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Article ; Online: Twin lossy mode resonance on a single D-shaped optical fiber.

Imas, J J / Zamarreño, C R / Zubiate, P / Del Villar, I / Pérez-Escudero, J M / Matías, I R

Optics letters

2021 Volume 46, Issue 13, Page(s) 3284–3287

Abstract: This Letter presents the fabrication of dual lossy mode resonance (LMR) refractometers based on titanium dioxide ( ...

Abstract	This Letter presents the fabrication of dual lossy mode resonance (LMR) refractometers based on titanium dioxide (
Language	English
Publishing date	2021-07-02
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.425928
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Article ; Online: Vitamin D is Related to Markers of Vulnerable Plaque in Acute Myocardial Infarction.

Machulsky, Nahuel Fernandez / Barchuk, Magali / Gagliardi, Juan / Gonzalez, Diego / Lombardo, Micaela / Escudero, Alejandro Garcia / Gigena, Gerardo / Blanco, Federico / Schreier, Laura / Fabre, Bibiana / Berg, Gabriela

Current vascular pharmacology

2017 Volume 16, Issue 4, Page(s) 355–360

Abstract: Background: Vitamin D is a fat soluble vitamin involved in calcium and bone metabolism; recently ... its deficiency has been related to cardiovascular disease. In cardiac tissue, vitamin D suppresses ... To investigate whether the association between vitamin D and leptin is related to markers of vulnerable plaque ...

Abstract	Background: Vitamin D is a fat soluble vitamin involved in calcium and bone metabolism; recently its deficiency has been related to cardiovascular disease. In cardiac tissue, vitamin D suppresses metalloproteinases (MMPs) expression, enzymes directly associated with vulnerable plaque. Objective: To investigate whether the association between vitamin D and leptin is related to markers of vulnerable plaque, such as MMPs in patients with acute myocardial infarction. Methods: We studied 66 male patients with acute myocardial infarction, undergoing primary angioplasty. Blood samples were obtained at admission and 24hs after the surgery. Leptin and vitamin D concentrations in serum and MMP-2 and -9 activities in plasma were determined. Results: MMP-2 activity was increased in Vitamin D deficient/insufficient patients at admission (p=0.04) and 24 hs later (p=0.05). In a linear regression model, vitamin D explained 24% of the variance of MMP-2 activity (F=2.839 p=0.04). At admission, vitamin D correlated with serum leptin (r=-0.302 p=0.033), and explained 39.5% of its variation (F=4.432 p=0.003). Conclusion: In the studied population, vitamin D was inversely related to MMP-2 and leptin which are involved in coronary artery disease and acute myocardial infarction. The decrease in this hormone levels would be associated with a worse metabolic profile in acute coronary syndrome patients.
MeSH term(s)	Adult ; Aged ; Biomarkers/blood ; Coronary Artery Disease/blood ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/pathology ; Humans ; Leptin/blood ; Male ; Matrix Metalloproteinase 2/blood ; Middle Aged ; Plaque, Atherosclerotic ; Rupture, Spontaneous ; ST Elevation Myocardial Infarction/blood ; ST Elevation Myocardial Infarction/diagnostic imaging ; ST Elevation Myocardial Infarction/pathology ; ST Elevation Myocardial Infarction/surgery ; Time Factors ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/diagnosis
Chemical Substances	Biomarkers ; Leptin ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H) ; MMP2 protein, human (EC 3.4.24.24) ; Matrix Metalloproteinase 2 (EC 3.4.24.24)
Language	English
Publishing date	2017-06-06
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2192362-0
ISSN	1875-6212 ; 1570-1611
ISSN (online)	1875-6212
ISSN	1570-1611
DOI	10.2174/1570161115666170609102506
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Zs.A 6282: Show issues

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Article ; Online: Neruodevelopmental Outcomes in Preschool Children Living With HIV-1 Subtypes A and D in Uganda.

Ruiseñor-Escudero, Horacio / Sikorskii, Alla / Familiar-Lopez, Itziar / Persaud, Deborah / Ziemniak, Carrie / Nakasujja, Noeline / Opoka, Robert / Boivin, Michael

The Pediatric infectious disease journal

2018 Volume 37, Issue 12, Page(s) e298–e303

Abstract: ... to relate test scores to HIV-1 subtype (A versus D) while adjusting for relevant covariates. The scores were ... percentage of children infected with subtype A versus 60% of children with subtype D were currently ... D (3.29 vs. 2.76 years, respectively, P = 0.03), but similar regarding sex, socioeconomic status ...

Abstract	Background: HIV is a neuropathogenic virus that may result in detrimental neurodevelopmental (ND) outcomes early in life. This is the first study to evaluate the effect of HIV-1 subtype on neurodevelopment of Ugandan preschool children. Methods: Neurodevelopment of 87 HIV-1 infected and 221 HIV exposed uninfected Ugandan children 1.8-4.9 years of age was assessed using 4 scales of the Mullen Scales of Early Learning (MSEL), 2 scales of the Color Object Association Test (COAT), and 1 score of the Early Childhood Vigilance Test. HIV-1 subtype was defined by phylogenetic analyses. General linear models were used to relate test scores to HIV-1 subtype (A versus D) while adjusting for relevant covariates. The scores were benchmarked against HIV exposed uninfected group to facilitate the interpretation. Results: Seventy-one percentage of children infected with subtype A versus 60% of children with subtype D were currently on antiretroviral therapy (P = 0.49). Children with HIV-1 subtype A infection were older when compared with subtype D (3.29 vs. 2.76 years, respectively, P = 0.03), but similar regarding sex, socioeconomic status, weight-for-age z-score, CD4+ and CD8+ (% and total), viral load. No statistically significant differences by HIV-1 subtype were observed in the MSEL, COAT and Early Childhood Vigilance Test. Differences ≥ 0.33 of the SD were observed for the MSEL Composite Score, Receptive Language (MSEL) and Total Memory (COAT). Conclusions: In contrast to previously reported differences in ND outcomes of school-age children by HIV-1 subtype, ND scores among preschool children were similar for subtypes A and D, with few potential differences on language production and memory outcomes that favored subtype A. Further investigation with larger sample sizes and longitudinal follow-up is needed.
MeSH term(s)	Child Development ; Child, Preschool ; Cross-Sectional Studies ; Female ; HIV Infections/complications ; HIV-1 ; Humans ; Infant ; Male ; Neurodevelopmental Disorders/epidemiology ; Neurodevelopmental Disorders/virology ; Neurologic Examination/methods ; Uganda/epidemiology
Language	English
Publishing date	2018-05-10
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000002097
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Zs.A 1852: Show issues

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Article ; Online: Age-adjusted D-dimer for the diagnosis of deep vein thrombosis.

Gómez-Jabalera, Efrem / Bellmunt Montoya, Sergio / Fuentes-Camps, Eva / Escudero Rodríguez, José Román

Phlebology

2017 Volume 33, Issue 7, Page(s) 458–463

Abstract: Objective In the diagnosis of deep vein thrombosis, new D-dimer cut-off values were defined ... Wells score, D-dimer and ultrasound data were collected. In low and intermediate clinical probability ... for the following cut-off values of D-dimer: age × 10 µg/L, age × 15 µg/L, age × 20 µg/L, age × 25 µg/L and age × 30 ...

Abstract	Objective In the diagnosis of deep vein thrombosis, new D-dimer cut-off values were defined by multiplying 10 µg/L × age. The objective of the present study is to define a more specific age-adjusted value, including the pre-test Wells score, without worsening sensitivity. Methods We designed a case-control study in patients attended in the emergency department with clinically suspected deep vein thrombosis. Demographics, Wells score, D-dimer and ultrasound data were collected. In low and intermediate clinical probability cases for deep vein thrombosis, we determined the specificity and sensitivity (false-negative rates) for the following cut-off values of D-dimer: age × 10 µg/L, age × 15 µg/L, age × 20 µg/L, age × 25 µg/L and age × 30 µg/L. The cut-off value with maximum specificity without any false-negative result (sensitivity 100%) was identified. Results We included 138 consecutive patients, 39.9% were men and the mean age was 71.6 years. Deep vein thrombosis was diagnosed in 16.7% of patients and the Wells score was low in 69.6%, intermediate in 21% and high in 9.4% of patients. Applying the conventional cut-off value of 500 µg/L, the specificity was 21.1% with a sensitivity of 100%. Maintaining 100% sensitivity, the highest specificity was reached with a cut-off value for D-dimer equivalent to the age × 25 µg/L in low-risk patients (67.1% specificity) and the age × 10 µg/L (50% specificity) in intermediate-risk patients. Conclusions In patients with low Wells score, the cut-off value can be raised to age × 25 µg/L in order to rule out deep vein thrombosis without jeopardizing safety. In intermediate-risk patients, the D-dimer cut-off value could be raised to age × 10 µg/L as previously suggested.
MeSH term(s)	Aged ; Aging/blood ; Case-Control Studies ; Female ; Fibrin Fibrinogen Degradation Products/metabolism ; Humans ; Male ; Venous Thrombosis/blood ; Venous Thrombosis/diagnosis
Chemical Substances	Fibrin Fibrinogen Degradation Products ; fibrin fragment D
Language	English
Publishing date	2017-07-05
Publishing country	England
Document type	Journal Article
ZDB-ID	645172-x
ISSN	1758-1125 ; 0268-3555
ISSN (online)	1758-1125
ISSN	0268-3555
DOI	10.1177/0268355517718762
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Zs.A 2538: Show issues

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Article: What is the optimal level of vitamin D in non-dialysis chronic kidney disease population?

Molina, Pablo / Górriz, José L / Molina, Mariola D / Beltrán, Sandra / Vizcaíno, Belén / Escudero, Verónica / Kanter, Julia / Ávila, Ana I / Bover, Jordi / Fernández, Elvira / Nieto, Javier / Cigarrán, Secundino / Gruss, Enrique / Fernández-Juárez, Gema / Martínez-Castelao, Alberto / Navarro-González, Juan F / Romero, Ramón / Pallardó, Luis M

World journal of nephrology

2016 Volume 5, Issue 5, Page(s) 471–481

Abstract: Aim: To evaluate thresholds for serum 25(OH)D concentrations in relation to death, kidney ... multicenter, cohort study, were prospectively evaluated and categorized into 3 groups according to 25(OH)D ... 25(OH)D between 20 and 29 ng/mL as reference group. Association between 25(OH)D levels and death ...

Abstract	Aim: To evaluate thresholds for serum 25(OH)D concentrations in relation to death, kidney progression and hospitalization in non-dialysis chronic kidney disease (CKD) population. Methods: Four hundred and seventy non-dialysis 3-5 stage CKD patients participating in OSERCE-2 study, a prospective, multicenter, cohort study, were prospectively evaluated and categorized into 3 groups according to 25(OH)D levels at enrollment (less than 20 ng/mL, between 20 and 29 ng/mL, and at or above 30 ng/mL), considering 25(OH)D between 20 and 29 ng/mL as reference group. Association between 25(OH)D levels and death (primary outcome), and time to first hospitalization and renal progression (secondary outcomes) over a 3-year follow-up, were assessed by Kaplan-Meier survival curves and Cox-proportional hazard models. To identify 25(OH)D levels at highest risk for outcomes, receiver operating characteristic (ROC) curves were performed. Results: Over 29 ± 12 mo of follow-up, 46 (10%) patients dead, 156 (33%) showed kidney progression, and 126 (27%) were hospitalized. After multivariate adjustment, 25(OH)D < 20 ng/mL was an independent predictor of all-cause mortality (HR = 2.33; 95%CI: 1.10-4.91; P = 0.027) and kidney progression (HR = 2.46; 95%CI: 1.63-3.71; P < 0.001), whereas the group with 25(OH)D at or above 30 ng/mL did not have a different hazard for outcomes from the reference group. Hospitalization outcomes were predicted by 25(OH) levels (HR = 0.98; 95%CI: 0.96-1.00; P = 0.027) in the unadjusted Cox proportional hazards model, but not after multivariate adjusting. ROC curves identified 25(OH)D levels at highest risk for death, kidney progression, and hospitalization, at 17.4 ng/mL [area under the curve (AUC) = 0.60; 95%CI: 0.52-0.69; P = 0.027], 18.6 ng/mL (AUC = 0.65; 95%CI: 0.60-0.71; P < 0.001), and 19.0 ng/mL (AUC = 0.56; 95%CI: 0.50-0.62; P = 0.048), respectively. Conclusion: 25(OH)D < 20 ng/mL was an independent predictor of death and progression in patients with stage 3-5 CKD, with no additional benefits when patients reached the levels at or above 30 ng/mL suggested as optimal by CKD guidelines.
Language	English
Publishing date	2016-09-12
Publishing country	United States
Document type	Journal Article
ISSN	2220-6124
ISSN	2220-6124
DOI	10.5527/wjn.v5.i5.471
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Article ; Online: Influencia del terroir en el perfil aromático de Tempranillo Blanco en la D.O.Ca. Rioja

Martínez Juana / Rubio-Bretón Pilar / Eva Vicente Mª / Enrique García-Escudero y

E3S Web of Conferences, Vol 50, p

2018 Volume 02003

Abstract: ... de Tempranillo Tinto por mutación natural, que desde el año 2008 está autorizada únicamente en la D.O.Ca. Rioja ... localizaciones geográficas de la D.O.Ca. Rioja durante la campaña 2016. Las parcelas se distribuyeron en las tres ...

Abstract	En los vinos blancos el aroma es uno de los principales atributos de calidad, siendo los compuestos aportados por la uva los que determinan el perfil varietal. Tempranillo Blanco es una variedad derivada de Tempranillo Tinto por mutación natural, que desde el año 2008 está autorizada únicamente en la D.O.Ca. Rioja. Sus vinos manifiestan características organolépticas de alta calidad, con notas afrutadas y florales intensas. En este trabajo se estudió el perfil aromático varietal de Tempranillo Blanco en siete localizaciones geográficas de la D.O.Ca. Rioja durante la campaña 2016. Las parcelas se distribuyeron en las tres subzonas que integran la denominación, con características vitivinícolas diferenciadas debido a las condiciones de clima y suelo. Los resultados obtenidos mostraron diferencias notables en el contenido aromático de la uva procedente de las distintas ubicaciones del viñedo. Los compuestos más abundantes fueron los norisoprenoides (48-70%), seguidos por los bencenoides (8-29%) y los aldehídos y cetonas (3-18%); otros muchos volátiles fueron detectados en menores porcentajes (compuestos C6, alcoholes, terpenos, ésteres, ácidos…). A pesar de las diferencias observadas, el perfil aromático varietal se mantuvo, por lo que se puede concluir que Tempranillo Blanco es una variedad con amplias posibilidades de adaptación a diferentes entornos vitícolas.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hypertension and the fat-soluble vitamins A, D and E.

Llopis-González, Agustin / Rubio-López, Nuria / Pineda-Alonso, Monica / Martín-Escudero, Juan Carlos / Chaves, Felipe Javier / Redondo, Maximino / Morales-Suarez-Varela, Maria

International journal of environmental research and public health

2015 Volume 12, Issue 3, Page(s) 2793–2809

Abstract: ... hypertension and intake of fat-soluble vitamins A, D and E. Participants were from the cross-sectional Hortega ... in the hypertensive subpopulation (1732.77±962.27 µg vs. 1655.89±902.81 µg), and vitamin D and E intakes were lower (8 ... of vitamins A, D and E with hypertension in people aged over 40. Future studies on this topic and a larger ...

Abstract	Hypertension affects populations globally and is thus a public health and socio-economic problem. Macronutrient and micronutrient deficiencies are common in the general population, and may be even more prevalent in hypertensive patients. This study aimed to determine a possible association between hypertension and intake of fat-soluble vitamins A, D and E. Participants were from the cross-sectional Hortega nutrition study conducted with a random sample of 1514 people (50.3% women, 49.7% men) and two groups: nonhypertensive controls≥40 years old (n=429; 28.3%); unknown untreated hypertension cases≥40 years old (n=246; 16.2%). Biochemical and anthropometric measurements were taken. Data on dietary intakes, education, socio-economic status, place of residence, health habits, comorbidities, alcohol consumption and smoking were collected and assessed. A descriptive data study was done and compared by ANOVA and Chi-Square. No p value higher than 0.05 was considered significant. The results showed that vitamin A intake was higher in the hypertensive subpopulation (1732.77±962.27 µg vs. 1655.89±902.81 µg), and vitamin D and E intakes were lower (8.13±9.71 µg vs. 8.25±9.52 µg and 18.79±7.84 mg vs. 18.60±8.20 mg, respectively). No statistically significant differences were found in any adjusted model. This study did not significantly associate intake of vitamins A, D and E with hypertension in people aged over 40. Future studies on this topic and a larger sample are necessary.
MeSH term(s)	Adult ; Aged ; Alcohol Drinking ; Cross-Sectional Studies ; Diet ; Female ; Humans ; Hypertension/drug therapy ; Hypertension/epidemiology ; Male ; Middle Aged ; Minerals ; Nutrition Surveys ; Nutritional Status ; Smoking ; Social Class ; Surveys and Questionnaires ; Vitamin A/administration & dosage ; Vitamin D/administration & dosage ; Vitamin E/administration & dosage ; Vitamins/therapeutic use
Chemical Substances	Minerals ; Vitamins ; Vitamin A (11103-57-4) ; Vitamin D (1406-16-2) ; Vitamin E (1406-18-4)
Language	English
Publishing date	2015-03-04
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph120302793
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Article ; Online: Role of vitamin D and sFlt-1/PlGF ratio in the development of early- and late-onset preeclampsia.

Álvarez-Fernández, Indira / Prieto, Belén / Rodríguez, Verónica / Ruano, Yolanda / Escudero, Ana I / Álvarez, Francisco V

Clinical chemistry and laboratory medicine

2015 Volume 53, Issue 7, Page(s) 1033–1040

Abstract: Background: The imbalanced production of placental biomarkers and vitamin D deficiency have been ... of 25-hydroxyvitamin D [25(OH)D] concentrations and the soluble fms-like tyrosine kinase 1 (sFlt-1 ... the relationship between 25(OH)D and the biomarkers.: Methods: A retrospective, full-blinded cohort study was ...

Abstract	Background: The imbalanced production of placental biomarkers and vitamin D deficiency have been proposed as risk factors for the development of preeclampsia (PE). However, little is known about the relationship between them and their role in early- versus late-onset PE. The objectives were to assess the role of 25-hydroxyvitamin D [25(OH)D] concentrations and the soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) ratio in the development of early- and late-onset PE; and to evaluate the relationship between 25(OH)D and the biomarkers. Methods: A retrospective, full-blinded cohort study was conducted at the Obstetric Emergency Service of a tertiary care hospital. Pregnant women (n=257) attending obstetric triage with suspicion of PE were included. sFlt-1, PlGF and 25(OH)D concentrations were measured by electrochemoluminescence (ECLIA) immunoassay and pregnancy outcome (development of PE) was registered from patients records. Results: PE women showed lower 25(OH)D concentrations at clinical presentation than non-PE women (median: 35.0 nmol/L and 39.6 nmol/L, respectively; p=0.027). Women with 25(OH)D levels <50 nmol/L experienced an increased risk of developing late-onset PE [odds ratio (OR) 4.6, 95% confidence interval (CI) 1.4-15], but no association was found for early-onset PE. However, a sFlt-1/PlGF ratio above the corresponding cutpoints increased the risk of developing both early- and late-onset PE [ORs 58 (95% CI 11-312) and 12 (95% CI 5.0-27), respectively]. No association was found between 25(OH)D levels and sFlt-1/PlGF ratio. Conclusions: Low vitamin D status in women with suspected late-onset PE increases the risk of imminent development of the disease.
MeSH term(s)	Adult ; Biomarkers/metabolism ; Female ; Humans ; Placenta Growth Factor ; Pre-Eclampsia/metabolism ; Pregnancy ; Pregnancy Proteins/metabolism ; Retrospective Studies ; Time Factors ; Vascular Endothelial Growth Factor Receptor-1/metabolism ; Vitamin D/analogs & derivatives ; Vitamin D/metabolism
Chemical Substances	Biomarkers ; PGF protein, human ; Pregnancy Proteins ; Vitamin D (1406-16-2) ; Placenta Growth Factor (144589-93-5) ; 25-hydroxyvitamin D (A288AR3C9H) ; FLT1 protein, human (EC 2.7.10.1) ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.10.1)
Language	English
Publishing date	2015-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2014-1039
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Zs.A 121: Show issues

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Article: Deficiencia de vitamina D en mujeres en edad fértil.

González Solanellas, Matilde / Romagosa Pérez-Portabella, Ana / Zabaleta del Olmo, Edurne / Gudiña Escudero, Nieves / Pozo Díaz, Cristina / Moreno Feliu, Ricard / Vilamala Muns, Maria

Atencion primaria

2008 Volume 40, Issue 8, Page(s) 393–399

Abstract: Objective: To determine the level of hypovitaminosis D in adult healthy women attended in primary ... years), skin phototype, sun exposure, vitamin D deficiency pain type, calcium, vitamin D consumed, and ... measurement of serum 25-hydroxyvitamin D (25[OH]D) or calcidiol and parathyroid hormone (PTH) if (25[OH]D) was ...

Title translation	Vitamin D deficiency in women of reproductive age.
Abstract	Objective: To determine the level of hypovitaminosis D in adult healthy women attended in primary care and their associated factors. Design: Cross-sectional, descriptive study. Setting: A neighbourhood of Barcelona, Spain, with a socially deprived population with a high percentage of immigrants, and urban factors which meant that they lived with hardly any sunlight. Participants: Women between 15-50 years seen between February and March 2005. Measurements and results: Primary: residence time (years), skin phototype, sun exposure, vitamin D deficiency pain type, calcium, vitamin D consumed, and measurement of serum 25-hydroxyvitamin D (25[OH]D) or calcidiol and parathyroid hormone (PTH) if (25[OH]D) was <10 ng/mL; 94 women were included. Mean age: 33 years (SD, 7.8); 62.8% immigrants (mean years of residence, 11.5). Mean (25[OH]D), 14.0 ng/mL (95% CI, 12.5-15.5). Skin phototype V-VI was associated with low levels of (25[OH]D) (P=.001). None of the women stated that they consumed the recommended amount of vitamin D and only 46% the recommended amount of calcium. Sun exposure of >4 hours/week: 37%. Sixteen percent had musculo-skeletal pain. No relationship was found between vitamin D levels and immigration. All the women had (25[OH]D) levels of <40 mg/mL, 47.9% had insufficient (25[OH]D), 10-20 ng/mL, and 37.2% were deficient: pound10 mg/mL. PTH was within the normal range. Conclusions: All the women had low levels of vitamin D, more than a third of these, deficient. No relationship with immigration was found. A relationship was established between skin phototype V-VI and (25[OH]D) deficiency. None of the cases consumed the recommended amounts of vitamin D.
MeSH term(s)	Adolescent ; Adult ; Cross-Sectional Studies ; Female ; Humans ; Middle Aged ; Vitamin D Deficiency/epidemiology ; Young Adult
Language	Spanish
Publishing date	2008-08-29
Publishing country	Spain
Document type	English Abstract ; Journal Article
ZDB-ID	1200787-0
ISSN	1578-1275 ; 0212-6567
ISSN (online)	1578-1275
ISSN	0212-6567
DOI	10.1157/13125404
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Zs.A 4054: Show issues

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Article ; Online: Hypertension and the Fat-Soluble Vitamins A, D and E

Agustin Llopis-González / Nuria Rubio-López / Monica Pineda-Alonso / Juan Carlos Martín-Escudero / Felipe Javier Chaves / Maximino Redondo / Maria Morales-Suarez-Varela

International Journal of Environmental Research and Public Health, Vol 12, Iss 3, Pp 2793-

2015 Volume 2809

Abstract: ... hypertension and intake of fat-soluble vitamins A, D and E. Participants were from the cross-sectional Hortega ... vitamin D and E intakes were lower (8.13 ± 9.71 µg vs. 8.25 ± 9.52 µg and 18.79 ± 7.84 mg vs. 18.60 ± 8.20 ... This study did not significantly associate intake of vitamins A, D and E with hypertension in people aged ...

Abstract	Hypertension affects populations globally and is thus a public health and socio-economic problem. Macronutrient and micronutrient deficiencies are common in the general population, and may be even more prevalent in hypertensive patients. This study aimed to determine a possible association between hypertension and intake of fat-soluble vitamins A, D and E. Participants were from the cross-sectional Hortega nutrition study conducted with a random sample of 1514 people (50.3% women, 49.7% men) and two groups: nonhypertensive controls ≥40 years old (n = 429; 28.3%); unknown untreated hypertension cases ≥40 years old (n = 246; 16.2%). Biochemical and anthropometric measurements were taken. Data on dietary intakes, education, socio-economic status, place of residence, health habits, comorbidities, alcohol consumption and smoking were collected and assessed. A descriptive data study was done and compared by ANOVA and Chi-Square. No p value higher than 0.05 was considered significant. The results showed that vitamin A intake was higher in the hypertensive subpopulation (1732.77 ± 962.27 µg vs. 1655.89 ± 902.81 µg), and vitamin D and E intakes were lower (8.13 ± 9.71 µg vs. 8.25 ± 9.52 µg and 18.79 ± 7.84 mg vs. 18.60 ± 8.20 mg, respectively). No statistically significant differences were found in any adjusted model. This study did not significantly associate intake of vitamins A, D and E with hypertension in people aged over 40. Future studies on this topic and a larger sample are necessary.
Keywords	hypertension ; fat-soluble vitamin ; nutritional deficiency ; Medicine ; R
Language	English
Publishing date	2015-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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