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  1. Article ; Online: Clinical and genomic analysis of baseline and acquired

    Jin, Bo / Ma, Yutong / Wu, Qian / Ou, Qiuxiang / Shao, Yang / Xu, Shun

    Genes & diseases

    2023  Volume 11, Issue 1, Page(s) 76–79

    Language English
    Publishing date 2023-04-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2821806-1
    ISSN 2352-3042 ; 2352-3042
    ISSN (online) 2352-3042
    ISSN 2352-3042
    DOI 10.1016/j.gendis.2023.02.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Identification and characterization of TatD DNase in planarian Dugesia japonica and its antibiofilm effect.

    Yu, Tong / Sun, Zhe / Cao, Xiangyu / Yang, Fengtang / Pang, Qiuxiang / Deng, Hongkuan

    Environmental research

    2024  Volume 251, Issue Pt 1, Page(s) 118534

    Abstract: TatD DNase, a key enzyme in vertebrates and invertebrates, plays a pivotal role in various physiological processes. Dugesia japonica (D. japonica), a flatworm species, has remarkable regenerative capabilities and possesses a simplified immune system. ... ...

    Abstract TatD DNase, a key enzyme in vertebrates and invertebrates, plays a pivotal role in various physiological processes. Dugesia japonica (D. japonica), a flatworm species, has remarkable regenerative capabilities and possesses a simplified immune system. However, the existence and biological functions of TatD DNase in D. japonica require further investigation. Here, we obtained the open reading frame (ORF) of DjTatD and demonstrated its conservation. The three-dimensional structure of DjTatD revealed its active site and binding mechanism. To investigate its enzymological properties, we overexpressed, purified, and characterized recombinant DjTatD (rDjTatD). We observed that DjTatD was primarily expressed in the pharynx and its expression could be significantly challenged upon stimulation with lipopolysaccharide, peptidoglycan, gram-positive and gram-negative bacteria. RNA interference results indicated that both DjTatD and DjDN2s play a role in pharyngeal regeneration and may serve as functional complements to each other. Additionally, we found that rDjTatD and recombinant T7
    Language English
    Publishing date 2024-02-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2024.118534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 726: Show issues Location:
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  3. Article ; Online: Leveraging aptamers for targeted protein degradation.

    Yang, Zhihao / Pang, Qiuxiang / Zhou, Jun / Xuan, Chenghao / Xie, Songbo

    Trends in pharmacological sciences

    2023  Volume 44, Issue 11, Page(s) 776–785

    Abstract: Targeted protein degradation (TPD) technologies, particularly proteolysis-targeting chimeras (PROTACs), have emerged as a significant advancement in drug discovery. However, several hurdles - such as the difficulty of identifying suitable ligands for ... ...

    Abstract Targeted protein degradation (TPD) technologies, particularly proteolysis-targeting chimeras (PROTACs), have emerged as a significant advancement in drug discovery. However, several hurdles - such as the difficulty of identifying suitable ligands for traditionally undruggable proteins, poor solubility and impermeability, nonspecific biodistribution, and on-target off-tissue toxicity - present challenges to their clinical applications. Aptamers are promising ligands for broad-ranging molecular recognition. Utilizing aptamers in TPD has shown potential advantages in overcoming these challenges. Here, we provide an overview of recent developments in aptamer-based TPD, emphasizing their potential to achieve targeted delivery and their promise for the spatiotemporal degradation of undruggable proteins. We also discuss the challenges and future directions of aptamer-based TPD with the goal of facilitating their clinical applications.
    Language English
    Publishing date 2023-06-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2023.05.008
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    Zs.A 1513: Show issues Location:
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  4. Article: Enhanced Corrosion Resistance of Layered Double Hydroxide Films on Mg Alloy: The Key Role of Cationic Surfactant.

    Yang, Qiuxiang / Tabish, Mohammad / Wang, Jingbao / Zhao, Jingmao

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 6

    Abstract: In this study, dense anticorrosion magnesium-aluminum layered double hydroxide (MgAl-LDH) films were prepared for the first time by introducing a cationic surfactant tetradecyltrimethyl ammonium bromide (TTAB) in the process of in situ hydrothermal ... ...

    Abstract In this study, dense anticorrosion magnesium-aluminum layered double hydroxide (MgAl-LDH) films were prepared for the first time by introducing a cationic surfactant tetradecyltrimethyl ammonium bromide (TTAB) in the process of in situ hydrothermal synthesis of Mg-Al LDH films on an AZ31 magnesium alloy. Results of XRD, FTIR, and SEM confirmed that TTAB forms the MgAl-LDH-TTAB, although TTAB cannot enter into LDH layers, and MgAl-LDH-TTAB powders are much smaller and more homogenous than MgAl-CO
    Language English
    Publishing date 2022-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15062028
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  5. Article ; Online: Comprehensive genomic analysis of early and late-onset hepatocellular carcinoma.

    Yang, Jialin / Chen, Chao / Wang, Song / Zhang, Yaru / Pang, Jiaohui / Wang, Yajun / Ou, Qiuxiang / Jiang, Hao / Liu, Juying

    Genes & diseases

    2023  Volume 11, Issue 4, Page(s) 101031

    Language English
    Publishing date 2023-07-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2821806-1
    ISSN 2352-3042 ; 2352-3042
    ISSN (online) 2352-3042
    ISSN 2352-3042
    DOI 10.1016/j.gendis.2023.06.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Consistent efficacy of B/F/TAF in treatment-naïve HIV patients across different baseline HIV-1 RNA levels at week 48.

    He, Kun / Zhou, Yihong / Yang, Honghong / Lu, Yanqiu / Tan, Qiuxiang / Qi, Weiwei / Liu, Min

    Chinese medical journal

    2023  Volume 136, Issue 22, Page(s) 2747–2749

    MeSH term(s) Humans ; HIV Infections/drug therapy ; HIV-1/genetics ; Tenofovir/therapeutic use ; Anti-HIV Agents/therapeutic use ; RNA ; Drug Combinations
    Chemical Substances Tenofovir (99YXE507IL) ; Anti-HIV Agents ; RNA (63231-63-0) ; Drug Combinations
    Language English
    Publishing date 2023-10-31
    Publishing country China
    Document type Letter
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000002887
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1207: Show issues Location:
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  7. Article: A case of mitochondrial myopathy and chronic progressive external ophthalmoplegia.

    Liu, Haokun / Gao, Ming / Sun, Qiying / Chen, Si / Luo, Yuebei / Yang, Huan / Li, Qiuxiang / Li, Jing / Yang, Guang

    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

    2024  Volume 48, Issue 11, Page(s) 1760–1768

    Abstract: Mitochondrial myopathy is a group of multi-system diseases in which mitochondrial DNA (mtDNA) or nuclear DNA (nDNA) defects lead to structural and functional dysfunction of mitochondria. The clinical manifestations of mitochondrial myopathy are complex ... ...

    Title translation 线粒体肌病合并慢性进行性眼外肌麻痹1例（英文）.
    Abstract Mitochondrial myopathy is a group of multi-system diseases in which mitochondrial DNA (mtDNA) or nuclear DNA (nDNA) defects lead to structural and functional dysfunction of mitochondria. The clinical manifestations of mitochondrial myopathy are complex and varied, and the testing for mtDNA and nDNA is not widely available, so misdiagnosis or missed diagnosis is common. Chronic progressive external ophthalmoplegia (CPEO) is a common type of mitochondrial myopathy, which is characterized by blepharoptosis. Here we report a 38-year-old female with mitochondrial myopathy presented with chronic numbness and weakness of the limbs, accompanied by blepharoptosis that was recently noticed. Laboratory and head magnetic resonance imaging (MRI) examinations showed no obvious abnormalities. Muscle and nerve biopsies showed characteristic ragged red fibers (RRFs) and large aggregates of denatured mitochondria. Testing for mtDNA and nDNA showed a known mutation c.2857C>T (p.R953C) and a novel variant c.2391G>C (p.M797I) in the polymerase gamma (
    MeSH term(s) Female ; Humans ; Adult ; Blepharoptosis/diagnosis ; Blepharoptosis/etiology ; Mitochondrial Myopathies ; Ophthalmoplegia, Chronic Progressive External/diagnosis ; Ophthalmoplegia, Chronic Progressive External/genetics ; DNA, Mitochondrial/genetics ; Mitochondria
    Chemical Substances DNA, Mitochondrial
    Language Chinese
    Publishing date 2024-03-01
    Publishing country China
    Document type Case Reports ; Journal Article
    ZDB-ID 2168533-2
    ISSN 1672-7347
    ISSN 1672-7347
    DOI 10.11817/j.issn.1672-7347.2023.220605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2681: Show issues Location:
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  8. Article ; Online: Breaking Surface Atomic Monogeneity of Rh

    Huang, Hongpu / Liu, Kai / Yang, Fulin / Cai, Junlin / Wang, Shupeng / Chen, Weizhen / Wang, Qiuxiang / Fu, Luhong / Xie, Zhaoxiong / Xie, Shuifen

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 52, Page(s) e202315752

    Abstract: Breaking atomic monogeneity of catalyst surfaces is promising for constructing synergistic active centers to cope with complex multi-step catalytic reactions. Here, we report a defect-derived strategy for creating surface phosphorous vacancies (P- ... ...

    Abstract Breaking atomic monogeneity of catalyst surfaces is promising for constructing synergistic active centers to cope with complex multi-step catalytic reactions. Here, we report a defect-derived strategy for creating surface phosphorous vacancies (P-vacancies) on nanometric Rh
    Language English
    Publishing date 2023-11-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202315752
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  9. Article ; Online: Kinematics Model Optimization Algorithm for Six Degrees of Freedom Parallel Platform

    Mingzhe Liu / Qiuxiang Gu / Bo Yang / Zhengtong Yin / Shan Liu / Lirong Yin / Wenfeng Zheng

    Applied Sciences, Vol 13, Iss 3082, p

    2023  Volume 3082

    Abstract: The attitude closed-loop control of the parallel platform in the working space needs to determine the relationship between the pose of the top moving platform and the length of each mechanical arm, that is, the kinematics problem of the parallel platform. ...

    Abstract The attitude closed-loop control of the parallel platform in the working space needs to determine the relationship between the pose of the top moving platform and the length of each mechanical arm, that is, the kinematics problem of the parallel platform. In this study, the kinematics model of the six-degree-of-freedom parallel platform was established. The kinematics forward solution algorithm based on Newton–Raphson iteration was studied. The kinematics forward solution method usually adopts a numerical solution, which often needs multiple iterations, and the algorithm has a poor real-time performance. In order to improve the real-time performance of the parallel platform control system, a multivariate polynomial regression kinematics forward solution algorithm is proposed in this paper. Moreover, by combining the multivariate polynomial regression with the Newton iterative method, we obtained an efficient solution algorithm with controllable solution accuracy. The effectiveness of the proposed method was verified by simulation tests and physical tests.
    Keywords parallel platform ; multivariate polynomial regression ; Newton iterative ; kinematics ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 518 ; 629
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Book ; Online: A Novel Node Selection Method in Wireless Distributed Edge Storage Based on SDN and Multi-attribute Decision Model

    Yang, Yejin / Ye, Miao / Jiang, Qiuxiang / Wen, Peng

    2023  

    Abstract: The distributed edge storage system can store data collected at the edge of the network in a decentralised manner, with low latency, high security, and flexibility. Traditional edge-distributed storage systems only consider one single factor, such as ... ...

    Abstract The distributed edge storage system can store data collected at the edge of the network in a decentralised manner, with low latency, high security, and flexibility. Traditional edge-distributed storage systems only consider one single factor, such as node capacity, when storing data, ignoring network and storage node load conditions that affecting the system's read/write performance. At the same time, it could be more scalable in the widely used wireless terminal application scenarios. To tackle these challenges, this paper proposes an innovative software-defined edge storage architecture based on SDN (Software-Defined Networking) and SMB (Server Message Block) protocols, A data storage node selection algorithm that integrates the network state and storage node load state is designed based on multi-attribute decision model, and a system prototype is realised in conjunction with 5G wireless communication technology. Experimental results demonstrate significant improvements in the performance of high-load write operations compared to traditional edge-distributed storage systems. The proposed wireless distributed edge storage system also demonstrates superior scalability and adaptability, effectively addressing the challenge of limited system scalability and improving compatibility with edge scenarios in mobile applications. In addition, it results in cost savings in hardware deployment and presents a promising advancement in edge storage technology.
    Keywords Computer Science - Networking and Internet Architecture
    Subject code 006
    Publishing date 2023-10-09
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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