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Article ; Online: Application of plasma circulating KRAS mutations as a predictive biomarker for targeted treatment of pancreatic cancer.

Lee, Mi Rim / Woo, Sang Myung / Kim, Min Kyeong / Han, Sung-Sik / Park, Sang-Jae / Lee, Woo Jin / Lee, Dong-Eun / Choi, Sun Il / Choi, Wonyoung / Yoon, Kyong-Ah / Chun, Jung Won / Kim, Yun-Hee / Kong, Sun-Young

Cancer science

2024 Volume 115, Issue 4, Page(s) 1283–1295

Abstract: Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations in circulating tumor deoxyribonucleic acid (ctDNA) have been reported as representative noninvasive prognostic markers for pancreatic ductal adenocarcinoma (PDAC). Here, we aimed to evaluate ... ...

Abstract	Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations in circulating tumor deoxyribonucleic acid (ctDNA) have been reported as representative noninvasive prognostic markers for pancreatic ductal adenocarcinoma (PDAC). Here, we aimed to evaluate single KRAS mutations as prognostic and predictive biomarkers, with an emphasis on potential therapeutic approaches to PDAC. A total of 128 patients were analyzed for multiple or single KRAS mutations (G12A, G12C, G12D, G12R, G12S, G12V, and G13D) in their tumors and plasma using droplet digital polymerase chain reaction (ddPCR). Overall, KRAS mutations were detected by multiplex ddPCR in 119 (93%) of tumor DNA and 68 (53.1%) of ctDNA, with a concordance rate of 80% between plasma ctDNA and tumor DNA in the metastatic stage, which was higher than the 44% in the resectable stage. Moreover, the prognostic prediction of both overall survival (OS) and progression-free survival (PFS) was more relevant using plasma ctDNA than tumor DNA. Further, we evaluated the selective tumor-suppressive efficacy of the KRAS G12C inhibitor sotorasib in a patient-derived organoid (PDO) from a KRAS G12C-mutated patient using a patient-derived xenograft (PDX) model. Sotorasib showed selective inhibition in vitro and in vivo with altered tumor microenvironment, including fibroblasts and macrophages. Collectively, screening for KRAS single mutations in plasma ctDNA and the use of preclinical models of PDO and PDX with genetic mutations would impact precision medicine in the context of PDAC.
MeSH term(s)	Humans ; Proto-Oncogene Proteins p21(ras)/genetics ; Biomarkers, Tumor/genetics ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/diagnosis ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/genetics ; DNA, Neoplasm/genetics ; Mutation ; Tumor Microenvironment
Chemical Substances	Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Biomarkers, Tumor ; DNA, Neoplasm ; KRAS protein, human
Language	English
Publishing date	2024-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1349-7006
ISSN (online)	1349-7006
ISSN	1349-7006
DOI	10.1111/cas.16104
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Low-dose methotrexate therapy for intravenous immunoglobulin-resistant Kawasaki disease.

Lee, Taek Jin / Kim, Ki Hwan / Chun, Jin-Kyong / Kim, Dong Soo

Yonsei medical journal

2008 Volume 49, Issue 5, Page(s) 714–718

Abstract: Purpose: The aim of this study was to evaluate the efficacy of low-dose oral methotrexate (MTX) as a treatment for patients with Kawasaki disease (KD) which was resistant to intravenous immunoglobulin (IVIG).: Patients and methods: The patients who ... ...

Abstract	Purpose: The aim of this study was to evaluate the efficacy of low-dose oral methotrexate (MTX) as a treatment for patients with Kawasaki disease (KD) which was resistant to intravenous immunoglobulin (IVIG). Patients and methods: The patients who had persistent or recrudescent fever after treatment with IVIG were subsequently treated with low-dose oral MTX [10mg/body surface area (BSA)] once weekly. Results: Seventeen patients developed persistent or recrudescent fever after treatment of KD with IVIG and were consequently given MTX. The proportion of children with coronary artery lesions (CALs) was 76%. The median value of maximum body temperatures decreased significantly within 24 hours of MTX therapy (38.6 degrees C vs. 37.0 degrees C, p < 0.001). The median CRP (C-reactive protein) level was found to be significantly lower 1 week after administering the first dose of MTX (8.9mg/dL vs. 1.2mg/dL, p < 0.001). The median duration of fever before MTX treatment was shorter in CALs (-) group than in CALs (+) group (7 days vs. 10 days, p = 0.023). No adverse effects of MTX were observed. Conclusion: MTX treatment for IVIG-resistant KD resulted in quick resolution of fever and rapid improvement of inflammation markers without causing any adverse effects. MTX therapy should further be assessed in a multicenter, placebo-blinded trial to evaluate whether it also improves coronary artery outcome.
MeSH term(s)	Child ; Child, Preschool ; Drug Resistance ; Female ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Infant ; Male ; Methotrexate/administration & dosage ; Methotrexate/therapeutic use ; Mucocutaneous Lymph Node Syndrome/drug therapy ; Treatment Outcome
Chemical Substances	Immunoglobulins, Intravenous ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2008-10-31
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	303740-x
ISSN	1976-2437 ; 0513-5796
ISSN (online)	1976-2437
ISSN	0513-5796
DOI	10.3349/ymj.2008.49.5.714
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Article ; Online: Design and Optimization of Composite Cathodes for Solid-State Batteries Using Hybrid Carbon Networks with Facile Electronic and Ionic Percolation Pathways.

Kim, Kyung Oh / Park, Sang-Hoon / Chun, Hye-Bin / Lee, Woo Young / Jang, Bo-Yun / Kim, Daeil / Yu, Ji Haeng / Yun, Kyong Sik / Kim, Jinsoo / Li, Oi Lun / Han, Yu-Jin

ACS applied materials & interfaces

2023 Volume 15, Issue 30, Page(s) 36748–36758

Abstract: Solid-state batteries (SSBs) have emerged as a promising alternative to conventional liquid electrolyte batteries due to their potential for higher energy density and improved safety. However, achieving high performance in SSBs is difficult because of ... ...

Abstract	Solid-state batteries (SSBs) have emerged as a promising alternative to conventional liquid electrolyte batteries due to their potential for higher energy density and improved safety. However, achieving high performance in SSBs is difficult because of inadequate contact and interfacial reactions that generate high interfacial resistance, as well as inadequate solid-solid contact between electrodes. These chronic issues are associated with inhomogeneous ion and electron transport networks owing to imperfect solid-solid interfacial contact. This study developed an optimal interfacial engineering strategy to facilitate an ion-electron transport network by designing an active material (NCM622) uniformly filled with a thin layer of a solid electrolyte (garnet-type Li
Language	English
Publishing date	2023-07-19
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c04394
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Article: Catalytic hydrocracking of heavy wax from pyrolysis of plastic wastes using Pd/Hβ for naphtha-ranged hydrocarbon production

Choi, Il-Ho / Lee, Hye-Jin / Rhim, Geun-Bae / Chun, Dong-Hyun / Lee, Kyong-Hwan / Hwang, Kyung-Ran

Journal of analytical and applied pyrolysis. 2022 Jan., v. 161

2022

Abstract: The catalytic hydrocracking of heavy wax derived from the pyrolysis of waste plastics was conducted for valuable naphtha production on the bifunctional catalyst. As the result of the support screening to prepare the bifunctional catalyst, the acidic Hβ ... ...

Abstract	The catalytic hydrocracking of heavy wax derived from the pyrolysis of waste plastics was conducted for valuable naphtha production on the bifunctional catalyst. As the result of the support screening to prepare the bifunctional catalyst, the acidic Hβ was chosen, which exhibited the reasonable wax conversion (64%) and the highest saturated and unsaturated hydrocarbon content (98%) in naphtha fraction at 380 ̊C. Then, Pd was impregnated on the Hβ as an active metal, and ≥ 0.6% Pd could dramatically improve the cracking and hydrogenation activities of the Hβ even at 360 ̊C from 47.9% to >97.5% conversion. Also, the liquid product mainly composed of saturated hydrocarbons (<2% olefin and >88% paraffins), which is quite suitable for naphtha. Especially, Pd[0.6]/Hβ, having 0.012 of the metal/acids ratio, exhibited the highest hydrocracking activity (99.2% conversion and 97.8% naphtha fraction in liquid), and that of >0.012 led catalyst’s isomerization activity increased.
Keywords	catalysts ; hydrogenation ; isomerization ; liquids ; olefin ; pyrolysis
Language	English
Dates of publication	2022-01
Publishing place	Elsevier B.V.
Document type	Article
ISSN	0165-2370
DOI	10.1016/j.jaap.2021.105424
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Dimensions of Online Conflict

Canute, Matt / Jin, Mali / holtzclaw, hannah / Lusoli, Alberto / Adams, Philippa R / Pandya, Mugdha / Taboada, Maite / Maynard, Diana / Chun, Wendy Hui Kyong

Towards Modeling Agonism

2023

Abstract: Agonism plays a vital role in democratic dialogue by fostering diverse perspectives and robust discussions. Within the realm of online conflict there is another type: hateful antagonism, which undermines constructive dialogue. Detecting conflict online ... ...

Abstract	Agonism plays a vital role in democratic dialogue by fostering diverse perspectives and robust discussions. Within the realm of online conflict there is another type: hateful antagonism, which undermines constructive dialogue. Detecting conflict online is central to platform moderation and monetization. It is also vital for democratic dialogue, but only when it takes the form of agonism. To model these two types of conflict, we collected Twitter conversations related to trending controversial topics. We introduce a comprehensive annotation schema for labelling different dimensions of conflict in the conversations, such as the source of conflict, the target, and the rhetorical strategies deployed. Using this schema, we annotated approximately 4,000 conversations with multiple labels. We then trained both logistic regression and transformer-based models on the dataset, incorporating context from the conversation, including the number of participants and the structure of the interactions. Results show that contextual labels are helpful in identifying conflict and make the models robust to variations in topic. Our research contributes a conceptualization of different dimensions of conflict, a richly annotated dataset, and promising results that can contribute to content moderation. Comment: To appear
Keywords	Computer Science - Computation and Language
Publishing date	2023-11-06
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of new hemagglutinin-based rapid antigen test for influenza A pandemic (H1N1) 2009.

Kim, Young Keun / Uh, Young / Chun, Jin-Kyong / Kim, Changsoo / Kim, Hyo Youl

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

2010 Volume 49, Issue 1, Page(s) 69–72

Abstract: Background: A new rapid antigen test (RAT), based on hemagglutinin, was developed for the improvement of influenza A pandemic (H1N1) 2009 detection.: Objective: To evaluate the performance of the new RAT for the diagnosis of influenza A pandemic ( ... ...

Abstract	Background: A new rapid antigen test (RAT), based on hemagglutinin, was developed for the improvement of influenza A pandemic (H1N1) 2009 detection. Objective: To evaluate the performance of the new RAT for the diagnosis of influenza A pandemic (H1N1) 2009. Study design: The new RAT included 2009 H1N1 hemagglutinin-based band and influenza A and influenza B nucleoprotein-based bands. During the period from November 24, 2009 to December 14, 2009, 948 patients underwent the new RAT and real-time reverse transcriptase polymerase chain reaction (rRT-PCR) at the same time. The result of the new RAT was compared with that of rRT-PCR, and the results of hemagglutinin-based and nucleoprotein-based antigen tests were compared. Result: Among the 260 patients confirmed by rRT-PCR, 153 (58.8%) were positive in the nucleoprotein-based antigen test, and 182 (70.0%) were positive in the hemagglutinin-based antigen test. These results show that the new hemagglutinin-based antigen test was more sensitive than the nucleoprotein-based antigen test for the detection of influenza A pandemic (H1N1) 2009 (p<0.001, the McNemar test). Conclusion: The new hemagglutinin-based antigen test improved the sensitivity of diagnosis for influenza A pandemic (H1N1) 2009 and it might be helpful for the diagnosis of influenza A pandemic (H1N1) 2009.
MeSH term(s)	Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Female ; Hemagglutinin Glycoproteins, Influenza Virus/immunology ; Humans ; Infant ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A Virus, H1N1 Subtype/immunology ; Influenza, Human/diagnosis ; Influenza, Human/immunology ; Influenza, Human/virology ; Male ; Middle Aged ; Pandemics ; Predictive Value of Tests ; Reverse Transcriptase Polymerase Chain Reaction ; Sensitivity and Specificity ; Time Factors ; Young Adult
Chemical Substances	H1N1 virus hemagglutinin ; Hemagglutinin Glycoproteins, Influenza Virus
Language	English
Publishing date	2010-09
Publishing country	Netherlands
Document type	Comparative Study ; Evaluation Studies ; Journal Article
ZDB-ID	1446080-4
ISSN	1873-5967 ; 1386-6532
ISSN (online)	1873-5967
ISSN	1386-6532
DOI	10.1016/j.jcv.2010.06.012
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Article ; Online: Periostin deficiency attenuates kidney fibrosis in diabetic nephropathy by improving pancreatic β-cell dysfunction and reducing kidney EMT.

Cho, Ara / Jin, Wencheng / Lee, Jeonghwan / Shin, Nayeon / Lee, Myoung Seok / Li, Lilin / Yang, Seung Hee / Park, Kyong Soo / Yang, Chul Woo / Kim, Dong Ki / Oh, Yun Kyu / Lim, Chun Soo / Lee, Jung Pyo

Scientific reports

2023 Volume 13, Issue 1, Page(s) 17599

Abstract: Diabetic nephropathy (DN) is associated with kidney fibrosis. A previous study revealed that periostin (POSTN) contributes to kidney fibrosis. This study examined the role of POSTN in DN. The urinary concentrations of POSTN and TNC increased according to ...

Abstract	Diabetic nephropathy (DN) is associated with kidney fibrosis. A previous study revealed that periostin (POSTN) contributes to kidney fibrosis. This study examined the role of POSTN in DN. The urinary concentrations of POSTN and TNC increased according to the severity of DN in human samples. Streptozotocin (STZ) was administered after unilateral nephrectomy (UNXSTZ) to induce DN in wild-type and Postn-null mice. Four experimental groups were generated: wild-typeham (WT Sham), wild-type UNXSTZ (WT STZ), Postn-null Sham (KO Sham), and Postn-null UNXSTZ (KO STZ). After 20 weeks, the KO STZ group had lower levels of urine albumin excretion, glomerular sclerosis, and interstitial fibrosis than those of the WT STZ group. Additionally, the KO STZ group had lower expression of fibrosis markers, including TNC. The KO STZ group showed better glucose regulation than the WT STZ model. Furthermore, the KO STZ group exhibited significantly preserved pancreatic islet integrity and insulin expression. HK-2 cells were used to observe the aggravation of fibrosis caused by POSTN under TGF-β conditions. We stimulated INS-1 cells with streptozotocin and evaluated the viability of these cells. The anti-POSTN antibody treatment of INS-1 cells with streptozotocin resulted in higher cell viability than that with treatment with streptozotocin alone. The absence of POSTN in DN contributes to renal fibrosis alleviation by improving pancreatic β-cell function. Additionally, there is an association between POSTN and TNC.
MeSH term(s)	Animals ; Humans ; Mice ; Diabetes Mellitus, Experimental/metabolism ; Diabetic Nephropathies/metabolism ; Fibrosis ; Kidney/metabolism ; Mice, Knockout ; Streptozocin
Chemical Substances	Streptozocin (5W494URQ81) ; Postn protein, mouse
Language	English
Publishing date	2023-10-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-44177-5
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Article ; Online: Programmed death-1 (PD-1) gene polymorphisms lodged in the genetic predispositions of Kawasaki Disease.

Chun, Jin-Kyong / Kang, Dong Won / Yoo, Byung Won / Shin, Jeon-Soo / Kim, Dong Soo

European journal of pediatrics

2009 Volume 169, Issue 2, Page(s) 181–185

Abstract: The purpose of this study is to investigate the association of programmed death-1 gene (PD-1) polymorphisms with genetic predispositions to Kawasaki disease (KD). A total of 73 patients with KD and 100 healthy controls were enrolled from 2007 to 2008. ... ...

Abstract	The purpose of this study is to investigate the association of programmed death-1 gene (PD-1) polymorphisms with genetic predispositions to Kawasaki disease (KD). A total of 73 patients with KD and 100 healthy controls were enrolled from 2007 to 2008. Two single nucleotide polymorphisms of the PD-1 gene, rs41386349 and rs2227981, were analyzed. Higher T allele frequency of rs41386349 was found in the patient group than the control group (p = 0.007, odds ratio (OR) = 1.9, 95% CI = 1.2-2.9). PD-1 rs2227981 polymorphism was not significant in patients with KD comparing with the control group (p = 0.4, OR = 1.2 (0.8-1.9)). Furthermore, no difference of PD-1 polymorphisms between patients with coronary artery dilatation (CAD) and those without CAD was found. Our data support the possibility that PD-1 gene polymorphism may be related with the genetic susceptibility of KD in Korean population.
MeSH term(s)	Adolescent ; Adult ; Antigens, CD/blood ; Antigens, CD/genetics ; Apoptosis Regulatory Proteins/blood ; Apoptosis Regulatory Proteins/genetics ; Child ; Child, Preschool ; DNA/genetics ; Female ; Genetic Predisposition to Disease/genetics ; Humans ; Incidence ; Lymphocyte Activation ; Male ; Mucocutaneous Lymph Node Syndrome/blood ; Mucocutaneous Lymph Node Syndrome/epidemiology ; Mucocutaneous Lymph Node Syndrome/genetics ; Odds Ratio ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Programmed Cell Death 1 Receptor ; Republic of Korea/epidemiology ; Retrospective Studies ; Young Adult
Chemical Substances	Antigens, CD ; Apoptosis Regulatory Proteins ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor ; DNA (9007-49-2)
Language	English
Publishing date	2009-05-26
Publishing country	Germany
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-009-1002-4
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Article ; Online: Elevated Serum Levels of IL-21 in Kawasaki Disease.

Bae, Yon Jung / Kim, Mi Hyun / Lee, Hae Yong / Uh, Young / Namgoong, Mee Kyung / Cha, Byung Ho / Chun, Jin-Kyong

Allergy, asthma & immunology research

2012 Volume 4, Issue 6, Page(s) 351–356

Abstract: Purpose: The serum level of immunoglobulin (Ig)E has been reported to be elevated in patients with Kawasaki disease (KD). We investigated whether interleukin (IL)-21, rather than IL-4, could be related to elevated serum levels of IgE in KD.: Methods: ...

Abstract	Purpose: The serum level of immunoglobulin (Ig)E has been reported to be elevated in patients with Kawasaki disease (KD). We investigated whether interleukin (IL)-21, rather than IL-4, could be related to elevated serum levels of IgE in KD. Methods: Sera from 48 patients with KD and 12 controls with high fever were collected to determine the level of IgE using an immunoassay system and the levels of IL-4 and IL-21 were determined using enzyme-linked immunosorbent assay kits. Results: The median IL-21 level of KD patients was significantly elevated, at 499.5 pg/mL (range: <62.5-1,544 pg/mL), whereas that of controls was <62.5 pg/mL (<62.5-825 pg/mL; P<0.001). The median IL-4 level of KD patients was not elevated (4.0 pg/mL; 2.1-7.6 pg/mL). The median level of total IgE in KD patients was 58.0 IU/mL (5-1,109 IU/mL). No statistically significant correlation was found between IL-21 and total IgE levels (Spearman's R=0.2; P=0.19). Conclusions: Patients with KD have elevated levels of IL-21 in the serum. IL-21 may play a role in the pathogenesis of KD.
Language	English
Publishing date	2012-06-29
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2545725-1
ISSN	2092-7363 ; 2092-7363
ISSN (online)	2092-7363
ISSN	2092-7363
DOI	10.4168/aair.2012.4.6.351
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Article: Analysis of clinical presentations of Bruton disease: a review of 20 years of accumulated data from pediatric patients at Severance Hospital.

Chun, Jin-Kyong / Lee, Taek Jin / Song, Jae Woo / Linton, John A / Kim, Dong Soo

Yonsei medical journal

2008 Volume 49, Issue 1, Page(s) 28–36

Abstract: Purpose: X-linked agammaglobulinemia (XLA) is a humoral immunodeficiency disease caused by a mutation in the Bruton tyrosine kinase (BTK) gene resulting in defective B cell differentiation. Because it is a relatively rare disorder, it is difficult for ... ...

Abstract	Purpose: X-linked agammaglobulinemia (XLA) is a humoral immunodeficiency disease caused by a mutation in the Bruton tyrosine kinase (BTK) gene resulting in defective B cell differentiation. Because it is a relatively rare disorder, it is difficult for clinicians to have a comprehensive understanding of XLA due to a lack of exposure to the disease. Clinical presentations of patients with XLA were analyzed and discussed to improve care plans. Materials and methods: During a 20 year period, from January 1987 to June 2006, a total of 19 patients were diagnosed as XLA in the Department of Pediatrics at Severance Hospital, Seoul, Korea. A retrospective analysis of the clinical presentations of those patients was performed. Results: The mean age of the XLA patients included in the study was 4.89 years, with a range of 6 months to 13 years. Twelve patients were diagnosed before age 5, while the other 7 patients were diagnosed after age 5. Recurrent infections observed in the patients included pneumonia, acute otitis media, septic arthritis, skin infection, sepsis, sinusitis, acute gastroenteritis, cervical lymphadenitis, epididymitis, meningitis, osteomyelitis, urinary tract infection and encephalitis. Frequency of admissions was variable from 0 to 12 times, depending on the time at which immunoglobulin therapy was started. Six cases had family histories positive for XLA. BTK gene mutations were found in 8 cases. Conclusion: The overall prognosis of XLA is good as long as patients are diagnosed and treated early with regular intra venous gamma globulin therapy before the sequelae of recurrent infections appear.
MeSH term(s)	Adolescent ; Agammaglobulinaemia Tyrosine Kinase ; Agammaglobulinemia/complications ; Agammaglobulinemia/diagnosis ; Agammaglobulinemia/drug therapy ; Agammaglobulinemia/genetics ; Child ; Child, Preschool ; Genetic Diseases, X-Linked/enzymology ; Genetic Diseases, X-Linked/genetics ; Genetic Diseases, X-Linked/pathology ; Hospitals ; Humans ; Infant ; Male ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/metabolism ; Retrospective Studies ; Time Factors
Chemical Substances	Protein-Tyrosine Kinases (EC 2.7.10.1) ; Agammaglobulinaemia Tyrosine Kinase (EC 2.7.10.2) ; BTK protein, human (EC 2.7.10.2)
Language	English
Publishing date	2008-02-27
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	303740-x
ISSN	1976-2437 ; 0513-5796
ISSN (online)	1976-2437
ISSN	0513-5796
DOI	10.3349/ymj.2008.49.1.28
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