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Article: Investigation of FGF21 mRNA levels and relative mitochondrial DNA copy number levels and their relation in nonalcoholic fatty liver disease: a case-control study.

Houshmand, Massoud / Zeinali, Vahide / Hosseini, Amirhossein / Seifi, Atena / Danaei, Bardia / Kamfar, Sharareh

2023 Volume 10, Page(s) 1203019

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-06-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2023.1203019
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Article ; Online: Evaluation of shear bond strength and enamel remineralizing effect of experimental orthodontic composite containing nano-hydroxyapatite: An in vitro study.

Rahmanpanah, Sina / Seifi, Massoud / Gharavi, Zahra / Sadighnia, Neda / Amdjadi, Parisa

International orthodontics

2023 Volume 21, Issue 1, Page(s) 100725

Abstract: Objective: The purpose of this study was to prepare an orthodontic composite containing hydroxyapatite nanoparticles to prevent demineralization and create a suitable environment for mineral deposition around orthodontic brackets, and to investigate the ...

Abstract	Objective: The purpose of this study was to prepare an orthodontic composite containing hydroxyapatite nanoparticles to prevent demineralization and create a suitable environment for mineral deposition around orthodontic brackets, and to investigate the mechanical and remineralizing properties of the experimental adhesive composite. Methods: Experimental orthodontic composite were formulated using varying percentages of nano-hydroxyapatite particles. Assessments were based on four groups: a control group (3M™ Transbond™ XT) and experimental composites containing 2% (HA2), 5% (HA5) and 10% (HA10) hydroxyapatite. Vickers Microhardness test was performed to investigate the remineralizing effect in 3 stages: initial stage, after demineralization and after 4 weeks of exposure to artificial saliva. Scanning electron microscopy with energy dispersive X-ray spectroscopy analyser (SEM/EDAX) was used to evaluate hydroxyapatite precipitation and elemental composition of enamel surface. Shear Bond Strength tests were carried out using a universal testing machine and the debonding pattern was assessed using Adhesive Remnant Index (ARI). Results: All groups showed clinically acceptable SBS values. The highest SBS was achieved in the HA2 group, followed by Transbond™ XT, HA5 and HA10. There was no significant difference in the ARI scores. In terms of microhardness properties, HA5 and HA10 demonstrated a significant increase after 4 weeks. The results of SEM analysis showed the precipitation of hydroxyapatite crystals and EDAX analysis indicated the increase of calcium and phosphate ion peaks compared to the demineralized sample. The data were analysed using one-way ANOVA and Tukey's Post-hoc test. Conclusions: Addition of hydroxyapatite nanoparticles to orthodontic composite can increase the mineral content and microhardness of the adjacent enamel. However, increasing the amount of nanoparticles reduces shear bond strength in a decreasing trend. The above-mentioned findings showed that incremental increase of nanoparticles of HA can be incorporated in composite to a certain extent and limitations are determined by mechanical properties (SBS) required for bracket bonding.
MeSH term(s)	Humans ; Adhesiveness ; Dental Bonding/methods ; Dental Enamel/chemistry ; Durapatite ; Materials Testing ; Orthodontic Brackets ; Resin Cements/chemistry ; Shear Strength ; Surface Properties ; Tooth Demineralization
Chemical Substances	Durapatite (91D9GV0Z28) ; Resin Cements
Language	English
Publishing date	2023-01-18
Publishing country	France
Document type	Journal Article
ISSN	1879-680X
ISSN (online)	1879-680X
DOI	10.1016/j.ortho.2023.100725
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Article ; Online: Comparative study of changes in the airway dimensions following the treatment of Class II malocclusion patients with the twin-block and Seifi appliances.

Tahmasbi, Soodeh / Seifi, Massoud / Soleymani, Ali Asghar / Mohamadian, Fatemeh / Alam, Mostafa

Dental and medical problems

2023 Volume 60, Issue 2, Page(s) 247–254

Abstract: ... patients with the twin-block and Seifi appliances.: Material and methods: Lateral cephalograms of 37 ... or the Seifi appliance (n = 17) were assessed in this before-and-after study. The preoperative and ... plane angle (IMPA) in the Seifi appliance group. The airway dimensions at the level of PP, OP and ...

Abstract	Background: Functional appliances are frequently used to stimulate mandibular growth in cases of Class II malocclusion with mandibular deficiency. Many studies have reported improved pharyngeal airway passage (PAP) dimensions following functional appliance therapy in children. Objectives: The present study aimed to assess changes in the airway dimensions following the treatment of Class II malocclusion patients with the twin-block and Seifi appliances. Material and methods: Lateral cephalograms of 37 patients with Class II malocclusion and mandibular deficiency treated with the twin-block appliance (n = 20) or the Seifi appliance (n = 17) were assessed in this before-and-after study. The preoperative and postoperative lateral cephalograms were compared to determine changes in the airway dimensions at the level of the palatal plane (PP), the occlusal plane (OP) and the 2nd-4th cervical vertebrae (C2-C4) in the 2 groups. The results were analyzed with the t test and the one-way analysis of covariance (ANCOVA). Results: After treatment, significant changes occurred in the point A-nasion-point B (ANB) and sellanasion-point B (SNB) skeletal cephalometric indices in the twin-block appliance group, and in ANB, SNB and incisor-mandibular plane angle (IMPA) in the Seifi appliance group. The airway dimensions at the level of PP, OP and the 3rd cervical vertebra (C3) significantly increased postoperatively as compared to the baseline in the twin-block appliance group (p < 0.05). The increases in the airway dimensions at the level of PP and C3 in the twin-block appliance group were significantly greater than in the Seifi appliance group (p < 0.05). Conclusions: The treatment of Class II Division I malocclusion with the twin-block appliance significantly increased the airway dimensions at the level of PP, OP and C3, whereas the Seifi appliance did not cause any significant changes in the airway dimensions.
MeSH term(s)	Child ; Humans ; Cephalometry ; Incisor ; Malocclusion, Angle Class II/diagnostic imaging ; Malocclusion, Angle Class II/therapy ; Mandible
Language	English
Publishing date	2023-06-26
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2592057-1
ISSN	2300-9020 ; 2300-9020
ISSN (online)	2300-9020
ISSN	2300-9020
DOI	10.17219/dmp/142292
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Article: Laser Surgery of Soft Tissue in Orthodontics: Review of the Clinical Trials.

Seifi, Massoud / Matini, Negin-Sadat

Journal of lasers in medical sciences

2017 Volume 8, Issue Suppl 1, Page(s) S1–S6

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2017-08-29
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	2658681-2
ISSN	2228-6721 ; 2008-9783
ISSN (online)	2228-6721
ISSN	2008-9783
DOI	10.15171/jlms.2017.s1
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Article ; Online: Investigation of FGF21 mRNA levels and relative mitochondrial DNA copy number levels and their relation in nonalcoholic fatty liver disease

Massoud Houshmand / Vahide Zeinali / Amirhossein Hosseini / Atena Seifi / Bardia Danaei / Sharareh Kamfar

Frontiers in Molecular Biosciences, Vol

a case-control study

2023 Volume 10

Abstract: Background: Although the exact mechanisms of nonalcoholic fatty liver disease (NAFLD) are not fully understood, numerous pieces of evidence show that the variations in mitochondrial DNA (mtDNA) level and hepatic Fibroblast growth factor 21 (FGF21) ... ...

Abstract	Background: Although the exact mechanisms of nonalcoholic fatty liver disease (NAFLD) are not fully understood, numerous pieces of evidence show that the variations in mitochondrial DNA (mtDNA) level and hepatic Fibroblast growth factor 21 (FGF21) expression may be related to NAFLD susceptibility.Objectives: The main objective of this study was to determine relative levels of mtDNA copy number and hepatic FGF21 expression in a cohort of Iranian NAFLD patients and evaluate the possible relationship.Methods: This study included 27 NAFLD patients (10 with nonalcoholic fatty liver (NAFL) and 17 with non-alcoholic steatohepatitis (NASH)) and ten healthy subjects. Total RNA and genomic DNA were extracted from liver tissue samples, and then mtDNA copy number and FGF21 expression levels were assessed by quantitative real-time PCR.Results: The relative level of hepatic mtDNA copy number was 3.9-fold higher in patients than in controls (p < 0.0001). NAFLD patients showed a 2.9-fold increase in hepatic FGF21 expression compared to controls (p < 0.013). Results showed that hepatic FGF21 expression was positively correlated with BMI, serum ALT, and AST levels (p < 0.05). The level of mitochondrial copy number and hepatic FGF21 expression was not significantly associated with stages of change in hepatic steatosis. Finally, there was a significant correlation between FGF21 expression and mitochondrial copy number in NAFLD patients (p = 0.027).Conclusion: Our findings suggest a considerable rise of hepatic FGF21 mRNA levels and mtDNA-CN and show a positive correlation between them in the liver tissue of NAFLD patients.
Keywords	fibroblast growth factor 21 ; mitochondrial DNA ; nonalcoholic fatty liver disease ; FGF21 ; NAFLD ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Comparison of the failure rate, bonding time and ARI score of two orthodontic bonding systems: Self-Etch Primer and Conventional Etching Primer: A systematic review and meta-analysis.

Namdari, Mahshid / Amdjadi, Parisa / Bayat, Amirreza / Seifi, Massoud / Alzwghaibi, Aws

International orthodontics

2021 Volume 19, Issue 4, Page(s) 566–579

Abstract: Objective: This study aimed to evaluate the failure incidence of brackets with at least six months follow-up between self-etch primer and conventional etch/primer, as well as to investigate the clinical duration of the bonding process and the amount of ... ...

Abstract	Objective: This study aimed to evaluate the failure incidence of brackets with at least six months follow-up between self-etch primer and conventional etch/primer, as well as to investigate the clinical duration of the bonding process and the amount of adhesive remnant index (ARI). Methods: Electronic search was conducted in databases including PubMed, Scopus, Web of Science, ProQuest, ClinicalTrials.gov, and ICTRP (International Clinical Trials Registry Platform). The electronic search targeted only randomized clinical trials and was limited from January 2000 to June 2021. Delphi list is used to evaluate the risk of bias and Stata Version14.2 software was used. This systematic review was conducted according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) and recorded on the Ethics Committee of Research Institute of Dental Sciences, SBMU (IR.SBMU.DRC.REC.1398.240). Results: Out of 2288 extracted studies, 30 of them entered the full-text evaluation process. According to the inclusion criteria, 15 studies entered this systematic review. Containing 607 participants and 10,563 brackets/teeth. All the included studies were of randomized clinical trials (RCT) design with either parallel or split-mouth design. Comparing the two groups, the risk difference effect (RD)=0.007 CI 95% (-0.004,0.018) indicated a neglectable difference in the risk of bracket failure during treatment between the two groups. The index I Conclusions: There was no difference between the self-etch primer and conventional etch/primer in bracket debonding at a medium level of evidence, However, there was statistically significant reduction in clinical bonding time using self-etch primer.
MeSH term(s)	Acid Etching, Dental ; Dental Bonding ; Dental Cements ; Humans ; Materials Testing ; Orthodontic Brackets ; Resin Cements ; Shear Strength
Chemical Substances	Dental Cements ; Resin Cements
Language	English
Publishing date	2021-10-08
Publishing country	France
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ISSN	1879-680X
ISSN (online)	1879-680X
DOI	10.1016/j.ortho.2021.09.001
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Article: Inhibitory Effect of

Khaleghi Rostamkolaie, Lida / Hamidinejat, Hossein / Razi Jalali, Mohammad Hossein / Najafzadeh Varzi, Hossein / Seifi Abadshapouri, Massoud Reza / Jafari, Hedieh

Iranian journal of parasitology

2022 Volume 17, Issue 1, Page(s) 79–89

Abstract: Background: The present study determined the effect of the fractions obtained from : Methods: The fractions of dried venom of : Results: The maximum effect on tachyzoite was observed in fraction 5 of venom. To further separate the protein, ... ...

Abstract	Background: The present study determined the effect of the fractions obtained from Methods: The fractions of dried venom of Results: The maximum effect on tachyzoite was observed in fraction 5 of venom. To further separate the protein, fraction 5 was used in high-performance liquid chromatography assay to purify its proteins. Based on the results of HPLC of fraction 5, among which the second peak, a peptide with <10 KDa representing a more potent effect in eliminating the tachyzoite of Conclusion: The scorpion venom-purified fractions possess anti-parasitic activity against the tachyzoite of
Language	English
Publishing date	2022-08-23
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2388453-8
ISSN	2008-238X ; 1735-7020
ISSN (online)	2008-238X
ISSN	1735-7020
DOI	10.18502/ijpa.v17i1.9019
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Article: Association between Lateral Cephalometric Changes in X-Y Coordinate System and Profile Changes among Skeletal Class III Patients after Orthognathic Surgery.

Seifi, Massoud / Jafarpour Boroujeni, Mahsa / Tabrizi, Reza / Tahmasbi, Soodeh

World journal of plastic surgery

2020 Volume 9, Issue 3, Page(s) 282–289

Abstract: Background: Since aesthetic issues are the most important causes of referring skeletal class III patients to surgeons, investigating the impact of orthognathic surgeries on improving patient profiles increases the quality of treatment and quality of ... ...

Abstract	Background: Since aesthetic issues are the most important causes of referring skeletal class III patients to surgeons, investigating the impact of orthognathic surgeries on improving patient profiles increases the quality of treatment and quality of life. Methods: In a retrospective observational-analytical study, 25 patients older than 18 years with class III skeletal malocclusion who had gone under both orthodontic and double-jaw orthognathic treatment were enrolled. Cephalometric imaging interval was before and at least 6 months after surgery. By defining a number of points and coordinate axes (X-Y), a criterion for comparing hard and soft tissue changes was obtained. These measurements were coordinated, linear and angular. The quantitative data were compared with data obtained using the Likert Scale Questionnaire by means of electronic "Google Forms" that was completed by orthodontists (n=5) and maxillofacial surgeons (n=5) to rank improvement in post-surgical profiles for both cephalometry and photography from poor to pleasant. Spearman Correlation Analysis was conducted between the quantitative and qualitative data. Results: Vertical changes of point B and horizontal changes of point PNS showed correlation with improvement of patient profile. Changes in N-Pog line (R=-0.4), mandibular plane angle (R=-0.4) and nasolabial angle (NLA) (R=0.38) were significantly correlated with improvement of profiles. Conclusion: In orthognathic double-jaw surgery on patients with skeletal Class III, forward movement of maxilla, upward positioning of mandible (decreasing anterior facial height), decreasing mandibular plane angle and increasing nasolabial angle would result in a better profile.
Language	English
Publishing date	2020-12-09
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2781494-4
ISSN	2252-0724 ; 2228-7914
ISSN (online)	2252-0724
ISSN	2228-7914
DOI	10.29252/wjps.9.3.282
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Article ; Online: Evaluation of caries risk reduction following preventive programs in orthodontic patients, using Cariogram computer model: A quasi-experimental trial.

Doost-Hoseini, Maryam / Seifi, Massoud / Pakkhesal, Mina / Saboury, Abolfazl / Amdjadi, Parisa / Naghavialhosseini, Aliakbar

Dental press journal of orthodontics

2021 Volume 26, Issue 5, Page(s) e2120218

Abstract: Objective: This study evaluated the effectiveness of preventive strategies on caries risk reduction in patients undergoing orthodontic treatment, using the Cariogram program.: Methods: In this quasi-experimental study, samples were selected using a ... ...

Abstract	Objective: This study evaluated the effectiveness of preventive strategies on caries risk reduction in patients undergoing orthodontic treatment, using the Cariogram program. Methods: In this quasi-experimental study, samples were selected using a convenience quota sampling technique, in a public dental school. At first, caries risk profile was determined for each subject using the Cariogram before brackets bonding. The sample size consisted of 36 patients. The intervention group (n = 18) received preventive programs, and the control group (n = 18) was trained based on the routine oral health education by means of pamphlets. Then, Cariogram parameters were calculated for patients in both groups after six months. Results: The age range of participants was from 12 to 29 years. The mean percentage of the "Actual chance of avoiding new cavities" section in the intervention group increased from 45.72 ± 21.64 to 62.50 ± 17.64. However, the mean percentage of other parameters - such as "Diet", "Bacteria" and "Susceptibility" - decreased after six months (p< 0.001). Besides, the differences in the mean percentage between intervention and control group at the end of the study period (T1) related to the Cariogram parameters were statistically significant (p< 0.001). Accordingly, the mean percentage of 'Actual chance of avoiding new cavities'' parameter in the intervention group (62.50) was statistically higher than in the control group (42.44) (p< 0.001). Conclusion: Implementing different preventive approaches is able to reduce the caries risk in patients undergoing fixed orthodontic treatment, which can be clearly demonstrated using Cariogram program.
MeSH term(s)	Adolescent ; Adult ; Child ; Computers ; Dental Caries/prevention & control ; Dental Caries Susceptibility ; Humans ; Preventive Health Services ; Risk Assessment/methods ; Risk Reduction Behavior ; Young Adult
Language	English
Publishing date	2021-10-25
Publishing country	Brazil
Document type	Controlled Clinical Trial ; Journal Article
ZDB-ID	2721511-8
ISSN	2177-6709 ; 2177-6709
ISSN (online)	2177-6709
ISSN	2177-6709
DOI	10.1590/2177-6709.26.5.e2120218.oar
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Article: The effect of CHRNA3 rs1051730 C>T and ABCB1 rs3842 A>G polymorphisms on non-small cell lung cancer and nicotine dependence in Iranian population.

Veiskarami, Parisa / Houshmand, Massoud / Seifi, Sharareh / Ansarinejad, Nafiseh / Fardad, Farshid / Abbasi, Bahareh

Heliyon

2021 Volume 7, Issue 9, Page(s) e07867

Abstract: Aims: Lung cancer is still the leading cause of cancer mortality in all over the world. Nicotine and its derivatives are the most well-known carcinogens that participate in both etiology and progression of lung cancer. The objective of the current study ...

Abstract	Aims: Lung cancer is still the leading cause of cancer mortality in all over the world. Nicotine and its derivatives are the most well-known carcinogens that participate in both etiology and progression of lung cancer. The objective of the current study was to investigate whether single nucleotide polymorphisms (SNPs) rs1051730C > T in CHRNA3 and rs3842A > G in ABCB1, two genes contributing in the mechanism of disposition and metabolism of nicotine and its derivatives, could modify the risk of developing lung cancer, as well as nicotine dependence in Iranian. Main methods: The genotyping analysis for these two SNPs was conducted in a case-control study of 108 lung cancer cases and 120 healthy controls using ARMS-PCR and Tetra-primer ARMS-PCR techniques. The correlation between studied SNPs and lung cancer was assessed by the regression analysis. Key findings: We observed a significant association between lung cancer and rs1051730C > T by using four genetic models: allele (OR:1.83; 95% CI:1.24-2.6; p = 0.002), dominant (OR: 2.19; 95% CI:1.27-3.78; p = 0.005), recessive (OR: 2.25; 95% CI: 1.02-4.95; p = 0.043) and additive (TT vs CC: OR:3.25; 95% CI:1.38-7.60; p = 0.007, CT vs CC: OR:1.96; 95% CI:1.10-3.48; p = 0.021). Furthermore, a significant association between this variant and nicotine dependence (OR: 2.27; 95% CI: 1.52-3.39; p = 0.00005) was reported. However, no association was found for rs3842A > G. Significance: The results suggested that the CHRNA3 rs1051730C > T via a smoking-dependent manner could modify susceptibility to lung cancer among Iranian population.
Language	English
Publishing date	2021-08-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2021.e07867
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