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  1. Article ; Online: Study on the chemical reactivity difference of primary hydroxyl groups in iridoid glycosides.

    Kong, Yuanfang / Xu, Jindan / Zhu, Pengbo / Wang, Shaopei / Yang, Bin / Zhang, Jingyu / Dong, Chunhong

    RSC advances

    2023  Volume 13, Issue 47, Page(s) 33204–33209

    Abstract: Iridoid glycoside, which belongs to the polyhydroxy compound, is a kind of active ingredient of traditional Chinese medicine with a wide range of sources, and has many pharmacological effects such as anti-cancer, anti-inflammatory, anti-virus, ... ...

    Abstract Iridoid glycoside, which belongs to the polyhydroxy compound, is a kind of active ingredient of traditional Chinese medicine with a wide range of sources, and has many pharmacological effects such as anti-cancer, anti-inflammatory, anti-virus, hypoglycemic and so on. Its structure contains many hydroxyl groups, including two primary hydroxyl groups. The chemical reactivity of primary hydroxyl groups has very little difference, so it is very important to control the selectivity of hydroxyl groups under certain conditions. In this paper, the difference between the two primary hydroxyl groups in iridoid glycoside was calculated based on computer simulation and verified this result through designed experiments. This study will provide an important way for site-directed modification of hydroxyl in iridoid glycoside in the future.
    Language English
    Publishing date 2023-11-10
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra05674k
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  2. Article ; Online: Design, Synthesis and Biological Evaluation of Novel Catalpol Derivatives as Potential Pancreatic Cancer Inhibitors.

    Kong, Yuanfang / Liu, Shuanglin / Wang, Shaopei / Xu, Jindan / Hu, Yulong / Jiang, Shiqing / Dong, Chunhong

    Chemistry, an Asian journal

    2023  Volume 18, Issue 12, Page(s) e202300185

    Abstract: A series of C10-position imidazole-modified catalpol derivatives are specifically designed and synthesized for serving as potential pancreatic cancer inhibitors, which are characterized ... ...

    Abstract A series of C10-position imidazole-modified catalpol derivatives are specifically designed and synthesized for serving as potential pancreatic cancer inhibitors, which are characterized by
    MeSH term(s) Humans ; Cell Line, Tumor ; Cell Proliferation ; Molecular Docking Simulation ; Vascular Endothelial Growth Factor A ; Antineoplastic Agents/chemistry ; Protein Kinase Inhibitors/chemistry ; Drug Design ; Structure-Activity Relationship ; Neoplasms ; Pancreatic Neoplasms
    Chemical Substances catalpol (2415-24-9) ; Vascular Endothelial Growth Factor A ; Antineoplastic Agents ; Protein Kinase Inhibitors
    Language English
    Publishing date 2023-05-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2233006-9
    ISSN 1861-471X ; 1861-4728
    ISSN (online) 1861-471X
    ISSN 1861-4728
    DOI 10.1002/asia.202300185
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  3. Article ; Online: Progress in small-molecule inhibitors targeting PD-L1.

    Xu, Jindan / Kong, Yuanfang / Zhu, Pengbo / Du, Mingyan / Liang, Xuan / Tong, Yan / Li, Xiaofei / Dong, Chunhong

    RSC medicinal chemistry

    2024  Volume 15, Issue 4, Page(s) 1161–1175

    Abstract: PD-L1 is a transmembrane protein overexpressed by tumor cells. It binds to PD-1 on the surface of T-cells, suppresses T-cell activity and hinders the immune response against cancer. Clinically, several monoclonal antibodies targeting PD-1/PD-L1 have ... ...

    Abstract PD-L1 is a transmembrane protein overexpressed by tumor cells. It binds to PD-1 on the surface of T-cells, suppresses T-cell activity and hinders the immune response against cancer. Clinically, several monoclonal antibodies targeting PD-1/PD-L1 have achieved significant success in cancer immunotherapy. Nevertheless, their disadvantages, such as unchecked immune responses, high cost and long half-life, stimulated pharmacologists to develop small-molecule inhibitors targeting PD-1/PD-L1. After a batch of excellent inhibitors with a biphenyl core structure were firstly reported by BMS, more and more researchers focused on small-molecule inhibitors targeting PD-L1 rather than PD-1. Numerous small-molecule inhibitors were extensively designed and synthesized in the past few years. In this paper, the structural characteristics of PD-L1 and complexes of PD-L1 with its inhibitors are elaborated and small molecule inhibitors developed in the last decade are summarized as well. This paper aims to provide insights into further designing and synthesis of small molecule inhibitors targeting PD-L1.
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2632-8682
    ISSN (online) 2632-8682
    DOI 10.1039/d3md00655g
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  4. Article: Gram-scale synthesis of splat-shaped Ag-TiO

    Jaber, Mohammad / Mushtaq, Asim / Zhang, Kebiao / Wu, Jindan / Luo, Dandan / Yi, Zihan / Iqbal, M Zubair / Kong, Xiangdong

    Beilstein journal of nanotechnology

    2020  Volume 11, Page(s) 1119–1125

    Abstract: The control over contagious diseases caused by pathogenic organisms has become a serious health issue. The extensive usage of antibiotics has led to the development of multidrug-resistant bacterial strains. In this regard, metal-oxide-based antibacterial ...

    Abstract The control over contagious diseases caused by pathogenic organisms has become a serious health issue. The extensive usage of antibiotics has led to the development of multidrug-resistant bacterial strains. In this regard, metal-oxide-based antibacterial nanomaterials have received potential research interest due to the efficient prevention of microorganism growth. In this study, splat-shaped Ag-TiO
    Language English
    Publishing date 2020-07-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2583584-1
    ISSN 2190-4286
    ISSN 2190-4286
    DOI 10.3762/bjnano.11.96
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  5. Article ; Online: Comparative study of hematological and radiological feature of severe/critically ill patients with COVID-19, influenza A H7N9, and H1N1 pneumonia.

    Kong, Jindan / Hao, Yan / Wan, Shan / Li, Zheng / Zou, Di / Zhang, Leisi / Lu, Yin / Wang, Jun / Chen, Xiaochen / Fu, Jianhong

    Journal of clinical laboratory analysis

    2021  Volume 35, Issue 12, Page(s) e24100

    Abstract: Objectives: This study aimed to explore clinical indexes for management of severe/critically ill patients with COVID-19, influenza A H7N9, and H1N1 pneumonia by comparing hematological and radiological characteristics.: Methods: Severe/critically ill ...

    Abstract Objectives: This study aimed to explore clinical indexes for management of severe/critically ill patients with COVID-19, influenza A H7N9, and H1N1 pneumonia by comparing hematological and radiological characteristics.
    Methods: Severe/critically ill patients with COVID-19, H7N9, and H1N1 pneumonia were retrospectively enrolled. The demographic data, clinical manifestations, hematological parameters, and radiological characteristics were compared.
    Results: In this study, 16 cases of COVID-19, 10 cases of H7N9, and 13 cases of H1N1 who met severe/critically ill criteria were included. Compared with COVID-19, H7N9 and H1N1 groups had more chronic diseases (80% and 92.3% vs. 25%, p < 0.05), higher APACHE Ⅱ scores (16.00 ± 8.63 and 15.08 ± 6.24, vs. 5.50 ± 2.58, p < 0.05), higher mortality rates (40% and 46.2% vs. 0%, p < 0.05), significant lymphocytopenia (0.59 ± 0.31 × 10
    Conclusions: The NLR can be used as a clinical parameter for the predication of risk stratification and outcome in COVID-19 and influenza A pneumonia. Manifestations of pleural effusion or GGO in chest CT may be helpful for the identification of different viral pneumonia.
    MeSH term(s) Aged ; Aged, 80 and over ; Blood Cell Count ; COVID-19/blood ; COVID-19/diagnostic imaging ; COVID-19/etiology ; Chronic Disease ; Critical Illness ; Female ; Humans ; Influenza A Virus, H1N1 Subtype ; Influenza A Virus, H7N9 Subtype ; Influenza, Human/blood ; Influenza, Human/diagnostic imaging ; Influenza, Human/etiology ; Influenza, Human/virology ; Male ; Middle Aged ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/mortality ; Pneumonia, Viral/virology ; Retrospective Studies ; Sex Factors
    Language English
    Publishing date 2021-11-11
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 645095-7
    ISSN 1098-2825 ; 0887-8013
    ISSN (online) 1098-2825
    ISSN 0887-8013
    DOI 10.1002/jcla.24100
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    Zs.A 2471: Show issues Location:
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  6. Article ; Online: The clinical implication of dynamic neutrophil to lymphocyte ratio and D-dimer in COVID-19

    Fu, Jianhong / Kong, Jindan / Wang, Wei / Wu, Meiying / Yao, Lin / Wang, Zhaoyue / Jin, Jun / Wu, Depei / Yu, Xin

    Thrombosis Research

    A retrospective study in Suzhou China

    2020  Volume 192, Page(s) 3–8

    Keywords Hematology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2020.05.006
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Gram-scale synthesis of splat-shaped Ag–TiO2 nanocomposites for enhanced antimicrobial properties

    Mohammad Jaber / Asim Mushtaq / Kebiao Zhang / Jindan Wu / Dandan Luo / Zihan Yi / M. Zubair Iqbal / Xiangdong Kong

    Beilstein Journal of Nanotechnology, Vol 11, Iss 1, Pp 1119-

    2020  Volume 1125

    Abstract: The control over contagious diseases caused by pathogenic organisms has become a serious health issue. The extensive usage of antibiotics has led to the development of multidrug-resistant bacterial strains. In this regard, metal-oxide-based antibacterial ...

    Abstract The control over contagious diseases caused by pathogenic organisms has become a serious health issue. The extensive usage of antibiotics has led to the development of multidrug-resistant bacterial strains. In this regard, metal-oxide-based antibacterial nanomaterials have received potential research interest due to the efficient prevention of microorganism growth. In this study, splat-shaped Ag–TiO2 nanocomposites (NCs) were synthesized on the gram scale and the enhanced antibacterial properties of TiO2 in the presence of silver were examined. The formation of Ag–TiO2 NCs was analyzed through various characterization techniques. The cell viability experimental results demonstrated that the Ag–TiO2 NCs have good biocompatibility. The antibacterial activity of the prepared Ag–TiO2 NCs was tested against the Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacterial strains. The Ag–TiO2 NCs exhibited promising and superior antibacterial properties compared to TiO2 nanospheres as confirmed by the bacterial growth and inhibition zone. The improvement in the antibacterial activity was attributed to the synergistic effect of the hybrid nature of TiO2 nanoparticles in the presence of Ag.
    Keywords antimicrobial properties ; biomaterials ; nanocomposites ; silver nanoparticles ; titanium dioxide ; Technology ; T ; Chemical technology ; TP1-1185 ; Science ; Q ; Physics ; QC1-999
    Subject code 620
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Beilstein-Institut
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: The clinical implication of dynamic neutrophil to lymphocyte ratio and D-dimer in COVID-19: A retrospective study in Suzhou China.

    Fu, Jianhong / Kong, Jindan / Wang, Wei / Wu, Meiying / Yao, Lin / Wang, Zhaoyue / Jin, Jun / Wu, Depei / Yu, Xin

    Thrombosis research

    2020  Volume 192, Page(s) 3–8

    Abstract: Objective: To investigate the clinical features of COVID-19 cases in Suzhou China. Biomarkers were screened out of hematological parameters for risk stratification.: Method: Confirmed COVID-19 adult patients in Suzhou were included. The patient data ... ...

    Abstract Objective: To investigate the clinical features of COVID-19 cases in Suzhou China. Biomarkers were screened out of hematological parameters for risk stratification.
    Method: Confirmed COVID-19 adult patients in Suzhou were included. The patient data was collected, and the results of laboratory examinations were compared between the mild/moderate and severe COVID-19 groups. A ROC was calculated to compare the diagnostic performance of candidate indexes, and dynamic levels of hematological indexes were compared between the two groups.
    Result: 75 patients were enrolled, with a mean age of 46.6 ± 14 years, and 45 patients were male. All patients were classified into two groups: the mild/moderate group and the severe group. WBC, neutrophil to lymphocyte ratio (NLR), D-dimer, and fibrinogen levels of the severe group were significantly higher (P < 0.05) than the mild/moderate, and the lymphocyte was lower. The ROC test showed that the hematological parameters had a larger AUC than that of inflammatory factors. There was a significant difference in lymphocyte and fibrinogen levels between the two groups on day 1 (P < 0.05). However, NLR of the severe group was higher than the mild/moderate on days 1, 4 and 14 (P < 0.01), and so was D-dimer on days 1, 7 and 14 (P < 0.05).
    Conclusion: The common COVID-19 abnormal hematological indexes on admission included hyperfibrinogenemia, lymphopenia, the elevation of D-dimer, and leukopenia, which were significantly different between the mild/moderate and severe COVID-19 groups. Furthermore, the dynamic change of NLR and D-dimer level can distinguish severe COVID-19 cases from the mild/moderate.
    MeSH term(s) Adult ; Aged ; Betacoronavirus/pathogenicity ; Biomarkers/blood ; COVID-19 ; COVID-19 Testing ; China ; Clinical Laboratory Techniques ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Coronavirus Infections/therapy ; Coronavirus Infections/virology ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Host-Pathogen Interactions ; Humans ; Lymphocyte Count ; Lymphocytes ; Male ; Middle Aged ; Neutrophils ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology ; Predictive Value of Tests ; Prognosis ; Reproducibility of Results ; Retrospective Studies ; SARS-CoV-2 ; Severity of Illness Index ; Young Adult
    Chemical Substances Biomarkers ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D
    Keywords covid19
    Language English
    Publishing date 2020-05-06
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2020.05.006
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    Zs.A 863: Show issues Location:
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  9. Article ; Online: Analysis of hematological indexes of COVID-19 patients from fever clinics in Suzhou, China.

    Kong, Jindan / Wang, Ting / Di, Zou / Shi, Bingyu / Yu, Xiaoming / Huang, Chaofa / Yang, Yan / Sun, Haiwei / Yuan, Dejing / Wu, Depei / Fu, Jianhong

    International journal of laboratory hematology

    2020  Volume 42, Issue 5, Page(s) e204–e206

    MeSH term(s) Adult ; Blood Cell Count ; C-Reactive Protein/metabolism ; COVID-19/blood ; COVID-19/epidemiology ; COVID-19/physiopathology ; China ; Female ; Fever/physiopathology ; Fibrinogen/metabolism ; Humans ; Lymphocytes/immunology ; Lymphopenia/blood ; Male ; Middle Aged ; Monocytes/immunology ; Neutrophils/immunology ; Pandemics
    Chemical Substances Fibrinogen (9001-32-5) ; C-Reactive Protein (9007-41-4)
    Keywords covid19
    Language English
    Publishing date 2020-07-13
    Publishing country England
    Document type Letter
    ZDB-ID 2268590-X
    ISSN 1751-553X ; 1751-5521 ; 0141-9854
    ISSN (online) 1751-553X
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.13290
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    Zs.A 1499: Show issues Location:
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  10. Article: Analysis of hematological indexes of COVID-19 patients from fever clinics in Suzhou, China

    Kong, Jindan / Wang, Ting / Di, Zou / Shi, Bingyu / Yu, Xiaoming / Huang, Chaofa / Yang, Yan / Sun, Haiwei / Yuan, Dejing / Wu, Depei / Fu, Jianhong

    Int. j. lab. hematol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #640720
    Database COVID19

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