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  1. Article ; Online: Palpebral perforation secondary to a dacryoadenitis: a rare complication of granulomatosis with polyangiitis.

    Philip, Rémi / Aouba, Achille / Martin-Silva, Nicolas

    Clinical rheumatology

    2023  Volume 42, Issue 8, Page(s) 2245–2246

    MeSH term(s) Humans ; Granulomatosis with Polyangiitis/complications ; Dacryocystitis/complications ; Tomography, X-Ray Computed
    Language English
    Publishing date 2023-04-22
    Publishing country Germany
    Document type Editorial
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-023-06601-z
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    Zs.A 1740: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Anakinra for patients with COVID-19.

    Martin-Silva, Nicolas / Boysson, Hubert de / Aouba, Achille

    The Lancet Rheumatology

    2020  Volume 2, Issue 7, Page(s) e382–e383

    Keywords covid19
    Language English
    Publishing date 2020-06-25
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(20)30178-8
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  3. Article ; Online: Acute liver failure revealing hepatic vasculitis associated to SLE.

    Philip, Rémi / Bazille, Céline / Fohlen, Audrey / Aouba, Achille / Martin-Silva, Nicolas

    Clinical rheumatology

    2022  Volume 41, Issue 7, Page(s) 2249–2251

    MeSH term(s) Humans ; Immunosuppressive Agents ; Liver Failure, Acute/diagnosis ; Liver Failure, Acute/etiology ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Vasculitis/complications
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2022-03-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-022-06142-x
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    Zs.A 1740: Show issues Location:
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  5. Article ; Online: Anakinra for patients with COVID-19

    Martin-Silva, Nicolas / Boysson, Hubert de / Aouba, Achille

    The Lancet Rheumatology

    2020  Volume 2, Issue 7, Page(s) e382–e383

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2665-9913
    DOI 10.1016/s2665-9913(20)30178-8
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Low total gamma globulin level discovery at diffuse large B-cell lymphoma diagnosis predicts high risk of infection-related death: data from a monocentric retrospective study.

    Nguyen, Alexandre / Martin-Silva, Nicolas / de Boysson, Hubert / Deshayes, Samuel / Gac, Anne-Claire / Reboursière, Emilie / Damaj, Gandhi / Aouba, Achille

    Swiss medical weekly

    2022  Volume 152, Page(s) w30143

    Abstract: Objective: Diffuse large B-cell lymphoma can complicate the course of B-cell primary immunodeficiencies or induce lowering of total gamma globulin levels, whose clinical status as an effective secondary immunodeficiency remains unspecified. This study ... ...

    Abstract Objective: Diffuse large B-cell lymphoma can complicate the course of B-cell primary immunodeficiencies or induce lowering of total gamma globulin levels, whose clinical status as an effective secondary immunodeficiency remains unspecified. This study aimed to assess the frequency, and clinical and prognostic relevance of the low total gamma-globulin levels discovered at diagnosis of diffuse large B-cell lymphoma.
    Results: In a 2-year monocentric retrospective study, 96 patients diagnosed with diffuse large B-cell lymphoma who had a serum electrophoresis were included. Patients were divided into those with lower (L-TGL and higher (H-TGL) total gamma-globulin levels (total gamma-globulin levels ≤5.5 g/l and >5.5 g/l) and compared for outcomes, including fatal infectious events. Twelve (12.5%; 8 males; age median 68 years, range 55-82 years) exhibited L-TGL. There was no difference between the both groups regarding demographics, Ann Arbor lymphoma stage, inflammatory parameters or chemotherapy regimen. However, overall death rates (10/12, 83.3% versus 22/96, 26.2%; p = 0.03) and infection-related death rates (10/12, 83% versus 6/96, 6.2%; p <0.001) were significantly higher in the L-TGL group.
    Conclusion: We demonstrate for the first time the strong negative impact of L-TGL on overall and infection-related mortality in diffuse large B-cell lymphoma. Prospective studies should distinguish immunodeficiencies secondary to the lymphoma from pre-existing humoral primary immunodeficiencies, using biomolecular testing and post-treatment total gamma-globulin level monitoring, to determine the best management strategy for infectious risk during diffuse large B-cell lymphoma treatment in the context of L-TGL.
    MeSH term(s) Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cyclophosphamide/therapeutic use ; Humans ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/pathology ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Retrospective Studies ; gamma-Globulins/therapeutic use
    Chemical Substances gamma-Globulins ; Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2022-06-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2036179-8
    ISSN 1424-3997 ; 1424-7860
    ISSN (online) 1424-3997
    ISSN 1424-7860
    DOI 10.4414/smw.2022.w30143
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    Ua VI Zs.152: Show issues Location:
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  7. Article ; Online: Preventive effect of beta-blockers in the development of aortic dilation in giant cell arteritis-related aortitis.

    Dumont, Anaël / Labombarda, Fabien / Gallou, Sophie / Deshayes, Samuel / Nguyen, Alexandre / Boutemy, Jonathan / Martin-Silva, Nicolas / Maigné, Gwénola / Aouba, Achille / de Boysson, Hubert

    Seminars in arthritis and rheumatism

    2022  Volume 57, Page(s) 152117

    Abstract: Objectives: To analyze whether beta-blockers (BBs), in addition to conventional care, can decrease the risk of aortic dilation in giant-cell arteritis (GCA)-related aortitis.: Methods: We conducted in a single medical center retrospective study ... ...

    Abstract Objectives: To analyze whether beta-blockers (BBs), in addition to conventional care, can decrease the risk of aortic dilation in giant-cell arteritis (GCA)-related aortitis.
    Methods: We conducted in a single medical center retrospective study including 65 consecutive patients with GCA-related aortitis who all underwent aortic morphology control during follow-up. The impact of previous cardiovascular (CV) risk factors and/or events on BB prescription and on the risk for new aortic dilation was analyzed using a weighted (8-point maximum) score between 0 (i.e., 0/8 CV risk factors and events) and 1 (i.e., 8/8).
    Results: Among the 65 patients with GCA-related aortitis, 15 (23%) were taking BBs before GCA diagnosis and continued them thereafter. The vascular score was significantly higher in patients who received BBs (0.25 [0.125-0.625] vs. 0.125 [0-0.625] in patients without BBs, p < 0.0001). The median follow-up was 91 [25-163] months in GCA patients taking BBs and 61 [14-248] months in patients not taking BBs (p = 0.13). None of the patients taking BBs developed a new aortic dilation, whereas 15 (15/50; 30%) patients not taking BBs did (p = 0.01), as detected at a median time of 38 [6-120] months after the first imaging. Rates of other CV events during follow-up did not differ between the groups (p = 1).
    Conclusions: This study is the first to suggest that BBs in addition to conventional care in patients with GCA-related aortitis may help to prevent the risk of aortic dilation during follow-up. Larger-sized studies are required to confirm these results.
    MeSH term(s) Humans ; Aortitis/complications ; Aortitis/diagnostic imaging ; Aortitis/drug therapy ; Giant Cell Arteritis/complications ; Giant Cell Arteritis/diagnostic imaging ; Giant Cell Arteritis/drug therapy ; Dilatation ; Retrospective Studies ; Aortic Diseases
    Language English
    Publishing date 2022-10-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120247-9
    ISSN 1532-866X ; 0049-0172
    ISSN (online) 1532-866X
    ISSN 0049-0172
    DOI 10.1016/j.semarthrit.2022.152117
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    Zs.A 790: Show issues Location:
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  8. Article ; Online: Targeting the inflammatory cascade with anakinra in moderate to severe COVID-19 pneumonia: case series.

    Aouba, Achille / Baldolli, Aurelie / Geffray, Loïk / Verdon, Renaud / Bergot, Emmanuel / Martin-Silva, Nicolas / Justet, Aurélien

    Annals of the rheumatic diseases

    2020  Volume 79, Issue 10, Page(s) 1381–1382

    MeSH term(s) Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use ; Azithromycin/therapeutic use ; Betacoronavirus ; C-Reactive Protein/immunology ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/drug therapy ; Coronavirus Infections/immunology ; Coronavirus Infections/physiopathology ; Disease Progression ; Enzyme Inhibitors/therapeutic use ; Female ; Hospitalization ; Humans ; Hydroxychloroquine/therapeutic use ; Intensive Care Units ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Lung/diagnostic imaging ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/immunology ; Pneumonia, Viral/physiopathology ; Respiratory Distress Syndrome, Adult/physiopathology ; Severity of Illness Index ; Tomography, X-Ray Computed ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents ; Enzyme Inhibitors ; Interleukin 1 Receptor Antagonist Protein ; Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5) ; C-Reactive Protein (9007-41-4)
    Keywords covid19
    Language English
    Publishing date 2020-05-06
    Publishing country England
    Document type Letter
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2020-217706
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  9. Article: Targeting the inflammatory cascade with anakinra in moderate to severe COVID-19 pneumonia: case series

    Aouba, Achille / Baldolli, Aurelie / Geffray, Loïk / Verdon, Renaud / Bergot, Emmanuel / Martin-Silva, Nicolas / Justet, Aurélien

    Ann Rheum Dis

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #197894
    Database COVID19

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  10. Book ; Online: Targeting the inflammatory cascade with anakinra in moderate to severe COVID-19 pneumonia

    Aouba, Achille / Baldolli, Aurelie / Geffray, Loïk / Verdon, Renaud / Bergot, Emmanuel / Martin-Silva, Nicolas / Justet, Aurélien

    case series

    2020  

    Keywords Letter ; covid19
    Language English
    Publishing date 2020-10-01 00:00:00.0
    Publisher BMJ Publishing Group Ltd
    Publishing country us
    Document type Book ; Online
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