 min. APAC, unfractionated heparin (UFH) (both at heparin equivalent doses of 0.5 mg/kg), or vehicle was intravenously administered 10 min before or 60 min after the start of ischemia. At 24 h later, mice were scored for their neurological and motor behavior, and brain damage was quantified. Results: Both APAC and UFH administered before the onset of ischemia reduced brain injury. APAC and UFH pretreated mice had better neurological and motor functions (p < 0.05 and p < 0.01, respectively) and had significantly reduced cerebral infarct sizes (p < 0.01 and p < 0.001, respectively) at 24 h after transient occlusion compared with vehicle-treated mice. Importantly, no macroscopic bleeding complications were observed in either APAC- or UFH-treated animals. However, when APAC or UFH was administered 60 min after the start of ischemia, the therapeutic effect was lost, but without hemorrhaging either. Conclusions: Pretreatment with APAC or UFH was safe and effective in reducing brain injury in a model of cerebral ischemia induced by transient middle cerebral artery occlusion. Further studies on the use of APAC to limit ischemic injury during temporary occlusion in neurovascular procedures are indicated.
MeSH term(s)	Mice ; Animals ; Anticoagulants/pharmacology ; Anticoagulants/therapeutic use ; Infarction, Middle Cerebral Artery/drug therapy ; Brain/metabolism ; Heparin/pharmacology ; Heparin/therapeutic use ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism ; Reperfusion Injury/drug therapy ; Brain Injuries
Chemical Substances	Anticoagulants ; Heparin (9005-49-6)
Language	English
Publishing date	2024-03-15
Publishing country	Austria
Document type	Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-024-06017-x
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Article ; Online: Friendly Neck Anatomy Does Not Prevent Neck-Related Adverse Events After EVAR.

Paajanen, Paavo / Karjalainen, Jari / Jaroma, Marianne / Tarkiainen, Mika / Manninen, Hannu / Mäkinen, Kimmo / Kärkkäinen, Jussi / Saari, Petri

Annals of vascular surgery

2023 Volume 104, Page(s) 71–80

Abstract: ... 1%, P = 0.78), major adverse events (20% vs. 16%, P = 0.43) or reinterventions during ... the hospital stay (8% vs. 4%, P = 0.20) between patients with hostile and friendly neck. Estimated survival at 1 ... year was 89 ± 3% for hostile neck and 95 ± 2% for friendly neck patients (P < 0.01). Five-year survival ...

Abstract	Background: Life-long follow-up after endovascular aneurysm repair (EVAR) is costly and burdensome to the patient. Follow-up should be stratified based on the risk of EVAR failure. Aneurysm neck is thought to be the single most important risk factor. This study investigated neck anatomy as a predictor of neck-related adverse events after EVAR. Methods: This retrospective single-center study included consecutive patients undergoing elective EVAR for infrarenal abdominal aortic aneurysms between 2011 and 2016 (n = 222) who were followed with yearly imaging until December 2020. Hostile neck was defined as neck length ≤15 mm, width ≥28 mm, angulation ≥60°, calcification, or thrombus ≥50% of circumference or conical neck based on preoperative computed tomography angiography. Neck-related adverse event was defined as aneurysm rupture, any neck-related reintervention or type 1a endoleak during follow-up. Results: Ninety (41%) patients had hostile neck and 132 (59%) had friendly neck. There were no differences in 30-day mortality (1% vs. 1%, P = 0.78), major adverse events (20% vs. 16%, P = 0.43) or reinterventions during the hospital stay (8% vs. 4%, P = 0.20) between patients with hostile and friendly neck. Estimated survival at 1 year was 89 ± 3% for hostile neck and 95 ± 2% for friendly neck patients (P < 0.01). Five-year survival estimates were 51 ± 6% and 66 ± 4%, respectively. Aneurysm-related mortality was higher after 6 years in patients with hostile neck (P < 0.01). Twenty-four patients (11%) suffered neck-related adverse events with mean time-to-event of 3.3 ± 2.8 years; there were no differences between the groups stratified by neck anatomy. Incidentally, preoperative aneurysm diameter was found to be an independent risk factor for neck-related adverse events and aneurysm-related mortality; 53 patients (24%) had aneurysm diameter ≥70 mm, which was associated with nearly 4-fold risk of neck-related complications during the follow-up. Conclusions: Friendly neck anatomy may not protect from neck-related adverse events after EVAR in the long-term. Especially patients with large aneurysms should be followed closely.
Language	English
Publishing date	2023-07-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1027366-9
ISSN	1615-5947 ; 0890-5096
ISSN (online)	1615-5947
ISSN	0890-5096
DOI	10.1016/j.avsg.2023.06.031
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Article ; Online: Recessive TMOD1 mutation causes childhood cardiomyopathy.

Vasilescu, Catalina / Colpan, Mert / Ojala, Tiina H / Manninen, Tuula / Mutka, Aino / Ylänen, Kaisa / Rahkonen, Otto / Poutanen, Tuija / Martelius, Laura / Kumari, Reena / Hinterding, Helena / Brilhante, Virginia / Ojanen, Simo / Lappalainen, Pekka / Koskenvuo, Juha / Carroll, Christopher J / Fowler, Velia M / Gregorio, Carol C / Suomalainen, Anu

Communications biology

2024 Volume 7, Issue 1, Page(s) 7

Abstract: ... variant in tropomodulin 1 (TMOD1; c.565C>T, p.R189W) in three individuals from two unrelated families ...

Abstract	Familial cardiomyopathy in pediatric stages is a poorly understood presentation of heart disease in children that is attributed to pathogenic mutations. Through exome sequencing, we report a homozygous variant in tropomodulin 1 (TMOD1; c.565C>T, p.R189W) in three individuals from two unrelated families with childhood-onset dilated and restrictive cardiomyopathy. To decipher the mechanism of pathogenicity of the R189W mutation in TMOD1, we utilized a wide array of methods, including protein analyses, biochemistry and cultured cardiomyocytes. Structural modeling revealed potential defects in the local folding of TMOD1
MeSH term(s)	Child ; Humans ; Actin Cytoskeleton/metabolism ; Actins/metabolism ; Myocytes, Cardiac/metabolism ; Mutation ; Cardiomyopathies/genetics ; Cardiomyopathies/metabolism ; Tropomodulin/genetics ; Tropomodulin/chemistry ; Tropomodulin/metabolism
Chemical Substances	Actins ; TMOD1 protein, human ; Tropomodulin
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-023-05670-9
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Article ; Online: Actin-rich lamellipodia-like protrusions contribute to the integrity of epithelial cell-cell junctions.

Senju, Yosuke / Mushtaq, Toiba / Vihinen, Helena / Manninen, Aki / Saarikangas, Juha / Ven, Katharina / Engel, Ulrike / Varjosalo, Markku / Jokitalo, Eija / Lappalainen, Pekka

The Journal of biological chemistry

2023 Volume 299, Issue 5, Page(s) 104571

Abstract: Metastasis-suppressor 1 (MTSS1) is a membrane-interacting scaffolding protein that regulates the integrity of epithelial cell-cell junctions and functions as a tumor suppressor in a wide range of carcinomas. MTSS1 binds phosphoinositide-rich membranes ... ...

Abstract	Metastasis-suppressor 1 (MTSS1) is a membrane-interacting scaffolding protein that regulates the integrity of epithelial cell-cell junctions and functions as a tumor suppressor in a wide range of carcinomas. MTSS1 binds phosphoinositide-rich membranes through its I-BAR domain and is capable of sensing and generating negative membrane curvature in vitro. However, the mechanisms by which MTSS1 localizes to intercellular junctions in epithelial cells and contributes to their integrity and maintenance have remained elusive. By carrying out EM and live-cell imaging on cultured Madin-Darby canine kidney cell monolayers, we provide evidence that adherens junctions of epithelial cells harbor lamellipodia-like, dynamic actin-driven membrane folds, which exhibit high negative membrane curvature at their distal edges. BioID proteomics and imaging experiments demonstrated that MTSS1 associates with an Arp2/3 complex activator, the WAVE-2 complex, in dynamic actin-rich protrusions at cell-cell junctions. Inhibition of Arp2/3 or WAVE-2 suppressed actin filament assembly at adherens junctions, decreased the dynamics of junctional membrane protrusions, and led to defects in epithelial integrity. Together, these results support a model in which membrane-associated MTSS1, together with the WAVE-2 and Arp2/3 complexes, promotes the formation of dynamic lamellipodia-like actin protrusions that contribute to the integrity of cell-cell junctions in epithelial monolayers.
MeSH term(s)	Animals ; Dogs ; Actin Cytoskeleton/metabolism ; Actin-Related Protein 2-3 Complex/metabolism ; Actins/metabolism ; Adherens Junctions/metabolism ; Epithelial Cells/metabolism ; Intercellular Junctions/metabolism ; Madin Darby Canine Kidney Cells ; Membrane Proteins/metabolism ; Pseudopodia/metabolism ; Microfilament Proteins/metabolism
Chemical Substances	Actin-Related Protein 2-3 Complex ; Actins ; Membrane Proteins ; Microfilament Proteins
Language	English
Publishing date	2023-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2023.104571
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Book ; Online: Towards High-Definition Maps

Manninen, Petri / Hyyti, Heikki / Kyrki, Ville / Maanpää, Jyri / Taher, Josef / Hyyppä, Juha

a Framework Leveraging Semantic Segmentation to Improve NDT Map Compression and Descriptivity

2023

Abstract: High-Definition (HD) maps are needed for robust navigation of autonomous vehicles, limited by the on-board storage capacity. To solve this, we propose a novel framework, Environment-Aware Normal Distributions Transform (EA-NDT), that significantly ... ...

Abstract	High-Definition (HD) maps are needed for robust navigation of autonomous vehicles, limited by the on-board storage capacity. To solve this, we propose a novel framework, Environment-Aware Normal Distributions Transform (EA-NDT), that significantly improves compression of standard NDT map representation. The compressed representation of EA-NDT is based on semantic-aided clustering of point clouds resulting in more optimal cells compared to grid cells of standard NDT. To evaluate EA-NDT, we present an open-source implementation that extracts planar and cylindrical primitive features from a point cloud and further divides them into smaller cells to represent the data as an EA-NDT HD map. We collected an open suburban environment dataset and evaluated EA-NDT HD map representation against the standard NDT representation. Compared to the standard NDT, EA-NDT achieved consistently at least 1.5x higher map compression while maintaining the same descriptive capability. Moreover, we showed that EA-NDT is capable of producing maps with significantly higher descriptivity score when using the same number of cells than the standard NDT. Comment: 8 pages, 8 figures, IROS22
Keywords	Computer Science - Robotics
Publishing date	2023-01-10
Publishing country	us
Document type	Book ; Online
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Article ; Online: Axon fiber orientation as the source of T

Kauppinen, Risto A / Thothard, Jeromy / Leskinen, Henri P P / Pisharady, Pramod K / Manninen, Eppu / Kettunen, Mikko / Lenglet, Christophe / Gröhn, Olli H J / Garwood, Michael / Nissi, Mikko J

Magnetic resonance in medicine

2023 Volume 90, Issue 2, Page(s) 708–721

Abstract: Purpose: Recent studies indicate that T: Methods: Volunteers were scanned for relaxometric and diffusion MRI at 3 T and 7 T. Angular T: Results: Angular T: Conclusion: These data causally link axon fiber orientation in ... ...

Abstract	Purpose: Recent studies indicate that T Methods: Volunteers were scanned for relaxometric and diffusion MRI at 3 T and 7 T. Angular T Results: Angular T Conclusion: These data causally link axon fiber orientation in B
MeSH term(s)	Humans ; White Matter/diagnostic imaging ; Corpus Callosum/diagnostic imaging ; Anisotropy ; Axons ; Diffusion Magnetic Resonance Imaging/methods ; Brain/diagnostic imaging
Language	English
Publishing date	2023-05-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	605774-3
ISSN	1522-2594 ; 0740-3194
ISSN (online)	1522-2594
ISSN	0740-3194
DOI	10.1002/mrm.29667
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Article ; Online: Metagenomic analysis of Mesolithic chewed pitch reveals poor oral health among stone age individuals.

Kırdök, Emrah / Kashuba, Natalija / Damlien, Hege / Manninen, Mikael A / Nordqvist, Bengt / Kjellström, Anna / Jakobsson, Mattias / Lindberg, A Michael / Storå, Jan / Persson, Per / Andersson, Björn / Aravena, Andrés / Götherström, Anders

Scientific reports

2024 Volume 13, Issue 1, Page(s) 22125

Abstract: Prehistoric chewed pitch has proven to be a useful source of ancient DNA, both from humans and their microbiomes. Here we present the metagenomic analysis of three pieces of chewed pitch from Huseby Klev, Sweden, that were dated to 9,890-9,540 before ... ...

Abstract	Prehistoric chewed pitch has proven to be a useful source of ancient DNA, both from humans and their microbiomes. Here we present the metagenomic analysis of three pieces of chewed pitch from Huseby Klev, Sweden, that were dated to 9,890-9,540 before present. The metagenomic profile exposes a Mesolithic oral microbiome that includes opportunistic oral pathogens. We compared the data with healthy and dysbiotic microbiome datasets and we identified increased abundance of periodontitis-associated microbes. In addition, trained machine learning models predicted dysbiosis with 70-80% probability. Moreover, we identified DNA sequences from eukaryotic species such as red fox, hazelnut, red deer and apple. Our results indicate a case of poor oral health during the Scandinavian Mesolithic, and show that pitch pieces have the potential to provide information on material use, diet and oral health.
MeSH term(s)	Animals ; Humans ; Dysbiosis/genetics ; Metagenome ; Microbiota/genetics ; Oral Health ; Periodontitis/genetics
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-48762-6
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Article ; Online: DLL4/Notch3/WNT5B axis mediates bidirectional prometastatic crosstalk between melanoma and lymphatic endothelial cells.

Alve, Sanni / Gramolelli, Silvia / Jukonen, Joonas / Juteau, Susanna / Pink, Anne / Manninen, Atte A / Hänninen, Satu / Monto, Elisa / Lackman, Madeleine H / Carpén, Olli / Saharinen, Pipsa / Karaman, Sinem / Vaahtomeri, Kari / Ojala, Päivi M

JCI insight

2024 Volume 9, Issue 1

Abstract: Despite strong indications that interactions between melanoma and lymphatic vessels actively promote melanoma progression, the molecular mechanisms are not yet completely understood. To characterize molecular factors of this crosstalk, we established ... ...

Abstract	Despite strong indications that interactions between melanoma and lymphatic vessels actively promote melanoma progression, the molecular mechanisms are not yet completely understood. To characterize molecular factors of this crosstalk, we established human primary lymphatic endothelial cell (LEC) cocultures with human melanoma cell lines. Here, we show that coculture with melanoma cells induced transcriptomic changes in LECs and led to multiple changes in their function. WNT5B, a paracrine signaling molecule upregulated in melanoma cells upon LEC interaction, was found to contribute to the functional changes in LECs. Moreover, WNT5B transcription was regulated by Notch3 in melanoma cells following the coculture with LECs, and Notch3 and WNT5B were coexpressed in melanoma patient primary tumor and metastasis samples. Moreover, melanoma cells derived from LEC coculture escaped efficiently from the primary site to the proximal tumor-draining lymph nodes, which was impaired upon WNT5B depletion. This supported the role of WNT5B in promoting the metastatic potential of melanoma cells through its effects on LECs. Finally, DLL4, a Notch ligand expressed in LECs, was identified as an upstream inducer of the Notch3/WNT5B axis in melanoma. This study elucidated WNT5B as a key molecular factor mediating bidirectional crosstalk between melanoma cells and lymphatic endothelium and promoting melanoma metastasis.
MeSH term(s)	Humans ; Adaptor Proteins, Signal Transducing/metabolism ; Calcium-Binding Proteins/metabolism ; Endothelial Cells/metabolism ; Lymphatic Metastasis/pathology ; Lymphatic Vessels/pathology ; Melanoma/pathology ; Signal Transduction ; Wnt Proteins/metabolism
Chemical Substances	Adaptor Proteins, Signal Transducing ; Calcium-Binding Proteins ; DLL4 protein, human ; Wnt Proteins ; WNT5B protein, human ; NOTCH3 protein, human
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.171821
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Article ; Online: Feasibility of Hyperspectral Single Photon Lidar for Robust Autonomous Vehicle Perception.

Taher, Josef / Hakala, Teemu / Jaakkola, Anttoni / Hyyti, Heikki / Kukko, Antero / Manninen, Petri / Maanpää, Jyri / Hyyppä, Juha

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 15

Abstract: Autonomous vehicle perception systems typically rely on single-wavelength lidar sensors to obtain three-dimensional information about the road environment. In contrast to cameras, lidars are unaffected by challenging illumination conditions, such as low ... ...

Abstract	Autonomous vehicle perception systems typically rely on single-wavelength lidar sensors to obtain three-dimensional information about the road environment. In contrast to cameras, lidars are unaffected by challenging illumination conditions, such as low light during night-time and various bidirectional effects changing the return reflectance. However, as many commercial lidars operate on a monochromatic basis, the ability to distinguish objects based on material spectral properties is limited. In this work, we describe the prototype hardware for a hyperspectral single photon lidar and demonstrate the feasibility of its use in an autonomous-driving-related object classification task. We also introduce a simple statistical model for estimating the reflectance measurement accuracy of single photon sensitive lidar devices. The single photon receiver frame was used to receive 30 12.3 nm spectral channels in the spectral band 1200-1570 nm, with a maximum channel-wise intensity of 32 photons. A varying number of frames were used to accumulate the signal photon count. Multiple objects covering 10 different categories of road environment, such as car, dry asphalt, gravel road, snowy asphalt, wet asphalt, wall, granite, grass, moss, and spruce tree, were included in the experiments. We test the influence of the number of spectral channels and the number of frames on the classification accuracy with random forest classifier and find that the spectral information increases the classification accuracy in the high-photon flux regime from 50% to 94% with 2 channels and 30 channels, respectively. In the low-photon flux regime, the classification accuracy increases from 30% to 38% with 2 channels and 6 channels, respectively. Additionally, we visualize the data with the t-SNE algorithm and show that the photon shot noise in the single photon sensitive hyperspectral data contributes the most to the separability of material specific spectral signatures. The results of this study provide support for the use of hyperspectral single photon lidar data on more advanced object detection and classification methods, and motivates the development of advanced single photon sensitive hyperspectral lidar devices for use in autonomous vehicles and in robotics.
MeSH term(s)	Algorithms ; Autonomous Vehicles ; Feasibility Studies ; Perception ; Photons
Language	English
Publishing date	2022-08-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22155759
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