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Article: Accurate closed-form solution of the SIR epidemic model.

Barlow, Nathaniel S / Weinstein, Steven J

2020 Volume 408, Page(s) 132540

Abstract: An accurate closed-form solution is obtained to the SIR Epidemic Model through the use of Asymptotic Approximants (Barlow et al., 2017). The solution is created by analytically continuing the divergent power series solution such that it matches the long- ... ...

Abstract	An accurate closed-form solution is obtained to the SIR Epidemic Model through the use of Asymptotic Approximants (Barlow et al., 2017). The solution is created by analytically continuing the divergent power series solution such that it matches the long-time asymptotic behavior of the epidemic model. The utility of the analytical form is demonstrated through its application to the COVID-19 pandemic.
Keywords	covid19
Language	English
Publishing date	2020-04-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1466587-6
ISSN	1872-8022 ; 0167-2789
ISSN (online)	1872-8022
ISSN	0167-2789
DOI	10.1016/j.physd.2020.132540
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Article ; Online: Long-term golimumab persistence: Five-year treatment retention data pooled from pivotal Phase III clinical trials in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.

Weinstein, Cindy L J / Meehan, Alan G / Lin, Jianxin / Briscoe, Steven D / Govoni, Marinella

Clinical rheumatology

2023 Volume 42, Issue 12, Page(s) 3397–3405

Abstract: Introduction: Golimumab, a monoclonal antibody against tumor necrosis factor-α (TNF-α), is used widely for treatment of rheumatic diseases. Long-term persistence is an important factor influencing therapeutic benefit and is a surrogate measure of ... ...

Abstract	Introduction: Golimumab, a monoclonal antibody against tumor necrosis factor-α (TNF-α), is used widely for treatment of rheumatic diseases. Long-term persistence is an important factor influencing therapeutic benefit and is a surrogate measure of efficacy. We compared five-year golimumab treatment persistence across studies, indications, and lines of therapy using pooled data from pivotal golimumab Phase III clinical trials. Methods: This post-hoc analysis evaluated use of golimumab administered subcutaneously (50 or 100 mg every four weeks) for up to five years in 2228 adult participants with rheumatoid arthritis (RA; GO-BEFORE, GO-AFTER, and GO-FORWARD studies), psoriatic arthritis (PsA; GO-REVEAL study), or ankylosing spondylitis (AS; GO-RAISE study). Retention rate differences were evaluated by study, indication, and line of therapy using log-rank tests, and probability of treatment persistence was estimated by Kaplan-Meier analysis. Results: Golimumab retention rates at Year 5 were consistently high when used as 1 Conclusions: These data support the value of long-term golimumab therapy in patients with chronic, immune-mediated rheumatic diseases when used as 1
MeSH term(s)	Adult ; Humans ; Spondylitis, Ankylosing/drug therapy ; Arthritis, Psoriatic/drug therapy ; Tumor Necrosis Factor-alpha/therapeutic use ; Antirheumatic Agents/adverse effects ; Treatment Outcome ; Arthritis, Rheumatoid ; Antibodies, Monoclonal
Chemical Substances	golimumab (91X1KLU43E) ; Tumor Necrosis Factor-alpha ; Antirheumatic Agents ; Antibodies, Monoclonal
Language	English
Publishing date	2023-09-26
Publishing country	Germany
Document type	Clinical Trial, Phase III ; Journal Article
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-023-06760-z
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Article: Accurate closed-form solution of the SIR epidemic model

Barlow, Nathaniel S / Weinstein, Steven J

Physica D

Abstract	An accurate closed-form solution is obtained to the SIR Epidemic Model through the use of Asymptotic Approximants (Barlow et al., 2017). The solution is created by analytically continuing the divergent power series solution such that it matches the long-time asymptotic behavior of the epidemic model. The utility of the analytical form is demonstrated through its application to the COVID-19 pandemic.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #177245
Database	COVID19

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Book ; Online: Accurate closed-form solution of the SIR epidemic model

Barlow, Nathaniel S. / Weinstein, Steven J.

2020

Abstract: An accurate closed-form solution is obtained to the SIR Epidemic Model through the use of Asymptotic Approximants (Barlow et. al, 2017, Q. Jl Mech. Appl. Math, 70 (1), 21-48). The solution is created by analytically continuing the divergent power series ... ...

Abstract	An accurate closed-form solution is obtained to the SIR Epidemic Model through the use of Asymptotic Approximants (Barlow et. al, 2017, Q. Jl Mech. Appl. Math, 70 (1), 21-48). The solution is created by analytically continuing the divergent power series solution such that it matches the long-time asymptotic behavior of the epidemic model. The utility of the analytical form is demonstrated through its application to the COVID-19 pandemic. Comment: Updates: Fixed a typo in previous version's equation 6c. Included link to Python code
Keywords	Quantitative Biology - Populations and Evolution ; Physics - Physics and Society ; covid19
Publishing date	2020-04-16
Publishing country	us
Document type	Book ; Online
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Article: Analytic solution of the SEIR epidemic model via asymptotic approximant.

Weinstein, Steven J / Holland, Morgan S / Rogers, Kelly E / Barlow, Nathaniel S

Physica D. Nonlinear phenomena

2020 Volume 411, Page(s) 132633

Abstract: An analytic solution is obtained to the SEIR Epidemic Model. The solution is created by constructing a single second-order nonlinear differential equation ... ...

Abstract	An analytic solution is obtained to the SEIR Epidemic Model. The solution is created by constructing a single second-order nonlinear differential equation in
Keywords	covid19
Language	English
Publishing date	2020-06-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1466587-6
ISSN	1872-8022 ; 0167-2789
ISSN (online)	1872-8022
ISSN	0167-2789
DOI	10.1016/j.physd.2020.132633
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Article: Accurate closed-form solution of the SIR epidemic model

Nathaniel Barlow S. / Steven Weinstein J.

Abstract	An accurate closed-form solution is obtained to the SIR Epidemic Model through the use of Asymptotic Approximants (Barlow et. al, 2017, Q. Jl Mech. Appl. Math, 70 (1), 21-48). The solution is created by analytically continuing the divergent power series solution such that it matches the long-time asymptotic behavior of the epidemic model. The utility of the analytical form is demonstrated through its application to the COVID-19 pandemic.
Keywords	covid19
Publisher	arxiv
Document type	Article
Database	COVID19

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Article ; Online: Lipidomics and pancreatic cancer risk in two prospective studies.

Naudin, Sabine / Sampson, Joshua N / Moore, Steven C / Albanes, Demetrius / Freedman, Neal D / Weinstein, Stephanie J / Stolzenberg-Solomon, Rachael

European journal of epidemiology

2023 Volume 38, Issue 7, Page(s) 783–793

Abstract: Pancreatic ductal carcinoma (PDAC) is highly fatal with limited understanding of mechanisms underlying its carcinogenesis. We comprehensively investigated whether lipidomic measures were associated with PDAC in two prospective studies. We measured 904 ... ...

Abstract	Pancreatic ductal carcinoma (PDAC) is highly fatal with limited understanding of mechanisms underlying its carcinogenesis. We comprehensively investigated whether lipidomic measures were associated with PDAC in two prospective studies. We measured 904 lipid species and 252 fatty acids across 15 lipid classes in pre-diagnostic serum (up to 24 years) in a PDAC nested-case control study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO, NCT00002540) with 332 matched case-control sets including 272 having serial blood samples and Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC, NCT00342992) with 374 matched case-control sets. Controls were matched to cases by cohort, age, sex, race, and date at blood draw. We used conditional logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI) per one-standard deviation increase in log-lipid concentrations within each cohort, and combined ORs using fixed-effects meta-analyses. Forty-three lipid species were associated with PDAC (false discovery rate, FDR ≤ 0.10), including lysophosphatidylcholines (LPC, n = 2), phosphatidylethanolamines (PE, n = 17), triacylglycerols (n = 13), phosphatidylcholines (PC, n = 3), diacylglycerols (n = 4), monoacylglycerols (MAG, n = 2), cholesteryl esters (CE, n = 1), and sphingomyelins (n = 1). LPC(18:2) and PE(O-16:0/18:2) showed significant inverse associations with PDAC at the Bonferroni threshold (P value < 5.5 × 10
MeSH term(s)	Male ; Humans ; Prospective Studies ; Lipidomics ; Risk Factors ; Case-Control Studies ; Pancreatic Neoplasms/epidemiology ; Fatty Acids ; Pancreatic Neoplasms
Chemical Substances	Fatty Acids
Language	English
Publishing date	2023-05-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	632614-6
ISSN	1573-7284 ; 0393-2990
ISSN (online)	1573-7284
ISSN	0393-2990
DOI	10.1007/s10654-023-01014-3
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Article ; Online: Dietary Quality and Circulating Lipidomic Profiles in 2 Cohorts of Middle-Aged and Older Male Finnish Smokers and American Populations.

Zhang, Ting / Naudin, Sabine / Hong, Hyokyoung G / Albanes, Demetrius / Männistö, Satu / Weinstein, Stephanie J / Moore, Steven C / Stolzenberg-Solomon, Rachael Z

The Journal of nutrition

2023 Volume 153, Issue 8, Page(s) 2389–2400

Abstract: Background: Higher dietary quality is associated with lower disease risks and has not been examined extensively with lipidomic profiles.: Objectives: Our goal was to examine associations of the Healthy Eating Index (HEI)-2015, Alternate HEI-2010 ( ... ...

Abstract	Background: Higher dietary quality is associated with lower disease risks and has not been examined extensively with lipidomic profiles. Objectives: Our goal was to examine associations of the Healthy Eating Index (HEI)-2015, Alternate HEI-2010 (AHEI-2010), and alternate Mediterranean Diet Index (aMED) diet quality indices with serum lipidomic profiles. Methods: We conducted a cross-sectional analysis of HEI-2015, AHEI-2010, and aMED with lipidomic profiles from 2 nested case-control studies within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (n = 627) and the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (n = 711). We used multivariable linear regression to determine associations of the indices, derived from baseline food-frequency questionnaires (Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial: 1993-2001, Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study: 1985-1988) with serum concentrations of 904 lipid species and 252 fatty acids (FAs) across 15 lipid classes and 28 total FAs, within each cohort and meta-analyzed results using fixed-effect models for lipids significant at Bonferroni-corrected threshold in common in both cohorts. Results: Adherence to HEI-2015, AHEI-2010, or aMED was associated positively with 31, 41, and 54 lipid species and 8, 6, and 10 class-specific FAs and inversely with 2, 8, and 34 lipid species and 1, 3, and 5 class-specific FAs, respectively. Twenty-five lipid species and 5 class-specific FAs were common to all indices, predominantly triacylglycerols, FA22:6 [docosahexaenoic acid (DHA)]-containing species, and DHA. All indices were positively associated with total FA22:6. AHEI-2010 and aMED were inversely associated with total FA18:1 (oleic acid) and total FA17:0 (margaric acid), respectively. The identified lipids were most associated with components of seafood and plant proteins and unsaturated:saturated fat ratio in HEI-2015; eicosapentaenoic acid plus DHA in AHEI-2010; and fish and monounsaturated:saturated fat ratio in aMED. Conclusions: Adherence to HEI-2015, AHEI-2010, and aMED is associated with serum lipidomic profiles, mostly triacylglycerols or FA22:6-containing species, which are related to seafood and plant proteins, eicosapentaenoic acid-DHA, fish, or fat ratio index components.
MeSH term(s)	Male ; Animals ; United States ; Humans ; Female ; Lipidomics ; Smokers ; Finland ; Cross-Sectional Studies ; alpha-Tocopherol ; beta Carotene ; Eicosapentaenoic Acid ; Diet ; Diet, Mediterranean ; Triglycerides ; Colorectal Neoplasms ; Ovarian Neoplasms
Chemical Substances	alpha-Tocopherol (H4N855PNZ1) ; beta Carotene (01YAE03M7J) ; Eicosapentaenoic Acid (AAN7QOV9EA) ; Triglycerides
Language	English
Publishing date	2023-06-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
DOI	10.1016/j.tjnut.2023.06.010
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Article ; Online: Posttreatment Exposure Rates for

Blum, Steven / Silvestrini, Eugenio / Weinstein, Jonathan / Greben, Craig

Journal of nuclear medicine technology

2022 Volume 51, Issue 1, Page(s) 60–62

Abstract: There has been a significant increase in the use ... ...

Abstract	There has been a significant increase in the use of
MeSH term(s)	Humans ; Microspheres ; Liver Neoplasms ; Radiopharmaceuticals/therapeutic use ; Yttrium Radioisotopes/therapeutic use
Chemical Substances	Radiopharmaceuticals ; Yttrium Radioisotopes
Language	English
Publishing date	2022-08-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	189163-7
ISSN	1535-5675 ; 0091-4916
ISSN (online)	1535-5675
ISSN	0091-4916
DOI	10.2967/jnmt.122.264335
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Article ; Online: Impact of COVID-19 on HIV service delivery in Miami-Dade County: a mixed methods study.

Harkness, Audrey / Morales, Vanessa / Defreitas, Wayne / Atuluru, Pranusha / Jaramillo, Jahn / Weinstein, Elliott R / Feaster, Daniel J / Safren, Steven / Balise, Raymond

BMC health services research

2022 Volume 22, Issue 1, Page(s) 1476

Abstract: Background: Facilitating access to HIV prevention and treatment is imperative in Miami-Dade County (MDC), a U.S. HIV epicenter. With COVID-19, disruptions to these services have occurred, leading HIV organizations to innovate and demonstrate resilience. ...

Abstract	Background: Facilitating access to HIV prevention and treatment is imperative in Miami-Dade County (MDC), a U.S. HIV epicenter. With COVID-19, disruptions to these services have occurred, leading HIV organizations to innovate and demonstrate resilience. This study documented COVID-19 related disruptions and resilient innovations in HIV services within MDC. Methods: This mixed methods cross-sectional study included HIV test counselors in MDC. In the quantitative component (N=106), participants reported COVID-19 impacts on HIV service delivery. Data visualization examined patterns within organizations and throughout the study period. Generalized estimating equation modeling examined differences in service disruptions and innovations. In the qualitative component, participants (N=20) completed interviews regarding COVID-19 impacts on HIV services. Rapid qualitative analysis was employed to analyze interviews. Results: Quantitative data showed that innovations generally matched or outpaced disruptions, demonstrating resilience on HIV service delivery during COVID-19. HIV testing (36%, 95%CI[28%, 46%]) and STI testing (42%, 95%CI[33%, 52%]) were most likely to be disrupted. Sexual/reproductive health (45%, 95%CI[35%, 55%]), HIV testing (57%, 95%CI[47%,66%]), HIV case management (51%, 95%CI[41%, 60%]), PrEP initiation (47%, 95%CI[37%,57%]), and STI testing (47%, 95%CI[37%, 57%]) were most likely to be innovated. Qualitative analysis revealed three orthogonal themes related to 1) disruptions (with five sub-components), 2) resilient innovations (with four sub-components), and 3) emerging and ongoing health disparities. Conclusions: HIV organizations faced service disruptions during COVID-19 while also meaningfully innovating. Our findings point to potential changes in policy and practice that could be maintained beyond the immediate impacts of COVID-19 to enhance the resilience of HIV services. Aligning with the US Ending the HIV Epidemic Plan and the National Strategy for HIV/AIDS, capitalizing on the observed innovations would facilitate improved HIV-related health services for people living in MDC and beyond.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Cross-Sectional Studies ; HIV Testing ; Epidemics ; Acquired Immunodeficiency Syndrome
Language	English
Publishing date	2022-12-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-022-08849-8
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