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Article ; Online: Ribosomal protein L31 (RPL31) inhibits the proliferation and migration of gastric cancer cells

Fang Wu / Yangyang Liu / Shenglin Hu / Canrong Lu

Heliyon, Vol 9, Iss 2, Pp e13076- (2023)

2023

Abstract: Gastric cancer (GC) is a digestive tract malignant tumor and causes the third cancer-related mortality in the world. Aberrant expression of Ribosomal Protein L31 (RPL31) has been reported in several human cancers. The aim of this study was to explore the ...

Abstract	Gastric cancer (GC) is a digestive tract malignant tumor and causes the third cancer-related mortality in the world. Aberrant expression of Ribosomal Protein L31 (RPL31) has been reported in several human cancers. The aim of this study was to explore the role and possible biological functions of RPL31 in GC. We firstly employed immunohistochemistry to examine RPL31 expression in tumor and para-cancerous tissues. By lentiviral transfection, we successfully constructed an RPL31-knockdown GC cell model and performed functional validation to reveal the effects of RPL31 on proliferation, apoptosis, cycle, migration, and tumor growth. Our data indicated that RPL31 was abundantly expressed in GC tissues and cell lines (AGS and MGC-803). In addition, RPL31 expression was positively correlated with the extent of tumor infiltrate of GC patients. Functionally, silencing RPL31 in AGS and MGC-803 cells significantly limited the ability of proliferation and migration, promoted cell apoptosis. Consistently, RPL31-knockdown GC cells inhibited the growth of xenografts in mice. Moreover, preliminary analysis on the downstream regulation mechanism revealed that RPL31 functioned as a tumor promoter through targeting JAK-STAT signaling pathway. In conclusion, inhibition of abnormally high expression of RPL31 in GC may be a potential therapeutic strategy for this disease.
Keywords	Gastric cancer ; RPL31 ; Cell migration ; Tumor growth ; JAK-STAT pathway ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Ribosomal protein L31 (RPL31) inhibits the proliferation and migration of gastric cancer cells.

Wu, Fang / Liu, Yangyang / Hu, Shenglin / Lu, Canrong

Heliyon

2023 Volume 9, Issue 2, Page(s) e13076

Abstract	Gastric cancer (GC) is a digestive tract malignant tumor and causes the third cancer-related mortality in the world. Aberrant expression of Ribosomal Protein L31 (RPL31) has been reported in several human cancers. The aim of this study was to explore the role and possible biological functions of RPL31 in GC. We firstly employed immunohistochemistry to examine RPL31 expression in tumor and para-cancerous tissues. By lentiviral transfection, we successfully constructed an RPL31-knockdown GC cell model and performed functional validation to reveal the effects of RPL31 on proliferation, apoptosis, cycle, migration, and tumor growth. Our data indicated that RPL31 was abundantly expressed in GC tissues and cell lines (AGS and MGC-803). In addition, RPL31 expression was positively correlated with the extent of tumor infiltrate of GC patients. Functionally, silencing RPL31 in AGS and MGC-803 cells significantly limited the ability of proliferation and migration, promoted cell apoptosis. Consistently, RPL31-knockdown GC cells inhibited the growth of xenografts in mice. Moreover, preliminary analysis on the downstream regulation mechanism revealed that RPL31 functioned as a tumor promoter through targeting JAK-STAT signaling pathway. In conclusion, inhibition of abnormally high expression of RPL31 in GC may be a potential therapeutic strategy for this disease.
Language	English
Publishing date	2023-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e13076
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Article ; Online: Ribosomal protein L31 (RPL31) inhibits the proliferation and migration of gastric cancer cells

Wu, Fang / Liu, Yangyang / Hu, Shenglin / Lu, Canrong

Heliyon. , p.e13076-

2023

Abstract	Gastric cancer (GC) is a digestive tract malignant tumor and causes the third cancer-related mortality in the world. Aberrant expression of Ribosomal Protein L31 (RPL31) has been reported in several human cancers. The aim of this study was to explore the role and possible biological functions of RPL31 in GC. We firstly employed immunohistochemistry to examine RPL31 expression in tumor and para-cancerous tissues. By lentiviral transfection, we successfully constructed an RPL31-knockdown GC cell model and performed functional validation to reveal the effects of RPL31 on proliferation, apoptosis, cycle, migration, and tumor growth. Our data indicated that RPL31 was abundantly expressed in GC tissues and cell lines (AGS and MGC-803). In addition, RPL31 expression was positively correlated with the extent of tumor infiltrate of GC patients. Functionally, silencing RPL31 in AGS and MGC-803 cells significantly limited the ability of proliferation and migration, promoted cell apoptosis. Consistently, RPL31-knockdown GC cells inhibited the growth of xenografts in mice. Moreover, preliminary analysis on the downstream regulation mechanism revealed that RPL31 functioned as a tumor promoter through targeting JAK-STAT signaling pathway. In conclusion, inhibition of abnormally high expression of RPL31 in GC may be a potential therapeutic strategy for this disease.
Keywords	apoptosis ; digestive tract ; humans ; immunohistochemistry ; models ; mortality ; ribosomal proteins ; stomach neoplasms ; transfection ; xenotransplantation ; Gastric cancer ; RPL31 ; Cell migration ; Tumor growth ; JAK-STAT pathway
Language	English
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version ; Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e13076
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Article: The pathological and therapeutic roles of mesenchymal stem cells in preeclampsia.

Jin, Sanshan / Wu, Canrong / Chen, Ming / Sun, Dongyan / Zhang, Hua

Frontiers in medicine

2022 Volume 9, Page(s) 923334

Abstract: Mesenchymal stem cells (MSCs) have made progress in the treatment of ischemic and inflammatory diseases. Preeclampsia (PE) is characterized by placenta ischemic and inflammatory injury. Our paper summarized the new role of MSCs in PE pathology and its ... ...

Abstract	Mesenchymal stem cells (MSCs) have made progress in the treatment of ischemic and inflammatory diseases. Preeclampsia (PE) is characterized by placenta ischemic and inflammatory injury. Our paper summarized the new role of MSCs in PE pathology and its potency in PE therapy and analyzed its current limitations. Intravenously administered MSCs dominantly distributed in perinatal tissues. There may be additional advantages to using MSCs-based therapies for reproductive disorders. It will provide new ideas for future research in this field.
Language	English
Publishing date	2022-07-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.923334
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Article ; Online: Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs.

Wang, James Jiqi / Jin, Sanshan / Zhang, Heng / Xu, Youwei / Hu, Wen / Jiang, Yi / Chen, Chen / Wang, Dao Wen / Xu, H Eric / Wu, Canrong

Science advances

2024 Volume 10, Issue 6, Page(s) eadk5184

Abstract: The prostacyclin ( ... ...

Abstract	The prostacyclin (PGI
MeSH term(s)	Humans ; Acetates ; Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use ; Cryoelectron Microscopy ; GTP-Binding Proteins ; Ligands ; Molecular Docking Simulation ; Pyrazines ; Receptors, Epoprostenol/agonists
Chemical Substances	(4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butoxy)acetic acid (E9PC7N0DID) ; Acetates ; Antihypertensive Agents ; GTP-Binding Proteins (EC 3.6.1.-) ; Ligands ; Pyrazines ; Receptors, Epoprostenol ; treprostinil (RUM6K67ESG)
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adk5184
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Article ; Online: Facile synthesis of spherical covalent organic frameworks for enrichment and quantification of aryl organophosphate esters in mouse serum and tissues.

Wu, Yijing / Zheng, Wenjun / Chen, Canrong / Yang, Linyan / Tong, Ping / Zhong, Yanhui / Lin, Zian / Cai, Zongwei

Journal of separation science

2023 Volume 46, Issue 22, Page(s) e2300482

Abstract: Here, an imine-linked-based spherical covalent organic framework (COF) was prepared at room temperature. The as-synthesized spherical COF served as an adsorbent in dispersive solid-phase extraction (dSPE), by its virtue of great surface area (1542.68 ... ...

Abstract	Here, an imine-linked-based spherical covalent organic framework (COF) was prepared at room temperature. The as-synthesized spherical COF served as an adsorbent in dispersive solid-phase extraction (dSPE), by its virtue of great surface area (1542.68 m
MeSH term(s)	Animals ; Mice ; Tandem Mass Spectrometry/methods ; Metal-Organic Frameworks/chemistry ; Chromatography, High Pressure Liquid ; Solid Phase Extraction/methods ; Adsorption ; Limit of Detection
Chemical Substances	Metal-Organic Frameworks
Language	English
Publishing date	2023-09-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.202300482
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Article: RPL35A is a key promotor involved in the development and progression of gastric cancer.

Wu, Fang / Sun, Dachuan / Liao, Yuqian / Shang, Kai / Lu, Canrong

Cancer cell international

2021 Volume 21, Issue 1, Page(s) 497

Abstract: Background: RPL35A has been reported to work as a biomarker in tumor angiogenesis. However, little work has been performed on the expression level and functional importance of RPL35A in gastric cancer (GC).: Methods: The protein expression level of ... ...

Abstract	Background: RPL35A has been reported to work as a biomarker in tumor angiogenesis. However, little work has been performed on the expression level and functional importance of RPL35A in gastric cancer (GC). Methods: The protein expression level of RPL35A was detected by immunohistochemical staining and western blot analysis. The Celigo cell counting assay was used to assess cell proliferation. Both the wound healing assay and the transwell assay were conducted to evaluate cell migration. Flow cytometric analysis was utilized to detect cell apoptosis and cell cycle. A mouse xenograft model was constructed for in vivo experiments. Results: The results demonstrated that RPL35A expression was abundantly up-regulated in GC and positively related to tumor infiltrate. In addition, RPL35A knockdown could significantly suppress cell proliferation, migration, enhance apoptosis and arrest cell cycle. The in vivo study also verified the inhibitory effects of RPL35A knockdown on GC tumorigenesis. Conclusions: The above mentioned results indicated that the knockdown of RPL35A might be a considerable therapeutic strategy for the treatment of gastric cancer.
Language	English
Publishing date	2021-09-17
Publishing country	England
Document type	Journal Article
ISSN	1475-2867
ISSN	1475-2867
DOI	10.1186/s12935-021-02199-x
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Article ; Online: Ligand-induced activation and G protein coupling of prostaglandin F

Wu, Canrong / Xu, Youwei / He, Qian / Li, Dianrong / Duan, Jia / Li, Changyao / You, Chongzhao / Chen, Han / Fan, Weiliang / Jiang, Yi / Eric Xu, H

Nature communications

2023 Volume 14, Issue 1, Page(s) 2668

Abstract: Prostaglandin ... ...

Abstract	Prostaglandin F
MeSH term(s)	Humans ; Cryoelectron Microscopy ; Ligands ; GTP-Binding Proteins ; Arachidonic Acid ; Prostaglandins
Chemical Substances	Ligands ; GTP-Binding Proteins (EC 3.6.1.-) ; Arachidonic Acid (27YG812J1I) ; Prostaglandins
Language	English
Publishing date	2023-05-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-38411-x
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Article ; Online: Ethylene and jasmonate signaling converge on gibberellin catabolism during thigmomorphogenesis in Arabidopsis.

Wang, Lei / Ma, Canrong / Wang, Shuanghua / Yang, Fei / Sun, Yan / Tang, Jinxiang / Luo, Ji / Wu, Jianqiang

Plant physiology

2023 Volume 194, Issue 2, Page(s) 758–773

Abstract: Touch induces marked morphological changes in plants, including reduced rosette diameters and delayed flowering, a process called thigmomorphogenesis. Previous studies have revealed that thigmomorphogenesis in Arabidopsis (Arabidopsis thaliana) results ... ...

Abstract	Touch induces marked morphological changes in plants, including reduced rosette diameters and delayed flowering, a process called thigmomorphogenesis. Previous studies have revealed that thigmomorphogenesis in Arabidopsis (Arabidopsis thaliana) results from touch-induced accumulation of jasmonic acid (JA) and GIBBERELLIN 2-OXIDASE7 (GA2ox7) transcripts, which encode a gibberellin (GA) catabolism enzyme, leading to reduced levels of active GAs. However, the mechanisms underlying thigmomorphogenesis remain uncharacterized. Here, we showed that touch induces ethylene (ET) production in Arabidopsis. After touch treatment, ET biosynthesis and signaling mutants exhibited even greater thigmomorphogenic changes and more decreased GA4 contents than did wild-type (WT) plants. Biochemical analysis indicated that the transcription factor ETHYLENE INSENSITIVE3 (EIN3) of the ET pathway binds to the promoter of GA2ox8 (encoding another GA 2-oxidase performing the same GA modification as GA2ox7) and represses GA2ox8 transcription. Moreover, MYC2, the master regulator of JA signaling, directly promoted GA2ox7 expression by binding the G-box motif on GA2ox7 promoter. Further genetic analysis suggested that the ET and JA pathways independently control the expression of GA2ox8 and GA2ox7, respectively. This study reveals that the ET pathway is a novel repressor of touch-induced thigmomorphogenesis and highlights that the ET and JA pathways converge on GA catabolism but play opposite roles to fine-tune GA4 content during thigmomorphogenesis.
MeSH term(s)	Arabidopsis/genetics ; Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Gibberellins/metabolism ; Plants, Genetically Modified/metabolism ; Cyclopentanes/metabolism ; Oxylipins/metabolism ; Ethylenes/metabolism ; Gene Expression Regulation, Plant
Chemical Substances	jasmonic acid (6RI5N05OWW) ; Arabidopsis Proteins ; Gibberellins ; Cyclopentanes ; Oxylipins ; ethylene (91GW059KN7) ; Ethylenes
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	208914-2
ISSN	1532-2548 ; 0032-0889
ISSN (online)	1532-2548
ISSN	0032-0889
DOI	10.1093/plphys/kiad556
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Article ; Online: ZmMYC2s play important roles in maize responses to simulated herbivory and jasmonate

Ma, Canrong / Li, Ruoyue / Sun, Yan / Zhang, Mou / Li, Sen / Xu, Yuxing / Song, Juan / Li, Jing / Qi, Jinfeng / Wang, Lei / Wu, Jianqiang

Journal of Integrative Plant Biology. 2023 Apr., v. 65, no. 4 p.1041-1058

2023

Abstract: Both herbivory and jasmonic acid (JA) activate the biosynthesis of defensive metabolites in maize, but the mechanism underlying this remains unclear. We generated maize mutants in which ZmMYC2a and ZmMYC2b, two transcription factor genes important in JA ... ...

Abstract	Both herbivory and jasmonic acid (JA) activate the biosynthesis of defensive metabolites in maize, but the mechanism underlying this remains unclear. We generated maize mutants in which ZmMYC2a and ZmMYC2b, two transcription factor genes important in JA signaling, were individually or both knocked out. Genetic and biochemical analyses were used to elucidate the functions of ZmMYC2 proteins in the maize response to simulated herbivory and JA. Compared with the wild‐type (WT) maize, the double mutant myc2ab was highly susceptible to insects, and the levels of benzoxazinoids and volatile terpenes, and the levels of their biosynthesis gene transcripts, were much lower in the mutants than in the WT maize after simulated insect feeding or JA treatment. Moreover, ZmMYC2a and ZmMYC2b played a redundant role in maize resistance to insects and JA signaling. Transcriptome and Cleavage Under Targets and Tagmentation‐Sequencing (CUT&Tag‐Seq) analysis indicated that ZmMYC2s physically targeted 60% of the JA‐responsive genes, even though only 33% of these genes were transcriptionally ZmMYC2‐dependent. Importantly, CUT&Tag‐Seq and dual luciferase assays revealed that ZmMYC2s transactivate the benzoxazinoid and volatile terpene biosynthesis genes IGPS1/3, BX10/11/12/14, and TPS10/2/3/4/5/8 by directly binding to their promoters. Furthermore, several transcription factors physically targeted by ZmMYC2s were identified, and these are likely to function in the regulation of benzoxazinoid biosynthesis. This work reveals the transcriptional regulatory landscapes of both JA signaling and ZmMYC2s in maize and provides comprehensive mechanistic insight into how JA signaling modulates defenses in maize responses to herbivory through ZmMYC2s.
Keywords	benzoxazinoids ; biosynthesis ; corn ; genes ; herbivores ; insects ; jasmonic acid ; luciferase ; metabolites ; mutants ; plant biology ; terpenoids ; transcription (genetics) ; transcription factors ; transcriptome
Language	English
Dates of publication	2023-04
Size	p. 1041-1058.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2130095-1
ISSN	1744-7909 ; 1672-9072
ISSN (online)	1744-7909
ISSN	1672-9072
DOI	10.1111/jipb.13404
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