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  1. Book ; Online: Innovations in Modeling and Simulation to Advance Translational Science

    Knothe Tate, Melissa / Angelone, Leonardo / Basciano, Christopher / Reiterer, Markus

    2020  

    Keywords Science: general issues ; Physiology ; computational modeling ; medical devices ; physiome ; medical technology ; medical translation ; virtual model ; technology translation ; health ; physiology
    Size 1 electronic resource (191 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230403
    ISBN 9782889662258 ; 288966225X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Parallel transmission to reduce absorbed power around deep brain stimulation devices in MRI: Impact of number and arrangement of transmit channels.

    Guerin, Bastien / Angelone, Leonardo M / Dougherty, Darin / Wald, Lawrence L

    Magnetic resonance in medicine

    2019  Volume 83, Issue 1, Page(s) 299–311

    Abstract: Purpose: To assess the mean and variance performance of parallel transmission (pTx) coils for reduction of the absorbed power around electrodes (APAE) in patients implanted with deep brain stimulation (DBS) devices.: Methods: We simulated 4 pTx coils ...

    Abstract Purpose: To assess the mean and variance performance of parallel transmission (pTx) coils for reduction of the absorbed power around electrodes (APAE) in patients implanted with deep brain stimulation (DBS) devices.
    Methods: We simulated 4 pTx coils (8 and 16 channels, head and body coils) and a birdcage body coil. We characterized the RF safety risk using the APAE, which is the integral of the deposited power (in Watts) in a small cylindrical volume of brain tissue surrounding the electrode tips. We assessed the APAE mean and variance by simulation of 5 realistic DBS patient models that include the full DBS implant length, extracranial loops, and implanted pulse generator.
    Results: PTx coils with 8 (16) channels were able to reduce the APAE by >18× (>169×) compared to the birdcage coil in average for all patient models, at no cost in term of flip angle uniformity or global specific absorption rate (SAR). Moreover, local pTx coils performed significantly better than body arrays.
    Conclusion: PTx is a possible solution to the problem of RF heating of DBS patients when performing MRI, but the large interpatient variability of the APAE indicates that patient-specific safety monitoring may be needed.
    MeSH term(s) Algorithms ; Computer Simulation ; Deep Brain Stimulation/instrumentation ; Deep Brain Stimulation/methods ; Electrodes ; Electrodes, Implanted ; Electromagnetic Radiation ; Head/diagnostic imaging ; Humans ; Magnetic Resonance Imaging/instrumentation ; Magnetic Resonance Imaging/methods ; Models, Anatomic ; Models, Statistical ; Patient Safety ; Phantoms, Imaging ; Radio Waves ; Risk
    Language English
    Publishing date 2019-08-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.27905
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1959: Show issues Location:
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  3. Article ; Online: Effect Of Incident Field Magnitude And Phase Distribution On Rfinduced Heating Due To Hip Implants.

    Kozlov, Mikhail / Horner, Marc / Kainz, Wolfgang / Angelone, Leonardo M

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2018  Volume 2018, Page(s) 1360–1363

    Abstract: We investigated how the distribution of magnitude and phase of incident electric field affects RFinduced heating near a hip implant. The results showed that varying the incident electric field, for example due to different phantom shape or different ... ...

    Abstract We investigated how the distribution of magnitude and phase of incident electric field affects RFinduced heating near a hip implant. The results showed that varying the incident electric field, for example due to different phantom shape or different landmark position, for two-or three-dimensional implants can result in up to 50% variation of estimated RF-induced temperature rise. To avoid systematic errors in predicting the RF-induced heating, varied distributions of the incident electric field should be applied.
    MeSH term(s) Heating ; Hip Prosthesis ; Magnetic Resonance Imaging ; Phantoms, Imaging ; Radio Waves
    Language English
    Publishing date 2018-09-17
    Publishing country United States
    Document type Journal Article
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC.2018.8512493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effects of tuning conditions on near field of MRI transmit birdcage coil at 64 MHz.

    Kozlov, Mikhail / Lucano, Elena / Angelone, Leonardo M

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2016  Volume 2016, Page(s) 6242–6245

    Abstract: This study investigates how the tuning conditions of a 64 MHz / 1.5 T radio frequency (RF) birdcage coil modeled with an RF circuit and 3D electromagnetic co-simulation affect the electric and magnetic near-field distribution. Four models were ... ...

    Abstract This study investigates how the tuning conditions of a 64 MHz / 1.5 T radio frequency (RF) birdcage coil modeled with an RF circuit and 3D electromagnetic co-simulation affect the electric and magnetic near-field distribution. Four models were implemented with different tuning conditions and difference between numerical results and measurements was evaluated. The results show that the simulated near-field depends significantly on coil tuning conditions, especially in volumes close to the ASTM phantom walls. Further extensive evaluations should be conducted to cover proper match between measurement and numerical results.
    MeSH term(s) Electromagnetic Fields ; Magnetic Resonance Imaging/instrumentation ; Models, Theoretical ; Phantoms, Imaging ; Radio Waves
    Language English
    Publishing date 2016-08
    Publishing country United States
    Document type Journal Article
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC.2016.7592155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Radio-Frequency Safety Assessment of Stents in Blood Vessels During Magnetic Resonance Imaging.

    Fujimoto, Kyoko / Angelone, Leonardo M / Lucano, Elena / Rajan, Sunder S / Iacono, Maria Ida

    Frontiers in physiology

    2018  Volume 9, Page(s) 1439

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2018-10-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2018.01439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The 'virtual DBS population': five realistic computational models of deep brain stimulation patients for electromagnetic MR safety studies.

    Guerin, Bastien / Iacono, Maria Ida / Davids, Mathias / Dougherty, Darin / Angelone, Leonardo M / Wald, Lawrence L

    Physics in medicine and biology

    2019  Volume 64, Issue 3, Page(s) 35021

    Abstract: We design, develop, and disseminate a 'virtual population' of five realistic computational models of deep brain stimulation (DBS) patients for electromagnetic (EM) analysis. We found five DBS patients in our institution' research patient database who ... ...

    Abstract We design, develop, and disseminate a 'virtual population' of five realistic computational models of deep brain stimulation (DBS) patients for electromagnetic (EM) analysis. We found five DBS patients in our institution' research patient database who received high quality post-DBS surgery computer tomography (CT) examinations of the head and neck. Three patients have a single implanted pulse generator (IPG) and the two others have two IPGs (one for each lead). Moreover, one patient has two abandoned leads on each side of the head. For each patient, we combined the head and neck volumes into a 'virtual CT', from which we extracted the full-length DBS path including the IPG, extension cables, and leads. We corrected topology errors in this path, such as self-intersections, using a previously published optimization procedure. We segmented the virtual CT volume into bones, internal air, and soft tissue classes and created two-manifold, watertight surface meshes of these distributions. In addition, we added a segmented model of the brain (grey matter, white matter, eyes and cerebrospinal fluid) to one of the model (nickname Freddie) that was derived from a T1-weighted MR image obtained prior to the DBS implantation. We simulated the EM fields and specific absorption rate (SAR) induced at 3 Tesla by a quadrature birdcage body coil in each of the five patient models using a co-simulation strategy. We found that inter-subject peak SAR variability across models was independent of the target averaging mass and equal to ~45%. In our simulations of the full brain segmentation and six simplified versions of the Freddie model, the error associated with incorrect dielectric property assignment around the DBS electrodes was greater than the error associated with modeling the whole model as a single tissue class. Our DBS patient models are freely available on our lab website (Webpage of the Martinos Center Phantom Resource 2018 https://phantoms.martinos.org/Main_Page).
    MeSH term(s) Adult ; Aged ; Computer Simulation ; Deep Brain Stimulation/methods ; Electromagnetic Fields ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Safety ; Tomography, X-Ray Computed ; User-Computer Interface ; Young Adult
    Language English
    Publishing date 2019-02-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/aafce8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 199: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Investigating the effect of coil model losses on computational electromagnetic exposure of an ASTM phantom at 64 MHz MRI.

    Kozlov, Mikhail / Horner, Marc / Kainz, Wolfgang / Angelone, Leonardo M

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2017  Volume 2017, Page(s) 1481–1484

    Abstract: The goal of this work is to investigate the effect of coil losses on the electromagnetic field generated in an ASTM phantom by a birdcage coil. The study was based on different numerical implementations of an RF body coil at 64 MHz, using the same 3D EM ... ...

    Abstract The goal of this work is to investigate the effect of coil losses on the electromagnetic field generated in an ASTM phantom by a birdcage coil. The study was based on different numerical implementations of an RF body coil at 64 MHz, using the same 3D EM and RF circuit co-simulation procedure. The coil quality factor was evaluated with respect to losses due to power feed mismatch and to resistive losses of the coil components. The results of the study showed that the magnetic field at the coil iso-center, normalized to the square root of the whole body specific absorption rate, depends on the coil quality factor.
    MeSH term(s) Electromagnetic Fields ; Magnetic Resonance Imaging ; Phantoms, Imaging ; Radio Waves
    Language English
    Publishing date 2017-10-20
    Publishing country United States
    Document type Journal Article
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC.2017.8037115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A Study on the Feasibility of the Deep Brain Stimulation (DBS) Electrode Localization Based on Scalp Electric Potential Recordings.

    Iacono, Maria Ida / Atefi, Seyed Reza / Mainardi, Luca / Walker, Harrison C / Angelone, Leonardo M / Bonmassar, Giorgio

    Frontiers in physiology

    2019  Volume 9, Page(s) 1788

    Abstract: Deep Brain Stimulation (DBS) is an effective therapy for patients disabling motor symptoms from Parkinson's disease, essential tremor, and other motor disorders. Precise, individualized placement of DBS electrodes is a key contributor to clinical ... ...

    Abstract Deep Brain Stimulation (DBS) is an effective therapy for patients disabling motor symptoms from Parkinson's disease, essential tremor, and other motor disorders. Precise, individualized placement of DBS electrodes is a key contributor to clinical outcomes following surgery. Electroencephalography (EEG) is widely used to identify the sources of intracerebral signals from the potential on the scalp. EEG is portable, non-invasive, low-cost, and it could be easily integrated into the intraoperative or ambulatory environment for localization of either the DBS electrode or evoked potentials triggered by stimulation itself. In this work, we studied with numerical simulations the principle of extracting the DBS electrical pulse from the patient's EEG - which normally constitutes an artifact - and localizing the source of the artifact (i.e., the DBS electrodes) using EEG localization methods. A high-resolution electromagnetic head model was used to simulate the EEG potential at the scalp generated by the DBS pulse artifact. The potential distribution on the scalp was then sampled at the 256 electrode locations of a high-density EEG Net. The electric potential was modeled by a dipole source created by a given pair of active DBS electrodes. The dynamic Statistical Parametric Maps (dSPM) algorithm was used to solve the EEG inverse problem, and it allowed localization of the position of the stimulus dipole in three DBS electrode bipolar configurations with a maximum error of 1.5 cm. To assess the accuracy of the computational model, the results of the simulation were compared with the electric artifact amplitudes over 16 EEG electrodes measured in five patients. EEG artifacts measured in patients confirmed that simulated data are commensurate to patients' data (0 ± 6.6 μV). While we acknowledge that further work is necessary to achieve a higher accuracy needed for surgical navigation, the results presented in this study are proposed as the first step toward a validated computational framework that could be used for non-invasive localization not only of the DBS system but also brain rhythms triggered by stimulation at both proximal and distal sites in the human central nervous system.
    Language English
    Publishing date 2019-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2018.01788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Assessment of MRI issues at 7 T.

    Woods, Terry O / Angelone, Leonardo M / Delfino, Jana G

    AJR. American journal of roentgenology

    2014  Volume 203, Issue 5, Page(s) W560

    MeSH term(s) Humans ; Magnetic Resonance Imaging/methods ; Prostheses and Implants
    Language English
    Publishing date 2014-11-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.14.12956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ue I Zs.57: Show issues Location:
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  10. Article: Numerical and Experimental Analysis of Radiofrequency-Induced Heating Versus Lead Conductivity During EEG-MRI at 3 T.

    Atefi, Seyed Reza / Serano, Peter / Poulsen, Catherine / Angelone, Leonardo M / Bonmassar, Giorgio

    IEEE transactions on electromagnetic compatibility

    2018  Volume 61, Issue 3, Page(s) 852–859

    Abstract: This study investigates radiofrequency (RF)-induced heating in a head model with a 256-channel electroencephalogram (EEG) cap during magnetic resonance imaging (MRI). Nine computational models were implemented each with different EEG lead electrical ... ...

    Abstract This study investigates radiofrequency (RF)-induced heating in a head model with a 256-channel electroencephalogram (EEG) cap during magnetic resonance imaging (MRI). Nine computational models were implemented each with different EEG lead electrical conductivity, ranging from 1 to 5.8 × 10
    Language English
    Publishing date 2018-06-25
    Publishing country United States
    Document type Journal Article
    ISSN 0018-9375
    ISSN 0018-9375
    DOI 10.1109/TEMC.2018.2840050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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