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Article ; Online: Optimized Extraction, Identification and Anti-Biofilm Action of Wu Wei Zi (

Zhang, Zongyi / Zhao, Yanan / Cai, Jing / Wang, Tong / Song, Yujie / Lu, Jingyi / Du, Hairuo / Wang, Wenfang / Zhao, Yan / Guo, Lei

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 5

Abstract: The pathogenicity of ... ...

Abstract	The pathogenicity of foodborne
MeSH term(s)	Vibrio parahaemolyticus/genetics ; Schisandra ; Biofilms
Chemical Substances	schizandrol B (58546-54-6) ; schizandrer A (82042-38-4) ; schizandrin C (C8754W6B3G)
Language	English
Publishing date	2023-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28052268
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Article: [Clinical Study of San Wei Sheng Huo Decoction in the Treatment of Refractory Chemotherapy-Induced Thrombocytopenia].

Li, Ru / Xiong, Shao-Quan / He, Li-Fang / Wu, Guo-Yu / Yuan, Yan-Wen

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

2023 Volume 54, Issue 1, Page(s) 161–164

Abstract: ... thrombocytopenia (RCIT) with San Wei Sheng Huo Decoction (SWSHD) as the main formula.: Methods ...

Abstract	Objective: To investigate the efficacy and safety of treating refractory chemotherapy-induced thrombocytopenia (RCIT) with San Wei Sheng Huo Decoction (SWSHD) as the main formula. Methods: A retrospective study was conducted and the data of RCIT patients treated with SWSHD as the main formula were collected. Changes in peripheral blood platelet (PLT) levels at different time points of treatment were examined and the significant effective rate (SER) and effective rate (ER) were analyzed. We measured the increase in peripheral blood PLT count before and after treatment, analyzed the differences in PLT count increase for different degrees of RCIT treatment, and evaluated the safety of the treatment. Results: A total of 35 cases of RCIT were included in the study. With SWSHD as the main treatment formula, the 2-week ER and SER were 74.29% and 14.29%, respectively, the 2-month ER and SER were 84.38% and 60.50, respectively, and the 1-year ER and SER were 92.31% and 80.77%, respectively. PLT count increased at all time points after treatment compared with that before treatment ( Conclusion: SWSHD takes effect rapidly and its effect is long-lasting and stable. Furthermore, SWSHD has a more significant effect on severe RCIT.
MeSH term(s)	Humans ; Retrospective Studies ; Thrombocytopenia/chemically induced ; Thrombocytopenia/drug therapy ; Platelet Count ; Blood Platelets ; Antineoplastic Agents/adverse effects
Chemical Substances	Antineoplastic Agents
Language	Chinese
Publishing date	2023-01-16
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2106840-9
ISSN	1672-173X
ISSN	1672-173X
DOI	10.12182/20230160506
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Article: Chinese herbal medicine Jia Wei Jing Xie Yin (JWJXY) ameliorates psoriasis via suppressing the Th17 cell response.

Yang, Dengke / Guo, Yiyu / Wu, Jun / Qin, Jianping / Wu, Jie / Lu, Yu / Xiao, Yan / Zhang, Xiaolin / Ye, Jianzhou

Annals of translational medicine

2022 Volume 10, Issue 6, Page(s) 332

Abstract: ... advantages. The Chinese herbal medicine Jia Wei Jing Xie Yin (JWJXY) has its origins in Jing Xie Yin ...

Abstract	Background: Psoriasis is a chronic autoimmune disease. At present, it is very difficult to treat; however, clinical trials have shown that the traditional Chinese medicine (TCM) treatment of psoriasis has certain advantages. The Chinese herbal medicine Jia Wei Jing Xie Yin (JWJXY) has its origins in Jing Xie Yin, a medicine created by the TCM doctor Wu Jun. Previous studies have shown that JWJXY has good clinical efficacy for patients with blood-heat type psoriasis, but its mechanism is unknown. Methods: This paper aimed to further study the therapeutic effect and mechanism of JWJXY on an imiquimod (IMQ)-induced, psoriasis-like mouse model (0.4 mL, i.g., 6 days). The histopathological skin changes were observed by hematoxylin and eosin (HE) staining, the infiltration of cluster of differentiation 11B (CD11b) and cluster of differentiation 4 (CD4) cells was observed by immunohistochemistry, lymphocyte subsets were detected by flow cytometry, T helper (Th)17 cell expression was perceived by flow cytometry, and Th17 cell-related gene expression was detected by real-time quantitative polymerase chain reaction (qPCR). Results: JWJXY significantly reduced the skin thickness of the IMQ-induced model mouse. Compared with that in the vehicle group, the skin tissue of the mice in the JWJXY group showed significantly reduced infiltration of CD11b Conclusions: The study confirmed the therapeutic effect of JWJXY on psoriasis. Its mechanism of action might be to inhibit the Th17 cell response but not the Th1 and Treg response.
Language	English
Publishing date	2022-04-01
Publishing country	China
Document type	Journal Article
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-22-967
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Article ; Online: Efficacy and safety of Jiu-Wei-Xi-Feng granules for treating tic disorders in children: study protocol for a randomized controlled equivalence trial.

Guo, Sheng-Xuan / Li, Rui-Ben / Hu, Si-Yuan / Cai, Qiu-Han / Zhong, Cheng-Liang / Hao, Rui-Min

Trials

2022 Volume 23, Issue 1, Page(s) 898

Abstract: ... in childhood. Jiu-Wei-Xi-Feng granules has been marketed in China for treating children with TD. As Long Gu (Os ... between Jiu-Wei-Xi-Feng granules (Os Draconis replaced by Concha Ostreae) (JWXFD) and Jiu-Wei-Xi-Feng ...

Abstract	Background: Tic disorders (TD) is a neuropsychiatric disease with twitch as the main manifestation in childhood. Jiu-Wei-Xi-Feng granules has been marketed in China for treating children with TD. As Long Gu (Os Draconis) in the composition of this Chinese patent medicine is a rare and expensive medicinal material protected by the Chinese government, therefore, we consider replacing it with Mu Li (Concha Ostreae) that has the same effect and is cheaper. This study is designed to evaluate the clinical equivalence between Jiu-Wei-Xi-Feng granules (Os Draconis replaced by Concha Ostreae) (JWXFD) and Jiu-Wei-Xi-Feng granules (original formula) (JWXFO) in children with TD (consumption of renal yin and liver wind stirring up internally syndrome). Methods/design: This is a multicenter, randomized, double-blind, equivalence trial comparing the efficacy and safety of JWXFD and JWXFO in treating Children with tic disorders (consumption of renal yin and liver wind stirring up internally syndrome). A total of 288 patients will be recruited and randomly assigned to two groups in a 1:1 ratio. The treatment course is 6 weeks, with a 2 weeks follow-up. The primary outcome is the mean change value from baseline to 6th week by the Yale Global Tic Severity Scale total tic score (YGTSS-TTS). Secondary outcomes include total effective rate of tic, Yale Global Tic Severity Scale (YGTSS) scores and its factor scores (the degree of motor tics, phonic tics and social function damage), Clinical Global Impression-Severity scale, and TCM syndrome efficacy. Discussion: The design of this study refers to a large number of similar research design points, and asked for opinions of peer experts, and finally reached a consensus. This trial will provide high-quality evidence on the clinical equivalence between JWXFD and JWXFO and provide a basis for the marketing of JWXFD. Trial registration: ChiCTR2000032312 Registered on 25 April 2020, http://www.chictr.org.cn/showproj.aspx?proj=52630.
MeSH term(s)	Child ; Humans ; Tics/therapy ; Treatment Outcome ; Tic Disorders/diagnosis ; Tic Disorders/drug therapy ; Double-Blind Method ; Syndrome ; Nonprescription Drugs ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic
Chemical Substances	Nonprescription Drugs
Language	English
Publishing date	2022-10-22
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-022-06802-y
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Article ; Online: Microplastics in surface waters and sediments of the Wei River, in the northwest of China.

Ding, Ling / Mao, Ruo Fan / Guo, Xuetao / Yang, Xiaomei / Zhang, Qian / Yang, Chen

The Science of the total environment

2019 Volume 667, Page(s) 427–434

Abstract: ... especially in northwest China. We investigated the occurrence and characteristics of microplastics in the Wei ... River Basin, which is located in northwestern China. The Wei River is the largest tributary ... of the Yellow River and runs through three major provinces. In the Wei River, the concentration of microplastics ...

Abstract	Microplastic pollution is an increasingly important environment problem. Many studies show the occurrence of microplastics in our environmental system. However, the freshwater system is less understood, especially in northwest China. We investigated the occurrence and characteristics of microplastics in the Wei River Basin, which is located in northwestern China. The Wei River is the largest tributary of the Yellow River and runs through three major provinces. In the Wei River, the concentration of microplastics in the surface waters varied from 3.67 to 10.7 items /L and in the sediments, the abundance of microplastics varied from 360 to 1320 items/kg. Fiber (50.1%)was the dominant types in water samples and sediments. The small size (<0.5 mm)(68.1%)were the main size of microplastics in Wei River. The types of microplastics were polyethylene, Polyvinyl chloride and polystyrene, as identified using a Fourier transform infrared spectrometer. This study could be a valuable reference for better understanding the microplastics pollution in inland northwestern China.
Language	English
Publishing date	2019-02-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2019.02.332
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Article: The Mechanisms of Improving IVF Outcomes of Liu-Wei-Di-Huang Pill Acting on DOR Patients.

Xiao, Jimei / Song, Jingyan / Sa, Yuanhong / Yuan, Lihua / Guo, Jiayin / Sun, Zhengao

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 5183017

Abstract: ... markers are still incompletely understood. Liu-Wei-Di-Huang (LWDH) pill, a traditional Chinese medicine ...

Abstract	Diminished ovarian reserve (DOR) is the weakening of ovarian oocyte production and quality. It will further become premature ovarian failure without timely cure. However, disease pathology and diagnostic markers are still incompletely understood. Liu-Wei-Di-Huang (LWDH) pill, a traditional Chinese medicine formula, is commonly used in the treatment of DOR in China. To explore the mechanism of the effect of LWDH on in vitro fertilization (IVF) outcomes in patients with DOR, a pseudotargeted metabolomics study combined with multivariate data processing strategy was carried out. A liquid chromatography tandem mass spectrometry-based metabolomics approach was applied to characterize metabolic biomarker candidates. Multiple pattern recognition was used to determine groups and confirm important variables. A total of 21 potential biomarkers were characterized, and related metabolic pathways were identified. The study displayed that the established pseudotargeted metabolomics strategy is a powerful approach for investigating the mechanism of DOR and LWDH. In addition, the approach may highlight biomarkers and metabolic pathways and can capture subtle metabolite changes from headache, which may lead to an improved mechanism understanding of DOR diseases and LWDH treatment.
Language	English
Publishing date	2020-10-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/5183017
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Article ; Online: Five-year lung cancer mortality risk analysis and topography in Xuan Wei: a spatiotemporal correlation analysis.

Li, Jinhui / Guo, Wenbo / Ran, Jinjun / Tang, Robert / Lin, Hualiang / Chen, Xiao / Ning, Bofu / Li, Jihua / Zhou, Yongchun / Chen, Lung-Chi / Tian, Linwei / Huang, Yunchao

BMC public health

2019 Volume 19, Issue 1, Page(s) 173

Abstract: Background: In Xuan Wei, China, the lung cancer mortality rate is rising significantly more ... the lung cancer mortality rates differ within Xuan Wei and how these spatiotemporal patterns are linked with local ... geographically-weighted regression to test for correlations among different towns within Xuan Wei.: Results ...

Abstract	Background: In Xuan Wei, China, the lung cancer mortality rate is rising significantly more than that of the nation overall. However, it remains unclear 1) if improved diagnosis can just partially explain this observation and how other local risk factors may be correlated with the lung cancer mortality rate and 2) how the lung cancer mortality rates differ within Xuan Wei and how these spatiotemporal patterns are linked with local risk factors. To increase etiological knowledge, this study evaluated the spatial and temporal distributions of the health effects (the lung cancer mortality rates) from 2011 to 2015. Methods: Four steps of spatial analysis were applied, as follows: 1) hotspot analysis to determine the geographical patterns of lung cancer mortality, 2) spatially-weighted sum to identify areas with higher health risks, 3) bivariate statistical analysis to assess the overall correlation between coal mines and lung cancer mortality, and 4) geographically-weighted regression to test for correlations among different towns within Xuan Wei. Results: Women had higher lung cancer mortality rates than those in men, with an increasing trend in both sexes over time. The incidence rates in Laibin Town were the highest in Xuan Wei every year. Over the 5-year study period, the lung cancer mortality was increasingly concentrated in Laibin, Shuanglong, and Longchang, where the smoky coal mines are most concentrated. The population-level health risks from the coal mine in Xuan Wei were mapped and divided into five types of risk areas (Type I - Type IV). Correlation analysis revealed that there was no significant correlation between lung cancer mortality as a whole and coal mine distribution during the 5-year study period. However, the geographically-weighted regression revealed a stronger correlation in medium (Type III) and second-lowest (Type IV) health risks. Conclusions: Xuan Wei lung cancer mortality has increased continuously since the third national retrospective surveys on the causes of death by the Ministry of Health of the People's Republic of China (2004-2005), especially for local women and residents over 35 years of age. Geographically, lung cancer in Xuan Wei showed unique spatiotemporal clustering. The local lung cancer mortality was significantly correlated with the smoky coal mine geographically. Some specific towns (Laibin, Shuanglong, and Longchang) within Xuan Wei manifested high correlations between lung cancer mortality and coal mines. The effects of coal mines on lung cancer mortality rates also spread geographically outward from these areas. Public health concern regarding lung cancer in Xuan Wei should prioritize higher-risk towns surrounded by smoking coal mines. Intervention strategies for particular toxic coal types require further studies on their chemical characteristics and mechanisms of carcinogenesis. Additional studies are also warranted to systematically examine the local environmental health risks related to coal industries and combustion air pollution and eventually to conduct early screening of lung cancer for local people who are more exposed to smoky coal in high-risk areas.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; China/epidemiology ; Female ; Humans ; Lung Neoplasms/mortality ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Spatio-Temporal Analysis
Language	English
Publishing date	2019-02-11
Publishing country	England
Document type	Journal Article
ISSN	1471-2458
ISSN (online)	1471-2458
DOI	10.1186/s12889-019-6490-1
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Article ; Online: Identification of sources, characteristics and photochemical transformations of dissolved organic matter with EEM-PARAFAC in the Wei River of China

Luo, Yuanyuan / Zhang, Yangyang / Lang, Mengfan / Guo, Xuetao / Xia, Tianjiao / Wang, Tiecheng / Jia, Hanzhong / Zhu, Lingyan

Front. Environ. Sci. Eng.. 2021 Oct., v. 15, no. 5 p.96-96

2021

Abstract: ... the sources and characteristics of DOM in surface water and sediment samples of the Wei River, China ... rapidly. These data describe the characteristics of DOM in the Wei River and are crucial to understanding ...

Abstract	Dissolved organic matter (DOM) in rivers is a critical regulator of the cycling and toxicity of pollutants and the behavior of DOM is a key indicator for the health of the environment. We investigated the sources and characteristics of DOM in surface water and sediment samples of the Wei River, China. Dissolved organic carbon (DOC) concentration and ultraviolet absorbance at 254 nm (UV₂₅₄) increased in the surface water and were decreased in the sediment downstream, indicating that the source of DOM in the water differed from the sediment. Parallel factor (PARAFAC) analysis of the excitation-emission matrices (EEM) revealed the presence of terrestrial humus-like, microbial humus-like and tryptophan-like proteins in the surface water, whereas the sediment contained UVA humic-like, UVC humic-like and fulvic-like in the sediment. The DOM in the surface water and sediment were mainly derived from microbial metabolic activity and the surrounding soil. Surface water DOM displayed greater photodegradation potential than sediment DOM. PARAFAC analysis indicated that the terrestrial humic-like substance in the water and the fulvic-like component in the sediment decomposed more rapidly. These data describe the characteristics of DOM in the Wei River and are crucial to understanding the fluctuations in environmental patterns.
Keywords	absorbance ; biochemical pathways ; dissolved organic carbon ; photolysis ; rivers ; sediments ; soil ; surface water ; toxicity ; China
Language	English
Dates of publication	2021-10
Size	p. 96.
Publishing place	Higher Education Press
Document type	Article ; Online
Note	NAL-AP-2-clean
ZDB-ID	2662203-8
ISSN	2095-221X ; 2095-2201
ISSN (online)	2095-221X
ISSN	2095-2201
DOI	10.1007/s11783-020-1340-z
Database	NAL-Catalogue (AGRICOLA)

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Article: Microplastics in surface waters and sediments of the Wei River, in the northwest of China

Ding, Ling / Ruo fan Mao / Xuetao Guo / Xiaomei Yang / Qian Zhang / Chen Yang

Science of the total environment. 2019 June 01, v. 667

2019

Abstract	Microplastic pollution is an increasingly important environment problem. Many studies show the occurrence of microplastics in our environmental system. However, the freshwater system is less understood, especially in northwest China. We investigated the occurrence and characteristics of microplastics in the Wei River Basin, which is located in northwestern China. The Wei River is the largest tributary of the Yellow River and runs through three major provinces. In the Wei River, the concentration of microplastics in the surface waters varied from 3.67 to 10.7 items /L and in the sediments, the abundance of microplastics varied from 360 to 1320 items/kg. Fiber (50.1%)was the dominant types in water samples and sediments. The small size (<0.5 mm)(68.1%)were the main size of microplastics in Wei River. The types of microplastics were polyethylene, Polyvinyl chloride and polystyrene, as identified using a Fourier transform infrared spectrometer. This study could be a valuable reference for better understanding the microplastics pollution in inland northwestern China.
Keywords	Fourier transform infrared spectroscopy ; freshwater ; microplastics ; pollution ; poly(vinyl chloride) ; polyethylene ; polystyrenes ; rivers ; sediments ; surface water ; watersheds ; China ; Yellow River
Language	English
Dates of publication	2019-0601
Size	p. 427-434.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2019.02.332
Database	NAL-Catalogue (AGRICOLA)

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Article: Efficacy and Safety of Wei Bi Mei, a Chinese Herb Compound, as an Alternative to Bismuth for Eradication of

Li, Lei / Meng, FanDong / Zhu, Shengtao / Guo, ShuiLong / Wang, YongJun / Zhao, Xin / Sun, YiLin / Zhang, Yan / Wang, QinQin / Xu, HuFeng / Zhang, ShuTian

Evidence-based complementary and alternative medicine : eCAM

2018 Volume 2018, Page(s) 4320219

Abstract: ... been raised. We first assessed the efficacy and safety of Wei Bi Mei granules, which are bismuth ...

Abstract	Bismuth-containing quadruple therapy has been recommended as the first line of treatment in areas of high clarithromycin or metronidazole resistance. However, safety concerns of bismuth agents have long been raised. We first assessed the efficacy and safety of Wei Bi Mei granules, which are bismuth compounds consisting of three synthetic drugs and five medicinal herbs, compared to bismuth aluminate and colloidal bismuth subcitrate (CBS) in
Language	English
Publishing date	2018-02-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2018/4320219
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