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Article ; Online: The interventional effect of Polygonatum cyrtonema Hua polysaccharide on atherosclerosis in mice of different sexes

Guo, Anjun / Li, Xueying / Pan, Lihua / Li, Qiangming / Luo, Jianping / Zha, Xueqiang

Food Science and Human Wellness. 2024 Jan., v. 13, no. 1 p.370-380

2024

Abstract: In the present study, we investigated the intervention effects of a purified Polygonatum cyrtonema polysaccharide (PCP) on high-fat diet (HFD)-induced atherosclerosis in male and female LDLr⁻/⁻ mice. Results showed that HFD caused severe dyslipidemia, ... ...

Abstract	In the present study, we investigated the intervention effects of a purified Polygonatum cyrtonema polysaccharide (PCP) on high-fat diet (HFD)-induced atherosclerosis in male and female LDLr⁻/⁻ mice. Results showed that HFD caused severe dyslipidemia, atherosclerotic lesions, oxidative damages and inflammation in male and female mice, and these effects seemed to be more pronounced in males than in females. However, the above variations could be dose-dependently reversed by PCP treatment, and the intervention effects on males were greater than those on females. Nuclear factor kappa-B (NF-κB), mitogen-activated protein kinase (MAPKs) and protein kinase B (Akt) are 3 pivotal signaling pathways mediating the development of atherosclerosis. Consistently, PCP was also found to significantly decrease the phosphorylation of p65, p38, extracellular-regulated kinase 1/2 (ERK1/2) and Akt, and increase the protein expression of inhibitor of NF-κB (IκB) in the aortas of male and female mice induced by HFD. Taken together, these findings indicated that PCP could be effective for the prevention of atherosclerosis, and the intervention effect of PCP on male mice was more obvious than that of female mice.
Keywords	Polygonatum cyrtonema ; atherosclerosis ; females ; food science ; high fat diet ; humans ; hyperlipidemia ; inflammation ; males ; mitogen-activated protein kinase ; non-specific serine/threonine protein kinase ; phosphorylation ; polysaccharides ; protein synthesis ; ERK1/2 ; GSH-Px ; HDL-C ; IκB ; IL-1β ; IL-10 ; IL-6 ; LDL-C ; MAPK ; MDA ; SOD ; TC ; TG ; TNF-α ; Polygonatum cyrtonema polysaccharide ; Anti-atherosclerosis ; Sex
Language	English
Dates of publication	2024-01
Size	p. 370-380.
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	2712869-6
ISSN	2213-4530
ISSN	2213-4530
DOI	10.26599/FSHW.2022.9250031
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Polygonatum cyrtonema Hua polysaccharide exhibits anti-fatigue activity via regulating osteocalcin signaling.

Shen, Wen-Di / Li, Xue-Ying / Deng, Yuan-Yuan / Zha, Xue-Qiang / Pan, Li-Hua / Li, Qiang-Ming / Luo, Jian-Ping

International journal of biological macromolecules

2021 Volume 175, Page(s) 235–241

Abstract: In the present study, we explored the anti-fatigue activity and its potential mechanism of a purified Polygonatum cyrtonema polysaccharide (PCP) on mice using weight-loaded swimming test. Results showed that PCP remarkably prolonged the exhaustive ... ...

Abstract	In the present study, we explored the anti-fatigue activity and its potential mechanism of a purified Polygonatum cyrtonema polysaccharide (PCP) on mice using weight-loaded swimming test. Results showed that PCP remarkably prolonged the exhaustive swimming time of mice when compared with normal control group. Meanwhile, PCP decreased serum levels of lactic acid (LA), blood uric nitrogen (BUN), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA), and increased the contents of liver glycogen, muscle glycogen and muscle ATP. These results revealed that PCP had good anti-fatigue ability. The histomorphologic analysis showed that PCP increased the cross-section area of the muscle fibers. Furthermore, PCP significantly enhanced the protein levels of bone morphogenetic protein-2 (BMP-2), phosphor-Smad1, Runt-related transcription factor 2 (Runx2) and osteocalcin (OC) in skeleton. Similar variation was also observed in the expression of osteocalcin signaling mediators of phosphorylated cAMP-response element binding protein (p-CREB) and phosphorylated hormone-sensitive lipase (p-HSL) in skeletal muscle. These results suggested that PCP resisted fatigue possibly via regulating osteocalcin signaling.
MeSH term(s)	Animals ; Body Weight/drug effects ; Catalase/metabolism ; Fatigue/drug therapy ; Fatigue/metabolism ; Glutathione Peroxidase/metabolism ; Glycogen/metabolism ; Male ; Malondialdehyde/metabolism ; Mice ; Mice, Inbred C57BL ; Muscle, Skeletal/metabolism ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Polygonatum/chemistry ; Polygonatum/metabolism ; Polysaccharides/metabolism ; Polysaccharides/pharmacology ; Signal Transduction ; Superoxide Dismutase/metabolism
Chemical Substances	Plant Extracts ; Polysaccharides ; Malondialdehyde (4Y8F71G49Q) ; Glycogen (9005-79-2) ; Catalase (EC 1.11.1.6) ; Glutathione Peroxidase (EC 1.11.1.9) ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2021-02-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2021.01.200
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Article: First Report of Polygonatum cyrtonema Hua Root Rot Caused by Trichoderma virens in China.

Gong, Zikun / Yang, Ying / Zhang, Linping / Wang, Shuqin / Luo, Jiayu / Luo, QianYing

Plant disease

2023

Abstract: Polygonatum cyrtonema Hua is a traditional Chinese medicine, which has anti-oxidant ...

Abstract	Polygonatum cyrtonema Hua is a traditional Chinese medicine, which has anti-oxidant, anti-inflammatory, immunomodulatory, and other pharmacological effects (Lu et al. 2023). In June 2022, A disease of root rot was observed on P. cyrtonema plants in Tonggu County (28°63'89″N, 114°48'07″E), Jiangxi Province, China. The disease incidence was approximately 30% in a surveyed area of 3 hectares, which contained approximately 20,000 plants. Initially, the above-ground parts of the plants did not show any obvious symptoms. However, the underground roots exhibited red-brown spots that gradually expanded and sunken areas appeared, and the diseased plants presented leaf chlorosis and red-brown discoloration of the tubers, eventually leading to plant death. To identify the pathogen, symptomatic root tissues (0.5×0.5×0.5cm) from the lesion margin surface were sterilized with 75% ethanol for 30s, 3% NaClO for 3 min followed by rinsing three times with sterile water. The sterile root pieces were placed on potato dextrose agar (PDA) and incubated at 25℃. Thirteen pure fungal isolates with the same morphological characteristics were obtained by monosporic isolation from 20 pieces of roots, and the representative isolates, HJGF1-1, HJGF1-2 were used for morphological studies and phylogenetic analyses. Initially, the two colonies on PDA appeared white with cotton-shaped aerial hyphae, which later turned light green to green and formed concentric rings. At the end of the conidiophores, 3 to 6 pear-shaped branches are irregularly gathered, and the angles between the branches are acute. The conidia were mostly solitary ellipsoid or obovate with the size of (3.7-5.9) × (3.6-4.5) μm (n=100). These morphological characteristics are consistent with the description of a Trichoderma spp. (Kamala et al. 2015). For molecular identification, the internal transcribed spacer (ITS), translation elongation factor 1-alpha (TEF-1α) and RNA polymerase II second largest subunit (RPB2) sequences were PCR amplified using primer pairs of ITS1/ITS4 (White et al. 1990), EF1-728F/EF1-986R (Carbone et al. 1999), and RPB2-5F2/RPB2-7cR (O'Donnell et al. 2022), respectively. BLAST analysis showed that the ITS, TEF-1α and RPB2 sequences of isolates HJGF1-1 (GenBank accession nos. OR229621, OR290791, OR334600) and HJGF1-2 (GenBank accession nos. OR229622, OR290792, OR334600) showed 99%-100% identity with multiple GenBank sequences of Trichoderma virens. A phylogenetic tree based on concatenated sequences of ITS, TEF-1α and RPB2 using maximum-likelihood analyses revealed that the two isolates HJGF1-1 and HJGF1-2 were in the same clade with T. virens strains. The two isolates were identified as T. virens based on the morphological characteristics and molecular phylogeny. To test pathogenicity, ten healthy P. cyrtonema plants (one tuber each, 5 tubers per isolate, n=10) in the field were pin-pricked with a sterile needle and pour-inoculated with 5 mL spore suspension per tuber (1× 107 conidia/ mL) with a temperature of about 28℃. Another five tubers were were pin-pricked with a sterile needle, inoculated with sterile water and served as controls. The resulting symptoms were similar to those on the original infected plants in the field, and control tubers remained symptomless fourteen days after inoculation. T. virens was reisolated from the diseased tubers, nevertheless no pathogenic fungus was isolated from the control tubers. T. virens has been reported causing disease on tulip bulb (Lou et al. 2003) but has not previously been reported causing disease on P. cyrtonema. Although several species of Trichoderma are known to be beneficial microorganisms, the beneficial fungus may have had an evolutionary period of interaction with plants in which it behaved as a plant pathogen (Poveda et al. 2022). To our knowledge, this is the first report of T. virens infecting P. cyrtonema in China. This result may expanded the etiological study of T. virens and the control strategy of P. cyrtonema root rot.
Language	English
Publishing date	2023-10-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-08-23-1647-PDN
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Article ; Online: Oligosaccharides of Polygonatum Cyrtonema Hua ameliorates dextran sulfate sodium-induced colitis and regulates the gut microbiota.

Xu, Jin / Tang, Chuankang / Din, Ahmad Ud / Lu, Yu / Ma, Xiaoyu / Zhang, Tao / Wu, Jiaqi / Zuoqin, Du / Luo, Pei / Wu, Jianbo

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 161, Page(s) 114562

Abstract: ... isolated from Polygonatum Cyrtonema Hua (PFOS) and exhibits anti-inflammatory effects. Therefore, we are ...

Abstract	Ulcerative colitis (UC) is one common chronic inflammatory bowel disease that causes severe side effects, and expensive treatment limits effective and sustained treatment of UC. Fructooligosaccharide was isolated from Polygonatum Cyrtonema Hua (PFOS) and exhibits anti-inflammatory effects. Therefore, we are curious whether PFOS could be used for the treatment of UC. PFOS was introduced via intragastric gavage to C57BL/6 J mice exposed to acute colitis induced by DSS. The results showed that doses of PFOS at 2 and 5 mg/kg/day alleviated the DSS-induced histopathological damage and improved intestinal barrier function. qPCR analysis revealed that PFOS exerted a significant downregulation of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) and upregulation of antioxidant genes, including superoxide dismutase1 (SOD1), glutathion peroxidase2 (GPX2), and nuclear factor erythroid 2 related factor2 (Nrf2). Furthermore, PFOS suppressed the DSS-induced disruption of the mucosal barrier by downregulating MMP13. Moreover, using 16 S rRNA gene-based microbiota analysis, PFOS could selectively enhance the growth of probiotics, including Bifidobacterium, Alloprevofella, and Alistipes. Our findings indicated that PFOS attenuated DSS-induced colitis in mice, suggesting that PFOS might be used as an efficacious supplement for reducing inflammatory bowel disease.
MeSH term(s)	Animals ; Mice ; Dextran Sulfate/pharmacology ; Polygonatum ; Gastrointestinal Microbiome ; Mice, Inbred C57BL ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/microbiology ; Colitis, Ulcerative/drug therapy ; Inflammatory Bowel Diseases/chemically induced ; Oligosaccharides/pharmacology ; Disease Models, Animal ; Colon
Chemical Substances	Dextran Sulfate (9042-14-2) ; Oligosaccharides
Language	English
Publishing date	2023-03-17
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114562
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Article ; Online: Branched fructo-oligosaccharides from Polygonatum Cyrtonema Hua as crosslinking agents for cellulose: A novel injectable and on-demand dissolution hydrogel for diabetic wound.

Ma, Hao / He, Lili / Yang, Yi / Wang, Tiantian / Li, Jiayao / Zhang, Zhifeng / Luo, Pei

International journal of biological macromolecules

2023 Volume 254, Issue Pt 3, Page(s) 128028

Abstract: ... derived from Polygonatum Cyrtonema Hua (referred to as PCOS). However, the characteristics of hydrogels ...

Abstract	Oligosaccharide-containing macromolecular bio adhesives are emerging as highly promising eco-friendly materials to enhance the cytocompatibility of viscous hydrogels for wound healing applications. In our prior research, we extensively elucidated the properties of branch-structure fructo-oligosaccharides derived from Polygonatum Cyrtonema Hua (referred to as PCOS). However, the characteristics of hydrogels based on fructo-oligosaccharides remain to be fully explored. In present work, we developed an injectable, PCOS/carboxymethyl cellulose (CMC) hydrogel which is a dual ion-physical cross-linked hydrogel that can be considered as a potential diabetic wound dressing. The tests showed that the optimal ratios for hydrogel preparation were 2 % CBM 940 (Carbomer 940), 5 % CMC and 10 % PCOS. The resultant hydrogel was formulated into composite hydrogels that were then used for the treatment of full-thickness excisional wounds in a db/db diabetic mouse model. Wound closure and histological evaluation confirmed its beneficial effect on wound healing. Further morphological analysis through scanning electron microscopy images revealed a porous hydrogel structure, while Fourier-transform infrared spectroscopy provided structural insights on the crosslinking reaction. Physicochemical properties of the hybrid hydrogels determined by rheological properties, thermogravimetric, water loss rate, et al., indicated that the double crosslinking PCOS/CMC hybrid hydrogel showed enhanced dynamic mechanical properties and water retention capacity compared to the CMC cellulose matrix hydrogels. Thus, this novel PCOS-hybrid hydrogel exhibited good dissolvability and injectable properties, which was proved to facilitate for the diabetic wound healing both in vitro and in vivo test and holds a potential clinical application in the wound healing.
MeSH term(s)	Humans ; Mice ; Animals ; Female ; Hydrogels/chemistry ; Cellulose/pharmacology ; Cellulose/chemistry ; Polygonatum ; Polycystic Ovary Syndrome/drug therapy ; Oligosaccharides ; Diabetes Mellitus/drug therapy ; Water ; Anti-Bacterial Agents/therapeutic use
Chemical Substances	Hydrogels ; Cellulose (9004-34-6) ; Oligosaccharides ; Water (059QF0KO0R) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-11-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.128028
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Article ; Online: Sheng-ji Hua-yu ointment ameliorates cutaneous wound healing in diabetes via up-regulating CCN1.

Yang, Dan / Tan, Yi-Mei / Zhang, Ying / Song, Jian-Kun / Luo, Yue / Luo, Ying / Fei, Xiao-Ya / Ru, Yi / Li, Bin / Jiang, Jing-Si / Kuai, Le

Journal of ethnopharmacology

2022 Volume 303, Page(s) 115954

Abstract: ... of diabetes, and efficacious therapeutic means are currently lacking. Sheng-ji Hua-yu (SJHY) ointment is ...

Abstract	Ethnopharmacological relevance: Diabetic ulcers (DUs) are one of the most severe complications of diabetes, and efficacious therapeutic means are currently lacking. Sheng-ji Hua-yu (SJHY) ointment is a classical Chinese traditional prescription that can significantly attenuate DU defects, but the specific mechanism remains to be fully elucidated. Aim of the study: In order to verify the underlying mechanism of SJHY ointment in accelerating the closure of DUs. Materials and methods: Modular pharmacology and molecular docking were utilized to predict the therapeutic targets of SJHY ointment against DUs. Male db/db diabetic mice and HaCaT cell models induced by methylglyoxal were used to validate the findings. Results: CCN1 was proven to be the core target of SJHY ointment involved in DUs treatment. CCN1 up-regulated by SJHY treatment (0.5 g/cm Conclusions: SJHY ointment ameliorates cutaneous wound healing by up-regulating CCN1.
Language	English
Publishing date	2022-11-24
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115954
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Article ; Online: De novo assembly and analysis of Polygonatum cyrtonema Hua and identification of genes involved in polysaccharide and saponin biosynthesis.

Li, Dandan / Wang, Qing / Chen, Songshu / Liu, Hongchang / Pan, Keqin / Li, Jinling / Luo, Chunli / Wang, Hualei

BMC genomics

2022 Volume 23, Issue 1, Page(s) 195

Abstract: ... metabolism is critical for genetic engineering of Polygonatum cyrtonema Hua to raise major active ingredient ...

Abstract	Background: The investigation of molecular mechanisms involved in polysaccharides and saponin metabolism is critical for genetic engineering of Polygonatum cyrtonema Hua to raise major active ingredient content. Up to now, the transcript sequences are available for different tissues of P. cyrtonema, a wide range scanning about temporal transcript at different ages' rhizomes was still absent in P. cyrtonema. Results: Transcriptome sequencing for rhizomes at different ages was performed. Sixty-two thousand six hundred thirty-five unigenes were generated by assembling transcripts from all samples. A total of 89 unigenes encoding key enzymes involved in polysaccharide biosynthesis and 56 unigenes encoding key enzymes involved in saponin biosynthesis. The content of total polysaccharide and total saponin was positively correlated with the expression patterns of mannose-6-phosphate isomerase (MPI), GDP-L-fucose synthase (TSTA3), UDP-apiose/xylose synthase (AXS), UDP-glucose 6-dehydrogenase (UGDH), Hydroxymethylglutaryl CoA synthase (HMGS), Mevalonate kinase (MVK), 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF), (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ispG), 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (ispH), Farnesyl diphosphate synthase (FPPS). Finally, a number of key genes were selected and quantitative real-time PCR were performed to validate the transcriptome analysis results. Conclusions: These results create the link between polysaccharides and saponin biosynthesis and gene expression, provide insight for underlying key active substances, and reveal novel candidate genes including TFs that are worth further exploration for their functions and values.
MeSH term(s)	Gene Expression Profiling ; Genes, Plant ; Polygonatum/genetics ; Polysaccharides ; Saponins/genetics
Chemical Substances	Polysaccharides ; Saponins
Language	English
Publishing date	2022-03-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2041499-7
ISSN	1471-2164 ; 1471-2164
ISSN (online)	1471-2164
ISSN	1471-2164
DOI	10.1186/s12864-022-08421-y
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Article ; Online: Transcriptomic and network pharmacology approaches revealed possible mechanisms underlying the 5-fluorouracil (5-FU)-sensitizing effect of Xuan-Fu-Hua decoction treatment on liver cancer cells.

Luo, Wen-Zhao / Dang, Zhong-Qin / Wu, Xiu-Xia / Shang, Yi-Wan / Meng, Dan-Hua / Chen, Yu-Long / Zhang, Qin-Sheng

Translational cancer research

2021 Volume 11, Issue 7, Page(s) 2398–2407

Abstract: Background: Xuan-Fu-Hua decoction is a traditional Chinese medicine formula widely used ... of Xuan-Fu-Hua decoction treatment on liver cancer cells and its mechanism of action.: Methods ... The impact of Xuan-Fu-Hua decoction treatment on the proliferation and apoptosis of SMMC-7721 liver cancer ...

Abstract	Background: Xuan-Fu-Hua decoction is a traditional Chinese medicine formula widely used for the treatment of inflammation-related disease in the lung and liver. This study aimed to investigate the effect of Xuan-Fu-Hua decoction treatment on liver cancer cells and its mechanism of action. Methods: The impact of Xuan-Fu-Hua decoction treatment on the proliferation and apoptosis of SMMC-7721 liver cancer cells with or without 5-fluorouracil (5-FU) cotreatment was determined in both Results: Xuan-Fu-Hua decoction alone did not significantly influence SMMC-7721 liver cancer cell growth, but it significantly increased the 5-Fu-induced growth inhibition and apoptosis of SMMC-7721 liver cancer cells Conclusions: Xuan-Fu-Hua decoction increased the sensitivity of liver cancer cells to the cytotoxicity of 5-FU treatment, possibly by potentiating cell apoptosis and inhibiting the prosurvival machinery.
Language	English
Publishing date	2021-10-27
Publishing country	China
Document type	Journal Article
ZDB-ID	2901601-0
ISSN	2219-6803 ; 2218-676X
ISSN (online)	2219-6803
ISSN	2218-676X
DOI	10.21037/tcr-22-1814
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Article ; Online: Corrigendum to "Application of omics technology to investigate the mechanism underlying the role of San Hua Tang in regulating microglia polarization and blood-brain barrier protection following ischemic stroke" [J. Ethnopharmacol. 314 (2023) 116640].

Luo, Shan / Chen, Yuanchun / Zhao, Ruoxi / Ma, Donglai / Zhao, Yanmeng / Zhang, Ying / Jiang, Jianming / Yu, Wentao

Journal of ethnopharmacology

2023 Volume 319, Issue Pt 1, Page(s) 117155

Language	English
Publishing date	2023-09-11
Publishing country	Ireland
Document type	Published Erratum
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117155
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Article: The Identification of the Biomarkers of Sheng-Ji Hua-Yu Formula Treated Diabetic Wound Healing Using Modular Pharmacology.

Jiang, Jing-Si / Zhang, Ying / Luo, Ying / Ru, Yi / Luo, Yue / Fei, Xiao-Ya / Song, Jian-Kun / Ding, Xiao-Jie / Zhang, Zhan / Yang, Dan / Yin, Shuang-Yi / Zhang, Hui-Ping / Liu, Tai-Yi / Li, Bin / Kuai, Le

Frontiers in pharmacology

2021 Volume 12, Page(s) 726158

Abstract: Sheng-Ji Hua-Yu (SJHY) formula has been proved to reduce the severity of diabetic wound healing ...

Abstract	Sheng-Ji Hua-Yu (SJHY) formula has been proved to reduce the severity of diabetic wound healing without significant adverse events in our previous clinical trials. However, based on multi-target characteristics, the regulatory network among herbs, ingredients, and hub genes remains to be elucidated. The current study aims to identify the biomarkers of the SJHY formula for the treatment of diabetic wound healing. First, a network of components and targets for the SJHY formula was constructed using network pharmacology. Second, the ClusterONE algorithm was used to build a modular network and identify hub genes along with kernel pathways. Third, we verified the kernel targets by molecular docking to select hub genes. In addition, the biomarkers of the SJHY formula were validated by animal experiments in a diabetic wound healing mice model. The results revealed that the SJHY formula downregulated the mRNA expression of
Language	English
Publishing date	2021-11-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.726158
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