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  1. Article ; Online: Social Media and the Idle No More Movement

    Jennifer Tupper

    Journal of Social Science Education, Vol 13, Iss

    Citizenship, Activism and Dissent in Canada

    2014  Volume 4

    Abstract: This paper, informed by a critique of traditional understandings of citizenship and civic education, explores the use of social media as a means of fostering activism and dissent. Specifically, the paper explores the ways in which the Idle No More ... ...

    Abstract This paper, informed by a critique of traditional understandings of citizenship and civic education, explores the use of social media as a means of fostering activism and dissent. Specifically, the paper explores the ways in which the Idle No More Movement, which began in Canada in 2012 marshalled social media to educate about and protest Bill C-45, an omnibus budget bill passed by the Federal Government. The paper argues that Idle No More is demonstrative of young people’s commitments to social change and willingness to participate in active forms of dissent. As such, it presents opportunities for fostering ethically engaged citizenship through greater knowledge and awareness of Indigenous issues in Canada, which necessarily requires an understanding of the historical and contemporary legacies of colonialism that continually position First Nations, Métis, and Inuit peoples as ‘lesser’ citizens. Finally, the paper suggests that the example of Idle No More stands in contrast to the notion of a “civic vacuum” that is often used to justify the re-entrenchment of traditional civic education programs in schools and as such, can be used as a pedagogic tool to teach for and about dissent.
    Keywords Special aspects of education ; LC8-6691 ; Social sciences (General) ; H1-99
    Language German
    Publishing date 2014-05-01T00:00:00Z
    Publisher Bielefeld University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Social Media and the Idle No More Movement

    Jennifer Tupper

    Journal of Social Science Education, Vol 13, Iss

    Citizenship, Activism and Dissent in Canada

    2014  Volume 4

    Abstract: This paper, informed by a critique of traditional understandings of citizenship and civic education, explores the use of social media as a means of fostering activism and dissent. Specifically, the paper explores the ways in which the Idle No More ... ...

    Abstract This paper, informed by a critique of traditional understandings of citizenship and civic education, explores the use of social media as a means of fostering activism and dissent. Specifically, the paper explores the ways in which the Idle No More Movement, which began in Canada in 2012 marshalled social media to educate about and protest Bill C-45, an omnibus budget bill passed by the Federal Government. The paper argues that Idle No More is demonstrative of young people’s commitments to social change and willingness to participate in active forms of dissent. As such, it presents opportunities for fostering ethically engaged citizenship through greater knowledge and awareness of Indigenous issues in Canada, which necessarily requires an understanding of the historical and contemporary legacies of colonialism that continually position First Nations, Métis, and Inuit peoples as ‘lesser’ citizens. Finally, the paper suggests that the example of Idle No More stands in contrast to the notion of a “civic vacuum” that is often used to justify the re-entrenchment of traditional civic education programs in schools and as such, can be used as a pedagogic tool to teach for and about dissent.
    Keywords Special aspects of education ; LC8-6691 ; Social sciences (General) ; H1-99
    Language German
    Publishing date 2014-05-01T00:00:00Z
    Publisher Bielefeld University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The current practice of social work in pain management: a scoping review on chronic disease.

    King, Jennifer / Tupper, Susan / Fletcher, Kara / Brose, Kelsey / Goodridge, Donna

    Social work in health care

    2021  Volume 60, Issue 3, Page(s) 256–271

    Abstract: While social workers have the capacity and scope of practice to make a significant contribution to pain management, little is understood about how they enact these roles. The initial goal of this scoping review was to examine the role of social work in ... ...

    Abstract While social workers have the capacity and scope of practice to make a significant contribution to pain management, little is understood about how they enact these roles. The initial goal of this scoping review was to examine the role of social work in pain management specifically in bleeding disorder care. Due to lack of published data on this topic, the review goal was broadened to chronic disease. Two electronic databases were searched providing a total of 13 published articles meeting the inclusion and exclusion criteria. Instrumental services, clinical services, and assessments were identified as primary roles of social workers, while advocacy, policy development, education, and skill development require further exploration in the literature.
    MeSH term(s) Chronic Disease ; Delivery of Health Care ; Humans ; Motivation ; Pain ; Social Work
    Language English
    Publishing date 2021-01-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 197616-3
    ISSN 1541-034X ; 0098-1389
    ISSN (online) 1541-034X
    ISSN 0098-1389
    DOI 10.1080/00981389.2021.1878318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Osimertinib and Selpercatinib Efficacy, Safety, and Resistance in a Multicenter, Prospectively Treated Cohort of EGFR-Mutant and RET Fusion-Positive Lung Cancers.

    Rotow, Julia / Patel, Jyoti D / Hanley, Matthew P / Yu, Helena / Awad, Mark / Goldman, Jonathan W / Nechushtan, Hovav / Scheffler, Matthias / Kuo, Chih-Hsi S / Rajappa, Senthil / Harada, Guilherme / Clifford, Sarah / Santucci, Alison / Silva, Laura / Tupper, Rebecca / Oxnard, Geoffrey R / Kherani, Jennifer / Drilon, Alexander

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2023  Volume 29, Issue 16, Page(s) 2979–2987

    Abstract: Purpose: Acquired RET fusions have been reported at resistance to treatment with EGFR inhibitors in EGFR-mutant non-small cell lung cancer (NSCLC); however, a multicenter cohort of patients with EGFR-mutant lung cancers treated with osimertinib and ... ...

    Abstract Purpose: Acquired RET fusions have been reported at resistance to treatment with EGFR inhibitors in EGFR-mutant non-small cell lung cancer (NSCLC); however, a multicenter cohort of patients with EGFR-mutant lung cancers treated with osimertinib and selpercatinib for RET fusion-mediated osimertinib resistance has not previously been published.
    Patients and methods: Patients who received selpercatinib in combination with osimertinib on a prospective expanded access clinical trial (NCT03906331) and single-patient compassionate use programs across five countries were centrally analyzed. All patients had advanced EGFR-mutant NSCLC with a RET fusion detected from tissue or plasma following osimertinib therapy. Clinicopathologic and outcomes data were collected.
    Results: Fourteen patients with EGFR-mutant and RET fusion-positive lung cancers who experienced prior progression on osimertinib received osimertinib and selpercatinib. EGFR exon 19 deletions (±T790M, 86%) and non-KIF5B fusions (CCDC6-RET 50%, NCOA4-RET 36%) predominated. Osimertinib 80 mg daily and selpercatinib 80 mg twice daily were the most commonly administered dosages. The response rate, disease control rate, and median treatment duration were 50% [95% confidence interval (CI), 25%-75%, n = 12], 83% (95% CI, 55%-95%), and 7.9 months (range, 0.8-25+), respectively. Resistance was complex, involving EGFR on-target (EGFR C797S), RET on-target (RET G810S), and off-target (EML4-ALK/STRN-ALK, KRAS G12S, BRAF V600E) mechanisms; RET fusion loss; or polyclonal mechanisms.
    Conclusions: For patients with EGFR-mutant NSCLC with an acquired RET fusion as a mechanism of EGFR inhibitor resistance, the addition of selpercatinib to osimertinib was feasible and safe and offered clinical benefit, supporting the prospective evaluation of this combination. See related commentary by Krebs and Popat, p. 2951.
    MeSH term(s) Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; ErbB Receptors/genetics ; Mutation/drug effects ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/administration & dosage ; Aniline Compounds/pharmacology ; Proto-Oncogene Proteins c-ret/genetics
    Chemical Substances ErbB Receptors (EC 2.7.10.1) ; osimertinib (3C06JJ0Z2O) ; selpercatinib (CEGM9YBNGD) ; Protein Kinase Inhibitors ; Aniline Compounds ; RET protein, human (EC 2.7.10.1) ; Proto-Oncogene Proteins c-ret (EC 2.7.10.1) ; EGFR protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-22-2189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Metabolomic, photoprotective, and photosynthetic acclimatory responses to post-flowering drought in sorghum.

    Baker, Christopher R / Patel-Tupper, Dhruv / Cole, Benjamin J / Ching, Lindsey G / Dautermann, Oliver / Kelikian, Armen C / Allison, Cayci / Pedraza, Julie / Sievert, Julie / Bilbao, Aivett / Lee, Joon-Yong / Kim, Young-Mo / Kyle, Jennifer E / Bloodsworth, Kent J / Paurus, Vanessa / Hixson, Kim K / Hutmacher, Robert / Dahlberg, Jeffery / Lemaux, Peggy G /
    Niyogi, Krishna K

    Plant direct

    2023  Volume 7, Issue 11, Page(s) e545

    Abstract: Climate change is globally affecting rainfall patterns, necessitating the improvement of drought tolerance in crops. ...

    Abstract Climate change is globally affecting rainfall patterns, necessitating the improvement of drought tolerance in crops.
    Language English
    Publishing date 2023-11-13
    Publishing country England
    Document type Journal Article
    ISSN 2475-4455
    ISSN (online) 2475-4455
    DOI 10.1002/pld3.545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Anaphylaxis: A review and update.

    Tupper, Jennifer / Visser, Shaun

    Canadian family physician Medecin de famille canadien

    2010  Volume 56, Issue 10, Page(s) 1009–1011

    MeSH term(s) Anaphylaxis/diagnosis ; Anaphylaxis/drug therapy ; Anti-Allergic Agents/administration & dosage ; Asthma/diagnosis ; Diagnosis, Differential ; Emergency Treatment ; Epinephrine/administration & dosage ; Female ; Fluid Therapy ; Humans ; Young Adult
    Chemical Substances Anti-Allergic Agents ; Epinephrine (YKH834O4BH)
    Language English
    Publishing date 2010-10-13
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 603565-6
    ISSN 1715-5258 ; 0008-350X
    ISSN (online) 1715-5258
    ISSN 0008-350X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Septic until proven otherwise: approach to and treatment of the septic joint in adult patients.

    Visser, Shaun / Tupper, Jennifer

    Canadian family physician Medecin de famille canadien

    2009  Volume 55, Issue 4, Page(s) 374–375

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Arthritis, Infectious/diagnosis ; Arthritis, Infectious/drug therapy ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Diagnosis, Differential ; Family Practice/methods ; Follow-Up Studies ; Humans ; Knee Joint/physiopathology ; Male ; Middle Aged ; Pain Measurement ; Physical Examination/methods ; Range of Motion, Articular/physiology ; Risk Assessment ; Synovial Fluid/microbiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2009-04-14
    Publishing country Canada
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 603565-6
    ISSN 1715-5258 ; 0008-350X
    ISSN (online) 1715-5258
    ISSN 0008-350X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Canadian surveillance study of complex regional pain syndrome in children.

    Baerg, Krista / Tupper, Susan M / Chu, Luan Manh / Cooke, Nicole / Dick, Bruce D / Doré-Bergeron, Marie-Joëlle / Findlay, Sheri / Ingelmo, Pablo M / Lamontagne, Christine / Mesaroli, Giulia / Oberlander, Tim F / Poolacherla, Raju / Spencer, Adam Oscar / Stinson, Jennifer / Finley, G Allen

    Pain

    2021  Volume 163, Issue 6, Page(s) 1060–1069

    Abstract: Abstract: This study describes the minimum incidence of pediatric complex regional pain syndrome (CRPS), clinical features, and treatments recommended by pediatricians and pain clinics in Canada. Participants in the Canadian Paediatric Surveillance ... ...

    Abstract Abstract: This study describes the minimum incidence of pediatric complex regional pain syndrome (CRPS), clinical features, and treatments recommended by pediatricians and pain clinics in Canada. Participants in the Canadian Paediatric Surveillance Program reported new cases of CRPS aged 2 to 18 years monthly and completed a detailed case reporting questionnaire from September 2017 to August 2019. Descriptive analysis was completed, and the annual incidence of CRPS by sex and age groupings was estimated. A total of 198 cases were reported to the Canadian Paediatric Surveillance Program, and 168 (84.8%) met the case definition. The minimum Canadian incidence of CRPS is estimated at 1.14/100,000 (95% confidence interval 0.93-1.35/100,000) children per year. Incidence was highest among girls 12 years and older (3.10, 95% confidence interval 2.76-3.44/100,000). The mean age of CRPS diagnosis was 12.2 years (SD = 2.4), with the mean time from symptom onset to diagnosis of 5.6 months (SD = 9.9) and no known inciting event for 19.6% of cases. Most cases had lower limb involvement (79.8%). Nonsteroidal anti-inflammatory drugs (82.7%) and acetaminophen (66.0%) were prescribed more commonly than antiepileptic drugs (52.3%) and antidepressants (32.0%). Referrals most commonly included physical therapy (83.3%) and multidisciplinary pain clinics (72.6%); a small number of patients withdrew from treatment because of pain exacerbation (5.3%). Pain education was recommended for only 65.6% of cases. Treatment variability highlights the need for empiric data to support treatment of pediatric CRPS and development of treatment consensus guidelines.
    MeSH term(s) Adolescent ; Canada/epidemiology ; Child ; Child, Preschool ; Complex Regional Pain Syndromes/diagnosis ; Complex Regional Pain Syndromes/epidemiology ; Female ; Humans ; Incidence ; Pain ; Pain Measurement
    Language English
    Publishing date 2021-09-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 193153-2
    ISSN 1872-6623 ; 0304-3959
    ISSN (online) 1872-6623
    ISSN 0304-3959
    DOI 10.1097/j.pain.0000000000002482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pain intensity variability and its relationship with quality of life in youths with juvenile idiopathic arthritis.

    Tupper, Susan M / Rosenberg, Alan M / Pahwa, Punam / Stinson, Jennifer N

    Arthritis care & research

    2013  Volume 65, Issue 4, Page(s) 563–570

    Abstract: Objective: To describe variability of pain intensity experienced by youths with juvenile idiopathic arthritis (JIA) and examine factors related to within-day patterns of pain and the relationship between magnitude of pain variability and quality of life. ...

    Abstract Objective: To describe variability of pain intensity experienced by youths with juvenile idiopathic arthritis (JIA) and examine factors related to within-day patterns of pain and the relationship between magnitude of pain variability and quality of life.
    Methods: Pain intensity was self-reported on a visual analog scale (VAS; range 0-100) by 112 youths with JIA ages 8-18 years using electronic diaries 3 times per day for 7 days. Average absolute change in pain (AAC) was computed as a measure of the magnitude of pain variability for each participant. Logistic regression was used to examine the relationship between demographic and disease characteristics and the probability of having high pain variability (AAC ≥10 VAS units). Linear regression was used to examine the relationship between quality of life (assessed by the Pediatric Quality of Life Inventory) and AAC. The generalized estimating equations approach was used to examine the relationship between the time of day and pain intensity.
    Results: The mean ± SD AAC was 15.6 ± 10.5. The majority of youths (65%) had high AAC (≥10 VAS units). Disease severity predicted high pain variability (β = 0.02, P = 0.044). Higher AAC predicted lower quality of life (adjusted R(2) = 0.194, β = -0.59, P = 0.003). Within-day patterns of pain intensity varied by JIA subtype and sex.
    Conclusion: This study characterized the pain intensity variability experienced by youths with JIA. Pain variability throughout the day was common, varied by JIA subtype and sex, and was related to quality of life. These findings have implications for future pain research, patient education, and development of clinical interventions for this population.
    MeSH term(s) Activities of Daily Living ; Adolescent ; Arthralgia/etiology ; Arthralgia/psychology ; Arthritis, Juvenile/complications ; Arthritis, Juvenile/psychology ; Child ; Female ; Humans ; Male ; Pain Measurement ; Quality of Life ; Severity of Illness Index
    Language English
    Publishing date 2013-04
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 645059-3
    ISSN 2151-4658 ; 0893-7524 ; 2151-464X
    ISSN (online) 2151-4658
    ISSN 0893-7524 ; 2151-464X
    DOI 10.1002/acr.21850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Digital Storytelling for Historical Understanding

    Katia Hildebrandt / Patrick Lewis / Claire Kreuger / Joseph Naytowhow / Jennifer Tupper / Alec Couros / Ken Montgomery

    Journal of Social Science Education, Vol 15, Iss

    Treaty Education for Reconciliation

    2016  Volume 1

    Abstract: This paper presents the findings of a research project that sought to interrogate the possibilities of digital storytelling as a pathway towards a more complete understanding of treaties and the treaty relationship in western Canada. This research is ... ...

    Abstract This paper presents the findings of a research project that sought to interrogate the possibilities of digital storytelling as a pathway towards a more complete understanding of treaties and the treaty relationship in western Canada. This research is situated in the province of Saskatchewan, where treaty education (that is, education about the history of the numbered treaties signed between First Nations people and the British Crown, as well as the subsequent history of the treaty relationship) has been mandatory for almost a decade. The paper details a two-year journey alongside elementary educators as they used digital storytelling to take up treaty education in their classrooms. We present an overview of the research project as well as the narratives of a teacher, a researcher, and a Cree knowledge keeper, all of whom were involved in and reflected on the research journey. We consider the research findings alongside these narratives in order to explore the possibilities that digital storytelling might offer as we, as a Canadian nation, move towards reconciliation with Aboriginal people within a Canadian context of ongoing colonialism. Questo articolo presenta i risultati di un progetto di ricerca che ha cercato di indagare sulle possibilità della narrazione digitale di storie (storytelling) come percorso verso una comprensione più completa dei trattati e del rapporto fra i trattati nel Canada occidentale. Questa indagine è situata nella provincia di Saskatchewan, dove l'istruzione sui trattati (cioè, l'educazione sulla storia dei trattati numerati firmati tra la Prima Nazione e la Corona Britannica, così come la storia successiva del rapporto fra i trattati) è stato obbligatorio per quasi un decennio. Il saggio riporta un percorso di due anni con insegnanti di scuola elementare che hanno usato lo storytelling digitale per fare l'educazione ai trattati nelle loro classi. Presentiamo una panoramica del progetto di ricerca ed i racconti di un insegnante, di un ricercatore, e un guardiano Cree della conoscenza, i ...
    Keywords Special aspects of education ; LC8-6691 ; Social sciences (General) ; H1-99
    Language German
    Publishing date 2016-03-01T00:00:00Z
    Publisher Bielefeld University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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