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Article ; Online: From A to E: Uniting vitamins against stroke risk-A systematic review and network meta-analysis.

Tripathi, Shashank / Nath, Manabesh / Misra, Shubham / Kumar, Pradeep

European journal of clinical investigation

2024 , Page(s) e14165

Abstract: Background and aim: Stroke represents a significant public health challenge, necessitating the exploration of preventive measures. This network meta-analysis aimed to assess the efficacy of different vitamin treatments compared to a placebo in ... ...

Abstract	Background and aim: Stroke represents a significant public health challenge, necessitating the exploration of preventive measures. This network meta-analysis aimed to assess the efficacy of different vitamin treatments compared to a placebo in preventing stroke. Methods: A systematic electronic search in databases including PubMed, EmBASE, Web of Science, clinicaltrials.gov, and Google Scholar until 31 May 2023 was conducted, to identify published studies investigating the association between vitamin intake and the risk of stroke. Pooled risk ratio (RR) with 95% confidence intervals (CIs) was calculated using a frequentist network meta-analysis. Furthermore, we ranked vitamins based on p-scores, facilitating a comparative assessment of their effectiveness in preventing stroke. Results: A total of 56 studies, including 17 randomized controlled trials (RCTs) and 39 cohort studies were analyzed. Direct estimates obtained from network meta-analysis, we found that vitamin A (RR: .81 [.72-.91]), vitamin B-complex (RR: .85 [.74-.97]), vitamin B Conclusion: Our study has established noteworthy connections between vitamin A, vitamin B-complex, vitamin B
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	186196-7
ISSN	1365-2362 ; 0014-2972 ; 0960-135X
ISSN (online)	1365-2362
ISSN	0014-2972 ; 0960-135X
DOI	10.1111/eci.14165
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Article ; Online: Salivary microbiomes: a potent evidence in forensic investigations.

Yadav, Shubham / Kumari, Pallavi / Sinha, Aditi / Tripathi, Vijay / Saran, Vaibhav

Forensic science, medicine, and pathology

2024

Abstract: Saliva components combine with oral cavity microorganisms, blood cells, and airway secretions after entering the oral cavity via salivary ducts; these factors provide relevant information about persons' health state, quality of life, and lifestyle, in ... ...

Abstract	Saliva components combine with oral cavity microorganisms, blood cells, and airway secretions after entering the oral cavity via salivary ducts; these factors provide relevant information about persons' health state, quality of life, and lifestyle, in addition to their age and gender due to which salivary microbiome has emerged as a subject of significant interest in the forensic domain. This study aims to provide an extensive review of the possible applications of the salivary microbiome in characterizing the habit-specific microbiomes. Thirty-three relevant articles were selected for inclusion in this study. The study highlighted the influence of habits on the salivary microbiome suggesting smokers have distinct bacteria like Synergistetes, Streptococcus, Prevotella, and Veillonella in relation to age; people of higher age have more Prevotella; further, dental plaque can be corelated with Streptococci and Actinomycetes. Likewise, dietary habits, alcoholism, and consumption of coffee also affect bacteria types in oral cavities. The study underscores the added benefits of salivary microbiome profiling in forensics, as it is evident that microbial DNA profiling holds substantial promise for enhancing forensic investigations; it enables the characterization of an individual's habits, such as smoking, alcohol consumption, and dietary preferences; bacteria specific to these habits can be identified, thereby helping to narrow down the pool of potential suspects. In conclusion, the salivary microbiome presents a valuable avenue for forensic science, offering a novel approach which not only enhances the prospects of solving complex cases but also underscores the rich potential of microbiome analysis in the realm of forensic investigation.
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2195904-3
ISSN	1556-2891 ; 1547-769X
ISSN (online)	1556-2891
ISSN	1547-769X
DOI	10.1007/s12024-023-00759-3
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Article ; Online: Systems immunology of regulatory T cells: can one circuit explain it all?

Tripathi, Shubham / Tsang, John S / Park, Kyemyung

Trends in immunology

2023 Volume 44, Issue 10, Page(s) 766–781

Abstract: Regulatory T (Treg) cells play vital roles in immune homeostasis and response, including discrimination between self- and non-self-antigens, containment of immunopathology, and inflammation resolution. These diverse functions are orchestrated by cellular ...

Abstract	Regulatory T (Treg) cells play vital roles in immune homeostasis and response, including discrimination between self- and non-self-antigens, containment of immunopathology, and inflammation resolution. These diverse functions are orchestrated by cellular circuits involving Tregs and other cell types across space and time. Despite dramatic progress in our understanding of Treg biology, a quantitative framework capturing how Treg-containing circuits give rise to these diverse functions is lacking. Here, we propose that different facets of Treg function can be interpreted as distinct operating regimes of the same underlying circuit. We discuss how a systems immunology approach, involving quantitative experiments, computational modeling, and machine learning, can advance our understanding of Treg function, and help identify general operating and design principles underlying immune regulation.
MeSH term(s)	Humans ; T-Lymphocytes, Regulatory ; Antigens/metabolism
Chemical Substances	Antigens
Language	English
Publishing date	2023-09-09
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2036831-8
ISSN	1471-4981 ; 1471-4906
ISSN (online)	1471-4981
ISSN	1471-4906
DOI	10.1016/j.it.2023.08.007
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Article ; Online: Identification of habit specific bacteria in human saliva through Next-Generation Sequencing.

Yadav, Shubham / Tripathi, Vijay / Saran, Vaibhav

Forensic science international

2023 Volume 353, Page(s) 111871

Abstract: Characterization of human saliva through Next-Generation Sequencing has emerged as a valuable tool for understanding the complex microbial communities residing in the oral cavity. This study aims to investigate the habit-based variations in the salivary ... ...

Abstract	Characterization of human saliva through Next-Generation Sequencing has emerged as a valuable tool for understanding the complex microbial communities residing in the oral cavity. This study aims to investigate the habit-based variations in the salivary microbiome using Next-Generation Sequencing technology. Saliva samples were collected from a diverse population representing different habits, including smoking, alcohol consumption, and vegan diet. The DNA from the samples was extracted, and the V3-V4 region of the 16 S rRNA gene was amplified for Next-Generation Sequencing analysis. The obtained sequences were processed and analysed using bioinformatics tools to determine the microbial composition and diversity. Preliminary results revealed distinct microbial profiles associated with different habits, indicating the potential influence of different habits on the salivary microbiome. Smokers exhibited a higher abundance of certain pathogenic bacteria, while alcohol consumers showed alterations in microbial diversity compared to non-consumers. Furthermore, individuals with vegan diet demonstrated an increased prevalence of specific bacteria. These findings highlight the significance of habit-based characterization of the salivary microbiome and its potential implications in the presence of certain bacteria. Understanding the relationship between habits and the salivary microbiome could contribute to developing personalized approaches for estimating and identifying any particular individual. Further research is warranted to explore additional factors and expand the scope of habit-based analysis in saliva-based microbial characterization through Next-Generation Sequencing.
MeSH term(s)	Humans ; Saliva/microbiology ; RNA, Ribosomal, 16S/genetics ; High-Throughput Nucleotide Sequencing/methods ; Bacteria/genetics ; Habits
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2023-10-28
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	424042-x
ISSN	1872-6283 ; 0379-0738
ISSN (online)	1872-6283
ISSN	0379-0738
DOI	10.1016/j.forsciint.2023.111871
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Article ; Online: Prolonged South Asian Monsoon variability and weakened denitrification during Mid-Pleistocene Transition

Tripathi, Shubham / Tiwari, Manish / Behera, Padmasini

Palaeogeography, Palaeoclimatology, Palaeoecology. 2023 Aug., v. 624 p.111637-

2023

Abstract: During Mid-Pleistocene Transition (MPT, 0.68 to 1.16 million years ago, Ma), the earth's climate cycle shifted from 41 kyr (thousand years) to quasi-100 kyr cyclicity. The South Asian Monsoon (SAM) variability and its forcing factors during MPT are not ... ...

Abstract	During Mid-Pleistocene Transition (MPT, 0.68 to 1.16 million years ago, Ma), the earth's climate cycle shifted from 41 kyr (thousand years) to quasi-100 kyr cyclicity. The South Asian Monsoon (SAM) variability and its forcing factors during MPT are not fully understood. We present a multiproxy record of productivity and denitrification related to SAM variability from the eastern Arabian Sea (IODP Expedition 355, Site 1457) during MPT. The denitrification and productivity vary distinctly during the early (1.19 Ma to 0.95 Ma), mid (0.95 Ma to 0.79 Ma), and late (0.79 Ma to 0.68 Ma) MPT. The long-term SAM variability followed the prolonged glacial-interglacial cycle as it shifted to quasi-100 kyr periodicity at 0.95 Ma. The SAM was strong (weak) during the interglacials (glacials) of MPT. During early MPT, the SAM intensity was high during one of the glacial periods (MIS 30) due to precessional and CO₂ forcing. At mid-MPT, the denitrification anomalously decreases, possibly, due to enhanced oxygen solubility during the extended glacial period. During the various phases of MPT, both the dynamic (precession, interhemispheric insolation gradient) and the thermodynamic (CO₂ variability) effects govern the SAM.
Keywords	carbon dioxide ; climate ; denitrification ; monsoon season ; oxygen ; palaeogeography ; paleoclimatology ; paleoecology ; periodicity ; solar radiation ; solubility ; Arabian Sea ; South Asian Monsoon ; Mid-Pleistocene Transition ; Stable isotopes ; Productivity ; Eastern Arabian Sea
Language	English
Dates of publication	2023-08
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	417718-6
ISSN	0031-0182
ISSN	0031-0182
DOI	10.1016/j.palaeo.2023.111637
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Tailored mesoporous γ-WO

Tripathi, Shubham / Yadav, Jyoti / Kumar, Atul / Yadav, Raj Kamal / Chauhan, Pratima / Rawat, Ravindra Kumar / Tripathi, Satyam

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 42, Page(s) 28784–28795

Abstract: Herein, the monoclinic phase of tungsten oxide (γ- ... ...

Abstract	Herein, the monoclinic phase of tungsten oxide (γ-WO
Language	English
Publishing date	2023-11-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp03353h
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Article ; Online: Minimal frustration underlies the usefulness of incomplete regulatory network models in biology.

Tripathi, Shubham / Kessler, David A / Levine, Herbert

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 120, Issue 1, Page(s) e2216109120

Abstract: Regulatory networks as large and complex as those implicated in cell-fate choice are expected to exhibit intricate, very high-dimensional dynamics. Cell-fate choice, however, is a macroscopically simple process. Additionally, regulatory network models ... ...

Abstract	Regulatory networks as large and complex as those implicated in cell-fate choice are expected to exhibit intricate, very high-dimensional dynamics. Cell-fate choice, however, is a macroscopically simple process. Additionally, regulatory network models are almost always incomplete and/or inexact, and do not incorporate all the regulators and interactions that may be involved in cell-fate regulation. In spite of these issues, regulatory network models have proven to be incredibly effective tools for understanding cell-fate choice across contexts and for making useful predictions. Here, we show that minimal frustration-a feature of biological networks across contexts but not of random networks-can compel simple, low-dimensional steady-state behavior even in large and complex networks. Moreover, the steady-state behavior of minimally frustrated networks can be recapitulated by simpler networks such as those lacking many of the nodes and edges and those that treat multiple regulators as one. The present study provides a theoretical explanation for the success of network models in biology and for the challenges in network inference.
MeSH term(s)	Frustration ; Cell Differentiation/physiology ; Biology ; Gene Regulatory Networks ; Algorithms ; Computational Biology/methods
Language	English
Publishing date	2022-12-29
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2216109120
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Article: A correlation study of sustainable development goal (SDG) interactions.

Pakkan, Sheeba / Sudhakar, Christopher / Tripathi, Shubham / Rao, Mahabaleshwara

Quality & quantity

2022 Volume 57, Issue 2, Page(s) 1937–1956

Abstract: As universities are the change agent of society, institutions from all nations set their goals to transform the world by exploring various societal challenges that humans are facing. Together, the higher education systems across the world developing ... ...

Abstract	As universities are the change agent of society, institutions from all nations set their goals to transform the world by exploring various societal challenges that humans are facing. Together, the higher education systems across the world developing strategies based on the United Nations' Sustainable Development Goals (SDGs). The current study aimed to provide policymakers, academics, and researchers an insight on the influence of 16 SDGs on each other paving the way for the universities to set a clear goal in attaining Sustainable Development goals by 2030. To analyze the SDGs' interactions towards each other, 201,844 research publications from India during five years on 16 SDGs are retrieved from the Scopus database. Spearman Rank Correlation is applied to understand the correlation of each SDG towards one another. We could observe converging results out of the interactions among the SDGs. A significant positive and moderately positive correlation between pairs of SDGs are identified. While a significant number of negative correlations is also classified which need deep thinking among researchers to develop healthy relationships. The most frequent interactions between SDGs is a positive sign for any university in strategizing the goal towards SDGs. The association of all university stakeholders and some constitutional and cultural changes are necessary to put SDGs at the core of the management of the university. Embracing this task by researchers will improve the overall performance of universities. The analysis presented in the present study is useful for academics, governments, funding agencies, researchers, and policy-makers.
Language	English
Publishing date	2022-06-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2003280-8
ISSN	1573-7845 ; 0033-5177
ISSN (online)	1573-7845
ISSN	0033-5177
DOI	10.1007/s11135-022-01443-4
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Book ; Online: Safe and Secure Smart Home using Cisco Packet Tracer

Walia, Shivansh / Iyer, Tejas / Tripathi, Shubham / Vanaparthy, Akshith

2023

Abstract: This project presents an implementation and designing of safe, secure and smart home with enhanced levels of security features which uses IoT-based technology. We got our motivation for this project after learning about movement of west towards smart ... ...

Abstract	This project presents an implementation and designing of safe, secure and smart home with enhanced levels of security features which uses IoT-based technology. We got our motivation for this project after learning about movement of west towards smart homes and designs. This galvanized us to engage in this work as we wanted for homeowners to have a greater control over their in-house environment while also promising more safety and security features for the denizen. This contrivance of smart-home archetype has been intended to assimilate many kinds of sensors, boards along with advanced IoT devices and programming languages all of which in conjunction validate control and monitoring prowess over discrete electronic items present in home. Comment: 11 pages
Keywords	Computer Science - Cryptography and Security ; Computer Science - Networking and Internet Architecture
Publishing date	2023-04-24
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Plantar Lichen Planus: An Atypical Presentation at a Young Age.

Sisodia, Paras / Tripathi, Shubham / Verma, Parul / Singhai, Atin

Cureus

2021 Volume 13, Issue 9, Page(s) e17851

Abstract: Lichen planus is a chronic lichenoid dermatosis commonly encountered by dermatologists worldwide, affecting skin, mucosa, and scalp. The current case describes a rare variant of lichen planus, plantar lichen planus, in a 17-year-old male who presented ... ...

Abstract	Lichen planus is a chronic lichenoid dermatosis commonly encountered by dermatologists worldwide, affecting skin, mucosa, and scalp. The current case describes a rare variant of lichen planus, plantar lichen planus, in a 17-year-old male who presented with erythematous scaly plaques on the sole for two years associated with walking discomfort. The lesion was subjected to skin biopsy and a diagnosis of lichen planus was made considering the histopathological and clinical findings. Plantar lichen planus can often be misdiagnosed. Treating plantar lichen planus can be a therapeutic challenge and, thus, more insight is needed regarding treatment protocol or outcome of such cases.
Language	English
Publishing date	2021-09-09
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.17851
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