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  1. Article: High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma cells in vitro.

    Zhao, Weiming / Xi, Lingling / Yu, Guoying / Wang, Gaiping / Chang, Cuifang

    Journal of cell communication and signaling

    2023  Volume 17, Issue 4, Page(s) 1435–1447

    Abstract: G protein-coupled receptors (GPCRs) play important roles in tumorigenesis and the development of hepatocellular carcinoma (HCC). GPR50 is an orphan GPCR. Previous studies have indicated that GPR50 could protect against breast cancer development and ... ...

    Abstract G protein-coupled receptors (GPCRs) play important roles in tumorigenesis and the development of hepatocellular carcinoma (HCC). GPR50 is an orphan GPCR. Previous studies have indicated that GPR50 could protect against breast cancer development and decrease tumor growth in a xenograft mouse model. However, its role in HCC remains indistinct. To detect the role and the regulation mechanism of GPR50 in HCC, GPR50 expression was analyzed in HCC patients (gene expression omnibus database (GEO) (GSE45436)) and detected in HCC cell line CBRH-7919, and the results showed that GPR50 was significantly up-regulated in HCC patients and CBRH-7919 cell line compared to the corresponding normal control. Gpr50 cDNA was transfected into HCC cell line CBRH-7919, and we found that Gpr50 promoted the proliferation, migration, and autophagy of CBRH-7919. The regulation mechanism of GPR50 in HCC was detected by isobaric tags for relative and absolute quantification (iTRAQ) analysis, and we found that GPR50 promoted HCC was closely related to CCT6A and PGK1. Taken together, GPR50 may promote HCC progression via CCT6A-induced proliferation and PGK1-induced migration and autophagy, and GPR50 could be an important target for HCC.
    Language English
    Publishing date 2023-06-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2299380-0
    ISSN 1873-961X ; 1873-9601
    ISSN (online) 1873-961X
    ISSN 1873-9601
    DOI 10.1007/s12079-023-00772-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Metabolome analysis reveals flavonoid changes during the leaf color transition in

    Chen, Mengjiao / Chang, Cuifang / Li, Hui / Huang, Lin / Zhou, Zongshun / Zhu, Jingle / Liu, Dan

    Frontiers in plant science

    2023  Volume 14, Page(s) 1162893

    Abstract: Introduction: To investigate the mechanism of leaf color change at different stages in : Methods: Leaf color phenotypes were determined and a metabolomic analysis was performed on leaves at three stages (R1, R2 and R3).: Results: The : ... ...

    Abstract Introduction: To investigate the mechanism of leaf color change at different stages in
    Methods: Leaf color phenotypes were determined and a metabolomic analysis was performed on leaves at three stages (R1, R2 and R3).
    Results: The
    Discussion: Here, we analyzed the expression of flavonoid metabolites in the leaves of 'Zhonghong' poplar at three stages and identified key metabolites closely related to leaf color change, providing an important genetic basis for the genetic improvement of this cultivar.
    Language English
    Publishing date 2023-05-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1162893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tunable Yellow to Near-Infrared Fluorescent Boron-Amino-Chelating Complexes with Stokes Shifts >100 nm.

    He, Jiang / Chang, Xiaoyong / Zou, Chao / Yu, Yanqin / Han, Shuang / Wu, Cuifang / Ou, Sha / Lu, Wei / Li, Kai

    The Journal of organic chemistry

    2023  Volume 88, Issue 20, Page(s) 14836–14841

    Abstract: A series of diphenylboron- ... ...

    Abstract A series of diphenylboron-chelating
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c01818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
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  4. Article: Comparative Transcriptome and Metabolome Profiling Reveal Mechanisms of Red Leaf Color Fading in

    Zhang, Shaowei / Yu, Xinran / Chen, Mengjiao / Chang, Cuifang / Zhu, Jingle / Zhao, Han

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 19

    Abstract: Anthocyanins are among the flavonoids that serve as the principal pigments affecting the color of plants. During leaf growth, the leaf color of 'Zhonghuahongye' gradually changes from copper-brown to yellow-green. At present, the mechanism of color ... ...

    Abstract Anthocyanins are among the flavonoids that serve as the principal pigments affecting the color of plants. During leaf growth, the leaf color of 'Zhonghuahongye' gradually changes from copper-brown to yellow-green. At present, the mechanism of color change at different stages has not yet been discovered. To find this, we compared the color phenotype, metabolome, and transcriptome of the three leaf stages. The results showed that the anthocyanin content of leaves decreased by 62.5% and the chlorophyll content increased by 204.35%, 69.23%, 155.56% and 60%, respectively. Differential metabolites and genes were enriched in the pathway related to the synthesis of 'Zhonghuahongye' flavonoids and anthocyanins and to the biosynthesis of secondary metabolites. Furthermore, 273 flavonoid metabolites were detected, with a total of eight classes.
    Language English
    Publishing date 2023-10-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12193511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Construction of SNP fingerprint and population genetic analysis of honeysuckle germplasm resources in China.

    Li, Jianjun / Chang, Xiaopei / Huang, Qian / Liu, Pengfei / Zhao, Xiting / Li, Fengmei / Wang, Yungang / Chang, Cuifang

    Frontiers in plant science

    2023  Volume 14, Page(s) 1080691

    Abstract: Introduction: The flower buds of : Methods: In this study, we evaluated the population structure, genetic relationships, and genetic fingerprints of 39 germplasm resources of : Results: A total of 13,143,268 single nucleotide polymorphisms (SNPs) ... ...

    Abstract Introduction: The flower buds of
    Methods: In this study, we evaluated the population structure, genetic relationships, and genetic fingerprints of 39 germplasm resources of
    Results: A total of 13,143,268 single nucleotide polymorphisms (SNPs) were identified. Thirty-nine samples of
    Discussion: To our knowledge, this is the first comprehensive study measuring the diversity and population structure of a large collection of
    Language English
    Publishing date 2023-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1080691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Overview of CircRNAs Roles and Mechanisms in Liver Fibrosis.

    Wang, Gaiping / Tong, Jiahui / Li, Yingle / Qiu, Xianglei / Chen, Anqi / Chang, Cuifang / Yu, Guoying

    Biomolecules

    2023  Volume 13, Issue 6

    Abstract: Liver fibrosis represents the reversible pathological process with the feature of the over-accumulation of extracellular matrix (ECM) proteins within the liver, which results in the deposition of fibrotic tissues and liver dysfunction. Circular noncoding ...

    Abstract Liver fibrosis represents the reversible pathological process with the feature of the over-accumulation of extracellular matrix (ECM) proteins within the liver, which results in the deposition of fibrotic tissues and liver dysfunction. Circular noncoding RNAs (CircRNAs) have the characteristic closed loop structures, which show high resistance to exonuclease RNase, making them far more stable and recalcitrant against degradation. CircRNAs increase target gene levels by playing the role of a microRNA (miRNA) sponge. Further, they combine with proteins or play the role of RNA scaffolds or translate proteins to modulate different biological processes. Recent studies have indicated that CircRNAs play an important role in the occurrence and progression of liver fibrosis and may be the potential diagnostic and prognostic markers for liver fibrosis. This review summarizes the CircRNAs roles and explores their underlying mechanisms, with a special focus on some of the latest research into key CircRNAs related to regulating liver fibrosis. Results in this work may inspire fruitful research directions and applications of CircRNAs in the management of liver fibrosis. Additionally, our findings lay a critical theoretical foundation for applying CircRNAs in diagnosing and treating liver fibrosis.
    MeSH term(s) Humans ; RNA, Circular/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Untranslated ; Liver Cirrhosis/genetics ; Fibrosis
    Chemical Substances RNA, Circular ; MicroRNAs ; RNA, Untranslated
    Language English
    Publishing date 2023-06-05
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13060940
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Characterization and engineering of peroxisome targeting sequences for compartmentalization engineering in Pichia pastoris.

    Ye, Cuifang / Hong, Haosen / Gao, Jucan / Li, Mengxin / Gou, Yuanwei / Gao, Di / Dong, Chang / Huang, Lei / Xu, Zhinan / Lian, Jiazhang

    Biotechnology and bioengineering

    2024  

    Abstract: Peroxisomal compartmentalization has emerged as a highly promising strategy for reconstituting intricate metabolic pathways. In recent years, significant progress has been made in the peroxisomes through harnessing precursor pools, circumventing ... ...

    Abstract Peroxisomal compartmentalization has emerged as a highly promising strategy for reconstituting intricate metabolic pathways. In recent years, significant progress has been made in the peroxisomes through harnessing precursor pools, circumventing metabolic crosstalk, and minimizing the cytotoxicity of exogenous pathways. However, it is important to note that in methylotrophic yeasts (e.g. Pichia pastoris), the abundance and protein composition of peroxisomes are highly variable, particularly when peroxisome proliferation is induced by specific carbon sources. The intricate subcellular localization of native proteins, the variability of peroxisomal metabolic pathways, and the lack of systematic characterization of peroxisome targeting signals have limited the applications of peroxisomal compartmentalization in P. pastoris. Accordingly, this study established a high-throughput screening method based on β-carotene biosynthetic pathway to evaluate the targeting efficiency of PTS1s (Peroxisome Targeting Signal Type 1) in P. pastoris. First, 25 putative endogenous PTS1s were characterized and 3 PTS1s with high targeting efficiency were identified. Then, directed evolution of PTS1s was performed by constructing two PTS1 mutant libraries, and a total of 51 PTS1s (29 classical and 22 noncanonical PTS1s) with presumably higher peroxisomal targeting efficiency were identified, part of which were further characterized via confocal microscope. Finally, the newly identified PTS1s were employed for peroxisomal compartmentalization of the geraniol biosynthetic pathway, resulting in more than 30% increase in the titer of monoterpene compared with when the pathway was localized to the cytosol. The present study expands the synthetic biology toolkit and lays a solid foundation for peroxisomal compartmentalization in P. pastoris.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 280318-5
    ISSN 1097-0290 ; 0006-3592
    ISSN (online) 1097-0290
    ISSN 0006-3592
    DOI 10.1002/bit.28706
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 960: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  8. Article: Integrated volatile metabolomic and transcriptomic analysis provides insights into the regulation of floral scents between two contrasting varieties of

    Li, Jianjun / Yu, Xinjie / Shan, Qianru / Shi, Zhaobin / Li, Junhua / Zhao, Xiting / Chang, Cuifang / Yu, Juanjuan

    Frontiers in plant science

    2022  Volume 13, Page(s) 989036

    Abstract: ... Lonicera ... ...

    Abstract Lonicera japonica
    Language English
    Publishing date 2022-09-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.989036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Establishing

    Zuo, Yimeng / Xiao, Feng / Gao, Jucan / Ye, Cuifang / Jiang, Lihong / Dong, Chang / Lian, Jiazhang

    Journal of agricultural and food chemistry

    2022  Volume 70, Issue 26, Page(s) 8024–8031

    Abstract: Santalene, a major component of the sandalwood essential oil, is a typical representative of sesquiterpenes and has important applications in medicine, food, flavors, and other fields. Due to the limited supply of natural sandalwood resources, there is a ...

    Abstract Santalene, a major component of the sandalwood essential oil, is a typical representative of sesquiterpenes and has important applications in medicine, food, flavors, and other fields. Due to the limited supply of natural sandalwood resources, there is a growing interest in engineering microbial cell factories for the mass production of santalene. In the present study,
    MeSH term(s) Metabolic Engineering ; Polycyclic Sesquiterpenes ; Saccharomycetales ; Santalum/genetics ; Santalum/metabolism ; Sesquiterpenes/metabolism
    Chemical Substances Polycyclic Sesquiterpenes ; Sesquiterpenes ; alpha-santalene
    Language English
    Publishing date 2022-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.2c02353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: The orphan GPR50 receptor interacting with TβRI induces G1/S-phase cell cycle arrest via Smad3-p27/p21 in BRL-3A cells.

    Chang, Cuifang / Wang, Danlin / Xi, Lingling / Guo, Xueqiang / Wang, Gaiping / Yu, Guoying

    Biochemical pharmacology

    2022  Volume 202, Page(s) 115117

    Abstract: The liver has the powerful capacity to regenerate after injury or resection. In one of our previous studies, GPR50 was observed to be significantly upregulated at 6 h, following a partial hepatectomy (PH) in rat liver regeneration (LR) via gene ... ...

    Abstract The liver has the powerful capacity to regenerate after injury or resection. In one of our previous studies, GPR50 was observed to be significantly upregulated at 6 h, following a partial hepatectomy (PH) in rat liver regeneration (LR) via gene expression profile. However, little research has been done on the regulation and mechanism of GPR50 in the liver. Herein, we observed that the overexpression of GPR50 inhibited the proliferation of BRL-3A cells. To further explore the molecular mechanisms of GPR50 in the regulation of BRL-3A cell proliferation, interaction between GPR50 and transforming growth factor-beta I (TβRI) and iTRAQ
    MeSH term(s) Animals ; Cell Cycle ; Cell Line, Tumor ; Cell Proliferation ; G1 Phase Cell Cycle Checkpoints ; Proteomics ; Rats ; Receptor, Transforming Growth Factor-beta Type I/metabolism ; Receptors, Melatonin ; S Phase
    Chemical Substances Receptors, Melatonin ; Receptor, Transforming Growth Factor-beta Type I (EC 2.7.11.30)
    Language English
    Publishing date 2022-06-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2022.115117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 19: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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