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Article ; Online: Description of Alvania wangi Xu, Qi & Kong, sp. nov. (Mollusca, Gastropoda, Littorinimorpha, Rissoidae) from the East China Sea

Xu, Biyang / Qi, Lu / Kong, Lingfeng / Li, Qi

ZooKeys. 2022 July 06, v. 1110 p.201-217

2022

Abstract: AbstractAlvania wangi Xu, Qi & Kong, sp. nov. (Mollusca, Gastropoda, Littorinimorpha, Rissoidae ...

Abstract	AbstractAlvania wangi Xu, Qi & Kong, sp. nov. (Mollusca, Gastropoda, Littorinimorpha, Rissoidae) was discovered within the intertidal zone in the Nanji Islands and Zhoushan Islands, Zhejiang Province, China. It has a radula characteristic of Alvania Risso, 1826, a protoconch sculptured with micro pits and lamellae between spiral lirae, and a teleoconch with growth lines and subobsolete cords. Specimens were examined using an integrative taxonomic approach incorporating morphological observations and phylogenetic analyses of concatenated mitochondrial 16S rRNA and nuclear 28S rRNA gene sequences. The findings suggest that the new species is sister to Alvania circinata A. Adams, 1861 and is probably endemic to the shallow waters of the East China Sea.
Keywords	Littorinimorpha ; genes ; littoral zone ; mitochondria ; new species ; phylogeny ; China ; East China Sea ; Micromolluscs ; morphology ; phylogenetics ; systematics
Language	English
Dates of publication	2022-0706
Size	p. 201-217.
Publishing place	Pensoft Publishers
Document type	Article ; Online
ZDB-ID	2445640-8
ISSN	1313-2970 ; 1313-2989
ISSN (online)	1313-2970
ISSN	1313-2989
DOI	10.3897/zookeys.1110.82173
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Qi Jing Mingmu decoction inhibits the p38 signaling pathway in conjunctivochalasis fibroblasts by down-regulation of Th17 cell differentiation.

Ma, Kai / Liu, Jiang / Sha, Yongyi / Zhang, Wei / Ni, Zhenhua / Kong, Xueqing / Xiang, Minhong

Journal of ethnopharmacology

2022 Volume 301, Page(s) 115812

Abstract: Ethnopharmacological relevance: Qi Jing Mingmu (QJMM) decoction is a traditional Chinese medicine ...

Abstract	Ethnopharmacological relevance: Qi Jing Mingmu (QJMM) decoction is a traditional Chinese medicine that has been widely used for the clinical treatment of conjunctivochalasis (CCH). It is an effective treatment to relieve ocular symptoms including improving tear film and promoting tear secretion. However, its effects and molecular mechanisms need to be elucidated. Aim of the study: To determine whether QJMM decoction affected T helper 17 (Th17) cell differentiation of CCH patients. Materials and methods: Blood samples and conjunctival tissues were collected from CCH patients and normal controls. The fibroblasts were separately induced, and CD4 Results: Compared with normal controls, Th17 cell numbers and serum levels of IL-17 and IL-22 were elevated in patients with CCH. QJMM decoction down-regulated the expressions of IL-17, IL-22, and STAT3 of CD4 Conclusion: QJMM decoction inhibited Th17 cell differentiation of CD4
MeSH term(s)	Humans ; Cell Differentiation ; Conjunctival Diseases/metabolism ; Down-Regulation ; Fibroblasts ; Interleukin-17/metabolism ; Qi ; Signal Transduction ; Th17 Cells ; p38 Mitogen-Activated Protein Kinases/metabolism
Chemical Substances	Interleukin-17 ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2022-10-09
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115812
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Article ; Online: Acidification and hypoxia in seawater, and pollutant enrichment in the sediments of Qi’ao Island mangrove wetlands, Pearl River Estuary, China

Ya Ma / Weiping Wang / Fei Gao / Chenxi Yu / Yanqing Feng / Lei Gao / Jusuo Zhou / Huaming Shi / Changjian Liu / Dingjiang Kong / Xinwen Zhang / Ruixiang Li / Jingqian Xie

Ecological Indicators, Vol 158, Iss , Pp 111589- (2024)

2024

Abstract: ... sedimentary environmental factors in the Qi'ao Island mangrove wetland. The study comprised two survey ...

Abstract	Mangrove forests are crucial in absorbing, storing, and purifying pollutants while maintaining ecological balance. A study was conducted in 2020 to investigate the biogeochemical processes of seawater and sedimentary environmental factors in the Qi'ao Island mangrove wetland. The study comprised two survey sections and ten survey stations within the mangrove forest and 16 large-scale survey stations in the adjacent sea area. During ebb tides, the mean concentrations of inorganic nitrogen and phosphate in Section D1 of the mangrove forest were 0.63 mg/L and 0.003 mg/L, respectively. These levels were significantly lower than the results observed in the adjacent sea area and Section D2 of the mangrove forest during flood tides. The mangrove forest efficiently absorbed and consumed nutrients, with the nitrogen-to-phosphorus ratio of consumed nutrients being notably higher than that typically utilized by plants during growth. We identified various biogeochemical processes, including nitrogen fixation, mineralization, nitrification, and denitrification, occurring within the mangrove forest. Seawater measurements in Section D1 during ebb tides showed the mean pH of 7.58 and dissolved oxygen levels of 4.52 mg/L, resulting in a dissolved oxygen saturation level of only 57.0 %. The low dissolved oxygen levels were attributed to organic matter degradation in the forest. Consequently, the longer the water retention time, the more obvious the trend of hypoxia and acidification was observed. In the adjacent sea area, the sedimentary environment was deemed healthy, with pollutants primarily originating from runoff and ship discharge from waterways and ports. However, within the mangrove forest, the sediments exhibited higher enrichment factors for organic carbon and sulfide, indicating significant pollution compared to the adjacent sea area. The sediments were conducive to the accumulation and burial of total Hg, Zn, and Cu, while other heavy metals did not show prominent deposition and enrichment. Notably, the enrichment ...
Keywords	Pearl River Estuary ; Qi’ao Island mangrove wetland ; Nutrients ; Heavy metal ; Purification ; Acidification ; Ecology ; QH540-549.5
Subject code	910 ; 333
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Qinanmer, a new compound from Chinese agarwood 'Qi-Nan' originating from Aquilaria sinensis.

Shao, Hang / Kong, Fan-Dong / Wang, Hao / Mei, Wen-Li / Dai, Hao-Fu

Journal of Asian natural products research

2017 Volume 19, Issue 9, Page(s) 935–940

Abstract: ... Chinese agarwood "Qi-Nan" originating from Aquilaria sinensis (Lour.) Glig. The structure of 1 was ...

Abstract	Qinanmer (1), a new compound comprising 2-(2-phenylethyl)chromone and sesquiterpene moieties, together with two known 2-(2-phenylethyl)chromone derivatives (2-3), was isolated from the high-quality Chinese agarwood "Qi-Nan" originating from Aquilaria sinensis (Lour.) Glig. The structure of 1 was elucidated by spectroscopic techniques (UV, IR, 1D and 2D NMR), MS analyses, ECD spectra analyses, and quantum
MeSH term(s)	Cholinesterase Inhibitors/chemistry ; Chromones/chemistry ; Drugs, Chinese Herbal/chemistry ; Flavonoids ; Molecular Structure ; Sesquiterpenes/chemistry ; Sesquiterpenes/isolation & purification ; Thymelaeaceae/chemistry ; Wood/chemistry
Chemical Substances	Cholinesterase Inhibitors ; Chromones ; Drugs, Chinese Herbal ; Flavonoids ; Sesquiterpenes ; qinanmer ; 2-(2-phenylethyl)chromone (61828-53-3)
Language	English
Publishing date	2017-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2016.1268602
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Article ; Online: Mesenchymal stem cells combined with traditional Chinese medicine (qi-fang-bi-min-tang) alleviates rodent allergic rhinitis.

Fu, Yanxia / Kong, Yanhua / Li, Jun / Wang, Yi / Li, Mengdi / Wang, Ying / Wang, Yinyin / Ren, Fangli / Ni, Jian / Li, Youlin / Chang, Zhijie

Journal of cellular biochemistry

2019 Volume 121, Issue 2, Page(s) 1541–1551

Abstract: ... immune reactions. Traditional Chinese medicine (TCM), qi-fang-bi-min-tang, is effective for some patients ... of allergic rhinitis (AR). In this study, we reported an additional effect of TCM (qi-fang-bi-min-tang ... through regulating the secretion of Th1, Th2, and Th17 cytokines. This study suggested that TCM (qi-fang-bi-min-tang ...

Abstract	Mesenchymal stem cells (MSCs) have been proved to exert anti-inflammatory effects and regulate immune reactions. Traditional Chinese medicine (TCM), qi-fang-bi-min-tang, is effective for some patients with allergic diseases. However, it remains unclear whether MSCs combined with TCM could benefit the treatment of allergic rhinitis (AR). In this study, we reported an additional effect of TCM (qi-fang-bi-min-tang) on the therapy of AR under MSCs treatment. Intriguingly, we observed that TCM-treated MSCs significantly inhibited the symptoms of AR and reduced the pathological changes of nasal mucosa in ovalbumin (OVA)-induced rats. The expression levels of interferon γ (IFN-γ), interleukin-17 (IL-17), and IL-4 were significantly decreased in the plasma of AR rats after injection of TCM-treated MSCs. TCM-treated MSCs reduced the levels of histamine secreted by mast cells and immunoglobulin E (IgE) secreted by plasma cells. In addition, we found that MSCs combined with TCM had a better therapeutic effect than TCM alone on AR in an OVA-induced mouse model. After OVA induction, MSCs combined with TCM significantly reduced the ratio of T helper type 1 (Th1), Th2, and Th17, but increased the proportion of Treg in the spleen of mice. Consistently, the expression levels of IFN-γ, IL-4, and IL-17 were significantly decreased, but transforming growth factor-β1 was significantly increased in the plasma of AR mice after treated with TCM and MSCs. Our results from both rats and mice indicated that the effects of TCM combined with MSCs on the AR might be through regulating the secretion of Th1, Th2, and Th17 cytokines. This study suggested that TCM (qi-fang-bi-min-tang)-treated MSCs could be used in the clinical therapy of AR.
MeSH term(s)	Allografts ; Animals ; Cytokines/immunology ; Drugs, Chinese Herbal/pharmacology ; Male ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells/immunology ; Mesenchymal Stem Cells/pathology ; Mice ; Mice, Inbred BALB C ; Rats ; Rats, Sprague-Dawley ; Rhinitis, Allergic/immunology ; Rhinitis, Allergic/pathology ; Rhinitis, Allergic/therapy ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Helper-Inducer/pathology
Chemical Substances	Cytokines ; Drugs, Chinese Herbal
Language	English
Publishing date	2019-09-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.29389
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Article ; Online: The roles of two myostatins and immune effects after inhibition in Qi river crucian carp (Carassius auratus).

Wu, Limin / Li, Yongjing / Xu, Yufeng / Wang, Lei / Ma, Xiao / Dong, Chuanju / Zhao, Xianliang / Tian, Xue / Li, Xuejun / Kong, Xianghui

Fish & shellfish immunology

2019 Volume 98, Page(s) 710–719

Abstract: ... in Qi river crucian carp (Carassius auratus). In the present study, we have cloned mstn2 cDNA, which was ...

Abstract	Myostatin, through type I receptor (kinase 4, 5, ALK4/5), functions to participate in the immune system and negatively regulate muscle growth in mammals. However, the role of myostatin (mstn) in the immune system of teleosts is largely unknown. In a previous study, we cloned the mstn1 cDNA encoding myostatin in Qi river crucian carp (Carassius auratus). In the present study, we have cloned mstn2 cDNA, which was characterized and analyzed together with mstn1. Tissue distribution analysis showed that both mstn genes are expressed in numerous tissues, with mstn1 dominantly expressed in the muscle and brain, whereas mstn2 is mainly expressed in the brain. During embryogenesis, mstn1 and mstn2 exhibit different expression patterns. Both mstn1 and mstn2 expression increased stepwise in the brain at different developmental stages. Furthermore, both genes are differentially regulated during different periods of fasting/re-feeding. Following the exposure of C. auratus to polyI:C, lipopolysaccharide (LPS), and Aeromonas hydrophila, both genes were upregulated in different tissues, which indicated that they might be involved in the immune response against pathogenic invasion. Blocking the Mstn signal pathway with SB-431542 (a chemical inhibitor of ALK4/5) resulted in significantly increased body length and weight. However, the mortality of SB-431542-treated fish was higher after A. hydrophila challenge. Moreover, decreased expression of lysozymes (lyz), complement component 3 (c3), β-defensin 3 (defb3), and interferon γ (ifnγ) were exhibited in treated fish, compared with the controls. Furthermore, the expression of nf-κb1, three pro-inflammatory cytokines (il1β, il6, and tnfα), and inflammatory cytokines (il8 and il10) were significantly increased in both the SB-431542-treated group and the control after A. hydrophila infection, suggesting that the NF-κB pathway was not suppressed in the SB-431542-treated fish. Taken together, our data suggest that both mstn1 and mstn2 play important roles in early body development, muscle growth, and the immune system by acting downstream of the NF-κB signal pathway.
MeSH term(s)	Aeromonas hydrophila/physiology ; Animals ; Carps/genetics ; Carps/immunology ; Fish Diseases/immunology ; Fish Proteins/genetics ; Fish Proteins/immunology ; Gene Expression Profiling/veterinary ; Gene Expression Regulation/immunology ; Goldfish/genetics ; Goldfish/immunology ; Gram-Negative Bacterial Infections/immunology ; Immunity, Innate/genetics ; Lipopolysaccharides/pharmacology ; Myostatin/genetics ; Myostatin/immunology ; Poly I-C/pharmacology
Chemical Substances	Fish Proteins ; Lipopolysaccharides ; Myostatin ; Poly I-C (O84C90HH2L)
Language	English
Publishing date	2019-11-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1067738-0
ISSN	1095-9947 ; 1050-4648
ISSN (online)	1095-9947
ISSN	1050-4648
DOI	10.1016/j.fsi.2019.11.015
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Article ; Online: Da-Cheng-Qi decoction improves severe acute pancreatitis-associated acute lung injury by interfering with intestinal lymphatic pathway and reducing HMGB1-induced inflammatory response in rats

Xiaowen Liu / Lin Yuan / Yishuang Tang / Yue Wu / Jing Kong / Bingduo Zhou / Xiaosu Wang / Min Lin / Yading Li / Gaofan Xu / Yi Wang / Tingting Xu / Cong He / Shengquan Fang / Shengliang Zhu

Pharmaceutical Biology, Vol 61, Iss 1, Pp 144-

2023 Volume 154

Abstract: AbstractContext Da-Cheng-Qi Decoction (DCQD) has a significant effect on Severe Acute Pancreatitis ...

Abstract	AbstractContext Da-Cheng-Qi Decoction (DCQD) has a significant effect on Severe Acute Pancreatitis-Associated Acute Lung Injury (SAP-ALI).Objective To explore the mechanism of DCQD in the treatment of SAP-ALI based on intestinal barrier function and intestinal lymphatic pathway.Materials and methods Forty-five Sprague-Dawley rats were divided into three groups: sham operation, model, and DCQD. The SAP model was induced by a retrograde infusion of 5.0% sodium taurocholate solution (1 mg/kg) at a constant rate of 12 mL/h using an infusion pump into the bile-pancreatic duct. Sham operation and model group were given 0.9% normal saline, while DCQD group was given DCQD (5.99 g/kg/d) by gavage 1 h before operation and 1, 11 and 23 h after operation. The levels of HMGB1, RAGE, TNF-α, IL-6, ICAM-1, d-LA, DAO in blood and MPO in lung were detected using ELISA. The expression of HMGB1, RAGE, NF-κB p65 in mesenteric lymph nodes and lung were determined.Results Compared with SAP group, DCQD significantly reduced the histopathological scoring of pancreatic tissue (SAP, 2.80 ± 0.42; DCQD, 2.58 ± 0.52), intestine (SAP, 3.30 ± 0.68; DCQD, 2.50 ± 0.80) and lung (SAP, 3.30 ± 0.68; DCQD, 2.42 ± 0.52). DCQD reduced serum HMGB1 level (SAP, 134.09 ± 19.79; DCQD, 88.05 ± 9.19), RAGE level (SAP, 5.05 ± 1.44; DCQD, 2.13 ± 0.54). WB and RT-PCR showed HMGB1-RAGE pathway was inhibited by DCQD (p < 0.01).Discussion and conclusions DCQD improves SAP-ALI in rats by interfering with intestinal lymphatic pathway and reducing HMGB1-induced inflammatory response.
Keywords	Intestinal barrier function ; traditional Chinese medicine ; NF-κB p65 ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
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Article ; Online: A new 2-(2-phenylethyl)chromone glycoside in Chinese agarwood "Qi-Nan" from Aquilaria sinensis.

Shao, Hang / Mei, Wen-Li / Kong, Fan-Dong / Dong, Wen-Hua / Li, Wei / Zhu, Guo-Peng / Dai, Hao-Fu

Journal of Asian natural products research

2017 Volume 19, Issue 1, Page(s) 42–46

Abstract: ... was isolated from the high-quality Chinese agarwood "Qi-Nan" originating from Aquilaria sinensis (Lour ...

Abstract	A new 2-(2-phenylethyl)chromone glycoside, 2-[2-(4-glucosyloxy-3-methoxyphenyl)ethyl]chromone (1), was isolated from the high-quality Chinese agarwood "Qi-Nan" originating from Aquilaria sinensis (Lour.) Glig. The structure including the absolute configuration of the sugar moiety was elucidated by spectroscopic techniques (UV, IR, 1D and 2D NMR), MS analysis, PMP-labeling HPLC analysis methods, as well as comparison with literature data. To the best of our knowledge, it is the first time that chromone glycoside was discovered in agarwood, or even in the whole Aquilaria plants.
MeSH term(s)	Cholinesterase Inhibitors/chemistry ; Chromatography, High Pressure Liquid ; Chromones/chemistry ; Chromones/isolation & purification ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/isolation & purification ; Glucosides/chemistry ; Glucosides/isolation & purification ; Glycosides/chemistry ; Glycosides/isolation & purification ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Thymelaeaceae/chemistry
Chemical Substances	2-(2-(4-glucosyloxy-3-methoxyphenyl)ethyl)chromone ; Cholinesterase Inhibitors ; Chromones ; Drugs, Chinese Herbal ; Glucosides ; Glycosides
Language	English
Publishing date	2017-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2016.1187602
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Article: The Anti-Inflammatory Effects of Invigorating Kidney and Supplementing Qi Chinese Herbal Formulae in Asthma Patients.

Kong, Lingwen / Zhang, Hongying / Cao, Yuxue / Le, Jingjing / Wu, Jinfeng / Liu, Baojun / Chen, Meixia / Du, Yijie / Wang, Jia / Wang, Genfa / Yi, Tao / Zhou, Xianmei / Wang, Gang / Miao, Qing / Li, Suyun / Zhao, Naiqing / Dong, Jingcheng

Evidence-based complementary and alternative medicine : eCAM

2017 Volume 2017, Page(s) 3754145

Abstract: Background: The theories of Shen-reinforcement and Qi-supplementation are important in asthma ... and Supplementing Qi herbal formulae, Bu Shen Fang Chuan (BSFC) and Bu Shen Yi Qi (BSYQ), conveyed ...

Abstract	Background: The theories of Shen-reinforcement and Qi-supplementation are important in asthma treatment based on traditional Chinese medicine theories. Early studies suggested that Invigorating Kidney and Supplementing Qi herbal formulae, Bu Shen Fang Chuan (BSFC) and Bu Shen Yi Qi (BSYQ), conveyed promising results in asthma treatment. However, the efficacy and safety of the formulae need to be further investigated by a randomized double-blind clinical trial. Methods: 328 eligible patients were randomly sent to BSFC, BSYQ, and placebo group. The two formulae were received as add-on therapy. The primary endpoints were rate of asthma exacerbation and Hamilton Rating Scale for Depression (HAM-D) score. The secondary endpoints included HPA axis function and inflammatory cytokine production profile. All indexes were measured before and after treatment. Results: The primary endpoints were not improved in both groups; however, the depression levels of subgroup patients with HAM-D score > 5 were improved in BSFC group. HPA axis functions and inflammatory cytokines level were also improved by two formulae. The incidences of adverse events were similar among groups. Conclusions: The two formulae had multiple advantage effects on neuroendocrine-immune system. They are worth used as a replacement therapy in asthma. Trial registration: This trial is registered with clinical trial number ChiCTR-PRC-09000529.
Language	English
Publishing date	2017-06-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2017/3754145
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Article: A Randomized Double-Blind Placebo-Controlled Trial to Evaluate Prophylactic Effect of Traditional Chinese Medicine Supplementing Qi and Hemostasis Formula on Gastrointestinal Bleeding after Percutaneous Coronary Intervention in Patients at High Risks.

Zhang, Chenhao / Huang, Chaolian / Kong, Xiaolin / Liu, Guannan / Li, Ning / Liu, Jie / Zhang, Zongyao / Yang, Dawei / Liang, Chunling / Wang, Jie

Evidence-based complementary and alternative medicine : eCAM

2018 Volume 2018, Page(s) 3852196

Abstract: ... Qi and hemostasis formula on gastrointestinal (GI) bleeding after percutaneous coronary intervention ... manifestation. When it came to TEG, however, MA: Conclusion: (1) Supplementing Qi and hemostasis formula is ... supplementing Qi and hemostasis formula is superior to Pantoprazole Sodium Enteric-Coated Capsule in improving ...

Abstract	Objective: To evaluate the clinical efficacy of traditional Chinese medicine (TCM) supplementing Qi and hemostasis formula on gastrointestinal (GI) bleeding after percutaneous coronary intervention (PCI) and thus find out the optimal therapeutic regimen to reduce incidence of GI bleeding without increase of major adverse cardiovascular events (MACEs). Methods: In the randomized, double-blinded, controlled trial, 117 participants who underwent PCI were enrolled and evenly distributed into treatment arm (59) and control arm (58). Numerous end points were assessed including the primary endpoint of GI bleeding and MACEs and secondary endpoint of thromboelastogram (TEG) (mainly MAadp, inhibition of ADP, and inhibition of AA) and TCM syndrome score during the follow-up phase of 90 days. Results: Incidence of bleeding including GI bleeding and MACE did not differ significantly between two arms (28.82% in treatment arm versus 24.44% in control). However, on both days 30 and 90, TCM treatment remarkably reduced the TCM syndrome total score with notable alteration (P<0.05) except for some parameters such as pulse manifestation. When it came to TEG, however, MA Conclusion: (1) Supplementing Qi and hemostasis formula is equal to Pantoprazole Sodium Enteric-Coated Capsule in hemostasis and gastric mucosal protection; (2) supplementing Qi and hemostasis formula is superior to Pantoprazole Sodium Enteric-Coated Capsule in improving TCM syndrome manifestation possibly through the multitarget mechanism; (3) interference on clopidogrel of supplementing Qi and hemostasis formula might be much less than Pantoprazole Sodium Enteric-Coated Capsule due to the potential CYP450-independent mechanism. This trial is registered with ChiCTR1800014485.
Language	English
Publishing date	2018-10-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2018/3852196
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