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Article ; Online: How does Mei-yu precipitation respond to climate change?

Sun, Bo / Xue, Rufan / Li, Wanling / Zhou, Siyu / Li, Huixin / Zhou, Botao / Wang, Huijun

2023 Volume 10, Issue 12, Page(s) nwad246

Abstract: Mei-yu is an important weather phenomenon in the middle-lower Yangtze River valley (YRV) region ... This study investigates the changes in the characteristics of Mei-yu under global warming and the potential ... the frequency and intensity of extreme precipitation events (EPEs) in the YRV region during the Mei-yu period ...

Abstract	Mei-yu is an important weather phenomenon in the middle-lower Yangtze River valley (YRV) region. This study investigates the changes in the characteristics of Mei-yu under global warming and the potential reasons based on observation and reanalysis data during 1961-2022. Notable increasing long-term trends are detected in the number of days without rainfall (NDWOR), the intensity of rainfall events, and the frequency and intensity of extreme precipitation events (EPEs) in the YRV region during the Mei-yu period (15 June-10 July) over past decades. The increasing trend in NDWOR is attributed to decreased relative humidity over land surface and a longer time for the air to be replenished with moisture after rainfall events in a warming climate. The increasing trends in the intensity of rainfall events and frequency/intensity of EPEs are attributed to the strengthened transient water vapor convergence and convection in the atmosphere under global warming. Furthermore, the response of Mei-yu to 2°C of global warming with respect to the pre-industrial climate is analysed using CMIP6 models. The results suggest that the NDWOR, intensity of rainfall events and frequency of EPEs will increase in the YRV region during the Mei-yu period under the 2°C warming scenario, which implies a more challenging climate risk management in the future. Overall, the intensity of rainfall events during the Mei-yu period has the most significant response to climate change in observations and projections. The model results have a relatively large uncertainty.
Language	English
Publishing date	2023-09-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2745465-4
ISSN	2053-714X ; 2053-714X
ISSN (online)	2053-714X
ISSN	2053-714X
DOI	10.1093/nsr/nwad246
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Study on the mechanism of action of Wu Mei Pill in inhibiting rheumatoid arthritis through TLR4-NF-κB pathway.

Fu, Yuheng / Gao, Chunyu / Sun, Xialin / Zhao, Yan / Zhang, Haibo

Journal of orthopaedic surgery and research

2024 Volume 19, Issue 1, Page(s) 65

Abstract: Background: Wu Mei Pills (WMP) is a traditional Chinese medication that exhibits considerable ...

Abstract	Background: Wu Mei Pills (WMP) is a traditional Chinese medication that exhibits considerable anti-inflammatory effects. While WMP has been documented for its efficacy in treating RA, its mechanism of action on the condition remains unestablished. Methods: The chemical composition of WMP was analyzed through UPLC-MS. Next, the enzyme-linked immunosorbent assay, cell scratch, Transwell, and Western blotting techniques were used to investigate its intrinsic mechanism. Lastly, the effect of WMP in inhibiting RA was explored by applying it to CIA rats. Result: UPLC-MS analysis detected 181 compounds in WMP. RA-FLS migration and invasion mechanisms were significantly hindered by serum containing WMP (2%, 8%). Moreover, WMP (0.5 g/kg, 2 g/kg) restricted arthritis and immune organ indices in CIA rats with type II collagen-induced rheumatoid arthritis by blocking TLR4-NF-κB inflammatory pathway activation. Conclusions: WMP is valuable in mitigating the course of RA through inhibiting the classical TLR4-NF-κB inflammatory pathway and reducing the secretion of inflammatory factors in the serum of RA-FLS and CIA rats. Moreover, it regulates the dynamic balance of MMP-2/TIMP-2, MMP-9/TIMP-1, modulates the mechanism of RA-FLS invasion, and safeguards articular cartilage tissues in RA.
MeSH term(s)	Rats ; Animals ; NF-kappa B/metabolism ; Toll-Like Receptor 4/metabolism ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Arthritis, Rheumatoid/metabolism ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/metabolism ; Fibroblasts/metabolism ; Synovial Membrane/metabolism ; Cells, Cultured
Chemical Substances	NF-kappa B ; Toll-Like Receptor 4
Language	English
Publishing date	2024-01-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2252548-8
ISSN	1749-799X ; 1749-799X
ISSN (online)	1749-799X
ISSN	1749-799X
DOI	10.1186/s13018-024-04551-z
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Article ; Online: Yang-Gan-Jiang-Mei formula alleviates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome through mitophagy.

Wu, Yuanyuan / Kuang, Yufeng / Wu, Yunbang / Dai, Heng / Bi, Ruiqi / Hu, Jiaming / Sun, Lixia

Biotechnology & genetic engineering reviews

2023 , Page(s) 1–20

Abstract: As an effective formula of traditional Chinese medicine, Yang-Gan-Jiang-Mei (YGJM) formula ...

Abstract	As an effective formula of traditional Chinese medicine, Yang-Gan-Jiang-Mei (YGJM) formula exhibited a unique advantage in ameliorating liver injury and hepatic steatosis of non-alcoholic steatohepatitis (NASH). Nevertheless, the related pharmacological mechanism needs to be elucidated. This study aimed to explore the molecular mechanism of YGJM formula on mitophagy mediated by PINK1/parkin signaling pathway and NOD-like receptor protein 3 (NLRP3) inflammasome in NASH. High-fat-diet rats and HepG2 cells induced by free fatty acid were used as NASH models
Language	English
Publishing date	2023-03-24
Publishing country	England
Document type	Journal Article
ZDB-ID	49457-4
ISSN	2046-5556 ; 0264-8725
ISSN (online)	2046-5556
ISSN	0264-8725
DOI	10.1080/02648725.2023.2193482
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Article ; Online: Comparative phytochemical property and antioxidant activity of sixteen Mei (Prunus mume) fruit cultivars from six provinces in China

Liu, Zhihua / Yang, Yezi / Sun, Chongzhi / Wu, Yang / Li, Xiaobo

International Journal of Food Properties. 2022 Dec. 31, v. 25, no. 1 p.617-633

2022

Abstract: Mei (Prunus mume) is widely planted in Eastern Asian countries. To evaluate the effect of cultivar ... and producing origin on the quality of Mei fruit, we studied the phytochemical properties and ... antioxidant activities of the 16 Mei fruit cultivars from 6 provinces in China, as well as their profiles ...

Abstract	Mei (Prunus mume) is widely planted in Eastern Asian countries. To evaluate the effect of cultivar and producing origin on the quality of Mei fruit, we studied the phytochemical properties and antioxidant activities of the 16 Mei fruit cultivars from 6 provinces in China, as well as their profiles of 121 volatile compounds, 5 organic acids, 13 minerals, 24 amino acids and 3 active peptides. Multivariate analysis revealed that the four Mei fruit cultivars with a drier climate in Yunnan province had the characteristics of low water moistures and proteins contents, high total acids, soluble solids, flavones, and phenols contents, and high antioxidant activities, which could be distinguished from fruits of other producing areas. Further component analysis showed that Mei fruits were rich in volatile compounds, organic acids (such as citric acid and malic acid), minerals (such as K, Ca, Mg, P, and Fe), and amino acids (such as Orn, Asn, and Asp), and the nutrient composition ratio in different cultivars was different. In conclusion, Mei fruits can be used as nutritious health food and different cultivars focus on different nutritional compositions.
Keywords	Prunus mume ; antioxidant activity ; antioxidants ; citric acid ; climate ; cultivars ; flavones ; fruits ; health foods ; malic acid ; multivariate analysis ; nutrient content ; peptides ; China ; origin ; cultivar ; phytochemical ; nutrient ; antioxidant ; amino acid ; organic acid ; volatile ; minerals
Language	English
Dates of publication	2022-1231
Size	p. 617-633.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1402715-x
ISSN	1532-2386 ; 1094-2912
ISSN (online)	1532-2386
ISSN	1094-2912
DOI	10.1080/10942912.2022.2053707
Database	NAL-Catalogue (AGRICOLA)

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Article: Efficacy and Safety of Wei Bi Mei, a Chinese Herb Compound, as an Alternative to Bismuth for Eradication of

Li, Lei / Meng, FanDong / Zhu, Shengtao / Guo, ShuiLong / Wang, YongJun / Zhao, Xin / Sun, YiLin / Zhang, Yan / Wang, QinQin / Xu, HuFeng / Zhang, ShuTian

Evidence-based complementary and alternative medicine : eCAM

2018 Volume 2018, Page(s) 4320219

Abstract: ... been raised. We first assessed the efficacy and safety of Wei Bi Mei granules, which are bismuth ...

Abstract	Bismuth-containing quadruple therapy has been recommended as the first line of treatment in areas of high clarithromycin or metronidazole resistance. However, safety concerns of bismuth agents have long been raised. We first assessed the efficacy and safety of Wei Bi Mei granules, which are bismuth compounds consisting of three synthetic drugs and five medicinal herbs, compared to bismuth aluminate and colloidal bismuth subcitrate (CBS) in
Language	English
Publishing date	2018-02-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2018/4320219
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Article: Germplasm resources and breeding of mei, an ornamental woody plant

Tang, J / F. Bao / H. T. Pan / J. Wang / K. F. Ma / L. D. Sun / Q. X. Zhang / T. R. Cheng / Y. Han

Acta horticulturae. 2017 Dec. 5, , no. 1185

2017

Abstract: Mei (Prunus mume Sieb.et Zucc.), originated in the Hengduan Mountains region in China, has been ... of germplasm resources of mei and its cold-resistance breeding and new cultivar breeding for both flower and fruit ... purposes had been reviewed. Mei has an abundant wild and semi-wild resources mainly distributed ...

Abstract	Mei (Prunus mume Sieb.et Zucc.), originated in the Hengduan Mountains region in China, has been domesticated as an important ornamental and fruit plant for more than 3,000 years. The distribution of germplasm resources of mei and its cold-resistance breeding and new cultivar breeding for both flower and fruit purposes had been reviewed. Mei has an abundant wild and semi-wild resources mainly distributed in southwestern China. Through long-term selection and breeding, mei has been domesticated to yield about 380 cultivars in 15 distinct regions of 20 Chinese provinces, some of which survive more than two hundred years (known as ancient mei). There are 75 ancient mei identified in six southwestern and southeastern provinces. Also, tremendous effort has been made to select mei for its cold hardiness, especially 'Three-North Areas' of China. By crossbreeding with apricot, a much cold-hardy species and many cold-resistance cultivars, such as 'Yan Xing', 'Hua Hudie', and 'Shan Taobai', had been cultivated in the past 60 years. These cultivars could tolerate and resist cold temperature of -15 to -35°C. Furthermore, according to the criteria developed on the basis of field investigations of mei cultivars in six provinces, several new cultivars for both flowers and fruits that including 'Yanwen Fenghou', 'Yulong Hongfei' and 'Judian No. 1' were selected and introduced. As an ornamental woody plant, mei has proven itself to be an important model plant for studying the evolution and diversification of genus Prunus.
Keywords	apricots ; cold tolerance ; crossing ; cultivars ; flowers ; fruits ; models ; mountains ; plant breeding ; Prunus mume ; temperature ; China
Language	English
Dates of publication	2017-1205
Size	p. 35-46.
Publishing place	International Society for Horticultural Science.
Document type	Article
Note	Paper presented at the II International Symposium on Germplasm of Ornamentals held August 8-12, 2016, Atlanta, Georgia, United States of America
ISSN	0567-7572
DOI	10.17660/ActaHortic.2017.1185.7
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Article ; Online: Efficacy and Safety of Wei Bi Mei, a Chinese Herb Compound, as an Alternative to Bismuth for Eradication of Helicobacter pylori

Lei Li / FanDong Meng / Shengtao Zhu / ShuiLong Guo / YongJun Wang / Xin Zhao / YiLin Sun / Yan Zhang / QinQin Wang / HuFeng Xu / ShuTian Zhang

Evidence-Based Complementary and Alternative Medicine, Vol

2018 Volume 2018

Abstract: ... been raised. We first assessed the efficacy and safety of Wei Bi Mei granules, which are bismuth ... by conducting clinical biochemistry tests in blood samples of experimental animals. Wei Bi Mei granules ... when compared to CBS and bismuth aluminate. Our findings show that Wei Bi Mei granules are a safe Chinese ...

Abstract	Bismuth-containing quadruple therapy has been recommended as the first line of treatment in areas of high clarithromycin or metronidazole resistance. However, safety concerns of bismuth agents have long been raised. We first assessed the efficacy and safety of Wei Bi Mei granules, which are bismuth compounds consisting of three synthetic drugs and five medicinal herbs, compared to bismuth aluminate and colloidal bismuth subcitrate (CBS) in H. pylori-infected mouse model. We then used atomic fluorescence spectroscopy and autometallography to measure the accumulation of three bismuth agents in the brain, heart, liver, and kidneys in adult Sprague-Dawley rats. We also evaluated the safety of bismuth agents by conducting clinical biochemistry tests in blood samples of experimental animals. Wei Bi Mei granules exhibited the highest efficacy of anti-H. pylori activity and yielded the lowest bismuth accumulation when compared to CBS and bismuth aluminate. Our findings show that Wei Bi Mei granules are a safe Chinese medicinal herb with potent anti-H. pylori activity and can be considered as an alternative to current bismuth compounds. Thus, Wei Bi Mei granules merit further evaluation, particularly with regard to efficacy and safety when they are combined with other H. pylori eradication medications in the clinical setting.
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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Article: [Investigation on the title of bu mei (sleepless)].

Sun, Hong-Sheng / Yan, Ji-Lan

Zhonghua yi shi za zhi (Beijing, China : 1980)

2004 Volume 34, Issue 4, Page(s) 214–217

Abstract: ... Moxibustion Classic of Yin-Yang Eleven Channels), while bu de wo, mu bu ming, and ye bu mei were appeared ... in Huang di nei jing (Inner Canon of Yellow Emperor), bu mei was first seen in Nan jing (Classic ... The title of bu mei was more popular after the Ming and Qing dynasties. This titles is the most appropriate ...

Abstract	There are various titles applied for "sleepless", including mu bu ming (unclosed eyes), bu de mian (unable to sleep), bu de wo (unable to lie down), shi mian (insomnia). The implications of the titles vary according to different periods. Bu de wo (unable to lie down) was first appeared in Zu bi shi yi mai jiu jing (Moxibustion Classic of Foot and Arm Eleven Channels) and Yin yang shi yi mai jiu jing (Moxibustion Classic of Yin-Yang Eleven Channels), while bu de wo, mu bu ming, and ye bu mei were appeared in Huang di nei jing (Inner Canon of Yellow Emperor), bu mei was first seen in Nan jing (Classic of Questioning). When bu de mian and bu de wo were applied in Zhang Zhongjing's Shang han lun (Treatise on Cold Pathogenic Diseases) and Jin kui yao lue (Synopsis of Golden Chamber), it exerted good influence in later generations. The title of bu mei was more popular after the Ming and Qing dynasties. This titles is the most appropriate one from the standpoint of syndrome itself as viewed from its semantic implication and its accuracy.
MeSH term(s)	History, 15th Century ; History, 16th Century ; History, 17th Century ; History, 18th Century ; History, 19th Century ; History, 20th Century ; History, Ancient ; History, Medieval ; Medicine, Chinese Traditional/history ; Sleep Initiation and Maintenance Disorders/history
Language	Chinese
Publishing date	2004-10
Publishing country	China
Document type	English Abstract ; Historical Article ; Journal Article
ZDB-ID	1052411-3
ISSN	0255-7053
ISSN	0255-7053
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Article: Developing the concept of MEI flower culture themed tourism - a case study of resources development of She County's Mei flower in Huangshan City

Wu, Gen-Song / Jia, Wang / Ming, Sun / Yang, Wei-Ru / Zhang, Qi-Xiang

Acta horticulturae. 2012 Sept., , no. 9372

2012

Abstract: Mei flower (Prunus mume Sieb. et Zucc.), as a representative of stanch national characteristics ... has a long history of cultivation in China. Chinese Mei flower culture has a rich connotation ... The development of the Mei flower industry has lead to Mei flower culture-themed tourism based on the exploration ...

Abstract	Mei flower (Prunus mume Sieb. et Zucc.), as a representative of stanch national characteristics, has a long history of cultivation in China. Chinese Mei flower culture has a rich connotation. The development of the Mei flower industry has lead to Mei flower culture-themed tourism based on the exploration of Mei Flower culture and the design of its tourism products. In this study, the SWOT method was used to analyze the conditions required to develop Mei flower culture themed tourism in She County. Based on the analysis, the goals of themed tourism were clearly positioned. A series of the tourism products were designed and arranged with spatial and temporal distribution. Four itineraries, in the county town-Xu cun-Shang feng, county town-Fu ye, county town-Bei an zhen-Chang xi, and county town-Xiong cun, were designed to attract tourists all year round.
Keywords	Prunus mume ; case studies ; flowers ; tourism ; China
Language	English
Size	p. 1201-1208.
Publishing place	International Society for Horticultural Science
Document type	Article
Note	Paper presented at the International Symposium on Advances in Ornamentals, Landscape and Urban Horticulture, volume 2, Organized on the Occasion of the 28th International Horticultural Congress on Science and Horticulture for People, held August 22-27, 2010, Lisbon, Portugal.
ISSN	0567-7572
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Genome-wide characterization and linkage mapping of simple sequence repeats in mei (Prunus mume Sieb. et Zucc.).

Sun, Lidan / Yang, Weiru / Zhang, Qixiang / Cheng, Tangren / Pan, Huitang / Xu, Zongda / Zhang, Jie / Chen, Chuguang

PloS one

2013 Volume 8, Issue 3, Page(s) e59562

Abstract: Because of its popularity as an ornamental plant in East Asia, mei (Prunus mume Sieb. et Zucc.) has ... of its genome. Here, we performed the genome-wide characterization of simple sequence repeats (SSRs) in the mei ... among the mei, strawberry (Fragaria vesca), and apple (Malus×domestica) genomes showed mei to have the highest ...

Abstract	Because of its popularity as an ornamental plant in East Asia, mei (Prunus mume Sieb. et Zucc.) has received increasing attention in genetic and genomic research with the recent shotgun sequencing of its genome. Here, we performed the genome-wide characterization of simple sequence repeats (SSRs) in the mei genome and detected a total of 188,149 SSRs occurring at a frequency of 794 SSR/Mb. Mononucleotide repeats were the most common type of SSR in genomic regions, followed by di- and tetranucleotide repeats. Most of the SSRs in coding sequences (CDS) were composed of tri- or hexanucleotide repeat motifs, but mononucleotide repeats were always the most common in intergenic regions. Genome-wide comparison of SSR patterns among the mei, strawberry (Fragaria vesca), and apple (Malus×domestica) genomes showed mei to have the highest density of SSRs, slightly higher than that of strawberry (608 SSR/Mb) and almost twice as high as that of apple (398 SSR/Mb). Mononucleotide repeats were the dominant SSR motifs in the three Rosaceae species. Using 144 SSR markers, we constructed a 670 cM-long linkage map of mei delimited into eight linkage groups (LGs), with an average marker distance of 5 cM. Seventy one scaffolds covering about 27.9% of the assembled mei genome were anchored to the genetic map, depending on which the macro-colinearity between the mei genome and Prunus T×E reference map was identified. The framework map of mei constructed provides a first step into subsequent high-resolution genetic mapping and marker-assisted selection for this ornamental species.
MeSH term(s)	Genome, Plant/genetics ; Genomics ; Microsatellite Repeats/genetics ; Phylogeny ; Physical Chromosome Mapping ; Prunus/genetics ; Synteny/genetics
Language	English
Publishing date	2013-03-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0059562
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