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  1. Article ; Online: Characterization of antibodies to SARS-CoV-2 in lyophilized plasma prepared with amotosalen-UVA pathogen reduction.

    Martinaud, Christophe / Bagri, Anil / Tsai, Cheng-Ting / de Assis, Rafael R / Gatmaitan, Michelle / Robinson, Peter V / Seftel, David / Khan, Saahir / Felgner, Philip L / Corash, Laurence M

    Transfusion

    2023  Volume 63, Issue 9, Page(s) 1633–1638

    Abstract: Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-infected patients exhibit disease ranging from asymptomatic to severe pneumonia, multi-organ failure, and death. convalescent COVID plasma (CCP) from recovered patients with high ... ...

    Abstract Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-infected patients exhibit disease ranging from asymptomatic to severe pneumonia, multi-organ failure, and death. convalescent COVID plasma (CCP) from recovered patients with high levels of neutralizing antibodies has demonstrated therapeutic efficacy to reduce the morbidity of coronavirus disease 2019 (COVID-19) in some studies. The development of assays to characterize the activity of CCP to neutralize SARS-CoV-2 infectivity offers the possibility to improve potential therapeutic efficacy. Lyophilization of CCP may increase the availability of this therapy. We hypothesized that SARS-CoV-2 antibody profiles of pooled lyophilized pathogen-reduced CCP from COVID-19-recovered blood donors retains virus-neutralizing efficacy as reported for frozen pathogen-reduced CCP.
    Methods: Pooled lyophilized pathogen-reduced plasma was prepared from recovered COVID plasma donors. Antibodies to SARS-CoV-2 were characterized in each donor plasma prior to pathogen reduction and lyophilization and after lyophilization of individual CCP, and in the lyophilized CCP pool. Several complimentary assays were used to characterize antibody levels, neutralizing capacity, and the spectrum of antigen reactivity. The mean values for individual plasma samples and the value in the pool were compared.
    Results: The mean ratio for antibody binding to SARS-CoV-2 antigens before and after treatment was 0.95 ± 0.22 mean fluorescent intensity (MFI) units. Antibody activity to an array of influenza virus antigens demonstrated a mean activity ratio of 0.92 ± 0.12 MFI before and after treatment.
    Conclusions: The antibody activity in pooled pathogen-reduced lyophilized CCPs demonstrated minimal impact due to pathogen reduction treatment and lyophilization.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19/therapy ; Furocoumarins ; Antibodies, Neutralizing
    Chemical Substances amotosalen (K1LDZ0VBC0) ; Furocoumarins ; Antibodies, Neutralizing
    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17506
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: The acquisition of humoral immune responses targeting

    de Jong, Roos M / Alkema, Manon / Oulton, Tate / Dumont, Elin / Teelen, Karina / Nakajima, Rie / de Assis, Rafael Ramiro / Press, Kathleen W Dantzler / Ngotho, Priscilla / Tetteh, Kevin K A / Felgner, Phil / Marti, Matthias / Collins, Katharine A / Drakeley, Chris / Bousema, Teun / Stone, Will J R

    Frontiers in immunology

    2022  Volume 13, Page(s) 930956

    Abstract: Individuals infected ... ...

    Abstract Individuals infected with
    MeSH term(s) Antibodies, Protozoan ; Humans ; Immunity, Humoral ; Malaria ; Malaria, Falciparum ; Plasmodium falciparum
    Chemical Substances Antibodies, Protozoan
    Language English
    Publishing date 2022-07-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.930956
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  3. Article: Natural Compounds as Non-Nucleoside Inhibitors of Zika Virus Polymerase through Integration of In Silico and In Vitro Approaches.

    Ramos, Paulo Ricardo Pimenta da Silva / Mottin, Melina / Lima, Caroline Sprengel / Assis, Letícia R / de Oliveira, Ketllyn Zagato / Mesquita, Nathalya Cristina de Moraes Roso / Cassani, Natasha Marques / Santos, Igor Andrade / Borba, Joyce Villa Verde Bastos / Fiaia Costa, Vinícius Alexandre / Neves, Bruno Junior / Guido, Rafael Victorio Carvalho / Oliva, Glaucius / Jardim, Ana Carolina Gomes / Regasini, Luis Octávio / Andrade, Carolina Horta

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 12

    Abstract: Although the past epidemic of Zika virus (ZIKV) resulted in severe neurological consequences for infected infants and adults, there are still no approved drugs to treat ZIKV infection. In this study, we applied computational approaches to screen an in- ... ...

    Abstract Although the past epidemic of Zika virus (ZIKV) resulted in severe neurological consequences for infected infants and adults, there are still no approved drugs to treat ZIKV infection. In this study, we applied computational approaches to screen an in-house database of 77 natural and semi-synthetic compounds against ZIKV NS5 RNA-dependent RNA-polymerase (NS5 RdRp), an essential protein for viral RNA elongation during the replication process. For this purpose, we integrated computational approaches such as binding-site conservation, chemical space analysis and molecular docking. As a result, we prioritized nine virtual hits for experimental evaluation. Enzymatic assays confirmed that pedalitin and quercetin inhibited ZIKV NS5 RdRp with IC
    Language English
    Publishing date 2022-11-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15121493
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  4. Article ; Online: Assessing the quality of constructed technosols enabled holistic monitoring of ecological restoration.

    Imbaná, Rugana / Daniele de Almeida Valente, Fernanda / Siqueira, Rafael Gomes / Moquedace, Cássio Marques / Rodrigues de Assis, Igor

    Journal of environmental management

    2024  Volume 353, Page(s) 120237

    Abstract: The soil quality index (SQI) serves as a general ecological restoration indicator, however, statistics approaches that accurately assess the minimum data set (MDS) for SQI remain susceptible. The present study aims to evaluate the short-term reclamation ... ...

    Abstract The soil quality index (SQI) serves as a general ecological restoration indicator, however, statistics approaches that accurately assess the minimum data set (MDS) for SQI remain susceptible. The present study aims to evaluate the short-term reclamation results at the Ferro-Carvão stream and propose a system for ecological restoration monitoring, by selecting influential attributes and indexing soil quality. We hypothesized that the reclamation activities at the Ferro-Carvão stream, referred to as the "Marco zero" (MZ) area, can bring its soil quality to levels comparable to those of the native area. We collected soil samples at 0-20 and 20-40 cm depths from transects of MZ and reference sites (R1 and R2). Principal component analysis showed the MDS for each soil depth. Permutational analysis of variance, in conjunction with Nonmetric Multidimensional Scaling, exposed relationships between transects of areas. An additive non-linear factorial algorithm allowed SQI assessment. The results indicated a similar soil quality between transects of areas at 0-20 cm depth, whereas a dissimilarity at 20-40 cm. To sum up, reclamation activities allowed MZ-constructed Technosol to present a soil quality similar to native areas. The soil quality assessment at both depths offered insights into reclamation activities' immediate and long-term impacts on the Ferro-Carvão stream. This robust framework effectively monitors ecological restoration progress and guides future efforts in post-mining and post-dam collapse sites.
    MeSH term(s) Soil ; Mining ; Principal Component Analysis ; Algorithms ; Ecosystem
    Chemical Substances Soil
    Language English
    Publishing date 2024-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2024.120237
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    Z 7556: Show issues

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  5. Article ; Online: Chlorine, chromium, proteins of oxidative stress and DNA repair pathways are related to prognosis in oral cancer.

    de Assis, Aricia Leone Evangelista Monteiro / Archanjo, Anderson Barros / Maranhão, Raul C / Mendes, Suzanny O / de Souza, Rafael P / de Cicco, Rafael / de Oliveira, Mayara M / Borçoi, Aline R / de L Maia, Lucas / Nunes, Fabio D / Dos Santos, Marcelo / Trivilin, Leonardo O / Pinheiro, Christiano J G / Álvares-da-Silva, Adriana M / Nogueira, Breno Valentim

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 22314

    Abstract: The comparison of chemical and histopathological data obtained from the analysis of excised tumor fragments oral squamous cell carcinoma (OSCC) with the demographic and clinical evolution data is an effective strategy scarcely explored in OSCC studies. ... ...

    Abstract The comparison of chemical and histopathological data obtained from the analysis of excised tumor fragments oral squamous cell carcinoma (OSCC) with the demographic and clinical evolution data is an effective strategy scarcely explored in OSCC studies. The aim was to analyze OSCC tissues for protein expression of enzymes related to oxidative stress and DNA repair and trace elements as candidates as markers of tumor aggressiveness and prognosis. Tumor fragments from 78 OSCC patients that had undergone ablative surgery were qualitatively analyzed by synchrotron micro-X-ray fluorescence for trace elements. Protein expression of SOD-1, Trx, Ref-1 and OGG1/2 was performed by immunohistochemistry. Sociodemographic, clinical, and histopathological data were obtained from 4-year follow-up records. Disease relapse was highest in patients with the presence of chlorine and chromium and lowest in those with tumors with high OGG1/2 expression. High expression of SOD-1, Trx, and Ref-1 was determinant of the larger tumor. Presence of trace elements can be markers of disease prognosis. High expression of enzymes related to oxidative stress or to DNA repair can be either harmful by stimulating tumor growth or beneficial by diminishing relapse rates. Interference on these players may bring novel strategies for the therapeutic management of OSCC patients.
    MeSH term(s) Aged ; Biomarkers, Tumor/metabolism ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Chlorine/metabolism ; Chromium/metabolism ; DNA Repair ; DNA, Neoplasm/metabolism ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/metabolism ; Mouth Neoplasms/pathology ; Neoplasm Proteins/metabolism ; Oxidative Stress ; Prognosis ; Retrospective Studies
    Chemical Substances Biomarkers, Tumor ; DNA, Neoplasm ; Neoplasm Proteins ; Chromium (0R0008Q3JB) ; Chlorine (4R7X1O2820)
    Language English
    Publishing date 2021-11-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-01753-x
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  6. Article ; Online: Small peptides inhibit gut trypsin-like proteases and impair Anticarsia gemmatalis (Lepidoptera: Noctuidae) survival and development.

    de Almeida Barros, Rafael / Meriño-Cabrera, Yaremis / Vital, Camilo E / da Silva Júnior, Neilier R / de Oliveira, Cauê N / Lessa Barbosa, Samuel / Marques Gonçalves Assis, João V / Ramos, Humberto Jo / de Almeida Oliveira, Maria G

    Pest management science

    2020  Volume 77, Issue 4, Page(s) 1714–1723

    Abstract: Background: Anticarsia gemmatalis larvae are key defoliating pests of soybean plants. Inorganic insecticides, harmful to the environment and human health, are the main molecules used in the control of this pest. To apply more sustainable management ... ...

    Abstract Background: Anticarsia gemmatalis larvae are key defoliating pests of soybean plants. Inorganic insecticides, harmful to the environment and human health, are the main molecules used in the control of this pest. To apply more sustainable management methods, organic molecules with high specificities, such as proteinaceous protease inhibitors, have been sought. Thus, molecular docking studies, kinetics assays, and biological tests were performed to evaluate the inhibitory activity of two peptides (GORE1 and GORE2) rationally designed to inhibit trypsin-like enzymes, which are the main proteases of A. gemmatalis midgut.
    Results: The molecular docking simulations revealed critical hydrogen bonding patterns of the peptides with key active site residues of trypsin-like proteases of A. gemmatalis and other Lepidopteran insects. The negative values of binding energy indicate that hydrogen bonds potentiate the tight binding of the peptides with trypsin-like proteases, predicting an effective inhibition. The inhibition's rate constants (Ki) were 0.49 and 0.10 mM for GORE1 and GORE2, resulting in effective inhibition of the activity trypsin on the L-BApNA substrate in the in vitro tests, indicating that the peptide GORE2 has higher inhibitory capacity on the A. gemmatalis trypsins. In addition, the two peptides were determined to be reversible competitive inhibitors. The in vivo test demonstrated that the peptides harm the survival and development of A. gemmatalis larvae.
    Conclusion: These results suggest that these peptides are potential candidates in the management of A. gemmatalis larvae and provide baseline information for the design of new trypsin-like inhibitors based on peptidomimetic tools. © 2020 Society of Chemical Industry.
    MeSH term(s) Animals ; Gastrointestinal Microbiome ; Humans ; Larva ; Lepidoptera ; Molecular Docking Simulation ; Moths ; Peptide Hydrolases ; Peptides ; Trypsin
    Chemical Substances Peptides ; Peptide Hydrolases (EC 3.4.-) ; Trypsin (EC 3.4.21.4)
    Language English
    Publishing date 2020-12-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001705-4
    ISSN 1526-4998 ; 1526-498X
    ISSN (online) 1526-4998
    ISSN 1526-498X
    DOI 10.1002/ps.6191
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    Z 2731: Show issues

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  7. Article ; Online: Antibody profiles in COVID-19 convalescent plasma prepared with amotosalen/UVA pathogen reduction treatment.

    Bagri, Anil / de Assis, Rafael R / Tsai, Cheng-Ting / Simmons, Graham / Mei, Zhen W / Von Goetz, Melissa / Gatmaitan, Michelle / Stone, Mars / Di Germanio, Clara / Martinelli, Rachel / Darst, Orsolya / Rioveros, Jowin / Robinson, Peter V / Ward, Dawn / Ziman, Alyssa / Seftel, David / Khan, Saahir / Busch, Michael P / Felgner, Philip L /
    Corash, Laurence M

    Transfusion

    2022  Volume 62, Issue 3, Page(s) 570–583

    Abstract: Background: COVID-19 convalescent plasma (CCP), from donors recovered from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, is one of the limited therapeutic options currently available for the treatment of critically ill patients ...

    Abstract Background: COVID-19 convalescent plasma (CCP), from donors recovered from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, is one of the limited therapeutic options currently available for the treatment of critically ill patients with COVID-19. There is growing evidence that CCP may reduce viral loads and disease severity; and reduce mortality. However, concerns about the risk of transfusion-transmitted infections (TTI) and other complications associated with transfusion of plasma, remain. Amotosalen/UVA pathogen reduction treatment (A/UVA-PRT) of plasma offers a mitigation of TTI risk, and when combined with pooling has the potential to increase the diversity of the polyclonal SARS-CoV-2 neutralizing antibodies.
    Study design and methods: This study assessed the impact of A/UVA-PRT on SARS-CoV-2 antibodies in 42 CCP using multiple complimentary assays including antigen binding, neutralizing, and epitope microarrays. Other mediators of CCP efficacy were also assessed.
    Results: A/UVA-PRT did not negatively impact antibodies to SARS-CoV-2 and other viral epitopes, had no impact on neutralizing activity or other potential mediators of CCP efficacy. Finally, immune cross-reactivity with other coronavirus antigens was observed raising the potential for neutralizing activity against other emergent coronaviruses.
    Conclusion: The findings of this study support the selection of effective CCP combined with the use of A/UVA-PRT in the production of CCP for patients with COVID-19.
    MeSH term(s) Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19/therapy ; Furocoumarins ; Humans ; Immunization, Passive ; SARS-CoV-2
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Furocoumarins ; amotosalen (K1LDZ0VBC0)
    Language English
    Publishing date 2022-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.16819
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    Zs.A 284: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Abundance of distal repetitive DNA sequences in

    de Assis, Rafael / Gonçalves, Leandro Simões Azeredo / Guyot, Romain / Vanzela, André Luis Laforga

    Genome

    2023  Volume 66, Issue 10, Page(s) 269–280

    Abstract: Chili peppers (Solanaceae family) have great commercial value. They are ... ...

    Abstract Chili peppers (Solanaceae family) have great commercial value. They are commercialized
    MeSH term(s) Capsicum/genetics ; Solanaceae/genetics ; Base Sequence ; DNA, Satellite/genetics ; Phylogeny ; Chromosomes ; Repetitive Sequences, Nucleic Acid ; Karyotype ; DNA, Ribosomal
    Chemical Substances DNA, Satellite ; DNA, Ribosomal
    Language English
    Publishing date 2023-06-26
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 639031-6
    ISSN 1480-3321 ; 0831-2796
    ISSN (online) 1480-3321
    ISSN 0831-2796
    DOI 10.1139/gen-2022-0083
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    Zs.A 1266: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming.

    Sanchez-Castro, E Eduardo / Pajuelo-Reyes, Cecilia / Tejedo, Rebeca / Soria-Juan, Bárbara / Tapia-Limonchi, Rafael / Andreu, Etelvina / Hitos, Ana B / Martin, Franz / Cahuana, Gladys M / Guerra-Duarte, Clara / de Assis, Thamyres C Silva / Bedoya, Francisco J / Soria, Bernat / Chávez-Olórtegui, Carlos / Tejedo, Juan R

    Frontiers in immunology

    2021  Volume 11, Page(s) 609961

    Abstract: Snakebite envenoming is a global neglected disease with an incidence of up to 2.7 million new cases every year. Although antivenoms are so-far the most effective treatment to reverse the acute systemic effects induced by snakebite envenoming, they have a ...

    Abstract Snakebite envenoming is a global neglected disease with an incidence of up to 2.7 million new cases every year. Although antivenoms are so-far the most effective treatment to reverse the acute systemic effects induced by snakebite envenoming, they have a limited therapeutic potential, being unable to completely neutralize the local venom effects. Local damage, such as dermonecrosis and myonecrosis, can lead to permanent sequelae with physical, social, and psychological implications. The strong inflammatory process induced by snake venoms is associated with poor tissue regeneration, in particular the lack of or reduced skeletal muscle regeneration. Mesenchymal stromal cells (MSCs)-based therapies have shown both anti-inflammatory and pro-regenerative properties. We postulate that using allogeneic MSCs or their cell-free products can induce skeletal muscle regeneration in snakebite victims, improving all the three steps of the skeletal muscle regeneration process, mainly by anti-inflammatory activity, paracrine effects, neovascularization induction, and inhibition of tissue damage, instrumental for microenvironment remodeling and regeneration. Since snakebite envenoming occurs mainly in areas with poor healthcare, we enlist the principles and potential of MSCs-based therapies and discuss regulatory issues, good manufacturing practices, transportation, storage, and related-procedures that could allow the administration of these therapies, looking forward to a safe and cost-effective treatment for a so far unsolved and neglected health problem.
    MeSH term(s) Animals ; Humans ; Inflammation Mediators/metabolism ; Mesenchymal Stem Cell Transplantation/adverse effects ; Mesenchymal Stem Cells/metabolism ; Muscle Development ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Muscle, Skeletal/physiopathology ; Necrosis ; Phenotype ; Regeneration ; Signal Transduction ; Snake Bites/diagnosis ; Snake Bites/metabolism ; Snake Bites/physiopathology ; Snake Bites/surgery ; Treatment Outcome
    Chemical Substances Inflammation Mediators
    Language English
    Publishing date 2021-02-03
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.609961
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  10. Article ; Online: Risk factors for SARS-CoV-2 seropositivity in a health care worker population during the early pandemic.

    Schubl, Sebastian D / Figueroa, Cesar / Palma, Anton M / de Assis, Rafael R / Jain, Aarti / Nakajima, Rie / Jasinskas, Algimantas / Brabender, Danielle / Hosseinian, Sina / Naaseh, Ariana / Hernandez Dominguez, Oscar / Runge, Ava / Skochko, Shannon / Chinn, Justine / Kelsey, Adam J / Lai, Kieu T / Zhao, Weian / Horvath, Peter / Tifrea, Delia /
    Grigorian, Areg / Gonzales, Abran / Adelsohn, Suzanne / Zaldivar, Frank / Edwards, Robert / Amin, Alpesh N / Stamos, Michael J / Barie, Philip S / Felgner, Philip L / Khan, Saahir

    BMC infectious diseases

    2023  Volume 23, Issue 1, Page(s) 330

    Abstract: Background: While others have reported severe acute respiratory syndrome-related coronavirus 2(SARS-CoV-2) seroprevalence studies in health care workers (HCWs), we leverage the use of a highly sensitive coronavirus antigen microarray to identify a group ...

    Abstract Background: While others have reported severe acute respiratory syndrome-related coronavirus 2(SARS-CoV-2) seroprevalence studies in health care workers (HCWs), we leverage the use of a highly sensitive coronavirus antigen microarray to identify a group of seropositive health care workers who were missed by daily symptom screening that was instituted prior to any epidemiologically significant local outbreak. Given that most health care facilities rely on daily symptom screening as the primary method to identify SARS-CoV-2 among health care workers, here, we aim to determine how demographic, occupational, and clinical variables influence SARS-CoV-2 seropositivity among health care workers.
    Methods: We designed a cross-sectional survey of HCWs for SARS-CoV-2 seropositivity conducted from May 15th to June 30th 2020 at a 418-bed academic hospital in Orange County, California. From an eligible population of 5,349 HCWs, study participants were recruited in two ways: an open cohort, and a targeted cohort. The open cohort was open to anyone, whereas the targeted cohort that recruited HCWs previously screened for COVID-19 or work in high-risk units. A total of 1,557 HCWs completed the survey and provided specimens, including 1,044 in the open cohort and 513 in the targeted cohort. Demographic, occupational, and clinical variables were surveyed electronically. SARS-CoV-2 seropositivity was assessed using a coronavirus antigen microarray (CoVAM), which measures antibodies against eleven viral antigens to identify prior infection with 98% specificity and 93% sensitivity.
    Results: Among tested HCWs (n = 1,557), SARS-CoV-2 seropositivity was 10.8%, and risk factors included male gender (OR 1.48, 95% CI 1.05-2.06), exposure to COVID-19 outside of work (2.29, 1.14-4.29), working in food or environmental services (4.85, 1.51-14.85), and working in COVID-19 units (ICU: 2.28, 1.29-3.96; ward: 1.59, 1.01-2.48). Amongst 1,103 HCWs not previously screened, seropositivity was 8.0%, and additional risk factors included younger age (1.57, 1.00-2.45) and working in administration (2.69, 1.10-7.10).
    Conclusion: SARS-CoV-2 seropositivity is significantly higher than reported case counts even among HCWs who are meticulously screened. Seropositive HCWs missed by screening were more likely to be younger, work outside direct patient care, or have exposure outside of work.
    MeSH term(s) Humans ; Male ; SARS-CoV-2 ; COVID-19/epidemiology ; Cross-Sectional Studies ; Pandemics ; Seroepidemiologic Studies ; Health Personnel ; Antibodies, Viral
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2023-05-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-023-08284-y
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