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  1. Article ; Online: Exploring the potential mechanism of Heng-Gu-Gu-Shang-Yu-He-Ji therapy for osteoporosis based on network pharmacology and transcriptomics.

    Xie, Linbi / Song, Xu / Lei, Ling / Chen, Chu / Zhao, Huan / Hu, Jingyi / Yu, Yue / Bai, Xiaolu / Wu, Xia / Li, Xiangfeng / Yang, Xiao / Yuan, Bo / Li, Dongxiao / Zhu, Xiangdong / Zhang, Xingdong

    Journal of ethnopharmacology

    2023  Volume 321, Page(s) 117480

    Abstract: Ethnopharmacological relevance: Heng-Gu-Gu-Shang-Yu-He-Ji (Osteoking, OK) is a well-known formula ...

    Abstract Ethnopharmacological relevance: Heng-Gu-Gu-Shang-Yu-He-Ji (Osteoking, OK) is a well-known formula for fracture therapy. In clinic, OK is effective in treating fractures while alleviating osteoporosis (OP) symptoms. However, active components of OK and the associated molecular mechanisms remain not fully elucidated.
    Aim of the study: This study aims to systematically evaluate the anti-osteoporosis efficacy of OK and for the first time combine network pharmacology with high-throughput whole gene transcriptome sequencing to study its underlying mechanism.
    Materials and methods: In this study, the osteoporosis model was established by the castration of both ovaries. The level of serum bone turnover factor was detected by enzyme-linked immunosorbent assay. Micro-CT and HE staining were used to observe the changes of bone histopathology, and nano-indentation technique was used to detect the biomechanical properties of rat bone. The main active Chemical components of OK were identified using UPLC-DAD. Efficacy verification and mechanism exploration were conducted by network pharmacology, molecular docking, whole gene transcriptomics and in vivo experiments.
    Results: In our study, OK significantly improved bone microarchitecture and bone biomechanical parameters in OVX rats, reduced osteoclast indexes such as C-telopeptide of type I collage (CTX-I) and increased Osteoprotegerin (OPG)/Receptor activator of NF-κB ligand (RANKL) levels. Mechanistically, PI3K/AKT pathway was a common pathway for genome enrichment analysis (KEGG) of both network pharmacology and RNA-seq studies. G protein-β-like protein (GβL), Ribosomal-protein S6 kinase homolog 2 (S6K2), and Phosphoinositide 3-kinase (PI3K) appeared differentially expression in the PI3K-AKT signaling pathway. These results were also confirmed by qRT-PCR and immunohistochemistry.
    Conclusions: OK may be used to treat osteoporosis, at least partly by activating PI3K/AKT/mTORC1 signaling pathway.
    MeSH term(s) Rats ; Animals ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Network Pharmacology ; Molecular Docking Simulation ; Rats, Sprague-Dawley ; Osteoprotegerin/genetics ; Osteoprotegerin/metabolism ; Osteoporosis/metabolism ; Gene Expression Profiling ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Osteoprotegerin ; Drugs, Chinese Herbal
    Language English
    Publishing date 2023-11-22
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117480
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  2. Article: Antioxidants enhance lipid productivity in Heveochlorella sp. Yu

    Cui, Na / Xiao, Junmu / Feng, Yongjie / Zhao, Yongteng / Yu, Xuya / Xu, Jun-Wei / Li, Tao / Zhao, Peng

    Algal research. 2021 May, v. 55

    2021  

    Abstract: In this study, crude lipids, including pigment accumulation, in Heveochlorella sp. Yu were ...

    Abstract In this study, crude lipids, including pigment accumulation, in Heveochlorella sp. Yu were evaluated after the addition of four antioxidants (melatonin, fulvic acid, butylhydroxytoluene and butylated hydroxyanisole). Melatonin enhanced crude lipid accumulation in this alga, with crude lipid productivity increasing by 31.83% (from 185.57 mg L⁻¹ d⁻¹ to 244.63 mg L⁻¹ d⁻¹). Moreover, the level of reactive oxygen species was reduced and the concentration of nitric oxide increased with melatonin addition. Such changes in reactive oxygen species and nitric oxide concentration might regulate signaling pathways related to lipid biosynthesis. Furthermore, the expression levels of key genes (accD, ME and rbcL) associated with the lipid biosynthesis pathway were analyzed, and melatonin addition was found to enhance expression of these genes. Collectively, biochemical analyses suggest that nitric oxide and reactive oxygen species levels and expression of key genes involved in lipid biosynthesis are closely connected with lipid accumulation under melatonin treatment.
    Keywords algae ; biosynthesis ; butylated hydroxyanisole ; butylated hydroxytoluene ; fulvic acids ; lipids ; melatonin ; nitric oxide ; pigments ; reactive oxygen species ; research
    Language English
    Dates of publication 2021-05
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ISSN 2211-9264
    DOI 10.1016/j.algal.2021.102235
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Uncovering the potential mechanism of Xue Fu Zhu Yu Decoction in the treatment of intracerebral hemorrhage.

    Xue, Dao-Jin / Zhen, Zheng / Wang, Ke-Xin / Zhao, Jia-Lin / Gao, Yao / Chen, Yu-Peng / Shen, You-Bi / Peng, Zi-Zhuang / Guan, Dao-Gang / Huang, Tao

    BMC complementary medicine and therapies

    2022  Volume 22, Issue 1, Page(s) 103

    Abstract: ... by CHM has been deeply researched. Xue Fu Zhu Yu Decoction (XFZYD), one of the commonly used ...

    Abstract Background: Chinese herbal medicine (CHM) is characterized by "multi- compounds, multi-targets and multi-pathway", which has advanced benefits for preventing and treating complex diseases, but there still exists unsolved issues, mainly include unclear material basis and underlying mechanism of prescription. Integrated pharmacology is a hot cross research area based on system biology, mathematics and poly-pharmacology. It can systematically and comprehensively investigate the therapeutic reaction of compounds or drugs on pathogenic genes network, and is especially suitable for the study of complex CHM systems. Intracerebral Hemorrhage (ICH) is one of the main causes of death among Chinese residents, which is characterized with high mortality and high disability rate. In recent years, the treatment of ICH by CHM has been deeply researched. Xue Fu Zhu Yu Decoction (XFZYD), one of the commonly used prescriptions in treating ICH at clinic level, has not been clear about its mechanism.
    Methods: Here, we established a strategy, which based on compounds-targets, pathogenetic genes, network analysis and node importance calculation. Using this strategy, the core compounds group (CCG) of XFZYD was predicted and validated by in vitro experiments. The molecular mechanism of XFZYD in treating ICH was deduced based on CCG and their targets.
    Results: The results show that the CCG with 43 compounds predicted by this model is highly consistent with the corresponding Compound-Target (C-T) network in terms of gene coverage, enriched pathway coverage and accumulated contribution of key nodes at 89.49%, 88.72% and 90.11%, respectively, which confirmed the reliability and accuracy of the effective compound group optimization and mechanism speculation strategy proposed by us.
    Conclusions: Our strategy of optimizing the effective compound groups and inferring the mechanism provides a strategic reference for explaining the optimization and inferring the molecular mechanism of prescriptions in treating complex diseases of CHM.
    MeSH term(s) Cerebral Hemorrhage/drug therapy ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Medicine, Chinese Traditional/methods ; Reproducibility of Results
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2022-04-12
    Publishing country England
    Document type Journal Article
    ISSN 2662-7671
    ISSN (online) 2662-7671
    DOI 10.1186/s12906-022-03577-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Effects of Jie Yu Wan on Generalized Anxiety Disorder: A Randomized Clinical Trial.

    Li, Xue / Zheng, Sisi / Feng, Sitong / Ma, Rui / Jia, Yuan / Zhao, Anquan / Wei, Dan / Guo, Hua / Duan, Na / Ding, Ying / Chen, Jindong / Zhu, Hong / Jia, Hongxiao

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 9951693

    Abstract: Objective: To systematically assess the clinical efficacy of the : Methods: A multicenter, prospective, double-blind, double-dummy, randomized controlled trial (RCT) was conducted at four hospitals in China. A total of one hundred thirty-three ... ...

    Abstract Objective: To systematically assess the clinical efficacy of the
    Methods: A multicenter, prospective, double-blind, double-dummy, randomized controlled trial (RCT) was conducted at four hospitals in China. A total of one hundred thirty-three patients with GAD were enrolled from 2017 to 2019. This study aimed to evaluate the effects of a Traditional Chinese Medicine (TCM) JYW formula on GAD at eight weeks, with the use of Buspirone as the comparator. A stepwise dosing protocol was used (JYW: high dose 24 g/day, low dose 12 g/day; Buspirone: high dose 30 mg/day, low dose 15 mg/day) and the dose was adjusted depending on whether the treatment response of Hamilton Anxiety Scale (HAMA) score was less than or equal to 25% after one week. The primary outcome was a change in total score on the HAMA. The secondary outcomes included the Hamilton Depression Scale (HAMD), Clinical Global Impression (CGI) scale, and TCM Syndrome Scale. Adverse events were recorded using the Treatment Emergent Symptom Scale (TESS). Assessments were conducted at the baseline and 1, 2, 4, and 8 weeks.
    Results: A total of one hundred thirty-three participants were randomly assigned to the JYW group (
    Conclusions: The conclusion of this study supports that JYW and Buspirone can effectively alleviate the anxiety symptoms of GAD patients, which are both effective and safe for treatment of mild to moderate GAD. Besides, high-dose JYW or Buspirone are more effective than low-dose, which is of great importance in assisting clinical medication choice.
    Language English
    Publishing date 2022-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/9951693
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  5. Article ; Online: Transcriptomic study of the mechanism by which the Kai Yu Zhong Yu recipe improves oocyte quality in a stressed mouse model.

    Zhao, Xiaoli / Ma, Ruihong / Zhang, Xiaoyu / Wang, Baojuan / Rong, Beilei / Jiang, Nan / Feng, Weihua / Chen, Mingli / Huo, Zhipeng / Li, Shuming / Xia, Tian

    Journal of ethnopharmacology

    2021  Volume 278, Page(s) 114298

    Abstract: Ethnopharmacological relevance: The Kai Yu Zhong Yu recipe (KYZY) is a classic herbal formula ...

    Abstract Ethnopharmacological relevance: The Kai Yu Zhong Yu recipe (KYZY) is a classic herbal formula in traditional Chinese medicine (TCM) that has been used to treat infertility associated with psychological stress for more than three hundred years.
    Aim of the study: Psychological stress has major impacts on fertility, with variable outcomes depending on the nature, strength, and duration of the stress. Stress can directly disturb ovulation, oocyte quality, maturation, and embryo development. The aim of this study is to investigate the molecular mechanism by which KYZY improves oocyte developmental potential under psychological stress.
    Materials and methods: ICR female mice aged 4-5 weeks were randomly divided into five groups: control, stressed in the chronic unpredictable stress model (CUSM), and stressed plus KYZY treatment at 38.2 g/kg (KYZYH), 19.1 g/kg (KYZYM), or 9.6 g/kg (KYZYL). Ovary function was assessed by measuring serum levels of estradiol (E2), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and anti-Müllerian hormone (AMH). Oocyte quality was evaluated in terms of reactive oxygen species (ROS) levels, apoptotic DNA fragmentation, and mitochondria distribution. We used RNA sequencing (RNAseq) to identify differentially expressed genes (DEGs) between groups and then further analyzed the DEGs for gene ontology (GO) term enrichment and protein-protein interactions.
    Results: Mice in the stressed group had reduced serum E2, LH, and FSH as well as increased ROS levels, increased apoptosis, and disturbed mitochondria distribution in oocytes. Treatment with KYZY at all three doses reversed or ameliorated these negative effects of stress. DEG analysis identified 187 common genes between the two comparisons (stressed vs. control and KYZYM vs. stressed), 33 of which were annotated with six gene ontology (GO)'s biological process (BP) terms: cell differentiation, apoptosis, ATP synthesis, protein homo-oligomerization, neuron migration, and negative regulation of peptidase activity. Protein-protein interaction network analysis of DEGs identified key hub genes. Notably, the genes Atp5o and Cyc1 were both involved in the ATP synthesis and among the top three hub genes, suggesting that regulation of oocyte mitochondrial electron transport and ATP synthesis is important in the response to stress and also is a possible mechanism of action for KYZY.
    Conclusions: KYZY was effective in ameliorating the adverse effects of stress on oocyte competence, possibly by targeting the mitochondrial respiratory chain and ATP synthase.
    MeSH term(s) Animals ; Apoptosis/drug effects ; Behavior, Animal/drug effects ; Body Weight/drug effects ; Depression/drug therapy ; Depression/etiology ; Drugs, Chinese Herbal ; Female ; Hypothalamo-Hypophyseal System/drug effects ; Hypothalamo-Hypophyseal System/metabolism ; Medicine, Chinese Traditional ; Mice ; Mice, Inbred ICR ; Motor Activity ; Oocytes/drug effects ; Phytotherapy ; Pituitary-Adrenal System/drug effects ; Pituitary-Adrenal System/metabolism ; Random Allocation ; Stress, Psychological/drug therapy ; Transcriptome
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2021-06-04
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2021.114298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Improvement of Cardiac and Endothelial Functions of Xue-Fu-Zhu-Yu Decoction for Patients with Acute Coronary Syndrome: A Meta-Analysis of Randomized Controlled Trials.

    Chen, Shiqi / Wu, Xiaoxiao / Li, Tong / Cheng, Weiting / Han, Xiaowan / Li, Yang / Wang, Baofu / Teng, Yu / Zhao, Mingjing / Wang, Yahong

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 2671343

    Abstract: Background: Xue-Fu-Zhu-Yu decoction (XFZYD) is a traditional Chinese prescription that has been ...

    Abstract Background: Xue-Fu-Zhu-Yu decoction (XFZYD) is a traditional Chinese prescription that has been used to treat patients with blood stasis in China for many years. The present study aimed to evaluate the improvement of cardiac and endothelial functions of XFZYD for patients with acute coronary syndrome (ACS) through a systematic review and meta-analysis.
    Methods: Six databases were searched to collect RCTs related to the treatment of XFZYD for ACS. The primary outcomes were cardiac and endothelial functions, including the levels of left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), and left ventricular end-systolic diameter (LVESD) in echocardiography, as well as the changes in the levels of nitric oxide (NO), endothelin-1 (ET-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in the serum. The secondary outcomes were the blood levels of oxidative damage markers (including superoxide dismutase (SOD) and malondialdehyde (MDA)), C-reactive protein (CRP), brain natriuretic peptide (BNP), creatine kinase-MB (CK-MB), and cardiac troponin I (cTnI) as well as the incidence of adverse drug reactions (ADRs). Weighted mean difference (WMD) was estimated for all the outcomes with the random effects model. This type of analysis was conducted in the subgroups of the ACS subtypes, and the methodological quality was assessed using the handbook of Cochrane Collaboration.
    Results: A total of 1,658 records were identified, and 16 randomized controlled trials (1,171 patients) were included. The primary outcomes suggested that XFZYD combined with routine treatment improved LVEF, reduced LVEDD and LVESD, and also improved the serum levels of NO, and reduced the levels of ET-1 and ICAM-1. XFZYD combination therapy significantly ameliorated the blood levels of SOD, MDA, BNP, CK-MB, and cTnI. However, the results indicated no significant difference between XFZYD plus routine treatment and routine treatment for the levels of VCAM-1 and CRP. Moreover, all the ADRs reported in the included studies were slight and the patients recovered soon.
    Conclusions: The present study suggested that XFZYD may improve the cardiac and endothelial functions of ACS patients without serious ADRs. However, based on the mediocre methodological quality, the aforementioned conclusion should be confirmed in a multicenter, large-scale, and accurately designed clinical trial.
    Language English
    Publishing date 2022-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/2671343
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  7. Article ; Online: Yu ping feng san for pediatric allergic rhinitis: A systematic review and meta-analysis of randomized controlled trials.

    Liao, Yong / Zhong, Juan / Liu, Shuqin / Dai, Menglin / Liu, Yang / Li, Xinrong / Yang, Yepeng / Zhang, Dazheng / Lai, Dan / Lu, Tao / Zhang, Qinxiu / Zhao, Yu

    Medicine

    2021  Volume 100, Issue 13, Page(s) e24534

    Abstract: Background: The potential treatment effects and safety of Yu ping feng san (YPFS) for pediatric ...

    Abstract Background: The potential treatment effects and safety of Yu ping feng san (YPFS) for pediatric allergic rhinitis (PAR) patients have yet to be studied systematically.
    Objectives: To assess the effects and safety of YPFS for treat pediatric patients, allergic rhinitis.
    Methods: We systematically searched PubMed, EMBASE (Excerpta Medical Database), Cochrane library, Chinese Cochrane Centre's Controlled Trials Register platform, Wanfang Chinese Digital Periodical and Conference Database, China National Knowledge Infrastructure Database, and VIP Chinese Science, from inception dates to November 1, 2019. Randomized controlled trials (RCTs) were included. The risk of bias in the trials was assessed in accordance with the Cochrane Handbook, version 5.1.0. RevMan 5.3 software was used to perform a meta-analysis. Grading of Recommendations Assessment, Development and Evaluation methodology was applied to evaluate the evidence quality for each outcome. The quality of evidence for each outcome measurement was low for 4 outcomes and very low for 5 outcomes.
    Results: A total of 10 RCTs involving 1069 participants (3-15 years old) fulfilled the inclusion criteria. After exclusion, 8 RCTs were pooled for efficacy assessment. The overall efficacy evaluation result did not show benefit for the experimental group (relative risk 0.32, CI 95% 0.24-0.45; P = .98;) Investigation of variation of serum IgA, immunoglobulin E, IgG in three studies in 2 groups returned no statistical significance. YPFS gave relatively better safety (relative risk 0.29, CI 95% 0.14-0.58; P = .0005; Fig. S8, http://links.lww.com/MD/F751) and lower recurrence rates than did Western medical therapy.
    Conclusions: Current evidence cannot support the routine use of YPFS for treatment of PAR. This may be due to poor-quality study-design limitations of the included YPFS studies. Our data showed that the use of YPFS for PAR is relatively safe compared to Western medical therapy, but a conclusion could not be drawn because only 5 studies were analyzed. Every study suffered from some methodological limitation. Therefore, further large, rigorously-designed studies are necessary to determine conclusively the utility of YPFS in PAR.
    MeSH term(s) Adolescent ; Child ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Male ; Randomized Controlled Trials as Topic ; Rhinitis, Allergic/drug therapy ; Treatment Outcome
    Chemical Substances Drugs, Chinese Herbal ; yu ping feng san
    Language English
    Publishing date 2021-04-23
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000024534
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  8. Article ; Online: Effects of Jie Yu Wan on Generalized Anxiety Disorder

    Xue Li / Sisi Zheng / Sitong Feng / Rui Ma / Yuan Jia / Anquan Zhao / Dan Wei / Hua Guo / Na Duan / Ying Ding / Jindong Chen / Hong Zhu / Hongxiao Jia

    Evidence-Based Complementary and Alternative Medicine, Vol

    A Randomized Clinical Trial

    2022  Volume 2022

    Abstract: Objective. To systematically assess the clinical efficacy of the Jie Yu Wan (JYW) formula ...

    Abstract Objective. To systematically assess the clinical efficacy of the Jie Yu Wan (JYW) formula in treating generalized anxiety disorder (GAD). Methods. A multicenter, prospective, double-blind, double-dummy, randomized controlled trial (RCT) was conducted at four hospitals in China. A total of one hundred thirty-three patients with GAD were enrolled from 2017 to 2019. This study aimed to evaluate the effects of a Traditional Chinese Medicine (TCM) JYW formula on GAD at eight weeks, with the use of Buspirone as the comparator. A stepwise dosing protocol was used (JYW: high dose 24 g/day, low dose 12 g/day; Buspirone: high dose 30 mg/day, low dose 15 mg/day) and the dose was adjusted depending on whether the treatment response of Hamilton Anxiety Scale (HAMA) score was less than or equal to 25% after one week. The primary outcome was a change in total score on the HAMA. The secondary outcomes included the Hamilton Depression Scale (HAMD), Clinical Global Impression (CGI) scale, and TCM Syndrome Scale. Adverse events were recorded using the Treatment Emergent Symptom Scale (TESS). Assessments were conducted at the baseline and 1, 2, 4, and 8 weeks. Results. A total of one hundred thirty-three participants were randomly assigned to the JYW group (n = 66) and the Buspirone group (n = 67). One hundred twenty-one patients (91%) completed at least one follow-up session. There were no significant differences between the two groups in terms of gender, age, disease course, HAMA, HAMD, CGI, and TCM Syndrome Scale scores at baseline (all P>0.05). Repeated-measures analysis of variance revealed statistically significant time effects for the HAMA (P=0.002), HAMD (P = 0.018), and CGI (P=0.001) in both groups. Sensitivity analyses supported the credibility of the main results (P>0.05). The group effect was not significant for the HAMA (P=0.43), HAMD (P=0.27), CGI (P=0.37), and TCM Syndrome Scale (P=0.86). Furthermore, there were no significant interaction effects between time and group in terms of the HAMA (P=0.47), HAMD ...
    Keywords Other systems of medicine ; RZ201-999
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: The Improvement of Cardiac and Endothelial Functions of Xue-Fu-Zhu-Yu Decoction for Patients with Acute Coronary Syndrome

    Shiqi Chen / Xiaoxiao Wu / Tong Li / Weiting Cheng / Xiaowan Han / Yang Li / Baofu Wang / Yu Teng / Mingjing Zhao / Yahong Wang

    Evidence-Based Complementary and Alternative Medicine, Vol

    A Meta-Analysis of Randomized Controlled Trials

    2022  Volume 2022

    Abstract: Background. Xue-Fu-Zhu-Yu decoction (XFZYD) is a traditional Chinese prescription that has been ...

    Abstract Background. Xue-Fu-Zhu-Yu decoction (XFZYD) is a traditional Chinese prescription that has been used to treat patients with blood stasis in China for many years. The present study aimed to evaluate the improvement of cardiac and endothelial functions of XFZYD for patients with acute coronary syndrome (ACS) through a systematic review and meta-analysis. Methods. Six databases were searched to collect RCTs related to the treatment of XFZYD for ACS. The primary outcomes were cardiac and endothelial functions, including the levels of left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), and left ventricular end-systolic diameter (LVESD) in echocardiography, as well as the changes in the levels of nitric oxide (NO), endothelin-1 (ET-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in the serum. The secondary outcomes were the blood levels of oxidative damage markers (including superoxide dismutase (SOD) and malondialdehyde (MDA)), C-reactive protein (CRP), brain natriuretic peptide (BNP), creatine kinase-MB (CK-MB), and cardiac troponin I (cTnI) as well as the incidence of adverse drug reactions (ADRs). Weighted mean difference (WMD) was estimated for all the outcomes with the random effects model. This type of analysis was conducted in the subgroups of the ACS subtypes, and the methodological quality was assessed using the handbook of Cochrane Collaboration. Results. A total of 1,658 records were identified, and 16 randomized controlled trials (1,171 patients) were included. The primary outcomes suggested that XFZYD combined with routine treatment improved LVEF, reduced LVEDD and LVESD, and also improved the serum levels of NO, and reduced the levels of ET-1 and ICAM-1. XFZYD combination therapy significantly ameliorated the blood levels of SOD, MDA, BNP, CK-MB, and cTnI. However, the results indicated no significant difference between XFZYD plus routine treatment and routine treatment for the levels of VCAM-1 and CRP. Moreover, all ...
    Keywords Other systems of medicine ; RZ201-999
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Uncovering the potential mechanism of Xue Fu Zhu Yu Decoction in the treatment of intracerebral hemorrhage

    Xue, Dao-jin / Zhen, Zheng / Wang, Ke-xin / Zhao, Jialin / Gao, Yao / Chen, Yu-peng / Shen, You-bi / Peng, Zi-zhuang / Guan, Dao-gang / Huang, Tao

    BMC Complement Med Ther. 2022 Dec., v. 22, no. 1 p.103-103

    2022  

    Abstract: ... by CHM has been deeply researched. Xue Fu Zhu Yu Decoction (XFZYD), one of the commonly used ...

    Abstract BACKGROUND: Chinese herbal medicine (CHM) is characterized by “multi- compounds, multi-targets and multi-pathway”, which has advanced benefits for preventing and treating complex diseases, but there still exists unsolved issues, mainly include unclear material basis and underlying mechanism of prescription. Integrated pharmacology is a hot cross research area based on system biology, mathematics and poly-pharmacology. It can systematically and comprehensively investigate the therapeutic reaction of compounds or drugs on pathogenic genes network, and is especially suitable for the study of complex CHM systems. Intracerebral Hemorrhage (ICH) is one of the main causes of death among Chinese residents, which is characterized with high mortality and high disability rate. In recent years, the treatment of ICH by CHM has been deeply researched. Xue Fu Zhu Yu Decoction (XFZYD), one of the commonly used prescriptions in treating ICH at clinic level, has not been clear about its mechanism. METHODS: Here, we established a strategy, which based on compounds-targets, pathogenetic genes, network analysis and node importance calculation. Using this strategy, the core compounds group (CCG) of XFZYD was predicted and validated by in vitro experiments. The molecular mechanism of XFZYD in treating ICH was deduced based on CCG and their targets. RESULTS: The results show that the CCG with 43 compounds predicted by this model is highly consistent with the corresponding Compound-Target (C-T) network in terms of gene coverage, enriched pathway coverage and accumulated contribution of key nodes at 89.49%, 88.72% and 90.11%, respectively, which confirmed the reliability and accuracy of the effective compound group optimization and mechanism speculation strategy proposed by us. CONCLUSIONS: Our strategy of optimizing the effective compound groups and inferring the mechanism provides a strategic reference for explaining the optimization and inferring the molecular mechanism of prescriptions in treating complex diseases of CHM.
    Keywords complement ; death ; genes ; hemorrhage ; herbal medicines ; mathematics ; models ; mortality ; pharmacology ; therapeutics
    Language English
    Dates of publication 2022-12
    Size p. 103.
    Publishing place BioMed Central
    Document type Article ; Online
    ISSN 2662-7671
    DOI 10.1186/s12906-022-03577-2
    Database NAL-Catalogue (AGRICOLA)

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