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Article ; Online: Intermittent Fasting on Human Health and Disease.

Margină, Denisa Marilena / Drăgoi, Cristina Manuela

2023 Volume 15, Issue 21

Abstract: Chronic non-communicable diseases (NCDs) are the leading cause of morbidity and mortality worldwide, but most of all in industrialized countries, and are fundamentally correlated to improper nutrition and impaired lifestyle behaviours [ ... ]. ...

Abstract	Chronic non-communicable diseases (NCDs) are the leading cause of morbidity and mortality worldwide, but most of all in industrialized countries, and are fundamentally correlated to improper nutrition and impaired lifestyle behaviours [...].
MeSH term(s)	Humans ; Intermittent Fasting ; Life Style ; Morbidity ; Developed Countries ; Global Health ; Chronic Disease
Language	English
Publishing date	2023-10-24
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15214491
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exploring the therapeutic potential of quercetin: A focus on its sirtuin-mediated benefits.

Ungurianu, Anca / Zanfirescu, Anca / Margină, Denisa

Phytotherapy research : PTR

2024 Volume 38, Issue 5, Page(s) 2361–2387

Abstract: As the global population ages, preventing lifestyle- and aging-related diseases is increasing, necessitating the search for safe and affordable therapeutic interventions. Among nutraceuticals, quercetin, a flavonoid ubiquitously present in various plants, ...

Abstract	As the global population ages, preventing lifestyle- and aging-related diseases is increasing, necessitating the search for safe and affordable therapeutic interventions. Among nutraceuticals, quercetin, a flavonoid ubiquitously present in various plants, has garnered considerable interest. This review aimed to collate and analyze existing literature on the therapeutic potentials of quercetin, especially its interactions with SIRTs and its clinical applicability based on its bioavailability and safety. This narrative review was based on a literature survey spanning from 2015 to 2023 using PUBMED. The keywords and MeSH terms used were: "quercetin" AND "bioavailability" OR "metabolism" OR "metabolites" as well as "quercetin" AND "SIRTuin" OR "SIRT*" AND "cellular effects" OR "pathway" OR "signaling" OR "neuroprotective" OR "cardioprotective" OR "nephroprotective" OR "antiatherosclerosis" OR "diabetes" OR "antidiabetic" OR "dyslipidemia" AND "mice" OR "rats". Quercetin demonstrates multiple therapeutic activities, including neuroprotective, cardioprotective, and anti-atherosclerotic effects. Its antioxidant, anti-inflammatory, antiviral, and immunomodulatory properties are well-established. At a molecular level, it majorly interacts with SIRTs, particularly SIRT1 and SIRT6, and modulates numerous signaling pathways, contributing to its therapeutic effects. These pathways play roles in reducing oxidative stress, inflammation, autophagy regulation, mitochondrial biogenesis, glucose utilization, fatty acid oxidation, and genome stability. However, clinical trials on quercetin's effectiveness in humans are scarce. Quercetin exhibits a wide range of SIRT-mediated therapeutic effects. Despite the compelling preclinical data, more standardized clinical trials are needed to fully understand its therapeutic potential. Future research should focus on addressing its bioavailability and safety concerns.
MeSH term(s)	Quercetin/pharmacology ; Quercetin/therapeutic use ; Humans ; Animals ; Sirtuins/metabolism ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Biological Availability ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Oxidative Stress/drug effects ; Sirtuin 1/metabolism ; Signal Transduction/drug effects
Chemical Substances	Quercetin (9IKM0I5T1E) ; Sirtuins (EC 3.5.1.-) ; Antioxidants ; Anti-Inflammatory Agents ; Neuroprotective Agents ; Sirtuin 1 (EC 3.5.1.-)
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.8168
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Article ; Online: Sirtuins, resveratrol and the intertwining cellular pathways connecting them.

Ungurianu, Anca / Zanfirescu, Anca / Margină, Denisa

Ageing research reviews

2023 Volume 88, Page(s) 101936

Abstract: Sirtuins are a family of ... ...

Abstract	Sirtuins are a family of NAD
MeSH term(s)	Humans ; Sirtuins/metabolism ; Resveratrol/pharmacology ; Sirtuin 1/metabolism ; Amyloid Precursor Protein Secretases ; NF-kappa B ; Aspartic Acid Endopeptidases ; Stilbenes/pharmacology ; Stilbenes/therapeutic use
Chemical Substances	Sirtuins (EC 3.5.1.-) ; Resveratrol (Q369O8926L) ; Sirtuin 1 (EC 3.5.1.-) ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; NF-kappa B ; Aspartic Acid Endopeptidases (EC 3.4.23.-) ; Stilbenes
Language	English
Publishing date	2023-04-26
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2075672-0
ISSN	1872-9649 ; 1568-1637
ISSN (online)	1872-9649
ISSN	1568-1637
DOI	10.1016/j.arr.2023.101936
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Article: Regulation of Gene Expression through Food-Curcumin as a Sirtuin Activity Modulator.

Ungurianu, Anca / Zanfirescu, Anca / Margină, Denisa

Plants (Basel, Switzerland)

2022 Volume 11, Issue 13

Abstract: The sirtuin family comprises ... ...

Abstract	The sirtuin family comprises NAD
Language	English
Publishing date	2022-06-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants11131741
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Article ; Online: Circadian Rhythms, Chrononutrition, Physical Training, and Redox Homeostasis-Molecular Mechanisms in Human Health.

Drăgoi, Cristina Manuela / Nicolae, Alina Crenguţa / Ungurianu, Anca / Margină, Denisa Marilena / Grădinaru, Daniela / Dumitrescu, Ion-Bogdan

Cells

2024 Volume 13, Issue 2

Abstract: A multitude of physiological processes, human behavioral patterns, and social interactions are intricately governed by the complex interplay between external circumstances and endogenous circadian rhythms. This multidimensional regulatory framework is ... ...

Abstract	A multitude of physiological processes, human behavioral patterns, and social interactions are intricately governed by the complex interplay between external circumstances and endogenous circadian rhythms. This multidimensional regulatory framework is susceptible to disruptions, and in contemporary society, there is a prevalent occurrence of misalignments between the circadian system and environmental cues, a phenomenon frequently associated with adverse health consequences. The onset of most prevalent current chronic diseases is intimately connected with alterations in human lifestyle practices under various facets, including the following: reduced physical activity, the exposure to artificial light, also acknowledged as light pollution, sedentary behavior coupled with consuming energy-dense nutriments, irregular eating frameworks, disruptions in sleep patterns (inadequate quality and duration), engagement in shift work, and the phenomenon known as social jetlag. The rapid evolution of contemporary life and domestic routines has significantly outpaced the rate of genetic adaptation. Consequently, the underlying circadian rhythms are exposed to multiple shifts, thereby elevating the susceptibility to disease predisposition. This comprehensive review endeavors to synthesize existing empirical evidence that substantiates the conceptual integration of the circadian clock, biochemical molecular homeostasis, oxidative stress, and the stimuli imparted by physical exercise, sleep, and nutrition.
MeSH term(s)	Humans ; Circadian Rhythm ; Homeostasis ; Circadian Clocks ; Exercise ; Oxidation-Reduction
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells13020138
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exploring the potential impact of probiotic use on drug metabolism and efficacy.

Purdel, Carmen / Ungurianu, Anca / Adam-Dima, Ines / Margină, Denisa

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 161, Page(s) 114468

Abstract: Probiotics are frequently consumed as functional food and widely used as dietary supplements, but are also recommended in treating or preventing various gastrointestinal diseases. Therefore, their co-administration with other drugs is sometimes ... ...

Abstract	Probiotics are frequently consumed as functional food and widely used as dietary supplements, but are also recommended in treating or preventing various gastrointestinal diseases. Therefore, their co-administration with other drugs is sometimes unavoidable or even compulsory. Recent technological developments in the pharmaceutical industry permitted the development of novel drug-delivery systems for probiotics, allowing their addition to the therapy of severely ill patients. Literature data regarding the changes that probiotics could impose on the efficacy or safety of chronic medication is scarce. In this context, the present paper aims to review probiotics currently recommended by the international medical community, to evaluate the relationship between gut microbiota and various pathologies with high impact worldwide and, most importantly, to assess the literature reports concerning the ability of probiotics to influence the pharmacokinetics/pharmacodynamics of some widely used drugs, especially for those with narrow therapeutic indexes. A better understanding of the potential influence of probiotics on drug metabolism, efficacy and safety could contribute to improving therapy management, facilitating individualized therapy and updating treatment guidelines.
MeSH term(s)	Humans ; Probiotics/therapeutic use ; Dietary Supplements ; Gastrointestinal Diseases ; Gastrointestinal Microbiome ; Functional Food
Language	English
Publishing date	2023-03-01
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114468
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Article ; Online: The Beneficial Effects of Dietary Interventions on Gut Microbiota-An Up-to-Date Critical Review and Future Perspectives.

Purdel, Carmen / Margină, Denisa / Adam-Dima, Ines / Ungurianu, Anca

Nutrients

2023 Volume 15, Issue 23

Abstract: Different dietary interventions, especially intermittent fasting, are widely used and promoted by physicians; these regimens have been studied lately for their impact on the gut microbiota composition/function and, consequently, on the general ... ...

Abstract	Different dietary interventions, especially intermittent fasting, are widely used and promoted by physicians; these regimens have been studied lately for their impact on the gut microbiota composition/function and, consequently, on the general physiopathological processes of the host. Studies are showing that dietary components modulate the microbiota, and, at the same time, the host metabolism is deeply influenced by the different products resulting from nutrient transformation in the microbiota compartment. This reciprocal relationship can potentially influence even drug metabolism for chronic drug regimens, significantly impacting human health/disease. Recently, the influence of various dietary restrictions on the gut microbiota and the differences between the effects were investigated. In this review, we explored the current knowledge of different dietary restrictions on animal and human gut microbiota and the impact of these changes on human health.
MeSH term(s)	Animals ; Humans ; Gastrointestinal Microbiome ; Diet
Language	English
Publishing date	2023-12-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15235005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Investigation of Serum Endocan Levels in SARS-CoV-2 Patients.

Constantin, Laura / Ungurianu, Anca / Streinu-Cercel, Anca / Săndulescu, Oana / Aramă, Victoria / Margină, Denisa / Țârcomnicu, Isabela

International journal of molecular sciences

2024 Volume 25, Issue 5

Abstract: Endocan is an endothelial-cell-specific proteoglycan (ESM-1) and has emerged as an endothelial dysfunction and inflammatory marker in recent years. Endocan can be used as a marker of inflammatory endothelial dysfunction in endothelium-dependent disease: ... ...

Abstract	Endocan is an endothelial-cell-specific proteoglycan (ESM-1) and has emerged as an endothelial dysfunction and inflammatory marker in recent years. Endocan can be used as a marker of inflammatory endothelial dysfunction in endothelium-dependent disease: cardiovascular disease, sepsis, lung and kidney disease and malignancies. Recent data suggest that endothelial dysfunction is a key mechanism in COVID-19 pathogenesis. Endotheliitis and thrombo-inflammation are associated with severe forms of SARS-CoV-2 infection, and endocan is currently under investigation as a potential diagnostic and prognostic marker. The aim of this study was to determine serum endocan levels in patients with COVID-19 to evaluate the correlation between endocan levels and clinical disease diagnosis and prognosis. This study enrolled 56 patients, divided into three groups depending on disease severity: mild (15), moderate (25) and severe (16). The biochemical, demographic, clinical and imagistic data were collected and evaluated in correlation with the endocan levels. Serum endocan levels were significantly higher in the COVID-19 patients compared to the control group; also, endocan concentration correlated with vaccination status. The results revealed significantly elevated serum endocan levels in COVID-19 patients compared to the control group, with a correlation observed between endocan concentration and vaccination status. These findings suggest that endocan may serve as a novel biomarker for detecting inflammation and endothelial dysfunction risk in COVID-19 patients. There was no significant relationship between serum endocan levels and disease severity or the presence of cardiovascular diseases. Endocan can be considered a novel biomarker for the detection of inflammation and endothelial dysfunction risk in COVID-19 patients.
MeSH term(s)	Humans ; Biomarkers ; Cardiovascular Diseases/etiology ; COVID-19/complications ; Inflammation/complications ; Neoplasm Proteins ; SARS-CoV-2 ; Vascular Diseases/complications
Chemical Substances	Biomarkers ; Neoplasm Proteins ; ESM1 protein, human
Language	English
Publishing date	2024-03-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25053042
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Vitamin E beyond Its Antioxidant Label.

Ungurianu, Anca / Zanfirescu, Anca / Nițulescu, Georgiana / Margină, Denisa

Antioxidants (Basel, Switzerland)

2021 Volume 10, Issue 5

Abstract: Vitamin E, comprising tocopherols and tocotrienols, is mainly known as an antioxidant. The aim of this review is to summarize the molecular mechanisms and signaling pathways linked to inflammation and malignancy modulated by its vitamers. Preclinical ... ...

Abstract	Vitamin E, comprising tocopherols and tocotrienols, is mainly known as an antioxidant. The aim of this review is to summarize the molecular mechanisms and signaling pathways linked to inflammation and malignancy modulated by its vitamers. Preclinical reports highlighted a myriad of cellular effects like modulating the synthesis of pro-inflammatory molecules and oxidative stress response, inhibiting the NF-κB pathway, regulating cell cycle, and apoptosis. Furthermore, animal-based models have shown that these molecules affect the activity of various enzymes and signaling pathways, such as MAPK, PI3K/Akt/mTOR, JAK/STAT, and NF-κB, acting as the underlying mechanisms of their reported anti-inflammatory, neuroprotective, and anti-cancer effects. In clinical settings, not all of these were proven, with reports varying considerably. Nonetheless, vitamin E was shown to improve redox and inflammatory status in healthy, diabetic, and metabolic syndrome subjects. The anti-cancer effects were inconsistent, with both pro- and anti-malignant being reported. Regarding its neuroprotective properties, several studies have shown protective effects suggesting vitamin E as a potential prevention and therapeutic (as adjuvant) tool. However, source and dosage greatly influence the observed effects, with bioavailability seemingly a key factor in obtaining the preferred outcome. We conclude that this group of molecules presents exciting potential for the prevention and treatment of diseases with an inflammatory, redox, or malignant component.
Language	English
Publishing date	2021-04-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10050634
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Article: Regulation of Gene Expression through Food—Curcumin as a Sirtuin Activity Modulator

Ungurianu, Anca / Zanfirescu, Anca / Margină, Denisa

Plants. 2022 June 30, v. 11, no. 13

2022

Abstract: The sirtuin family comprises NAD⁺-dependent protein lysine deacylases, mammalian sirtuins being either nuclear (SIRT1, SIRT2, SIRT6, and SIRT7), mitochondrial (SIRT3, SIRT4, and SIRT5) or cytosolic enzymes (SIRT2 and SIRT5). They are able to catalyze ... ...

Abstract	The sirtuin family comprises NAD⁺-dependent protein lysine deacylases, mammalian sirtuins being either nuclear (SIRT1, SIRT2, SIRT6, and SIRT7), mitochondrial (SIRT3, SIRT4, and SIRT5) or cytosolic enzymes (SIRT2 and SIRT5). They are able to catalyze direct metabolic reactions, thus regulating several physiological functions, such as energy metabolism, stress response, inflammation, cell survival, DNA repair, tissue regeneration, neuronal signaling, and even circadian rhythms. Based on these data, recent research was focused on finding molecules that could regulate sirtuins’ expression and/or activity, natural compounds being among the most promising in the field. Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) can induce, through SIRT, modulation of cancer cell senescence, improve endothelial cells protection against atherosclerotic factors, enhance muscle regeneration in atrophy models, and act as a pro-longevity factor counteracting the neurotoxicity of amyloid-beta. Although a plethora of protective effects was reported (antioxidant, anti-inflammatory, anticancer, etc.), its therapeutical use is limited due to its bioavailability issues. However, all the reported effects may be explained via the bioactivation theory, which postulates that curcumin’s observed actions are modulated via its metabolites and/or degradation products. The present article is focused on bringing together the literature data correlating the ability of curcumin and its metabolites to modulate SIRT activity and its consequent beneficial effects.
Keywords	DNA repair ; antioxidants ; atrophy ; bioavailability ; cell senescence ; cell viability ; curcumin ; energy metabolism ; gene expression regulation ; inflammation ; lysine ; mammals ; metabolites ; mitochondria ; muscle development ; neoplasm cells ; neurons ; neurotoxicity ; sirtuins ; stress response ; tissue repair
Language	English
Dates of publication	2022-0630
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants11131741
Database	NAL-Catalogue (AGRICOLA)

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