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  1. Article: Chemical Modification of Cytochrome C for Acid-Responsive Intracellular Apoptotic Protein Delivery for Cancer Eradication.

    Tang, Bo / Lau, Kwai Man / Zhu, Yunxin / Shao, Chihao / Wong, Wai-Ting / Chow, Larry M C / Wong, Clarence T T

    Pharmaceutics

    2024  Volume 16, Issue 1

    Abstract: ... Cytochrome C, a protein known for inducing apoptosis, served as a model for intracellular delivery ... the modified cytochrome C could induce apoptosis in cancer cells in a pH-selective manner. These findings ...

    Abstract Delivering bioactive proteins into cells without carriers presents significant challenges in biomedical applications due to limited cell membrane permeability and the need for targeted delivery. Here, we introduce a novel carrier-free method that addresses these challenges by chemically modifying proteins with an acid-responsive cell-penetrating peptide (CPP) for selective intracellular delivery within tumours. Cytochrome C, a protein known for inducing apoptosis, served as a model for intracellular delivery of therapeutic proteins for cancer treatment. The CPP was protected with 2,3-dimethyl maleic anhydride (DMA) and chemically conjugated onto the protein surface, creating an acid-responsive protein delivery system. In the acidic tumour microenvironment, DMA deprotects and exposes the positively charged CPP, enabling membrane penetration. Both in vitro and in vivo assays validated the pH-dependent shielding mechanism, demonstrating the modified cytochrome C could induce apoptosis in cancer cells in a pH-selective manner. These findings provide a promising new approach for carrier-free and tumour-targeted intracellular delivery of therapeutic proteins for a wide range of potential applications.
    Language English
    Publishing date 2024-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16010071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reward System in Late-Life Depression: a Cross-Sectional Case-Control Study.

    Ngan, J S T / Chan, W C / Wong, S T / Wong, C S M / Cheng, C P W

    East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan

    2023  Volume 33, Issue 2, Page(s) 71–76

    Abstract: Objective: Anhedonia, commonly defined as a reduced ability to feel pleasure, is a core clinical symptom of late-life depression (LLD). Deficits in reward processing are hypothesised to be associated with anhedonia. We examined differences in reward ... ...

    Abstract Objective: Anhedonia, commonly defined as a reduced ability to feel pleasure, is a core clinical symptom of late-life depression (LLD). Deficits in reward processing are hypothesised to be associated with anhedonia. We examined differences in reward sensitivity between patients with LLD and healthy controls and explored the associations between LLD-related symptomatology, global cognition, and the reward system.
    Methods: The reward responsiveness of 63 patients with LLD and 58 healthy controls aged ≥60 years was assessed using the probabilistic reward learning task with an asymmetric reward schedule.
    Results: Compared with healthy controls, patients with LLD displayed lower response bias and reward learning. Global cognition of all participants was positively correlated with response bias. In patients with LLD, anhedonia severity explained impaired reward learning.
    Conclusion: A deficit in reward processing is implicated in patients with LLD. Our findings suggest that executive dysfunction and anhedonia contribute to lower sensitivity to reward learning in patients with LLD.
    MeSH term(s) Humans ; Anhedonia/physiology ; Depression ; Case-Control Studies ; Cross-Sectional Studies ; Reward
    Language English
    Publishing date 2023-05-30
    Publishing country China
    Document type Journal Article
    ZDB-ID 2568836-4
    ISSN 2224-7041 ; 2224-7041
    ISSN (online) 2224-7041
    ISSN 2224-7041
    DOI 10.12809/eaap2309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The role of a single-shot higher-valency pneumococcal vaccine in overcoming challenges regarding invasive pneumococcal disease in Hong Kong.

    Hui, C K M / Hung, I F N / Lam, B / Lin, A W C / So, T M K / Wong, A T Y / Wong, M C S

    Hong Kong medical journal = Xianggang yi xue za zhi

    2023  Volume 29, Issue 1, Page(s) 11–14

    MeSH term(s) Humans ; Infant ; Pneumococcal Vaccines ; Hong Kong ; Pneumococcal Infections/prevention & control ; Streptococcus pneumoniae
    Chemical Substances Pneumococcal Vaccines
    Language English
    Publishing date 2023-02-08
    Publishing country China
    Document type Editorial
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    DOI 10.12809/hkmj235141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4347: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Examining the role of attention focus walking training on conscious motor processing during rehabilitation by older adults at risk of falling: A randomized controlled trial.

    Mak, Toby C T / Ng, Shamay S M / Leung, Melody C Y / Wong, Thomson W L

    Archives of gerontology and geriatrics

    2024  Volume 121, Page(s) 105352

    Abstract: This study examined the impact of walking training with different attention focus instructions on real-time conscious motor processing and fall-related rehabilitation outcomes in older adults at risk of falling. A total of 102 community-dwelling older ... ...

    Abstract This study examined the impact of walking training with different attention focus instructions on real-time conscious motor processing and fall-related rehabilitation outcomes in older adults at risk of falling. A total of 102 community-dwelling older adults (mean age = 75.2 years, SD = 6.8 years) were randomly assigned to three groups: no attention focus walking group (NAFWG), external attention focus walking group (EAFWG), or internal attention focus walking group (IAFWG). All groups underwent 12 training sessions. Assessments were conducted at baseline, post-training, and six months later, measuring real-time conscious motor processing, functional balance and gait, balance ability, functional mobility, walking ability, trait conscious motor processing propensity, fear of falling, and recurrent falls. The EAFWG showed significant reduction on real-time conscious motor processing immediately after training (p = 0.015). No changes were observed for the IAFWG and NAFWG. All groups showed significant improvements in functional balance and gait (p < 0.001) and balance ability (p < 0.001) post-training. Implementing external focus instructions during walking training could be a feasible and beneficial strategy for reducing real-time conscious motor processing, which may improve walking performance and prevent falls in older adults. Further research is needed to examine the sustained benefits of these interventions and determine optimal training dosage for older adults with different risks of falling in fall prevention.
    MeSH term(s) Aged ; Humans ; Attention ; Fear ; Gait ; Postural Balance ; Walking ; Aged, 80 and over
    Language English
    Publishing date 2024-01-28
    Publishing country Netherlands
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 603162-6
    ISSN 1872-6976 ; 0167-4943
    ISSN (online) 1872-6976
    ISSN 0167-4943
    DOI 10.1016/j.archger.2024.105352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1729: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Liver injury associated with the use of health supplement HemoHIM.

    Chan, C K / Wong, R S M / Chan, J C M / Chong, Y K / Au Yeung, J / Yung, T H

    Hong Kong medical journal = Xianggang yi xue za zhi

    2024  Volume 28, Issue 5, Page(s) 413–414

    MeSH term(s) Humans ; Plant Extracts ; Liver ; Chemical and Drug Induced Liver Injury/etiology
    Chemical Substances HemoHIM ; Plant Extracts
    Language English
    Publishing date 2024-01-15
    Publishing country China
    Document type Letter
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    DOI 10.12809/hkmj219950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4347: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Environmental-relevant bisphenol A exposure promotes ovarian cancer stemness by regulating microRNA biogenesis.

    Lam, Sophia S N / Shi, Zeyu / Ip, Carman K M / Wong, Chris K C / Wong, Alice S T

    Journal of cellular and molecular medicine

    2023  Volume 27, Issue 18, Page(s) 2792–2803

    Abstract: Bisphenol A (BPA) is a ubiquitous environmental xenobiotic impacting millions of people worldwide. BPA has long been proposed to promote ovarian carcinogenesis, but the detrimental mechanistic target remains unclear. Cancer stem cells (CSCs) are ... ...

    Abstract Bisphenol A (BPA) is a ubiquitous environmental xenobiotic impacting millions of people worldwide. BPA has long been proposed to promote ovarian carcinogenesis, but the detrimental mechanistic target remains unclear. Cancer stem cells (CSCs) are considered as the trigger of tumour initiation and progression. Here, we show for the first time that nanomolar (environmentally relevant) concentration of BPA can markedly increase the formation and expansion of ovarian CSCs concomitant. This effect is observed in both oestrogen receptor (ER)-positive and ER-defective ovarian cancer cells, suggesting that is independent of the classical ERs. Rather, the signal is mediated through alternative ER G-protein-coupled receptor 30 (GPR30), but not oestrogen-related receptor α and γ. Moreover, we report a novel role of BPA in the regulation of Exportin-5 that led to dysregulation of microRNA biogenesis through miR-21. The use of GPR30 siRNA or antagonist to inhibit GPR30 expression or activity, respectively, resulted in significant inhibition of ovarian CSCs. Similarly, the CSCs phenotype can be reversed by expression of Exportin-5 siRNA. These results identify for the first time non-classical ER and microRNA dysregulation as novel mediators of low, physiological levels of BPA function in CSCs that may underlie its significant tumour-promoting properties in ovarian cancer.
    MeSH term(s) Humans ; Female ; Ovarian Neoplasms/genetics ; MicroRNAs/genetics ; Karyopherins
    Chemical Substances bisphenol A (MLT3645I99) ; MicroRNAs ; Karyopherins
    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.17920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5752: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: WhatsApp group discussion for smoking relapse prevention: a randomised controlled trial (abridged secondary publication).

    Cheung, D Y T / Chan, H C H / Conway, M / Wong, C K H / Li, W H C / Wang, M P / Lam, T H

    Hong Kong medical journal = Xianggang yi xue za zhi

    2023  Volume 29 Suppl 3, Issue 3, Page(s) 16–18

    MeSH term(s) Humans ; Neoplasm Recurrence, Local ; Smoking/adverse effects ; Smoking/epidemiology ; Smoking Cessation ; Secondary Prevention ; Smoking Prevention
    Language English
    Publishing date 2023-06-26
    Publishing country China
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4347: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Radiosensitivity index as a predictive biomarker for radiotherapy de-intensification in nasopharyngeal carcinoma: abridged secondary publication.

    Chiang, C L / Lee, W M A / Choi, C W H / Ngan, K C R / Ng, W T / Lee, H F V / Lam, T C / Lam, K O / Tsang, K C / Wong, W H J

    Hong Kong medical journal = Xianggang yi xue za zhi

    2024  Volume 30 Suppl 1, Issue 1, Page(s) 27–28

    MeSH term(s) Humans ; Nasopharyngeal Carcinoma/radiotherapy ; Nasopharyngeal Neoplasms/radiotherapy ; Carcinoma ; Biomarkers ; Radiation Tolerance ; Cell Line, Tumor
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-02-27
    Publishing country China
    Document type Journal Article
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4347: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Humoral responses to coronavirus disease 2019 vaccines in people with HIV: authors' reply.

    Wong, Ngai Sze / Wong, Bonnie C K / Chan, Jacky M C / Wong, Ka Hing / Tsang, Owen T Y / Lee, Shui Shan / Chan, Denise P C

    AIDS (London, England)

    2022  Volume 36, Issue 12, Page(s) 1747–1748

    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines ; HIV Infections/complications ; Humans ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-09-02
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000003295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2228: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Editorial: Hikikomori: an international perspective on assessment, treatment, and community intervention.

    Lo, T Wing / Wong, John C M / Chan, Gloria Hongyee / Kato, Takahiro A

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1297898

    Language English
    Publishing date 2023-10-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1297898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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