LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 2771

Search options

  1. Article ; Online: Informative Artifacts in AI-Assisted Care.

    Azizi, Zahra / Vedelli, Jordan K H / Anand, Kanwaljeet J S

    The New England journal of medicine

    2023  Volume 389, Issue 22, Page(s) 2113

    MeSH term(s) Humans ; Artifacts ; Artificial Intelligence
    Language English
    Publishing date 2023-12-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2311525
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Missing Race and Ethnicity Data in Pediatric Studies.

    Vedelli, Jordan K H / Azizi, Zahra / Anand, Kanwaljeet J S

    JAMA pediatrics

    2023  Volume 178, Issue 1, Page(s) 6–8

    MeSH term(s) Child ; Humans ; Ethnicity ; Demography ; Racial Groups ; Research Design ; Data Collection
    Language English
    Publishing date 2023-11-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2023.4745
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.74: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: The National Prevalence of Supplemental Oxygen Use in Persons with Chronic Obstructive Pulmonary Disease: A Comparison of Claims-based and Self-reported Supplemental Oxygen Use.

    Suen, Angela O / Cenzer, Irena / Iyer, Anand S / Witt, Leah J / Smith, Alexander K / Kotwal, Ashwin

    Annals of the American Thoracic Society

    2024  Volume 21, Issue 5, Page(s) 838–840

    MeSH term(s) Humans ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/therapy ; Oxygen Inhalation Therapy/statistics & numerical data ; United States/epidemiology ; Male ; Female ; Aged ; Self Report ; Middle Aged ; Prevalence
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Letter ; Comparative Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202311-949RL
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5828: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: A pH-dependent cluster of charges in a conserved cryptic pocket on flaviviral envelopes.

    Zuzic, Lorena / Marzinek, Jan K / Anand, Ganesh S / Warwicker, Jim / Bond, Peter J

    eLife

    2023  Volume 12

    Abstract: Flaviviruses are enveloped viruses which include human pathogens that are predominantly transmitted by mosquitoes and ticks. Some, such as dengue virus, exhibit the phenomenon of antibody-dependent enhancement (ADE) of disease, making vaccine-based ... ...

    Abstract Flaviviruses are enveloped viruses which include human pathogens that are predominantly transmitted by mosquitoes and ticks. Some, such as dengue virus, exhibit the phenomenon of antibody-dependent enhancement (ADE) of disease, making vaccine-based routes of fighting infections problematic. The pH-dependent conformational change of the envelope (E) protein required for fusion between the viral and endosomal membranes is an attractive point of inhibition by antivirals as it has the potential to diminish the effects of ADE. We examined six flaviviruses by employing large-scale molecular dynamics (MD) simulations of raft systems that represent a substantial portion of the flaviviral envelope. We utilised a benzene-mapping approach that led to a discovery of shared hotspots and conserved cryptic sites. A cryptic pocket previously shown to bind a detergent molecule exhibited strain-specific characteristics. An alternative conserved cryptic site at the E protein domain interfaces showed a consistent dynamic behaviour across flaviviruses and contained a conserved cluster of ionisable residues. Constant-pH simulations revealed cluster and domain-interface disruption under low pH conditions. Based on this, we propose a cluster-dependent mechanism that addresses inconsistencies in the histidine-switch hypothesis and highlights the role of cluster protonation in orchestrating the domain dissociation pivotal for the formation of the fusogenic trimer.
    MeSH term(s) Animals ; Humans ; Flavivirus ; Molecular Dynamics Simulation ; Histidine/metabolism ; Hydrogen-Ion Concentration ; Viral Envelope Proteins/metabolism
    Chemical Substances Histidine (4QD397987E) ; Viral Envelope Proteins
    Language English
    Publishing date 2023-05-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.82447
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Reshaping healthcare supply chain using chain-of-things technology and key lessons experienced from COVID-19 pandemic.

    Sathiya, V / Nagalakshmi, K / Jeevamalar, J / Anand Babu, R / Karthi, R / Acevedo-Duque, Ángel / Lavanya, R / Ramabalan, S

    Socio-economic planning sciences

    2023  Volume 85, Page(s) 101510

    Abstract: The COVID-19 (Corona virus disease 2019) pandemic continues to slash through the entire humanity on the earth causing an international health crisis and financial uncertainty. The pandemic has formed a colossal disruption in supply chain networks. It has ...

    Abstract The COVID-19 (Corona virus disease 2019) pandemic continues to slash through the entire humanity on the earth causing an international health crisis and financial uncertainty. The pandemic has formed a colossal disruption in supply chain networks. It has caused piling higher mortality in patients with comorbidities and generated a surging demand for critical care equipment, vaccines, pharmaceuticals, and cutting-edge technologies. Personal protective equipment, masks, ventilators, testing kits, and even commodities required for daily care have been scarce as lockdown and social distancing guidelines have kicked in. Amidst COVID-19, implementing and executing key processes of the healthcare supply chain (HSC) in a secured, trusted, effective, universally manageable, and the traceable way is perplexing owing to the fragile nature of the HSC, which is susceptible to redundant efforts and systemic risks that can lead to adverse impacts on consumer health and safety. Though the crisis shone a harsh light on the cracks and weaknesses of the HSC, it brings some significant insights into how HSC can be made more resilient and how healthcare industries figure out solutions to mitigate disruptions. While there are innumerable experiences learned from the disruption of this crisis, in this paper, five important areas to analyze the most vital and immediate HSC enhancements including building a resilient supply chain, thinking localization, implementing reliable reverse logistics, breaking down extant silos to achieve end-to-end visibility, and redesigning HSC using digitalization are emphasized. This work identifies important features related to CoT and HSC. Also, this study links these lessons to a potential solution through Chain of Things (CoT) technology. CoT technology provides a better way to monitor HSC products by integrating the Internet of Things (IoT) with blockchain networks. However, such an integrated solution should not only focus on the required features and aspects but also on the correlation among different features. The major objective of this study is to reveal the influence path of CoT on smart HSC development. Hence, this study exploits (i) fuzzy set theory to eliminate redundant and unrelated features; (ii) the Decision-Making and Experimental Evaluation Laboratory (DEMATEL) method to handle the intricate correlation among different features. This fuzzy-DEMATEL (F-DEMATEL) model attempts to direct CoT technology towards smart HSC by identifying the most influencing factors and investors are recommended to contribute to the development of application systems. This work also demonstrates how CoT can act a vital role in handling the HSC issues triggered by the pandemic now and in the post-COVID-19 world. Also, this work proposes different CoT design patterns for increasing opportunities in the HSC network and applied them as imperative solutions for major challenges related to traditional HSC networks.
    Language English
    Publishing date 2023-01-13
    Publishing country United States
    Document type Journal Article
    ISSN 0038-0121
    ISSN 0038-0121
    DOI 10.1016/j.seps.2023.101510
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Establishing proof of concept for utility of Trueprep

    Rajendran, P / Saini, S / Kumar, N / Vashistha, H / Thiruvengadam, K / Ramamoorthy, T / Gopalaswamy, R / Kayesth, J / Alavadi, U / Moore, M / Joshi, R P / Ramachandran, R / Anand, S / Shanmugam, S / Padmapriyadarsini, C

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2023  Volume 27, Issue 10, Page(s) 742–747

    Abstract: BACKGROUND AND OBJECTIVES: ...

    Abstract BACKGROUND AND OBJECTIVES:
    MeSH term(s) Humans ; Rifampin ; Mycobacterium tuberculosis/genetics ; Tuberculosis, Multidrug-Resistant/diagnosis ; Point-of-Care Testing ; Sputum ; Sensitivity and Specificity
    Chemical Substances Rifampin (VJT6J7R4TR)
    Language English
    Publishing date 2023-09-25
    Publishing country France
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.23.0003
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4776: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 261: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: A pH-dependent cluster of charges in a conserved cryptic pocket on flaviviral envelopes

    Lorena Zuzic / Jan K Marzinek / Ganesh S Anand / Jim Warwicker / Peter J Bond

    eLife, Vol

    2023  Volume 12

    Abstract: Flaviviruses are enveloped viruses which include human pathogens that are predominantly transmitted by mosquitoes and ticks. Some, such as dengue virus, exhibit the phenomenon of antibody-dependent enhancement (ADE) of disease, making vaccine-based ... ...

    Abstract Flaviviruses are enveloped viruses which include human pathogens that are predominantly transmitted by mosquitoes and ticks. Some, such as dengue virus, exhibit the phenomenon of antibody-dependent enhancement (ADE) of disease, making vaccine-based routes of fighting infections problematic. The pH-dependent conformational change of the envelope (E) protein required for fusion between the viral and endosomal membranes is an attractive point of inhibition by antivirals as it has the potential to diminish the effects of ADE. We examined six flaviviruses by employing large-scale molecular dynamics (MD) simulations of raft systems that represent a substantial portion of the flaviviral envelope. We utilised a benzene-mapping approach that led to a discovery of shared hotspots and conserved cryptic sites. A cryptic pocket previously shown to bind a detergent molecule exhibited strain-specific characteristics. An alternative conserved cryptic site at the E protein domain interfaces showed a consistent dynamic behaviour across flaviviruses and contained a conserved cluster of ionisable residues. Constant-pH simulations revealed cluster and domain-interface disruption under low pH conditions. Based on this, we propose a cluster-dependent mechanism that addresses inconsistencies in the histidine-switch hypothesis and highlights the role of cluster protonation in orchestrating the domain dissociation pivotal for the formation of the fusogenic trimer.
    Keywords flavivirus ; enveloped virus ; benzene-mapping ; cryptic pockets ; constant-pH simulations ; molecular dynamics simulations ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 541
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: Airway management of a patient with extensive upper airway hemangioma for total thyroidectomy.

    Rajan, Sunil / Sasikumar, Niranjan K / Anand, Ramya / Paul, Jerry

    Journal of anaesthesiology, clinical pharmacology

    2023  Volume 39, Issue 4, Page(s) 677–678

    Language English
    Publishing date 2023-02-02
    Publishing country India
    Document type Journal Article
    ZDB-ID 1401760-x
    ISSN 0970-9185
    ISSN 0970-9185
    DOI 10.4103/joacp.joacp_167_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4830: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Can Translational Social Neuroscience Research Offer Insights to Mitigate Structural Racism in the United States?

    Singh, Manpreet K / Nimarko, Akua / Bruno, Jennifer / Anand, Kanwaljeet J S / Singh, Swaran P

    Biological psychiatry. Cognitive neuroscience and neuroimaging

    2022  Volume 7, Issue 12, Page(s) 1258–1267

    Abstract: Social isolation and conflict due to structural racism may result in human suffering and loneliness across the life span. Given the rising prevalence of these problems in the United States, combined with disruptions experienced during the COVID-19 ... ...

    Abstract Social isolation and conflict due to structural racism may result in human suffering and loneliness across the life span. Given the rising prevalence of these problems in the United States, combined with disruptions experienced during the COVID-19 pandemic, the neurobiology of affiliative behaviors may offer practical solutions to the pressing challenges associated with structural racism. Controlled experiments across species demonstrate that social connections are critical to survival, although strengthening individual resilience is insufficient to address the magnitude and impact of structural racism. In contrast, the multilevel construct of social resilience, defined by the power of groups to cultivate, engage in, and sustain positive relationships that endure and recuperate from social adversities, offers unique insights that may have greater impact, reach, and durability than individual-level interventions. Here, we review putative social resilience-enhancing interventions and, when available, their biological mediators, with the hope to stimulate discovery of novel approaches to mitigate structural racism. We first explore the social neuroscience principles underlying psychotherapy and other psychiatric interventions. Then, we explore translational efforts across species to tailor treatments that increase social resilience, with context and cultural sensitivity in mind. Finally, we conclude with some practical future directions for understudied areas that may be essential for progress in biological psychiatry, including ethical ways to increase representation in research and developing social paradigms that inform dynamics toward or away from socially resilient outcomes.
    MeSH term(s) United States ; Humans ; Cognitive Neuroscience ; Systemic Racism ; Pandemics ; COVID-19 ; Translational Research, Biomedical
    Language English
    Publishing date 2022-05-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2879089-3
    ISSN 2451-9030 ; 2451-9022
    ISSN (online) 2451-9030
    ISSN 2451-9022
    DOI 10.1016/j.bpsc.2022.05.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Adenomyoepithelial adenosis mimicking phylloides: A diagnostic dilemma.

    Singh, Jyoty / Singhai, Atin / Babu, Suresh / Singh, Kulranjan / Mishra, Anand

    Indian journal of pathology & microbiology

    2024  Volume 67, Issue 1, Page(s) 223–225

    Abstract: Benign proliferative breast diseases are well recognized in young females. Benign biphasic proliferation of epithelial and myoepithelial cells has been observed, among which adeno-myoepithelial adenosis is one of the rare morphologies published in the ... ...

    Abstract Benign proliferative breast diseases are well recognized in young females. Benign biphasic proliferation of epithelial and myoepithelial cells has been observed, among which adeno-myoepithelial adenosis is one of the rare morphologies published in the literature with the tendency to recur and poses a risk for low-grade malignant transformation. Here, we report a case of a young female who had a history of recurrent breast lump mimicking phyllodes tumor and eventually diagnosed as adeno-myoepithelial adenosis on histopathological examination. Benign proliferative breast diseases are well recognized in young females. Benign biphasic proliferation of epithelial and myoepithelial cells has been observed, among which adeno-myoepithelial adenosis is one of the rare morphologies published in the literature with the tendency to recur and poses a risk for low-grade malignant transformation. Here, we report a case of a young female who had a history of recurrent breast lump mimicking phyllodes tumor and eventually diagnosed as adeno-myoepithelial adenosis on histopathological examination.
    MeSH term(s) Female ; Humans ; Phyllodes Tumor/diagnosis ; Phyllodes Tumor/pathology ; Neoplasm Recurrence, Local/pathology ; Fibrocystic Breast Disease/diagnosis ; Fibrocystic Breast Disease/pathology ; Epithelial Cells/pathology ; Hyperplasia/pathology ; Cell Transformation, Neoplastic/pathology ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Myoepithelioma/pathology
    Language English
    Publishing date 2024-02-12
    Publishing country India
    Document type Case Reports ; Journal Article
    ZDB-ID 197621-7
    ISSN 0974-5130 ; 0377-4929
    ISSN (online) 0974-5130
    ISSN 0377-4929
    DOI 10.4103/ijpm.ijpm_925_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 862: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top