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Article ; Online: Manœuvre de Demelin pour le relèvement des bras lors d’un accouchement voie basse d’une présentation du siège.

Bassi, R / Lallemant, M / Riethmuller, D / Laroche, J / Ramanah, R / Gay, C / Mottet, N

Gynecologie, obstetrique, fertilite & senologie

2021 Volume 50, Issue 1, Page(s) 40–44

Abstract: Objectives: To evaluate Demelin's maneuver for arm entrapment's dystocia during vaginal breech deliveries after failure of the usual Lovset maneuver.: Methods: We led a retrospective cohort study in two French maternities. Between January 2013 and ... ...

Title translation	Demelin's maneuver for arm entrapment during vaginal breech delivery.
Abstract	Objectives: To evaluate Demelin's maneuver for arm entrapment's dystocia during vaginal breech deliveries after failure of the usual Lovset maneuver. Methods: We led a retrospective cohort study in two French maternities. Between January 2013 and June 2020, we included all vaginal breech deliveries of live newborns after 32 weeks of gestation requiring Demelin's maneuver for persistent arm entrapment despite the Lovset maneuver. The primary endpoint was the Demelin's maneuver success without the existence of a neonatal trauma related to the maneuver. Results: Among 1611 vaginal breech deliveries, 29 with Demelin's maneuver for an arm entrapment were enrolled (prevalence 0,02%). No failure of this maneuver was found. There was 10 nulliparous (34.5%). Mean gestational age was 38±2.4 weeks of gestation. The success of Demelin's maneuver without trauma related to it was estimated at 82.8%. No serious neonatal trauma was noticed. Five fractures (17.2%), one humeral and four clavicular, without sequelae were diagnosed. Mean weight of newborns was 2945.5 grams and the median arterial pH was 7.17. The median 5-minutes-Apgar score was 10. Maternal morbidity was low: one case (3.4%) of obstetric anal sphincter injuries (type III). Conclusion: Demelin's maneuver seems to be an effective and safe method to treat an arm entrapment's dystocia during vaginal breech delivery after failure of the Lovset's maneuver.
MeSH term(s)	Arm ; Breech Presentation/therapy ; Cesarean Section ; Delivery, Obstetric/methods ; Female ; Humans ; Infant ; Infant, Newborn ; Pregnancy ; Retrospective Studies
Language	French
Publishing date	2021-09-01
Publishing country	France
Document type	Journal Article
ZDB-ID	2887456-0
ISSN	2468-7189
ISSN (online)	2468-7189
DOI	10.1016/j.gofs.2021.08.003
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Article ; Online: Effects of phospholipase D during cultured osteoblast mineralization and bone formation.

Abdallah, Dina / Skafi, Najwa / Hamade, Eva / Borel, Mathieu / Reibel, Sophie / Vitale, Nicolas / El Jamal, Alaeddine / Bougault, Carole / Laroche, Norbert / Vico, Laurence / Badran, Bassam / Hussein, Nader / Magne, David / Buchet, Rene / Brizuela, Leyre / Mebarek, Saida

Journal of cellular biochemistry

2018 Volume 120, Issue 4, Page(s) 5923–5935

Abstract: Mammalian phospholipase D (PLD) mostly hydrolyzes phosphatidylcholine producing phosphatidic acid ...

Abstract	Mammalian phospholipase D (PLD) mostly hydrolyzes phosphatidylcholine producing phosphatidic acid. PLD activity was previously detected in different osteoblastic cell models, and was increased by several growth factors involved in bone homeostasis. To confirm possible actions of PLD isoforms during mineralization process, we analyzed their effects in osteoblastic cell models and during bone formation. PLD1 expression, along with PLD activity, increased during differentiation of primary osteoblasts and Saos-2 cells, and peaked at the onset of mineralization. Subsequently, both PLD1 expression and PLD activity decreased, suggesting that PLD1 function is regulated during osteoblast maturation. In contrast, PLD2 expression was not significantly affected during differentiation of osteoblasts. Overexpression of PLD1 in Saos-2 cells improved their mineralization potential. PLD inhibitor Halopemide or PLD1-selective inhibitor, led to a decrease in mineralization in both cell types. On the contrary, the selective inhibitor of PLD2, did not affect the mineralization process. Moreover, primary osteoblasts isolated from PLD1 knockout (KO) mice were significantly less efficient in mineralization as compared with those isolated from wild type (WT) or PLD2 KO mice. In contrast, bone formation, as monitored by high-resolution microcomputed tomography analysis, was not impaired in PLD1 KO nor in PLD2 KO mice, indicating that the lack of PLD1 or that of PLD2 did not affect the bone structure in adult mice. Taken together, our findings indicate that PLD activity, especially which of PLD1 isoform, may enhance the mineralization process in osteoblastic cells. Nonetheless, the lack of PLD1 or PLD2 do not seem to significantly affect bone formation in adult mice.
MeSH term(s)	Alkaline Phosphatase/metabolism ; Animals ; Blotting, Western ; Calcification, Physiologic/physiology ; Cell Differentiation/physiology ; Cell Line, Tumor ; Female ; Mice ; Mice, Knockout ; Osteoblasts/cytology ; Osteoblasts/metabolism ; Osteogenesis/physiology ; Phospholipase D/genetics ; Phospholipase D/metabolism ; Real-Time Polymerase Chain Reaction
Chemical Substances	Alkaline Phosphatase (EC 3.1.3.1) ; phospholipase D2 (EC 3.1.4.-) ; Phospholipase D (EC 3.1.4.4) ; phospholipase D1 (EC 3.1.4.4)
Language	English
Publishing date	2018-10-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.27881
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Article ; Online: Diminished bone resorption in overweight/obese women despite vitamin D insufficiency.

Laroche, Michel / Pouilles, Jean Michel / Trémollières, Florence / Vallet, Marion / Lassoued, Slim / Nigon, Delphine / Tack, Ivan

Joint bone spine

2016 Volume 84, Issue 1, Page(s) 119–120

MeSH term(s)	Biomarkers/blood ; Body Mass Index ; Bone Resorption/epidemiology ; Bone Resorption/physiopathology ; Cohort Studies ; Female ; Humans ; Hyperparathyroidism, Secondary/diagnosis ; Hyperparathyroidism, Secondary/epidemiology ; Incidence ; Male ; Middle Aged ; Obesity/epidemiology ; Obesity/physiopathology ; Overweight/epidemiology ; Overweight/physiopathology ; Parathyroid Hormone/blood ; Prognosis ; Risk Assessment ; Vitamin D Deficiency/diagnosis ; Vitamin D Deficiency/epidemiology
Chemical Substances	Biomarkers ; Parathyroid Hormone
Language	English
Publishing date	2016-04-23
Publishing country	France
Document type	Letter
ZDB-ID	2020487-5
ISSN	1778-7254 ; 1297-319X
ISSN (online)	1778-7254
ISSN	1297-319X
DOI	10.1016/j.jbspin.2016.03.001
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Zs.A 4590: Show issues

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Article ; Online: Diagnostic de la lymphogranulomatose vénérienne : à propos d’une série de 5 cas.

Fabre-Baudouin, A / Roux, A L / Marin, C / Lachatre, M / De Laroche, M / Ponsoye, M / Hanslik, T / Trad, S

La Revue de medecine interne

2017 Volume 38, Issue 12, Page(s) 794–799

Abstract: Introduction: Lymphogranuloma venereum (LG) is a sexually transmitted infection (STI) caused by Chlamydia trachomatis L serovar.: Methods: These five consecutive cases aim to highlight the risk of LG misdiagnosis, in case of initial presentation with ...

Title translation	Diagnostic issues of lymphogranuloma venereum: A case series of 5 patients.
Abstract	Introduction: Lymphogranuloma venereum (LG) is a sexually transmitted infection (STI) caused by Chlamydia trachomatis L serovar. Methods: These five consecutive cases aim to highlight the risk of LG misdiagnosis, in case of initial presentation with isolated inguinal adenitis. Results: Five men (mean age: 30±7 years) were seen in an internal medicine department, for inguinal adenopathy. One patient had clinical signs of urethritis. None presented an associated rectitis. Three patients had a history of STI, and two had a discovery of related HIV disease. Urinary polymerase chain reaction (PCR) was positive for the symptomatic patient and negative for the others. Lymph node PCR was positive in all patients within a L2b serotype (searched in 4 out of 5 cases). Conclusion: LG should be evoked in any patient with inguinal adenomegaly, particularly in case of STI history or risk factors. Negativity of urinary PCR should lead to further investigations, essentially a lymph node cytopuncture to evidence C. trachomatis.
MeSH term(s)	Adult ; Chlamydia trachomatis/genetics ; Chlamydia trachomatis/isolation & purification ; Diagnosis, Differential ; Humans ; Lymphadenopathy/diagnosis ; Lymphadenopathy/microbiology ; Lymphogranuloma Venereum/diagnosis ; Lymphogranuloma Venereum/microbiology ; Male ; Polymerase Chain Reaction ; Young Adult
Language	French
Publishing date	2017-12
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	604679-4
ISSN	1768-3122 ; 0248-8663
ISSN (online)	1768-3122
ISSN	0248-8663
DOI	10.1016/j.revmed.2017.09.014
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Article ; Online: Le déficit en vitamine D, très fréquent, n'entraîne qu'exceptionnellement une hyperparathyroïdie secondaire chez des sujets sains de la cinquantaine: cohorte de 526 sujets.

Laroche, Michel / Nigon, Delphine / Gennero, Isabelle / Lassoued, Slim / Pouilles, Jean-Michel / Trémolières, Florence / Vallet, Marion / Tack, Ivan

Presse medicale (Paris, France : 1983)

2015 Volume 44, Issue 7-8, Page(s) e283–90

Abstract: Introduction: Can vitamin D deficiency be predicted by patient questionnaire? Does it lead ... in whom vitamin D levels are often tested.: Patients and methods: Patients hospitalised for degenerative ... osteoarthritis or consulting for assessment of menopause, without renal failure and not treated with vitamin D ...

Title translation	Vitamin D deficiency prediction by patient questionnaire and secondary hyperparathyroidism in a cohort of 526 healthy subjects in their fifties.
Abstract	Introduction: Can vitamin D deficiency be predicted by patient questionnaire? Does it lead to secondary hyperparathyroidism that may cause excessive bone resorption? We studied non-osteoporotic subjects in their fifties, in whom vitamin D levels are often tested. Patients and methods: Patients hospitalised for degenerative osteoarthritis or consulting for assessment of menopause, without renal failure and not treated with vitamin D, completed a questionnaire on sun exposure and underwent measurement of serum calcium, creatinine, 25OH vitamin D, PTH and CTX. Results: Five hundred and twenty-six subjects, mean age 54.6 years (71% women), were investigated throughout the year. 25OH vitamin D levels were correlated with sun exposure and varied according to the month of the year, unlike PTH and CTX levels. From November to May, over 90% of subjects had 25OH vitamin D levels<30ng/mL. Of the subjects who did not expose their face, arms and legs to the sun for at least 20min/day, 94% had 25OH vitamin D levels<30ng/mL. PTH levels were negatively correlated with those of 25OH vitamin D. Serum CTX levels were not correlated with PTH or 25OH vitamin D. Only 13% of subjects presented with secondary hyperparathyroidism, characterised by serum calcium<2.55mmol/L and PTH>65pg/mL, associated with increased CTX levels. Conclusion: Vitamin D deficiency can be predicted by patient questionnaire. It very rarely leads to secondary hyperparathyroidism.
MeSH term(s)	Calcium/blood ; Cohort Studies ; Collagen Type I/blood ; Female ; Healthy Volunteers/statistics & numerical data ; Humans ; Hyperparathyroidism, Secondary/diagnosis ; Hyperparathyroidism, Secondary/etiology ; Male ; Middle Aged ; Parathyroid Hormone/blood ; Peptides/blood ; Prognosis ; Surveys and Questionnaires ; Vitamin D/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/diagnosis
Chemical Substances	Collagen Type I ; Parathyroid Hormone ; Peptides ; collagen type I trimeric cross-linked peptide ; Vitamin D (1406-16-2) ; Calcium (SY7Q814VUP)
Language	French
Publishing date	2015-07
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	120943-7
ISSN	2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0032-7867 ; 0755-4982 ; 0301-1518
DOI	10.1016/j.lpm.2015.01.012
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Zs.A 794: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Ua VI Zs.87: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article: Utilité du TTR (temps passé dans la cible thérapeutique) dans le suivi des patients sous antivitamine K : analyse d’une cohorte de patients.

Valdelièvre, E / Quéré, I / Caré, B / Laroche, J P / Schved, J F

Journal de medecine vasculaire

2018 Volume 43, Issue 3, Page(s) 155–162

Abstract: Introduction: Despite the increasing utilization of direct oral anticoagulant (DOAC) prescriptions, vitamin K antagonists (VKAs) remain the treatment of choice for treating and preventing thromboembolic events. The morbidity and mortality of VKAs are ... ...

Title translation	Time in therapeutic range (TTR) and follow-up of patients on vitamin K antagonist: A cohort analysis.
Abstract	Introduction: Despite the increasing utilization of direct oral anticoagulant (DOAC) prescriptions, vitamin K antagonists (VKAs) remain the treatment of choice for treating and preventing thromboembolic events. The morbidity and mortality of VKAs are partly due to the difficulty of keeping the patient within the therapeutic range. For patients treated by VKA, time in therapeutic range (TTR) is a quality parameter of treatment, widely used in clinical trials but rarely by prescribers. It is well established that its use correlates with the risk of hemorrhage, thrombosis or mortality. We studied this parameter in a cohort of patients to evaluate the quality of their therapeutic follow-up and tried to identify risk factors for low TTR. Methods: The study was made in collaboration with LaboSud Oc Biologie for a duration of 4 months. It included 3387 patients representing 2,4029 INR. We calculated the patients' TTR. The laboratory transmitted to us the sex and age of each patient and the VKA molecule used, the therapeutic range and the specialty of the prescriber. We then analyzed the odds ratio associated with these different factors. Results: The mean TTR was 68%, close to the TTR recommended by scientific societies. Patient's sex was the only statistically correlated factor, with a worse equilibrium in females taking VKAs (OR=1.22, 95% CI: 1.06-1.39, P=0.00552). Many factors usually correlated with poor equilibrium under VKA have not been studied due to lack of information. Conclusion: Given the context of economic restriction and the TTR of our cohort close to the recommended 70%, there would be no benefit in terms of safety to prefer DOAC for the patients involved in this study. Regular monitoring of the individual patient's as well as the cohort's TTR should optimize the management of patients receiving VKAs.
MeSH term(s)	Acenocoumarol/therapeutic use ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Anticoagulants/therapeutic use ; Atrial Fibrillation/complications ; Cohort Studies ; Female ; Humans ; International Normalized Ratio ; Male ; Middle Aged ; Phenindione/analogs & derivatives ; Phenindione/therapeutic use ; Risk Factors ; Sex Factors ; Thromboembolism/drug therapy ; Thromboembolism/prevention & control ; Treatment Outcome ; Vitamin K/antagonists & inhibitors ; Vitamin K/blood ; Warfarin/therapeutic use
Chemical Substances	Anticoagulants ; Vitamin K (12001-79-5) ; Phenindione (5M7Y6274ZE) ; Warfarin (5Q7ZVV76EI) ; fluindione (EQ35YMS20Q) ; Acenocoumarol (I6WP63U32H)
Language	French
Publishing date	2018-03-17
Publishing country	France
Document type	Journal Article
ISSN	2542-4513
ISSN	2542-4513
DOI	10.1016/j.jdmv.2018.02.001
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Article ; Online: Quelle démarche d’éducation thérapeutique (ETP) pour les adolescents et jeunes adultes atteints de cancer ? Expérience du groupe ETP de « Go-AJA ».

Corradini, Nadège / Dagorne, Loïc / Retailleau, Marielle / Rédini, Françoise / Sudour-Bonnange, Hélène / Gofti-Laroche, Leila / Le Rhun, Anne / Gaspar, Nathalie

Bulletin du cancer

2016 Volume 103, Issue 12, Page(s) 966–978

Abstract: Introduction: Therapeutic education (TE) is a practice developed over 40 years at an international level to give people with chronic illness the skills necessary to help them better manage their disease. The lengthening survival time of cancer patients ... ...

Title translation	Which approach of therapeutic education (TE) for adolescents and young adults with cancer? Experience from the TE working group of "Go-AJA".
Abstract	Introduction: Therapeutic education (TE) is a practice developed over 40 years at an international level to give people with chronic illness the skills necessary to help them better manage their disease. The lengthening survival time of cancer patients as well as changes in the patient-caregiver relationship have contributed to the development of TE in oncologic diseases. Every year in France, about 1900 adolescents and young adults (15-25 years old) are diagnosed with cancer which is the second leading cause of death in this age group. The observed survival rates for these patients are lower when compared with children's. Some of the hypotheses put forward to explain this difference include a lack of constancy in care and a non-following treatment, as failure to adhere to therapies is common in this age group. "Go-AJA", an interdisciplinary national organization established in 2012, aims to improve the quality of care and treatment results for AYA living with cancer. Therapeutic education for AYA in oncology is an active working group of "Go-AJA" and intends to draw recommendations and to improve adapted communication on different education topics. Elaboration and preparation of TE programs by skilled multidisciplinary teams engaged in interactive educational actions is the first and most crucial step. Materials and methods: The TE "Go-AJA" working group has federated pediatric and adult oncologists, nurses, psychologists, TE professionals, and resource patients, thanks to the commitment of professionals from the 8 national teams supported by the National Cancer Institute. Physical meetings and conference calls were organized from 2012 to 2015 to construct TE tools and programs for AYA with cancer. Results: A competence referential was built and adapted to AYA population with cancer, after focused groups organized in 2 main oncology centers with on-therapy sarcoma patients and members of the multidisciplinary TE working group. Tools were validated and adapted to adolescents or young adults with cancer, to help in the 4 stages of TE: the "educational diagnosis" allowing the caregiver to better understand the patient in his life journey with the disease; the "therapeutic alliance" allowing to agree with the patient on his/her priorities; the "implementation" which is an action step: information, awareness, learning and psychosocial support. The final step called "assessment" allows the caregiver to take stock on the changes and difficulties with the patient. TE for AYA with cancer included individual and/or group sessions to improve self-care skills: knowledge about the disease (group sessions "what is cancer?" with use of microscopes to visualize sarcoma cells, and guided tours in a tumor research laboratory), and details about the treatment and its consequences (workshops about "management of febrile neutropenia"). Moreover, TE aimed to enrich the field of coping skills, in particular to improve the coordination and experience of cares between the different complex and varied network of care (group and/or individual sessions focused on physical rehabilitation, and adapted school/professional orientation). Conclusion: Regardless of the care system, care workers dedicated to AYA with cancer should use TE-specific actions to reinforce treatment participation and therapeutic relationships. This active multidisciplinary TE working group dedicated to AYA with cancer elaborated TE programs by skilled multidisciplinary teams engaged in interactive educational actions. After this work of a national TE organization, more studies using methodological tools are still required to evaluate the impact of such implemented programs on the treatment results and the quality of life.
MeSH term(s)	Adolescent ; Disease Management ; Focus Groups ; France ; Humans ; Neoplasms/diagnosis ; Neoplasms/mortality ; Neoplasms/therapy ; Patient Care Team/organization & administration ; Patient Education as Topic ; Physician-Patient Relations ; Self Care/methods ; Young Adult
Language	French
Publishing date	2016-12
Publishing country	France
Document type	Journal Article
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2016.10.006
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Article ; Online: Carfilzomib: Looking for 'The Holy Grail' to treat antibody-mediated rejection.

Laroche, Camille / Marks, Stephen D

Pediatric transplantation

2023 Volume 27, Issue 7, Page(s) e14533

Language	English
Publishing date	2023-05-02
Publishing country	Denmark
Document type	Editorial
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.14533
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Article ; Online: Vitamin D deficiency does not alter biochemical markers of bone metabolism before or after autograft in patients with multiple myeloma.

Laroche, Michel / Lemaire, Olivia / Attal, Michel

European journal of haematology

2010 Volume 85, Issue 1, Page(s) 65–67

Abstract: Unlabelled: So far, only one study has demonstrated a high incidence of vitamin D deficiency ... in patients with multiple myeloma. Vitamin D deficiency may alter bone remodelling in myeloma. In this study ... we aimed to determine the prevalence of vitamin D deficiency and to assess its impact on bone remodelling ...

Abstract	Unlabelled: So far, only one study has demonstrated a high incidence of vitamin D deficiency in patients with multiple myeloma. Vitamin D deficiency may alter bone remodelling in myeloma. In this study, we aimed to determine the prevalence of vitamin D deficiency and to assess its impact on bone remodelling and bone mineral density before and after autologous stem cell transplantation (ASCT). Patients and methods: In 39 consecutive patients receiving high-dose chemotherapy (melphalan 200 mg/m(2)) followed by ASCT for multiple myeloma, we measured before (T0) and 12 months after ASCT (T12) serum calcium, 25-OH-D, PTH 1-84, bone alkaline phosphatase (bALP), serum C-terminal cross-linking telopeptide and lumbar spine bone mineral density (BMD). Results: Mean vitamin D levels were low: 15 +/- 5 ng/mL (9-18) at T0 and 16 +/- 5 ng/mL (14-22) at T12. Twenty-six patients (68%) had vitamin D deficiency (25-OH-D < 20 ng/mL) at T0 and 58% at T12. Patients in the vitamin D-deficient group had higher serum PTH levels than those in the vitamin D-sufficient group : 71 +/- 24 pg/mL vs. 52 +/- 18 pg/mL (P = 0.04). Biochemical bone markers were identical in both groups at T0 and T12. Z-score values did not significantly differ between the two groups at T0 and T12. There were no correlations between 25-OH-D and BMD or bone marker levels. Conclusion: Vitamin D deficiency does not impair biochemical markers of bone metabolism in patients with multiple myeloma, before or after ASCT.
MeSH term(s)	Alkaline Phosphatase/blood ; Biomarkers/blood ; Bone Density ; Bone Remodeling ; Calcifediol/blood ; Calcium/blood ; Collagen Type I ; Humans ; Middle Aged ; Multiple Myeloma/complications ; Multiple Myeloma/metabolism ; Multiple Myeloma/therapy ; Parathyroid Hormone/blood ; Peptide Fragments/blood ; Peptides ; Procollagen/blood ; Stem Cell Transplantation ; Transplantation, Autologous ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/metabolism
Chemical Substances	Biomarkers ; Collagen Type I ; Parathyroid Hormone ; Peptide Fragments ; Peptides ; Procollagen ; collagen type I trimeric cross-linked peptide ; Alkaline Phosphatase (EC 3.1.3.1) ; Calcifediol (P6YZ13C99Q) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2010-07
Publishing country	England
Document type	Journal Article
ZDB-ID	392482-8
ISSN	1600-0609 ; 0902-4441
ISSN (online)	1600-0609
ISSN	0902-4441
DOI	10.1111/j.1600-0609.2010.01436.x
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Article: Preventing Blindness with Early Cataract Surgery and Micro-Invasive Glaucoma Surgery in Patients Over 50: Guidance for Patients, Physicians and World Governments in Dealing with Glaucoma.

Laroche, Daniel / Madu, Chisom T

Clinical ophthalmology (Auckland, N.Z.)

2023 Volume 17, Page(s) 2929–2938

Abstract: Purpose: To offer clinical guidance and address safety and efficacy concerns regarding the growing use of micro-invasive glaucoma surgery (MIGS) as an initial treatment for glaucoma in adult patients.: Design: Narrative literature review.: Methods!# ...

Abstract	Purpose: To offer clinical guidance and address safety and efficacy concerns regarding the growing use of micro-invasive glaucoma surgery (MIGS) as an initial treatment for glaucoma in adult patients. Design: Narrative literature review. Methods: A review was conducted to assess outcomes and complications of MIGS in the treatment of glaucoma, both alone and in combination with lens replacement. These outcomes were compared with those of standard glaucoma surgery and/or glaucoma management with medication. Results: MIGS are effective at lowering intraocular pressure (IOP) over long periods of follow-up. These techniques share a similarly high safety profile between one another. MIGS were found to have lower complication rates and to be more effective in reducing the total amount of medication needed to maintain control of intraocular pressure than standard surgery approaches. Conclusion: MIGS techniques are growing in popularity and have been demonstrated to be a safe and effective alternative to standard glaucoma surgery. Guidance in the implementation of these procedures has been outlined.
Language	English
Publishing date	2023-10-04
Publishing country	New Zealand
Document type	Journal Article ; Review
ISSN	1177-5467
ISSN	1177-5467
DOI	10.2147/OPTH.S422415
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In stock of ZB MED Cologne/Königswinter

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Inter-library loan at ZB MED