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Article: Diagnosis of soft tissue tumors using immunohistochemistry as a surrogate for recurrent fusion oncoproteins.

Black, Margaret A / Charville, Gregory W

2021 Volume 39, Issue 1, Page(s) 38–47

Abstract: Soft tissue neoplasms encompass a broad spectrum of clinicopathologic manifestations. In a subset of soft tissue tumors, spanning a wide range of clinical behavior from indolent to highly aggressive, recurrent genetic translocations yield oncogenic ... ...

Abstract	Soft tissue neoplasms encompass a broad spectrum of clinicopathologic manifestations. In a subset of soft tissue tumors, spanning a wide range of clinical behavior from indolent to highly aggressive, recurrent genetic translocations yield oncogenic fusion proteins that drive neoplastic growth. Beyond functioning as primary mechanisms of tumorigenesis, recurrent translocations represent key diagnostic features insofar as the presence of a particular oncogenic gene fusion generally points to specific tumor entities. In addition to more direct methods for identifying recurrent translocations, such as conventional cytogenetics or fluorescence in situ hybridization, immunohistochemistry for a component of the fusion oncoprotein increasingly is being used as a surrogate marker, exploiting the tendency of these fusion components to be distinctively overexpressed by translocation-bearing tumor cells. Diagnostic immunohistochemistry can also be used to identify the characteristic gene expression changes that occur downstream of oncogenic fusions. Here, we review the use of immunohistochemistry to detect surrogate markers of recurrent translocations in soft tissue tumors, focusing on the practical applications and limitations of this diagnostic approach.
MeSH term(s)	Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Oncogene Proteins ; Soft Tissue Neoplasms/genetics
Chemical Substances	Oncogene Proteins
Language	English
Publishing date	2021-11-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	605834-6
ISSN	1930-1111 ; 0740-2570
ISSN (online)	1930-1111
ISSN	0740-2570
DOI	10.1053/j.semdp.2021.10.005
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Article ; Online: Optimising child and adolescent health and development in the post-pandemic world.

Bhutta, Zulfiqar A / Boerma, Ties / Black, Maureen M / Victora, Cesar G / Kruk, Margaret E / Black, Robert E

Lancet (London, England)

2022 Volume 399, Issue 10337, Page(s) 1759–1761

MeSH term(s)	Adolescent ; Adolescent Health ; COVID-19/epidemiology ; Child ; Family ; Humans ; Influenza, Human/epidemiology ; Pandemics/prevention & control ; SARS-CoV-2
Language	English
Publishing date	2022-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(21)02789-6
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Article: A toxicology study of

Arumugam, Paritha / Carey, Brenna C / Wikenheiser-Brokamp, Kathryn A / Krischer, Jeffrey / Wessendarp, Matthew / Shima, Kenjiro / Chalk, Claudia / Stock, Jennifer / Ma, Yan / Black, Diane / Imbrogno, Michelle / Collins, Margaret / Kalenda Yombo, Dan Justin / Sakthivel, Haripriya / Suzuki, Takuji / Lutzko, Carolyn / Cancelas, Jose A / Adams, Michelle / Hoskins, Elizabeth /

Lowe-Daniels, Dawn / Reeves, Lilith / Kaiser, Anne / Trapnell, Bruce C

Molecular therapy. Methods & clinical development

2024 Volume 32, Issue 2, Page(s) 101213

Abstract: Pulmonary macrophage transplantation (PMT) is a gene and cell transplantation approach in development as therapy for hereditary pulmonary alveolar proteinosis (hPAP), a surfactant accumulation disorder caused by mutations ... ...

Abstract	Pulmonary macrophage transplantation (PMT) is a gene and cell transplantation approach in development as therapy for hereditary pulmonary alveolar proteinosis (hPAP), a surfactant accumulation disorder caused by mutations in
Language	English
Publishing date	2024-02-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2872938-9
ISSN	2329-0501 ; 2329-0501
ISSN (online)	2329-0501
ISSN	2329-0501
DOI	10.1016/j.omtm.2024.101213
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Article: Development of a medical education podcast in obstetrics and gynecology.

Black, Kristin A / Drummond, Lindsay / Jain, Venu / Sagle, Margaret

Canadian medical education journal

2021 Volume 12, Issue 2, Page(s) e103–e105

Abstract: Podcasts are used in medical education to supplement conventional teaching methods such as lectures and reading. We identified a lack of Canadian medical education podcasts covering obstetrics and gynecology (Ob/Gyn) content and created a podcast ... ...

Abstract	Podcasts are used in medical education to supplement conventional teaching methods such as lectures and reading. We identified a lack of Canadian medical education podcasts covering obstetrics and gynecology (Ob/Gyn) content and created a podcast specific for Canadian medical students and residents. The podcast called "OB-G in YEG" is freely available and currently has fourteen episodes that cover common topics in Ob/Gyn. We describe the process for creating a high-quality medical education resource that is widely accessible to learners that readers may be able to replicate in their own discipline.
Language	English
Publishing date	2021-04-30
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2689512-2
ISSN	1923-1202
ISSN	1923-1202
DOI	10.36834/cmej.71139
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Article ; Online: Development of a medical education podcast in obstetrics and gynecology

Kristin A Black / Lindsay Drummond / Venu Jain / Margaret Sagle

Canadian Medical Education Journal, Vol 12, Iss

2021 Volume 2

Abstract: Implication Statement: Podcasts are used in medical education to supplement conventional teaching methods such as lectures and reading. We identified a lack of Canadian medical education podcasts covering obstetrics and gynecology (Ob/Gyn) content and ... ...

Abstract	Implication Statement: Podcasts are used in medical education to supplement conventional teaching methods such as lectures and reading. We identified a lack of Canadian medical education podcasts covering obstetrics and gynecology (Ob/Gyn) content and created a podcast specific for Canadian medical students and residents. The podcast called “OB-G in YEG” is freely available and currently has fourteen episodes that cover common topics in Ob/Gyn. We describe the process for creating a high-quality medical education resource that is widely accessible to learners that readers may be able to replicate in their own discipline.
Keywords	Education (General) ; L7-991 ; Medicine (General) ; R5-920
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Canadian Medical Education Journal
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Associations of household unmet basic needs and health outcomes among very low birth weight children.

Parker, Margaret G / de Cuba, Stephanie Ettinger / Rateau, Lindsey J / Shea, Margaret / Sandel, Megan T / Frank, Deborah A / Cutts, Diana B / Heeren, Timothy / Lê-Scherban, Félice / Black, Maureen M / Ochoa, Eduardo R / Rose-Jacobs, Ruth / Garg, Arvin

Journal of perinatology : official journal of the California Perinatal Association

2023 Volume 43, Issue 3, Page(s) 364–370

Abstract: Objective: We examined associations of past year household hardships (housing, energy, food, and healthcare hardships) with postnatal growth, developmental risk, health status, and hospitalization among children 0-36 months born with very low birth ... ...

Abstract	Objective: We examined associations of past year household hardships (housing, energy, food, and healthcare hardships) with postnatal growth, developmental risk, health status, and hospitalization among children 0-36 months born with very low birth weight (VLBW) and the extent that these relationships differed by receipt of child supplemental security income (SSI). Study design: We examined cross-sectional data from 695 families. Growth was measured as weight-for-age z-score change. Developmental risk was defined as ≥1 concerns on the "Parents' Evaluation of Developmental Status" screening tool. Child health status was categorized as excellent/good vs. fair/poor. Hospitalizations excluded birth hospitalizations. Results: Compared to children with no household hardships, odds of developmental risk were greater with 1 hardship (aOR 2.0 [1.26, 3.17]) and ≥2 hardships (aOR) 1.85 [1.18, 2.91], and odds of fair/poor child health (aOR) 1.59 [1.02, 2.49] and hospitalizations (aOR) 1.49 [1.00, 2.20] were greater among children with ≥2 hardships. In stratified analysis, associations of hardships and developmental risk were present for households with no child SSI and absent for households with child SSI. Conclusion: Household hardships were associated with developmental risk, fair/poor health status, and hospitalizations among VLBW children. Child SSI may be protective against developmental risk among children living in households with hardships.
MeSH term(s)	Humans ; Child ; Infant ; Infant, Newborn ; Poverty ; Cross-Sectional Studies ; Income ; Infant, Very Low Birth Weight ; Outcome Assessment, Health Care
Language	English
Publishing date	2023-02-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	645021-0
ISSN	1476-5543 ; 0743-8346
ISSN (online)	1476-5543
ISSN	0743-8346
DOI	10.1038/s41372-023-01626-3
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Article ; Online: Increased PI3K pathway activity is associated with recurrent breast cancer in patients with low and intermediate 21-gene recurrence score.

Lin, Lawrence Hsu / Wesseling-Rozendaal, Yvonne / Vasudevaraja, Varshini / Shen, Guomiao / Black, Margaret / van Strijp, Dianne / Neerken, Sigi / van de Wiel, Paul A / Jour, George / Cotzia, Paolo / Darvishian, Farbod / Snuderl, Matija

Journal of clinical pathology

2024

Abstract: Aims: We investigated key signalling pathways' activity and mutational status of early-stage breast carcinomas with low and intermediate 21-gene recurrence score (RS) to identify molecular features that may predict recurrence.: Methods: This is a ... ...

Abstract	Aims: We investigated key signalling pathways' activity and mutational status of early-stage breast carcinomas with low and intermediate 21-gene recurrence score (RS) to identify molecular features that may predict recurrence. Methods: This is a retrospective case-control study of 18 patients with recurrent breast carcinoma with low and intermediate 21-gene RS (<25) and control group of 15 non-recurrent breast cancer patients. DNA and mRNA were extracted from tumour tissue. mRNA expression of genes involved in oestrogen receptor (ER), androgen receptor (AR), PI3K and MAPK signalling pathways was measured by real-time quantitative reverse transcription-qPCR (OncoSIGNal G4 test, InnoSIGN). Tumour mutational landscape was assessed by targeted DNA sequencing (Oncomine Precision Assay). Results: There were no statistical differences between the groups' demographic and clinicopathological characteristics. PI3K pathway showed significantly higher activity in cases compared with controls (p=0.0014). Receiver operating characteristic curve analysis showed an area under the curve of 0.79 for PI3K pathway activity in the prediction of recurrent disease in low and intermediate 21-gene RS breast cancer. There was no difference in ER, AR and MAPK pathway activity.
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	80261-x
ISSN	1472-4146 ; 0021-9746
ISSN (online)	1472-4146
ISSN	0021-9746
DOI	10.1136/jcp-2023-209344
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Article ; Online: Geographic Access to Early Pregnancy Loss Management.

Krashin, Jamie W / Black, Patricia / Brannen, Eric / Gard, Charlotte C / Lin, Yan / Greenwood-Ericksen, Margaret / Trujillo, Victoria Y / Burkhardt, Gillian / Schreiber, Courtney A

Obstetrics and gynecology

2024 Volume 143, Issue 3, Page(s) 435–439

Abstract: Early pregnancy loss (EPL) is common, but patients face barriers to the most effective medication (mifepristone followed by misoprostol) and procedural (uterine aspiration) management options. This cross-sectional geospatial analysis evaluated access in ... ...

Abstract	Early pregnancy loss (EPL) is common, but patients face barriers to the most effective medication (mifepristone followed by misoprostol) and procedural (uterine aspiration) management options. This cross-sectional geospatial analysis evaluated access in New Mexico to mifepristone and misoprostol and uterine aspiration in emergency departments (comprehensive) and to uterine aspiration anywhere in a hospital (aspiration) for EPL. Access was defined as a 60-minute car commute. We collected data from hospital key informants and public databases and performed logistical regression to evaluate associations between access and rurality, area deprivation, race, and ethnicity. Thirty-five of 42 (83.3%) hospitals responded between October 2020 and August 2021. Two hospitals (5.7%) provided comprehensive management; 24 (68.6%) provided aspiration. Rural and higher deprivation areas had statistically significantly lower adjusted odds ratios for comprehensive management (0.03-0.07 and 0.3-0.4, respectively) and aspiration (0.03-0.06 and 0.1-0.3, respectively) access. Mifepristone and uterine aspiration implementation would address disparate access to EPL treatment.
MeSH term(s)	Pregnancy ; Female ; Humans ; Mifepristone/therapeutic use ; Abortion, Spontaneous/epidemiology ; Abortion, Spontaneous/therapy ; Misoprostol/therapeutic use ; Abortion, Induced ; Cross-Sectional Studies ; Respiratory Aspiration
Chemical Substances	Mifepristone (320T6RNW1F) ; Misoprostol (0E43V0BB57)
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	207330-4
ISSN	1873-233X ; 0029-7844
ISSN (online)	1873-233X
ISSN	0029-7844
DOI	10.1097/AOG.0000000000005505
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Article ; Online: A qualitative exploration of individual differences in wellbeing for highly sensitive individuals

Becky A. Black / Margaret L. Kern

Palgrave Communications, Vol 6, Iss 1, Pp 1-

2020 Volume 11

Abstract: Abstract Cultures explicitly and implicitly create and reinforce social norms and expectations, which impact upon how individuals make sense of and experience their place within that culture. Numerous studies find substantial differences across a range ... ...

Abstract	Abstract Cultures explicitly and implicitly create and reinforce social norms and expectations, which impact upon how individuals make sense of and experience their place within that culture. Numerous studies find substantial differences across a range of behavioral and cognitive indices between what have been called “Western, Educated, Industrialized, Rich, and Democratic (WEIRD)” societies and non-WEIRD cultures. Indeed, lay conceptions and social norms around wellbeing tend to emphasize social outgoingness and high-arousal positive emotions, with introversion and negative emotion looked down upon or even pathologized. However, this extravert-centric conception of wellbeing does not fit many individuals who live within WEIRD societies, and studies find that this mismatch can have detrimental effects on their wellbeing. There is a need to better understand how wellbeing is created and experienced by the large number of people for whom wellbeing manifests in alternative ways. This study investigated one such manifestation—the personality trait of sensory processing sensitivity (SPS)—qualitatively investigating how sensitive individuals experience and cultivate wellbeing within a WEIRD society. Twelve adults participated in semi-structured interviews. Findings suggest that highly sensitive individuals perceive that wellbeing arises from harmony across multiple dimensions. Interviewees emphasized the value of low-intensity positive emotion, self-awareness, self-acceptance, positive social relationships balanced by times of solitude, connecting with nature, contemplative practices, emotional self-regulation, practicing self-compassion, having a sense of meaning, and hope/optimism. Barriers of wellbeing included physical health issues and challenges with saying no to others. This study provides a rich idiographic representation of SPS wellbeing, highlighting diverse pathways, which can lead to wellbeing for individuals for whom wellbeing manifests in ways that contradict the broader social narratives in which they reside.
Keywords	Social Sciences ; H
Subject code	360
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Palgrave Macmillan
Document type	Article ; Online
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Article ; Online: Synthesis of Radiolabeled Technetium- and Rhenium-Luteinizing Hormone-Releasing Hormone (

Calderon, Lindsay E / Black, Carrie A / Rollins, Joseph D / Overbay, Brittany / Shiferawe, Semekidus / Elliott, Andrew / Reitz, Sara / Liu, Shu / Li, Junling / Ng, Chin K / Ndinguri, Margaret W

ACS omega

2021 Volume 6, Issue 3, Page(s) 1846–1856

Abstract: Currently, ...

Abstract	Currently,
Language	English
Publishing date	2021-01-08
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.0c03991
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