LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 7 of total 7

Search options

  1. Article: Fluoxetine and Molnupiravir: A Synergistic Combination for COVID-19 Treatment?

    Pashaei, Yaser

    Hospital pharmacy

    2022  Volume 57, Issue 5, Page(s) 603–604

    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1468893-1
    ISSN 0018-5787
    ISSN 0018-5787
    DOI 10.1177/00185787211073465
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1758: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 21: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Drug repurposing of selective serotonin reuptake inhibitors: Could these drugs help fight COVID-19 and save lives?

    Pashaei, Yaser

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2021  Volume 88, Page(s) 163–172

    Abstract: The current 2019 novel coronavirus disease (COVID-19), an emerging infectious disease, is undoubtedly the most challenging pandemic in the 21st century. A total of 92,977,768 confirmed cases of COVID-19 and 1,991,289 deaths were reported globally up to ... ...

    Abstract The current 2019 novel coronavirus disease (COVID-19), an emerging infectious disease, is undoubtedly the most challenging pandemic in the 21st century. A total of 92,977,768 confirmed cases of COVID-19 and 1,991,289 deaths were reported globally up to January 14, 2021. COVID-19 also affects people's mental health and quality of life. At present, there is no effective therapeutic strategy for the management of this disease. Therefore, in the absence of a specific vaccine or curative treatment, it is an urgent need to identify safe, effective and globally available drugs for reducing COVID-19 morbidity and fatalities. In this review, we focus on selective serotonin reuptake inhibitors (SSRIs: a class of antidepressant drugs with widespread availability and an optimal tolerability profile) that can potentially be repurposed for COVID-19 and are currently being tested in clinical trials. We also summarize the existing literature on what is known about the link between serotonin (5-HT) and the immune system. From the evidence reviewed here, we propose fluoxetine as an adjuvant therapeutic agent for COVID-19 based on its known immunomodulatory, anti-inflammatory and antiviral properties. Fluoxetine may potentially reduce pro-inflammatory chemokine/cytokines levels (such as CCL-2, IL-6, and TNF-α) in COVID-19 patients. Furthermore, fluoxetine may help to attenuate neurological complications of COVID-19.
    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; COVID-19/complications ; Drug Repositioning ; Fluoxetine/therapeutic use ; Humans ; Pandemics ; Selective Serotonin Reuptake Inhibitors/therapeutic use ; COVID-19 Drug Treatment
    Chemical Substances Anti-Inflammatory Agents ; Serotonin Uptake Inhibitors ; Fluoxetine (01K63SUP8D)
    Language English
    Publishing date 2021-03-19
    Publishing country Scotland
    Document type Journal Article ; Review
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2021.03.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3999: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Analytical methods for the determination of remdesivir as a promising antiviral candidate drug for the COVID-19 pandemic.

    Pashaei, Yaser

    Drug discoveries & therapeutics

    2020  Volume 14, Issue 6, Page(s) 273–281

    Abstract: Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is undoubtedly the most challenging pandemic in the current century. A total of 73,953,702 confirmed cases of COVID-19 and 1,644,416 ... ...

    Abstract Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is undoubtedly the most challenging pandemic in the current century. A total of 73,953,702 confirmed cases of COVID-19 and 1,644,416 deaths were reported globally up to December 17, 2020. Therefore, in the absence of a safe and effective vaccine, it is urgent to identify a novel antiviral drug to effectively treat patients with COVID-19. On October 22, the U.S. Food and Drug Administration approved remdesivir, a nucleotide analog prodrug with broad antiviral activity, for adults and children (12 years of age and older and weighing at least 40 kg) who need to be admitted to hospital for covid-19 treatment. In order to monitor the optimization of patient clinical response profile, as well as address the challenges associated with remdesivir metabolism, highly sensitive, selective and accurate analytical methods are necessary. This review clearly covers all the analytical methods developed for the identification and quantitative determination of remdesivir and its metabolites in biological matrices, which helps the researchers in developing new methods for the analysis of remdesivir by considering the pros and cons of the previously reported methods.
    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/analysis ; Adenosine Monophosphate/pharmacokinetics ; Alanine/analogs & derivatives ; Alanine/analysis ; Alanine/pharmacokinetics ; Antiviral Agents/analysis ; Antiviral Agents/pharmacokinetics ; COVID-19/diagnosis ; COVID-19/drug therapy ; COVID-19/virology ; Drug Monitoring/methods ; Humans ; Predictive Value of Tests ; Treatment Outcome
    Chemical Substances Antiviral Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2020-12-30
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2568828-5
    ISSN 1881-784X ; 1881-7831
    ISSN (online) 1881-784X
    ISSN 1881-7831
    DOI 10.5582/ddt.2020.03097
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Magnetic-Dispersive Solid Phase Extraction Based on Graphene Oxide-Fe3O4 Nanocomposites Followed by High Performance Liquid Chromatography-Fluorescence for the Preconcentration and Determination of Terazosin Hydrochloride in Human Plasma.

    Pashaei, Yaser / Daraei, Bahram / Shekarchi, Maryam

    Journal of chromatographic science

    2019  Volume 58, Issue 2, Page(s) 178–186

    Abstract: In the present study, a facile modified impregnation method was employed to synthesize superparamagnetic graphene oxide-Fe3O4 (GO-Fe3O4) nanocomposites. Based on the GO-Fe3O4 as adsorbent, a simple and fast magnetic-dispersive solid phase extraction ... ...

    Abstract In the present study, a facile modified impregnation method was employed to synthesize superparamagnetic graphene oxide-Fe3O4 (GO-Fe3O4) nanocomposites. Based on the GO-Fe3O4 as adsorbent, a simple and fast magnetic-dispersive solid phase extraction followed by high performance liquid chromatography with fluorescence detection (M-dSPE-HPLC-FL) method was established and validated for the preconcentration and determination of terazosin hydrochloride (TRZ) in human plasma samples. The obtained nanomaterials were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy and vibrating sample magnetometry. Different parameters affecting the extraction efficiency, such as sample pH, amount of sorbent, extraction time, elution solvent and its volume and desorption time, were evaluated and optimized. The linearity of the proposed method was excellent over the range 0.3-50.0 ng mL-1 with an acceptable coefficient of determination (R2 = 0.9989). The limit of quantification and limit of detection were found to be 0.3 and 0.09 ng mL-1, respectively, and the preconcentration factor of 10 was achieved. Intra- and inter-day precision expressed as relative standard deviation (RSD %, n = 6) were between 2.2-3.8% and 4.7-6.4%, respectively. Accuracy, estimated by recovery assays, was 97.7-106.6% with RSD ≤ 5.2%. Ultimately, the applicability of the method was successfully confirmed by the extraction and determination of TRZ in human plasma samples.
    MeSH term(s) Chromatography, High Pressure Liquid/methods ; Ferrosoferric Oxide/chemistry ; Graphite/chemistry ; Humans ; Magnetics/methods ; Plasma/chemistry ; Prazosin/analogs & derivatives ; Prazosin/blood ; Prazosin/isolation & purification ; Solid Phase Extraction/instrumentation ; Solid Phase Extraction/methods
    Chemical Substances graphene oxide ; Graphite (7782-42-5) ; Terazosin (8L5014XET7) ; Prazosin (XM03YJ541D) ; Ferrosoferric Oxide (XM0M87F357)
    Language English
    Publishing date 2019-11-19
    Publishing country United States
    Document type Evaluation Study ; Journal Article
    ZDB-ID 80141-0
    ISSN 1945-239X ; 0021-9665
    ISSN (online) 1945-239X
    ISSN 0021-9665
    DOI 10.1093/chromsci/bmz085
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 895: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Superparamagnetic graphene oxide-based dispersive-solid phase extraction for preconcentration and determination of tamsulosin hydrochloride in human plasma by high performance liquid chromatography-ultraviolet detection.

    Pashaei, Yaser / Ghorbani-Bidkorbeh, Fatemeh / Shekarchi, Maryam

    Journal of chromatography. A

    2017  Volume 1499, Page(s) 21–29

    Abstract: In the present study, superparamagnetic graphene oxide- ... ...

    Abstract In the present study, superparamagnetic graphene oxide-Fe
    MeSH term(s) Blood Chemical Analysis/instrumentation ; Blood Chemical Analysis/methods ; Chromatography, High Pressure Liquid ; Graphite/chemistry ; Humans ; Limit of Detection ; Magnetics ; Magnetite Nanoparticles/chemistry ; Microscopy, Electron, Scanning ; Nanocomposites/chemistry ; Oxides/chemistry ; Plasma/chemistry ; Solid Phase Extraction/methods ; Spectroscopy, Fourier Transform Infrared ; Sulfonamides/analysis ; Sulfonamides/blood ; Sulfonamides/isolation & purification ; Ultraviolet Rays ; X-Ray Diffraction
    Chemical Substances Magnetite Nanoparticles ; Oxides ; Sulfonamides ; Graphite (7782-42-5) ; tamsulosin (G3P28OML5I)
    Language English
    Publishing date 2017-05-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1171488-8
    ISSN 1873-3778 ; 0021-9673
    ISSN (online) 1873-3778
    ISSN 0021-9673
    DOI 10.1016/j.chroma.2017.03.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 813: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Superparamagnetic graphene oxide-based dispersive-solid phase extraction for preconcentration and determination of tamsulosin hydrochloride in human plasma by high performance liquid chromatography-ultraviolet detection

    Pashaei, Yaser / Fatemeh Ghorbani-Bidkorbeh / Maryam Shekarchi

    Journal of chromatography. 2017 May 26, v. 1499

    2017  

    Abstract: In the present study, superparamagnetic graphene oxide-Fe3O4 nanocomposites were successfully prepared by a modified impregnation method (MGOmi) and their application as a sorbent in the magnetic-dispersive solid phase extraction (M-dSPE) mode to the ... ...

    Abstract In the present study, superparamagnetic graphene oxide-Fe3O4 nanocomposites were successfully prepared by a modified impregnation method (MGOmi) and their application as a sorbent in the magnetic-dispersive solid phase extraction (M-dSPE) mode to the preconcentration and determination of tamsulosin hydrochloride (TMS) in human plasma was investigated by coupling with high performance liquid chromatography-ultraviolet detection (HPLC-UV). The structure, morphology and magnetic properties of the prepared nanocomposites were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), and vibrating sample magnetometry (VSM). Some factors affecting the extraction efficiency, including the pH value, amount of sorbent, extraction time, elution solvent and its volume, and desorption time were studied and optimized. Magnetic nanocomposites plasma extraction of TMS following HPLC analyses showed a linear calibration curve in the range of 0.5–50.0ngmL−1 with an acceptable correlation coefficient (R2=0.9988). The method was sensitive, with a low limit of detection (0.17ngmL−1) and quantification (0.48ngmL−1). Inter- and intra-day precision expressed as relative standard deviation (n=3) and the preconcentration factor, were found to be 5.6–7.2%, 2.9–4.2% and 10, respectively. Good recoveries (98.1–101.4%) with low relative standard deviations (4.2–5.0%) indicated that the matrices under consideration do not significantly affect the extraction process. Due to its high precision and accuracy, the developed method may be a HPLC-UV alternative with M-dSPE for bioequivalence analysis of TMS in human plasma.
    Keywords desorption ; detection limit ; energy-dispersive X-ray analysis ; Fourier transform infrared spectroscopy ; graphene ; high performance liquid chromatography ; humans ; magnetic properties ; nanocomposites ; pH ; pharmacokinetics ; scanning electron microscopy ; solid phase extraction ; solvents ; sorbents ; statistical analysis ; X-ray diffraction
    Language English
    Dates of publication 2017-0526
    Size p. 21-29.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 218139-3
    ISSN 0021-9673 ; 0378-4355 ; 0376-737X
    ISSN 0021-9673 ; 0378-4355 ; 0376-737X
    DOI 10.1016/j.chroma.2017.03.038
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 813: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Graphene Oxide-Based Dispersive-Solid Phase Extraction for Preconcentration and Determination of Ampicillin Sodium and Clindamycin Hydrochloride Antibiotics in Environmental Water Samples Followed by HPLC-UV Detection.

    Mohammad Nejad, Leila / Pashaei, Yaser / Daraei, Bahram / Forouzesh, Mehdi / Shekarchi, Maryam

    Iranian journal of pharmaceutical research : IJPR

    2019  Volume 18, Issue 2, Page(s) 642–657

    Abstract: In this work, a reusable graphene oxide (GO) based dispersive-solid phase extraction (d-SPE) was synthesized and used for the analysis of trace ampicillin sodium (AMP) and clindamycin hydrochloride (CLI) in water samples followed by high performance ... ...

    Abstract In this work, a reusable graphene oxide (GO) based dispersive-solid phase extraction (d-SPE) was synthesized and used for the analysis of trace ampicillin sodium (AMP) and clindamycin hydrochloride (CLI) in water samples followed by high performance liquid chromatography-UV detection (HPLC-UV). Batch experiments were conducted to investigate the effects of pH and volume of the sample solution, contact time, adsorption isotherms, temperature, and desorption conditions. The maximum adsorption capacities of AMP and CLI on GO nanosheets were found to be 33.33 mg g
    Language English
    Publishing date 2019-08-21
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2578271-X
    ISSN 1726-6890 ; 1735-0328 ; 1735-0328
    ISSN (online) 1726-6890 ; 1735-0328
    ISSN 1735-0328
    DOI 10.22037/ijpr.2019.1100676
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top