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Article ; Online: Anaesthetic management of patients with COVID-19: infection prevention and control measures in the operating theatre. Comment on Br J Anaesth 2020; 125: e239-e241.

Saxena, Sudeep / Kumar, Chandra M

2020 Volume 125, Issue 3, Page(s) e317–e318

MeSH term(s)	Anesthetics ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Operating Rooms ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
Chemical Substances	Anesthetics
Keywords	covid19
Language	English
Publishing date	2020-05-16
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	80074-0
ISSN	1471-6771 ; 0007-0912
ISSN (online)	1471-6771
ISSN	0007-0912
DOI	10.1016/j.bja.2020.05.007
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Article ; Online: Does the Use of Regional Anesthesia for Below-Knee Amputation Reduce the Need for Perioperative Blood Transfusions?

Saxena, Sudeep / Loganathan, Suresh Babu

Regional anesthesia and pain medicine

2018 Volume 43, Issue 6, Page(s) 646–647

MeSH term(s)	Amputation ; Anesthesia, Conduction ; Blood Transfusion ; Leg/surgery
Language	English
Publishing date	2018-07-23
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1425299-5
ISSN	1532-8651 ; 1098-7339 ; 0146-521X
ISSN (online)	1532-8651
ISSN	1098-7339 ; 0146-521X
DOI	10.1097/AAP.0000000000000829
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Article: Anaesthetic management of patients with COVID-19: infection prevention and control measures in the operating theatre. Comment on Br J Anaesth 2020; 125: e239-e241

Saxena, Sudeep / Kumar, Chandra M

Br J Anaesth

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #831062
Database	COVID19

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Article ; Online: Anaesthetic management of patients with COVID-19

Saxena, Sudeep / Kumar, Chandra M.

British Journal of Anaesthesia

infection prevention and control measures in the operating theatre. Comment on Br J Anaesth 2020; 125: e239–e241

2020 Volume 125, Issue 3, Page(s) e317–e318

Keywords	Anesthesiology and Pain Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	80074-0
ISSN	1471-6771 ; 0007-0912
ISSN (online)	1471-6771
ISSN	0007-0912
DOI	10.1016/j.bja.2020.05.007
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Use of ROTEM in correction of unexpected oozing in a child with a preexisting normal coagulation profile undergoing splenectomy.

Saxena, Sudeep / Hee, Hwan Ing

Pediatric blood & cancer

2018 Volume 65, Issue 11, Page(s) e27270

MeSH term(s)	Blood Coagulation Tests ; Child ; Factor VIIa ; Hemostatics ; Humans ; Recombinant Proteins ; Splenectomy
Chemical Substances	Hemostatics ; Recombinant Proteins ; recombinant FVIIa (AC71R787OV) ; Factor VIIa (EC 3.4.21.21)
Language	English
Publishing date	2018-06-05
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.27270
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Article: Papaya Leaf Curl Virus (PaLCuV) Infection on Papaya (

Soni, Sumit K / Mishra, Manoj Kumar / Mishra, Maneesh / Kumari, Swati / Saxena, Sangeeta / Shukla, Virendra / Tiwari, Sudeep / Shirke, Pramod

Plants (Basel, Switzerland)

2022 Volume 11, Issue 5

Abstract: Papaya leaves are used frequently for curing scores of ailments. The medicinal properties of papaya leaves are due to presence of certain bioactive/pharmacological compounds. However, the papaya leaf curl virus (PaLCuV), a geminivirus, is a major threat ... ...

Abstract	Papaya leaves are used frequently for curing scores of ailments. The medicinal properties of papaya leaves are due to presence of certain bioactive/pharmacological compounds. However, the papaya leaf curl virus (PaLCuV), a geminivirus, is a major threat to papaya cultivation globally. During the present investigation, we observed that PaLCuV infection significantly altered the anatomy, physiology, and bioactive properties of papaya leaves. As compared to healthy leaves, the PaLCuV-infected leaves were found to have reduced stomatal density (76.83%), stomatal conductance (78.34%), photosynthesis rate (74.87%), water use efficiency (82.51%), chlorophyll (72.88%), carotenoid (46.63%), osmolality (48.55%), and soluble sugars (70.37%). We also found lower enzymatic activity (superoxide dismutase (SOD), ascorbate peroxidase (APX), and catalase (CAT)-56.88%, 85.27%, and 74.49%, respectively). It was found that the size of guard cells (50%), transpiration rate (45.05%), intercellular CO
Language	English
Publishing date	2022-02-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants11050579
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Papaya Leaf Curl Virus (PaLCuV) Infection on Papaya (Carica papaya L.) Plants Alters Anatomical and Physiological Properties and Reduces Bioactive Components

Soni, Sumit K. / Mishra, Manoj Kumar / Mishra, Maneesh / Kumari, Swati / Saxena, Sangeeta / Shukla, Virendra / Tiwari, Sudeep / Shirke, Pramod

Plants. 2022 Feb. 22, v. 11, no. 5

2022

Abstract	Papaya leaves are used frequently for curing scores of ailments. The medicinal properties of papaya leaves are due to presence of certain bioactive/pharmacological compounds. However, the papaya leaf curl virus (PaLCuV), a geminivirus, is a major threat to papaya cultivation globally. During the present investigation, we observed that PaLCuV infection significantly altered the anatomy, physiology, and bioactive properties of papaya leaves. As compared to healthy leaves, the PaLCuV-infected leaves were found to have reduced stomatal density (76.83%), stomatal conductance (78.34%), photosynthesis rate (74.87%), water use efficiency (82.51%), chlorophyll (72.88%), carotenoid (46.63%), osmolality (48.55%), and soluble sugars (70.37%). We also found lower enzymatic activity (superoxide dismutase (SOD), ascorbate peroxidase (APX), and catalase (CAT)—56.88%, 85.27%, and 74.49%, respectively). It was found that the size of guard cells (50%), transpiration rate (45.05%), intercellular CO₂ concentration (47.81%), anthocyanin (27.47%), proline content (74.17%), malondialdehyde (MDA) (106.65%), and electrolyte leakage (75.38%) was elevated in PaLCuV-infected leaves. The chlorophyll fluorescence analysis showed that the infected plant leaves had a significantly lower value of maximal quantum yield of photosystem II (PSII (Fv/Fm), photochemical quantum yield of photosystem I (PSI (Y(I)), and effective quantum yield of PSII (Y(II)). However, in non-photochemical quenching mechanisms, the proportion of energy dissipated in heat form (Y(NPQ)) was found to be significantly higher. We also tested the bioactivity of infected and healthy papaya leaf extracts on a Caenorhabditis elegans (C. elegans) model system. It was found that the crude extract of papaya leaves significantly enhanced the life span of C. elegans (29.7%) in comparison to virus-infected leaves (18.4%) on application of 100 µg/mL dose of the crude extract. Our research indicates that the PaLCuV-infected leaves not only had anatomical and physiological losses, but that pharmacological potential was also significantly decreased.
Keywords	Caenorhabditis elegans ; Carica papaya ; Papaya leaf curl virus ; anthocyanins ; ascorbate peroxidase ; carbon dioxide ; carotenoids ; catalase ; chlorophyll ; electrolyte leakage ; energy ; enzyme activity ; heat ; leaves ; longevity ; malondialdehyde ; osmolality ; papayas ; photochemistry ; photosystem II ; proline ; stomatal conductance ; superoxide dismutase ; water use efficiency
Language	English
Dates of publication	2022-0222
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants11050579
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Synthesis of eugenol derivatives and its anti-inflammatory activity against skin inflammation.

Maurya, Anil Kumar / Agarwal, Karishma / Gupta, Amit Chand / Saxena, Archana / Nooreen, Zulfa / Tandon, Sudeep / Ahmad, Ateeque / Bawankule, Dnyaneshwar Umrao

Natural product research

2018 Volume 34, Issue 2, Page(s) 251–260

Abstract: Eugenol is a phytochemical present in aromatic plants has generated considerable interest in the pharmaceutical industries mainly in cosmetics. A series of eugenol esters (ST1-ST7) and chloro eugenol ( ...

Abstract	Eugenol is a phytochemical present in aromatic plants has generated considerable interest in the pharmaceutical industries mainly in cosmetics. A series of eugenol esters (ST1-ST7) and chloro eugenol (
MeSH term(s)	Animals ; Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/pharmacology ; Cytokines/antagonists & inhibitors ; Dermatitis/drug therapy ; Eugenol/analogs & derivatives ; Eugenol/chemical synthesis ; Eugenol/pharmacology ; Macrophages/drug effects ; Macrophages/pathology ; Phytochemicals/pharmacology
Chemical Substances	Anti-Inflammatory Agents ; Cytokines ; Phytochemicals ; Eugenol (3T8H1794QW)
Language	English
Publishing date	2018-12-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2018.1528585
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Anti-psoriatic effect of Lavandula angustifolia essential oil and its major components linalool and linalyl acetate.

Rai, Vineet Kumar / Sinha, Priyam / Yadav, Kuldeep Singh / Shukla, Aparna / Saxena, Archana / Bawankule, Dnyaneshwar Umrao / Tandon, Sudeep / Khan, Feroz / Chanotiya, Chandan Singh / Yadav, Narayan Prasad

Journal of ethnopharmacology

2020 Volume 261, Page(s) 113127

Abstract: Ethno-pharmacological relevance: Lavender oil (LO) is an aromatic/essential oil extracted from Lavandula angustifolia and traditionally used as an aromatherapy massage oil due to its anti-inflammatory and wound healing property and also for providing ... ...

Abstract	Ethno-pharmacological relevance: Lavender oil (LO) is an aromatic/essential oil extracted from Lavandula angustifolia and traditionally used as an aromatherapy massage oil due to its anti-inflammatory and wound healing property and also for providing the relief in other skin conditions such as psoriasis, dermatitis and eczema. However, LO has not been evaluated scientifically for psoriasis like skin inflammation. Aim of the study: This study was aimed to investigate the LO and its major components linalool (L) and linalyl acetate (LA) against psoriasis like skin inflammation. Materials and methods: Anti-psoriatic activity was done using Imiquimod (IMQ) induced psoriasis like skin inflammation in BALB/c mice. Assessment of anti-psoriatic effect of LO, L and LA was done on the basis of change in ear thickness, psoriasis area severity index (PASI) scoring at alternative day, CosCam scoring using skin analyzer equipped with SkinSys software, biochemical, immunohistochemical and histological investigations. Level of effectiveness against psoriasis was investigated by percent reduction in PASI scores, CosCam scores and level of Th-1 and Th-17 cell expressing cytokines, as compared to the diseased mice. Results: Topical application of LO 10% showed 73.67% recovery in PASI and 87% in Th-17 cell-specific cytokines towards normal as compared to disease group. L and LA were identified as the major components of LO and favoured ligands for selected psoriasis targets. At 2% topical dose, L and LA showed 64% and 47.61% recovery in PASI scores, respectively. Both, L and LA showed significant recovery in Th-1 specific TNF-α and IL-1β however, only L showed significant recovery of Th-17 cytokines (IL-17 and IL-22). In contrast to LA (which restored granulosis), L restored epidermal hyperplasia and parakeratosis toward the normal condition. On the other hand, L also reduced the expression of NF-κβ, ccr6 and IL-17, while LA reduced the expression of NF-κβ only. At 10% topical dose, LO was observed to be slight irritant while at 2% topical dose, L and LA were found non-irritant to the skin. Conclusion: This study proves the effectiveness of LO and its major phytoconstituents linalool and linalyl acetate against IMQ induced psoriasis like skin inflammation and provides the scientific evidence for topical use of lavender oil.
MeSH term(s)	Acyclic Monoterpenes/administration & dosage ; Acyclic Monoterpenes/isolation & purification ; Acyclic Monoterpenes/pharmacology ; Administration, Cutaneous ; Animals ; Cytokines/metabolism ; Dermatologic Agents/administration & dosage ; Dermatologic Agents/isolation & purification ; Dermatologic Agents/pharmacology ; Disease Models, Animal ; Female ; Imiquimod ; Inflammation Mediators/metabolism ; Lavandula/chemistry ; Mice, Inbred BALB C ; Monoterpenes/administration & dosage ; Monoterpenes/isolation & purification ; Monoterpenes/pharmacology ; Oils, Volatile/administration & dosage ; Oils, Volatile/isolation & purification ; Oils, Volatile/pharmacology ; Plant Oils/administration & dosage ; Plant Oils/isolation & purification ; Plant Oils/pharmacology ; Psoriasis/chemically induced ; Psoriasis/metabolism ; Psoriasis/pathology ; Psoriasis/prevention & control ; Rabbits ; Signal Transduction ; Skin/drug effects ; Skin/metabolism ; Skin/pathology
Chemical Substances	Acyclic Monoterpenes ; Cytokines ; Dermatologic Agents ; Inflammation Mediators ; Monoterpenes ; Oils, Volatile ; Plant Oils ; linalyl acetate (5K47SSQ51G) ; linalool (D81QY6I88E) ; Imiquimod (P1QW714R7M) ; lavender oil (ZBP1YXW0H8)
Language	English
Publishing date	2020-07-03
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.113127
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Article ; Online: Transcatheter pulmonary valve perforation using chronic total occlusion wire in pulmonary atresia with intact ventricular septum

Shweta Bakhru / Shilpa Marathe / Manish Saxena / Sudeep Verma / Rajan Saileela / Tapan K Dash / Nageswara Rao Koneti

Annals of Pediatric Cardiology, Vol 10, Iss 1, Pp 5-

2017 Volume 10

Abstract: Background: Perforation of pulmonary valve using radiofrequency ablation in pulmonary atresia with intact ventricular septum (PA IVS) is a treatment of choice. However, significant cost of the equipment limits its utility, especially in the developing ... ...

Abstract	Background: Perforation of pulmonary valve using radiofrequency ablation in pulmonary atresia with intact ventricular septum (PA IVS) is a treatment of choice. However, significant cost of the equipment limits its utility, especially in the developing economies. Objective: To assess the feasibility, safety, and efficacy of perforation of pulmonary valve using chronic total occlusion (CTO) wires in patients with PA IVS as an alternative to radiofrequency ablation. Methods: This is a single.center, nonrandomized, retrospective study conducted during June 2008 to September 2015. Twenty-four patients with PA IVS were selected for the procedure during the study period. The median age and weight of the study population were 8. days and 2.65 kg, respectively. Four patients were excluded after right ventricular angiogram as they showed right ventricular-dependent coronary circulation. The pulmonary valve perforation was attempted using various types of CTO wires based on the tip load with variable penetrating characteristics. Results: The procedure was successful in 16 of twenty patients using CTO wires: Shinobi in nine, Miracle in four, CROSS-IT in two, and Conquest Pro in one. Two patients had perforation of right ventricular outflow tract (RVOT). Pericardiocentesis was required in one patient to relieve cardiac tamponade. Later, the same patient underwent successful hybrid pulmonary valvotomy. The other patient underwent ductus arteriosus. (DA) stenting. Balloon atrial septostomy was needed in three cases with systemic venous congestion. Desaturation was persistent in five cases necessitating DA or RVOT stenting to augment pulmonary blood flow. There were two early and two late deaths. The mean follow-up was 22.66. ± 16 months. Three patients underwent one and half ventricle repair and one Blalock-Taussig shunt during follow-up. Conclusion: Perforation of the pulmonary valve can be done successfully using CTO wires in selected cases of pulmonary atresia with intact ventricular septum.
Keywords	Chronic total occlusion wire ; percutaneous balloon dilatation of pulmonary valve ; pulmonary atresia with intact ventricular septum ; pulmonary valve perforation ; Medicine ; R ; Pediatrics ; RJ1-570 ; Diseases of the circulatory (Cardiovascular) system ; RC666-701
Subject code	610 ; 616
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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