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  1. Article: Translational Regulation by hnRNP H/F Is Essential for the Proliferation and Survival of Glioblastoma.

    Le Bras, Morgane / Gorelick, Noah / Pautet, Sylvain / Tyler, Betty / Manenti, Stéphane / Skuli, Nicolas / Millevoi, Stefania / Cammas, Anne

    Cancers

    2022  Volume 14, Issue 5

    Abstract: ... development, progression and response to therapy remain to be fully understood. Here, we showed that hnRNP H/F ... the expression and/or the activity of translation initiation factors. Among these, hnRNP H/F regulate ...

    Abstract Deregulation of mRNA translation is a widespread characteristic of glioblastoma (GBM), aggressive malignant brain tumors that are resistant to conventional therapies. RNA-binding proteins (RBPs) play a critical role in translational regulation, yet the mechanisms and impact of these regulations on cancer development, progression and response to therapy remain to be fully understood. Here, we showed that hnRNP H/F RBPs are potent regulators of translation through several mechanisms that converge to modulate the expression and/or the activity of translation initiation factors. Among these, hnRNP H/F regulate the phosphorylation of eIF4E and its translational targets by controlling RNA splicing of the
    Language English
    Publishing date 2022-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14051283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A novel alternative to F-tests for ecological studies

    Pertoldi, C. / Faurby, S. / Loeschcke, V. / Thirstrup, J. / Ruiz-Gonzalez, A. / Kjærsgaard, A. / Manenti, T. / Bahrndorff, S.

    Ecological indicators

    2016  Volume 67, Issue -, Page(s) 484

    Language English
    Document type Article
    ZDB-ID 2036774-0
    ISSN 1470-160x
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Z 7436: Show issues

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  3. Article: A novel alternative to F-tests for ecological studies

    Pertoldi, Cino / Anders Kjærsgaard / Aritz Ruiz-Gonzalez / Janne Thirstrup / Simon Bahrndorff / Søren Faurby / Tommaso Manenti / Volker Loeschcke

    Ecological indicators. 2016 Aug., v. 67

    2016  

    Abstract: Differences or similarities in the variance of fitness traits are crucial in several biological disciplines, e.g. ecological, toxicological, developmental and evolutionary studies. For example the variance of traits can be utilized as a biomarker of ... ...

    Abstract Differences or similarities in the variance of fitness traits are crucial in several biological disciplines, e.g. ecological, toxicological, developmental and evolutionary studies. For example the variance of traits can be utilized as a biomarker of differences in environmental conditions. In the absence of environmental variability, the differences of the variance of a trait can be interpreted as differences of the genetic background. Several tests and transformations are utilized when testing differences between variances. There is, however, a biological tendency for the variance to scale proportionally to the square of the mean (scaling effect) which can considerably bias the results of the tests. We propose a novel method which allows for a more precise correction of the scaling effect and proper comparisons among treatment groups and between investigations. This is relevant for all data sets of distributions with different means and suggests the reanalysis of comparisons among treatment groups. This correction will provide a more reliable method when using bioindicators.
    Keywords biomarkers ; data collection ; environmental factors ; genetic background ; genetic variation ; variance
    Language English
    Dates of publication 2016-08
    Size p. 484-490.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2036774-0
    ISSN 1872-7034 ; 1470-160X
    ISSN (online) 1872-7034
    ISSN 1470-160X
    DOI 10.1016/j.ecolind.2016.02.061
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 7436: Show issues

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  4. Article ; Online: Comment on: Influence of cardiometabolic medications on abdominal aortic aneurysm growth in the UK Aneurysm Growth Study: metformin and angiotensin-converting enzyme inhibitors associated with slower aneurysm growth.

    Manenti, Antonio / Manco, Gianrocco / Silingardi, Roberto / Coppi, Francesca

    The British journal of surgery

    2024  Volume 111, Issue 3

    MeSH term(s) Humans ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Metformin/therapeutic use ; Aortic Aneurysm, Abdominal/drug therapy ; Aorta, Abdominal ; United Kingdom
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Metformin (9100L32L2N)
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znae055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.66: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Spatial-Temporal resolution implementation of cloud-aerosols data through satellite cross-correlation.

    Manenti, Francesca / Cavazzani, Stefano / Bertolin, Chiara / Ortolani, Sergio / Fiorentin, Pietro

    MethodsX

    2024  Volume 12, Page(s) 102547

    Abstract: The Moderate Resolution Imaging Spectroradiometer (MODIS) instrument aboard Terra and Aqua satellites provides measurements of several atmospheric parameters. This paper focuses on the cloud fraction data representing the number of cloudy pixels divided ... ...

    Abstract The Moderate Resolution Imaging Spectroradiometer (MODIS) instrument aboard Terra and Aqua satellites provides measurements of several atmospheric parameters. This paper focuses on the cloud fraction data representing the number of cloudy pixels divided by the total number of pixels, and available through 1° x 1° grids spatial resolution with daily or monthly temporal resolution. The aim of the study is to propose a novel method called The Spatial-Temporal Implementation Algorithm (STIA) for analysing satellite daily 1° x 1°grid cloud fraction average values for•Comparing two datasets retrieved by MODIS aboard Aqua and Terra satellites to obtain information on the cloud formation in the afternoon and morning, respectively, thus enhancing the temporal resolution.•Comparing the actual parameter with others retrieved by instruments aboard of different satellites characterized by a better resolution. As an example of STIA application, this study uses the Aerosol Optical Depth (AOD) collected by the Ozone Monitoring Instrument (OMI) on board of Aura satellite for comparison with MODIS instrument to achieve and enhanced spatial resolution of the grid-cell.
    Language English
    Publishing date 2024-01-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2830212-6
    ISSN 2215-0161
    ISSN 2215-0161
    DOI 10.1016/j.mex.2024.102547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Innate Immunity Stimulation during the COVID-19 Pandemic: Challenge by Parvulan.

    Palmieri, Beniamino / Manenti, Antonio / Galotti, Francesca / Vadalà, Maria

    Journal of immunology research

    2022  Volume 2022, Page(s) 4593598

    Abstract: Aim: We report an open spontaneous anecdotical retrospective survey of : Methods: A total of 4000 patients (1900 men and 2100 women) with mild, moderate, or chronic disease, appealing to our Second Opinion Medical Consultation Network, signed an ... ...

    Abstract Aim: We report an open spontaneous anecdotical retrospective survey of
    Methods: A total of 4000 patients (1900 men and 2100 women) with mild, moderate, or chronic disease, appealing to our Second Opinion Medical Consultation Network, signed an informed consent form and were injected subcutaneously with
    Results: The main efficacy endpoints, as assessed by the SF-36 questionnaire are: significant improvements in the mental and physical role functioning score (
    Conclusions: Our results confirm that
    MeSH term(s) COVID-19 ; Female ; Humans ; Immunity, Innate ; Male ; Pandemics ; Retrospective Studies ; SARS-CoV-2 ; Treatment Outcome
    Language English
    Publishing date 2022-04-29
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2817541-4
    ISSN 2314-7156 ; 2314-7156
    ISSN (online) 2314-7156
    ISSN 2314-7156
    DOI 10.1155/2022/4593598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Enhancement of anaerobic digestion digital twin through aerobic simulation and kinetic optimization for co-digestion scenarios.

    Moretta, Federico / Rizzo, Eleonora / Manenti, Flavio / Bozzano, Giulia

    Bioresource technology

    2021  Volume 341, Page(s) 125845

    Abstract: An upgraded digital twin of the Anaerobic Digestion Model 1 is proposed to enhance its industrial applicability and range of use. Through the optimization and generalization of kinetic coefficients toward co-digestion reactors simulation and insertion of ...

    Abstract An upgraded digital twin of the Anaerobic Digestion Model 1 is proposed to enhance its industrial applicability and range of use. Through the optimization and generalization of kinetic coefficients toward co-digestion reactors simulation and insertion of new equations for the complete biokinetics modeling of H
    MeSH term(s) Anaerobiosis ; Biofuels ; Bioreactors ; Digestion ; Methane
    Chemical Substances Biofuels ; Methane (OP0UW79H66)
    Language English
    Publishing date 2021-08-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1065195-0
    ISSN 1873-2976 ; 0960-8524
    ISSN (online) 1873-2976
    ISSN 0960-8524
    DOI 10.1016/j.biortech.2021.125845
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 3258: Show issues

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  8. Article ; Online: The Effects of Directional and Non-Directional Stimuli during a Visuomotor Task and Their Correlation with Reaction Time: An ERP Study.

    Miraglia, Francesca / Pappalettera, Chiara / Di Ienno, Sara / Nucci, Lorenzo / Cacciotti, Alessia / Manenti, Rosa / Judica, Elda / Rossini, Paolo Maria / Vecchio, Fabrizio

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 6

    Abstract: ... and ERPs, the participants were divided into faster (F) and slower (S) groups based ... participants was subdivided into F and S trials based on the specific RT. ERP latencies were analysed between ... conditions ((DS, nDS); (F, S subjects); (F, S trials)). Correlation was analysed between CNV and RTs ...

    Abstract Different visual stimuli can capture and shift attention into different directions. Few studies have explored differences in brain response due to directional (DS) and non-directional visual stimuli (nDS). To explore the latter, event-related potentials (ERP) and contingent negative variation (CNV) during a visuomotor task were evaluated in 19 adults. To examine the relation between task performance and ERPs, the participants were divided into faster (F) and slower (S) groups based on their reaction times (RTs). Moreover, to reveal ERP modulation within the same subject, each recording from the single participants was subdivided into F and S trials based on the specific RT. ERP latencies were analysed between conditions ((DS, nDS); (F, S subjects); (F, S trials)). Correlation was analysed between CNV and RTs. Our results reveal that the ERPs' late components are modulated differently by DS and nDS conditions in terms of amplitude and location. Differences in ERP amplitude, location and latency, were also found according to subjects' performance, i.e., between F and S subjects and trials. In addition, results show that the CNV slope is modulated by the directionality of the stimulus and contributes to motor performance. A better understanding of brain dynamics through ERPs could be useful to explain brain states in healthy subjects and to support diagnoses and personalized rehabilitation in patients with neurological diseases.
    MeSH term(s) Adult ; Humans ; Reaction Time/physiology ; Evoked Potentials/physiology ; Brain/physiology ; Contingent Negative Variation ; Attention/physiology ; Electroencephalography
    Language English
    Publishing date 2023-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23063143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Evaluating Healthcare Performance in Low- and Middle-Income Countries: A Pilot Study on Selected Settings in Ethiopia, Tanzania, and Uganda.

    Belardi, Paolo / Corazza, Ilaria / Bonciani, Manila / Manenti, Fabio / Vainieri, Milena

    International journal of environmental research and public health

    2022  Volume 20, Issue 1

    Abstract: The literature reports some experiences regarding the design of integrated healthcare Performance Evaluation Systems (PES) applied in Low- and Middle-income Countries (LMIC). This study describes the design of an integrated and bottom-up PES aimed at ... ...

    Abstract The literature reports some experiences regarding the design of integrated healthcare Performance Evaluation Systems (PES) applied in Low- and Middle-income Countries (LMIC). This study describes the design of an integrated and bottom-up PES aimed at evaluating healthcare services delivery in rural settings. The analysis involved four hospitals and their relative health districts in Ethiopia, Tanzania, and Uganda. The evaluation process was undertaken for those indicators that could be evaluated using the same reference standard. The evaluation scores were determined through the international standards identified in the literature or through benchmarking assessment. Both administrative and health data were extracted from the hospitals' registers and District Health Information Systems (DHIS) from 2017 to 2020. We defined 128 indicators: 88 were calculated at the hospital level and 40 at the health district level. The evaluation process was undertaken for 48 indicators. The evaluated indicators are represented using effective graphical tools. In settings characterised by multiple healthcare providers, this framework may contribute to achieving good governance through performance evaluation, benchmarking, and accountability. It may promote evidence-based decision-making in the planning and allocation of resources, thus ultimately fostering quality improvement processes and practices, both at the hospital and health district level.
    MeSH term(s) Developing Countries ; Pilot Projects ; Uganda ; Tanzania ; Ethiopia ; Delivery of Health Care
    Language English
    Publishing date 2022-12-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20010041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Low-Dose Occupational Exposure to Ionizing Radiation and Cardiovascular Effects: A Narrative Review.

    Manenti, Guglielmo / Coppeta, Luca / Kirev, Ivan Valentinov / Verno, Greta / Garaci, Francesco / Magrini, Andrea / Floris, Roberto

    Healthcare (Basel, Switzerland)

    2024  Volume 12, Issue 2

    Abstract: Historically, non-cancer diseases have not been considered a health risk following low-dose exposure to ionizing radiation. However, it is now well known that high-dose ionizing radiation causes cardiovascular disease, and emerging epidemiological ... ...

    Abstract Historically, non-cancer diseases have not been considered a health risk following low-dose exposure to ionizing radiation. However, it is now well known that high-dose ionizing radiation causes cardiovascular disease, and emerging epidemiological evidence suggests an excess risk of non-cancer diseases even following exposure to lower doses of ionizing radiation than previously thought. In fact, the evidence is strongest for cardiovascular disease (CVD). The aim of this review was to report the most representative studies and data on the risk of CVD from low-dose radiation in people with occupational exposure. We reported the results of 27 articles selected from a database search of 1151 studies. The results show a complex evidence landscape on the relationship between radiation exposure and cardiovascular disease. In general, published papers show a positive association between ionizing radiation exposure and dermal microcirculation damage, ischemic heart disease, and cerebrovascular disease. Overall, they highlight the need for comprehensive and detailed research to clarify this relationship. Due to limited statistical power, the dose-risk relationship below 0.5 Gy is inconclusive, but if this relationship is found to have no threshold, it could have a significant impact on current estimates of health risks at low doses.
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare12020238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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