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Article: A prospective-randomized placebo-controlled trial comparing the effects of nebulized dexmedetomidine v/s dexmedetomidine-lignocaine mixture on intraoperative hemodynamics and surgical field quality in patients undergoing endoscopic transnasal transsphenoidal pituitary tumor surgery.

Praveen, Ranganatha / Sethuraman, Manikandan / Vimala, Smita / Prathapadas, Unnikrishnan / Hrishi, Ajay Prasad / Nair, Prakash / Surendran, Sarath / Ahuja, Arvin / Sreekumar, Revikrishnan / Vishnu, Bijith / Gowtham, Matham

Surgical neurology international

2023 Volume 14, Page(s) 431

Abstract: ... in dexmedetomidine-lignocaine (DL) group and normal saline in the control (S) group. Heart rate (HR), mean ... Group S had significantly higher HR and mean arterial pressure than the other two groups across various ...

Abstract	Background: During transnasal transsphenoidal pituitary surgery (TNTSS), the primary objective is to maintain stable hemodynamics while ensuring ideal surgical conditions. This study aimed to investigate the effect of nebulized dexmedetomidine on hemodynamic parameters and the quality of the surgical field during TNTSS. Methods: Seventy-five patients scheduled for TNTSS were randomized into three groups of 25 each and received preoperative nebulization with 5 mL of nebulizing fluid consisting of 1.5 μg/kg of dexmedetomidine with saline in dexmedetomidine (D) group; 1.5 μg/kg of dexmedetomidine with 2% lignocaine in dexmedetomidine-lignocaine (DL) group and normal saline in the control (S) group. Heart rate (HR), mean blood pressure, Formmers score, anesthetic requirement, and emergence were evaluated for each group. Results: Group S had significantly higher HR and mean arterial pressure than the other two groups across various time points during surgery ( Conclusion: The administration of nebulized dexmedetomidine, both alone and in combination with lignocaine, resulted in stable hemodynamics, favorable operative conditions, reduced anesthetic requirement, and facilitated prompt emergence during TNTSS. Nebulized dexmedetomidine proved superior to its combination with lignocaine across all evaluated parameters.
Language	English
Publishing date	2023-12-15
Publishing country	United States
Document type	Journal Article
ISSN	2229-5097
ISSN	2229-5097
DOI	10.25259/SNI_858_2023
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Radiofrequency ablation of surface v/s intraparenchymal hepatocellular carcinoma in cirrhotic patients.

Patidar, Yashwant / Singhal, Praveen / Gupta, Shailesh / Mukund, Amar / Sarin, Shiv K

The Indian journal of radiology & imaging

2018 Volume 27, Issue 4, Page(s) 496–502

Abstract: Objective: To retrospectively evaluate the safety and technical efficacy of percutaneous radiofrequency ablation (RFA) of surface hepatocellular carcinoma (HCC) in comparison to intraparenchymal HCC in cirrhotic patients.: Materials and methods: ... ...

Abstract	Objective: To retrospectively evaluate the safety and technical efficacy of percutaneous radiofrequency ablation (RFA) of surface hepatocellular carcinoma (HCC) in comparison to intraparenchymal HCC in cirrhotic patients. Materials and methods: Surface lesions were defined as tumours located or reaching within 1cm of liver capsule including exophytic lesions. Seventy-four surface HCC including 21 exophytic in 58 patients (surface group) and 60 intraparenchymal HCC in 54 patients (intraparenchymal group) measuring up to 4 cm in maximum extent underwent percutaneous [ultrasound (US) or computed tomography-guided (CT-guided)] RFA. The response to the treatment was assessed by contrast enhanced CT/magnetic resonance imaging (MRI) done at 1, 3, 6, 9, and 12 months of RFA and thereafter every 4-6 months. In case of features suggesting residual disease, a repeat RFA was performed. The technical success after single-session RFA, complications and disease recurrence rates were calculated and compared between two groups. Results: Technical success achieved after first session of RFA in surface HCC was 95% (70/74) and intraparenchymal HCC was 97% (58/60). Hundred percent secondary success rate was achieved in both groups after second repeat RFA in residual lesion. No major difference in complication and local recurrence rate in both group on follow-up in surface HCC and intraparenchymal HCC. No case of needle track, peritoneal seeding, and treatment mortality was found. Conclusions: The complication rate and efficacy of RFA for surface and exophytic HCC's were comparable to that of intraparenchymal HCC. Hence surface and exophytic lesions should not be considered a contraindication for RFA in cirrhotic patients.
Language	English
Publishing date	2018-01-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	605869-3
ISSN	0971-3026 ; 0970-2016
ISSN	0971-3026 ; 0970-2016
DOI	10.4103/ijri.IJRI_490_16
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Article ; Online: Radiofrequency ablation of surface v/s intraparenchymal hepatocellular carcinoma in cirrhotic patients

Yashwant Patidar / Praveen Singhal / Shailesh Gupta / Amar Mukund / Shiv K Sarin

Indian Journal of Radiology and Imaging, Vol 27, Iss 04, Pp 496-

2017 Volume 502

Abstract	Objective: To retrospectively evaluate the safety and technical efficacy of percutaneous radiofrequency ablation (RFA) of surface hepatocellular carcinoma (HCC) in comparison to intraparenchymal HCC in cirrhotic patients. Materials and Methods: Surface lesions were defined as tumours located or reaching within 1cm of liver capsule including exophytic lesions. Seventy-four surface HCC including 21 exophytic in 58 patients (surface group) and 60 intraparenchymal HCC in 54 patients (intraparenchymal group) measuring up to 4 cm in maximum extent underwent percutaneous [ultrasound (US) or computed tomography-guided (CT-guided)] RFA. The response to the treatment was assessed by contrast enhanced CT/magnetic resonance imaging (MRI) done at 1, 3, 6, 9, and 12 months of RFA and thereafter every 4–6 months. In case of features suggesting residual disease, a repeat RFA was performed. The technical success after single-session RFA, complications and disease recurrence rates were calculated and compared between two groups. Results: Technical success achieved after first session of RFA in surface HCC was 95% (70/74) and intraparenchymal HCC was 97% (58/60). Hundred percent secondary success rate was achieved in both groups after second repeat RFA in residual lesion. No major difference in complication and local recurrence rate in both group on follow-up in surface HCC and intraparenchymal HCC. No case of needle track, peritoneal seeding, and treatment mortality was found. Conclusions: The complication rate and efficacy of RFA for surface and exophytic HCC's were comparable to that of intraparenchymal HCC. Hence surface and exophytic lesions should not be considered a contraindication for RFA in cirrhotic patients.
Keywords	cirrhotic patients ; hepatocellular carcinoma ; intraparenchymal ; radiofrequency ablation ; surface ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	616
Language	English
Publishing date	2017-10-01T00:00:00Z
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online ; E-Book: Conceptualizing plant-based nutrition

Ramesh S. V. / Praveen, Shelly

bioresources, nutrients repertoire and bioavailability

2022

Abstract: Chapter 1. Biodiversity for Nutritive Gains: Values, Benefits and Threats -- Chapter 2. Biofortification of crops: novel insights and approaches for enhanced nutrient accumulation -- Chapter 3.Food matrix-implications for nutritional quality -- Chapter 4. ...

Author's details	Ramesh S. V., Shelly Praveen, editors
Abstract	Chapter 1. Biodiversity for Nutritive Gains: Values, Benefits and Threats -- Chapter 2. Biofortification of crops: novel insights and approaches for enhanced nutrient accumulation -- Chapter 3.Food matrix-implications for nutritional quality -- Chapter 4. Plant-based nutraceuticals -- Chapter 5. Plant-based milk alternatives: nutritional potential and challenges -- Chapter 6.Legumes and Pulses: Ways and Means to Enhance the Protein Quality -- Chapter 7. Microgreens: A novelfood for nutritional security -- Chapter 8.Anti-nutritional Factors: Nutrient Bioavailability and Health Beneficial Effects -- Chapter 9. Metabolic fate of food and its bioavailability -- Chapter 10. Nutrigenomics – Insights and Implications for Genome-based Nutrition -- Chapter 11. Next Gen Biotech Crops for Human Nutrition -- Chapter 12. Food Safety: A multidimensional concept -- Chapter 13. Future Perspectives-plant based nutrition. This book deliberates on the various aspects of plant-based nutrition. Plant-based nutrition has numerous potential health benefits as it is low on calories nevertheless high on nutrient density and satiety, and also nutrient supplementation makes them wholesome diets. Starting with the importance of biodiversity contributing to the nutrition, the book discusses the development or utilization of nutrient-dense crops/foods with their bioavailability properties and health effects. Further, it deals with the enrichment of micronutrients through bio-fortification, fortification, the role of food matrix, and nutrient bioavailability, including the role of plant-based milk alternatives. The linkage between food and health is also being discussed in the context of anti-nutritional factors, metabolic fate of the food, and genomics. Finally, the implications of next-gen biotech crops and food safety issues imperative to define the concept of safe nutrition are discussed. With contributions from plant nutrition experts, this book serves as a one-stop reference for plant scientists, food technologists, and nutritionists looking to understand the concept of plant-based nutrition and its linkage with human health.
Keywords	Food science ; Agriculture ; Nutrition
Language	English
Size	1 Online-Ressource (XVIII, 272 Seiten)
Publisher	Springer Nature Singapore
Publishing place	Singapore
Publishing country	Singapore
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT021699703
ISBN	978-981-19459-0-8 ; 9789811945892 ; 9789811945915 ; 9789811945922 ; 981-19459-0-X ; 9811945896 ; 9811945918 ; 9811945926
DOI	10.1007/978-981-19-4590-8
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Radiofrequency ablation of surface v/s intraparenchymal hepatocellular carcinoma in cirrhotic patients

Patidar, Yashwant / Singhal, Praveen / Gupta, Shailesh / Mukund, Amar / Sarin, Shiv K

Indian Journal of Radiology and Imaging

2017 Volume 27, Issue 04, Page(s) 496–502

Abstract	Objective: To retrospectively evaluate the safety and technical efficacy of percutaneous radiofrequency ablation (RFA) of surface hepatocellular carcinoma (HCC) in comparison to intraparenchymal HCC in cirrhotic patients. Materials and Methods: Surface lesions were defined as tumours located or reaching within 1cm of liver capsule including exophytic lesions. Seventy-four surface HCC including 21 exophytic in 58 patients (surface group) and 60 intraparenchymal HCC in 54 patients (intraparenchymal group) measuring up to 4 cm in maximum extent underwent percutaneous [ultrasound (US) or computed tomography-guided (CT-guided)] RFA. The response to the treatment was assessed by contrast enhanced CT/magnetic resonance imaging (MRI) done at 1, 3, 6, 9, and 12 months of RFA and thereafter every 4–6 months. In case of features suggesting residual disease, a repeat RFA was performed. The technical success after single-session RFA, complications and disease recurrence rates were calculated and compared between two groups. Results: Technical success achieved after first session of RFA in surface HCC was 95% (70/74) and intraparenchymal HCC was 97% (58/60). Hundred percent secondary success rate was achieved in both groups after second repeat RFA in residual lesion. No major difference in complication and local recurrence rate in both group on follow-up in surface HCC and intraparenchymal HCC. No case of needle track, peritoneal seeding, and treatment mortality was found. Conclusions: The complication rate and efficacy of RFA for surface and exophytic HCC's were comparable to that of intraparenchymal HCC. Hence surface and exophytic lesions should not be considered a contraindication for RFA in cirrhotic patients.
Keywords	Cirrhotic patients ; hepatocellular carcinoma ; intraparenchymal ; radiofrequency ablation ; surface
Language	English
Publishing date	2017-10-01
Publisher	Thieme Medical and Scientific Publishers Private Ltd.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	605869-3
ISSN	1998-3808 ; 0971-3026 ; 0970-2016
ISSN (online)	1998-3808
ISSN	0971-3026 ; 0970-2016
DOI	10.4103/ijri.IJRI_490_16
Database	Thieme publisher's database

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Article ; Online: COMPARATIVE STUDY OF BUPIVACAINE V/S BUPIVACAINE WITH CLONIDINE FOR BRACHIAL PLUXUS BLOCK

Praveen Kumar / Nagarjun Reddy / Srinivas Rao / Murali / Rajeshwari / Srinath

Journal of Evolution of Medical and Dental Sciences, Vol 4, Iss 80, Pp 13973-

2015 Volume 13986

Abstract: BACKGROUND : The prime duty of any anesthesiologist is to relive pain in the perioperative period. Today regional anesthesia is well established as equal to general anesthesia in effectiveness and patient acceptability. Regional anesthesia is blocking of ...

Abstract	BACKGROUND : The prime duty of any anesthesiologist is to relive pain in the perioperative period. Today regional anesthesia is well established as equal to general anesthesia in effectiveness and patient acceptability. Regional anesthesia is blocking of peripheral ne rve conduction in a reversible way using local anesthetic agents. For surgeries on upper extremities, particularly in emergency surgeries, regional anesthesia has many advantages over general anesthesia. The brachial plexus is approached at the level of tr unks and the compact arrangement of trunks at the supraclavicular level gives a high success rate with minimum local anesthetic drug volume and a dense and fast onset of the block. To prolong the duration of analgesia various drugs have been studied as adj uvants to the local anesthetics. This study is intended to determine the effects of adding Clonidine to Bupivacaine in brachial plexus blockade by Nerve locator assisted supraclavicular approach, with regard to the onset, intensity and duration of blockade along with its analgesic efficacy. METHODS : Forty adult patients of both sexes in the age group of 20 - 60 years of weight ranging from 50 - 70kg belonging to ASA I/II category posted for various types of upper limb surgeries the patients were randomly alloca ted into two groups,. Supraclavicular brachial plexus block was performed via peripheral nerve locator assisted subclavian perivascular technique. Group – B ( B upivacaine alone) – 20 patients received 30 ml of 0.375%Bupivacaine with 2ml of 0.9% sodium chloride solution. Group – BC ( B upivacaine + C lonidine) – 20 patients received 30ml of 0.375%Bupivacaine with Clonidine hydrochloride 100μg (1ml of 150μg diluted with 2ml 0.9% Na C l solution. From that 2ml used fo r study. ( T he following parameters are assessed Onset of blockade, Duration of blockade, Intensity of blockade, Sedation, Quality of analgesia, Haemodynamic changes & Complications if any RESULTS: Onset time for both motor and sensory block was quicker in the Bupivacaine with clonidine group, Time taken for completion of both motor and sensory blockade was, significantly lesser in clonidine group, There was no difference between the groups in the intensity of blockade., The mean duration of both sensory & m otor blockade was significantly prolonged in clonidine group, Sedation was statistically significant with Bupivacaine - clonidine group in the intraoperative period, There was no haemodynamic instability in both the groups in the study period, There was no c omplication due to the addition of 100μg clonidine to Bupivacaine CONCLUSION : clonidine 100μg (in 2ml)when used as an additive to 0.375% Bupivacaine(30ml) solution for Supraclavicular brachial plexus block, quickens the onset of sensory & motor blockade an d prolongs the duration of sensory & motor blockade. It also improves the quality of post - operative analgesia with mild intraoperative sedation and decreases the heart rate without any haemodynamic instability. Hence, clonidine can be considered as a safe additive to local anaesthetic solution for brachial plexus blocks.
Keywords	Brachial Pl e xus Block ; Bupivacaine ; Clonidine ; Supraclavicular Approach . ; Dentistry ; RK1-715 ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2015-10-01T00:00:00Z
Publisher	Akshantala Enterprises
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A COMPARATIVE STUDY OF BUPIVACAINE AND FENTANYL V/s BUPIVACAINE AND BUTORPHANOL IN LABOUR ANALGESIA BY EPIDURAL TECHNIQUE

Nagarjuna Reddy / Sachidanand / Srinivas Rao / Praveen Kumar / Nagender / Srinath

Journal of Evolution of Medical and Dental Sciences, Vol 4, Iss 79, Pp 13799-

2015 Volume 13813

Abstract: BACKGROUND: Pain is a subjective experience with sensory and emotional components that are inextricably linked to each other. P ain during labour is very intense for many mothers. Severe labour pains may adversely affect both mother and fetus. Variety of ...

Abstract	BACKGROUND: Pain is a subjective experience with sensory and emotional components that are inextricably linked to each other. P ain during labour is very intense for many mothers. Severe labour pains may adversely affect both mother and fetus. Variety of regional anal gesia techniques are available, Of all these techniques epidural analgesia using local anaesthetics and opiates has gained popularity as a safe and effective technique of pain relief largely replacing other modalities. AIM: The present study was undertaken to compare bupivacaine and fentanyl with a combination of bupivacaine and butorphanol by intermittent bolus epidural technique in relieving pain during labour. DESIGN: Randomized control study . METHODS: A total number of 100 parturients studied were divid ed into two groups randomly. Group - 1: received a combination of Bupivacaine and Fentanyl. The initial bolus dose was 0.1% Bupivacaine 10ml with 2mcg/ml [20mcg] of Fentanyl and top up doses were 0.1% Bupivacaine with Fentanyl 2mcg/ml [10ml]. Group - 2: This G roup received a combination of Bupivacaine and Butorphanol. The initial bolus dose was 0.1% Bupivacaine 10ml with 0.01% of Butorphanol [1mg] and top up doses were with 0.1% Bupivacaine [10ml]. Maternal blood pressure, pulse rate, fetal heart rate were moni tored every 1 - 2 min for first 10 min and then every 5 - 10 min for subsequent 30 min and later every half an hour. Time of onset of analgesia, level of sensory blockade and motor blockade, if any was noted. VISUAL ANALOGUE PAIN SCALE [VAPS] assessed pain a t different time intervals. The sedation was assessed by WILSON GRADING, BROMAGE SCALE assessed the motor blockade. RESULTS: The onsets of analgesia were quicker in group - 1 parturients who received 0.1% bupivacaine with 0.0002% fentanyl. The duration of anal gesia with the 1st dose was significantly more in the group - 2 also the requirement of top up doses was also less in group - 2 and also the quality in group - 2 was superior. There was no significant increase in the requirement of instrumentation, surgical inte rvention in both the groups. Neonatal outcome was good and almost equal in both the groups without any respiratory depression even with addition of low dose butorphanol by epidural route. CONCLUSION : From this study it may be concluded that using a combina tion of 0.1% Bupivacaine with 1mg Butorphanol during epidural analgesia for labour provides excellent pain relief, prolonged duration of action with simultaneously decreasing the top - ups required, thereby reducing the total local anesthetic requirement com pared to 0.1% bupivacaine with 0.0002% fentanyl [20mcg]
Keywords	Bupivacaine ; Butorphanol ; Epidural Analgesia ; Fentanyl ; Labour Analgesia . ; Dentistry ; RK1-715 ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	630
Language	English
Publishing date	2015-09-01T00:00:00Z
Publisher	Akshantala Enterprises
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exploring infection clinicians' perceptions of bias in Large Language Models (LLMs) like ChatGPT: A deep learning study.

Praveen, S V / Vijaya, S

The Journal of infection

2023 Volume 87, Issue 6, Page(s) 579–580

MeSH term(s)	Humans ; Deep Learning ; Infections ; Bias
Language	English
Publishing date	2023-09-22
Publishing country	England
Document type	Letter
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2023.09.006
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Article ; Online: Examining otolaryngologists' attitudes towards large language models (LLMs) such as ChatGPT: a comprehensive deep learning analysis.

Praveen, S V / Vijaya, S

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2023 Volume 281, Issue 2, Page(s) 1061–1063

MeSH term(s)	Humans ; Otolaryngologists ; Deep Learning ; Otolaryngology
Language	English
Publishing date	2023-11-13
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-023-08325-x
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Article ; Online: Can ChatGPT be Trusted for Consulting? Uncovering Doctor's Perceptions Using Deep Learning Techniques.

Praveen, S V / Vajrobol, Vajratiya

Annals of biomedical engineering

2023 Volume 51, Issue 10, Page(s) 2116–2119

Abstract: Since the introduction of ChatGPT by OpenAI in late 2022, the question of whether doctors can employ it for consultation has been a subject of debate. ChatGPT is a deep learning model trained on a vast dataset, but concerns about the reliability of its ... ...

Abstract	Since the introduction of ChatGPT by OpenAI in late 2022, the question of whether doctors can employ it for consultation has been a subject of debate. ChatGPT is a deep learning model trained on a vast dataset, but concerns about the reliability of its output have been a subject of debate in recent times. In this article, we have employed cutting-edge bidirectional encoder representations from transformers (BERT) sentiment analysis and topic modeling techniques to comprehend doctors' attitudes toward using ChatGPT in consultation.
MeSH term(s)	Deep Learning ; Reproducibility of Results ; Referral and Consultation ; Electric Power Supplies
Language	English
Publishing date	2023-05-19
Publishing country	United States
Document type	Letter
ZDB-ID	185984-5
ISSN	1573-9686 ; 0191-5649 ; 0090-6964
ISSN (online)	1573-9686
ISSN	0191-5649 ; 0090-6964
DOI	10.1007/s10439-023-03245-7
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