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Book ; Conference proceedings: Locating corporate R&D facilities

Lund, Leonard

a research report from the Conference Board

(Report : the Conference Board ; 892)

1986

Author's details	by Leonard Lund
Series title	Report : the Conference Board ; 892
Keywords	Industrieforschung ; USA ; 12*21
Language	English
Size	VI, 21 S
Document type	Book ; Conference proceedings
ISBN	0823703347 ; 9780823703340
Database	ECONomics Information System

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Article: The new interventional centre--a multidisciplinary R&D clinic for interventional radiology and minimal access surgery.

Laerum, F / Borchgrevink, H M / Fosse, E / Faye-Lund, P

Computer methods and programs in biomedicine

1998 Volume 57, Issue 1-2, Page(s) 29–34

Abstract: The National Hospital wanted to coordinate and promote the development of new minimally invasive procedures by structuring collaboration and communication across traditional speciality boundaries. To achieve this, a new hospital department has been ... ...

Abstract	The National Hospital wanted to coordinate and promote the development of new minimally invasive procedures by structuring collaboration and communication across traditional speciality boundaries. To achieve this, a new hospital department has been established, a 'neutral ground' for working with such clinical applications in multi-disciplinary teams with surgeons, radiologists, cardiologists etc., individually composed for the type of intervention to be performed. The Interventional Centre also represents a full fusion of a modern radiology department with a state-of-the-art operating department, securing the use of relevant imaging technologies, aseptic conditions and options of converting any 'key-hole' procedure to open, conventional surgery within minutes. The Centre represents a new organizational model for such activities. It is also a technology centre, a common 'tool-box' securing better access and higher quality for the use of advanced radiological and surgical technology in our hospital.
MeSH term(s)	Hospital Departments/organization & administration ; Medical Laboratory Science ; Norway ; Radiology Department, Hospital/organization & administration ; Research ; Surgery Department, Hospital/organization & administration
Language	English
Publishing date	1998-08
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632564-6
ISSN	1872-7565 ; 0169-2607
ISSN (online)	1872-7565
ISSN	0169-2607
DOI	10.1016/s0169-2607(98)00041-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evidence-based research in orthopaedics, sports medicine and rehabilitation-Why new studies should rely on earlier work.

Prill, Robert / Pieper, Dawid / Klugar, Miloslav / Ayeni, Olufemi R / Karlsson, Jon / Lund, Hans

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

2024 Volume 32, Issue 2, Page(s) 203–205

MeSH term(s)	Humans ; Orthopedics ; Sports Medicine ; Orthopedic Procedures ; Research
Language	English
Publishing date	2024-01-09
Publishing country	Germany
Document type	Editorial
ZDB-ID	1159064-6
ISSN	1433-7347 ; 0942-2056
ISSN (online)	1433-7347
ISSN	0942-2056
DOI	10.1002/ksa.12047
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Article ; Online: Voltage-Controlled High-Bandwidth Terahertz Oscillators Based on Antiferromagnets.

Lund, Mike A / Rodrigues, Davi R / Everschor-Sitte, Karin / Hals, Kjetil M D

Physical review letters

2023 Volume 131, Issue 15, Page(s) 156704

Abstract: Producing compact voltage-controlled frequency generators and sensors operating in the terahertz (THz) regime represents a major technological challenge. Here, we show that noncollinear antiferromagnets (NCAFMs) with kagome structure host gapless self- ... ...

Abstract	Producing compact voltage-controlled frequency generators and sensors operating in the terahertz (THz) regime represents a major technological challenge. Here, we show that noncollinear antiferromagnets (NCAFMs) with kagome structure host gapless self-oscillations whose frequencies are tunable from 0 Hz to the THz regime via electrically induced spin-orbit torques (SOTs). The auto-oscillations' initiation, bandwidth, and amplitude are investigated by deriving an effective theory, which captures the reactive and dissipative SOTs. We find that the dynamics strongly depends on the ground state's chirality, with one chirality having gapped excitations, whereas the opposite chirality provides gapless self-oscillations. Our results reveal that NCAFMs offer unique THz functional components, which could play a significant role in filling the THz technology gap.
Language	English
Publishing date	2023-10-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.156704
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Article ; Online: Performance of a Claims-Based Frailty Proxy Using Varying Frailty Ascertainment Lookback Windows.

Duchesneau, Emilie D / Stürmer, Til / Kim, Dae Hyun / Reeder-Hayes, Katherine / Edwards, Jessie K / Faurot, Keturah R / Lund, Jennifer L

Medical care

2024 Volume 62, Issue 5, Page(s) 305–313

Abstract: Background: Frailty is an aging-related syndrome of reduced physiological reserve to maintain homeostasis. The Faurot frailty index has been validated as a Medicare claims-based proxy for predicting frailty using billing information from a user- ... ...

Abstract	Background: Frailty is an aging-related syndrome of reduced physiological reserve to maintain homeostasis. The Faurot frailty index has been validated as a Medicare claims-based proxy for predicting frailty using billing information from a user-specified ascertainment window. Objectives: We assessed the validity of the Faurot frailty index as a predictor of the frailty phenotype and 1-year mortality using varying frailty ascertainment windows. Research design: We identified older adults (66+ y) in Round 5 (2015) of the National Health and Aging Trends Study with Medicare claims linkage. Gold standard frailty was assessed using the frailty phenotype. We calculated the Faurot frailty index using 3, 6, 8, and 12 months of claims prior to the survey or all-available lookback. Model performance for each window in predicting the frailty phenotype was assessed by quantifying calibration and discrimination. Predictive performance for 1-year mortality was assessed by estimating risk differences across claims-based frailty strata. Results: Among 4253 older adults, the 6 and 8-month windows had the best frailty phenotype calibration (calibration slopes: 0.88 and 0.87). All-available lookback had the best discrimination (C-statistic=0.780), but poor calibration. Mortality associations were strongest using a 3-month window and monotonically decreased with longer windows. Subgroup analyses revealed worse performance in Black and Hispanic individuals than counterparts. Conclusions: The optimal ascertainment window for the Faurot frailty index may depend on the clinical context, and researchers should consider tradeoffs between discrimination, calibration, and mortality. Sensitivity analyses using different durations can enhance the robustness of inferences. Research is needed to improve prediction across racial and ethnic groups.
MeSH term(s)	Humans ; Aged ; United States/epidemiology ; Frailty ; Frail Elderly ; Medicare ; Geriatric Assessment ; Surveys and Questionnaires
Language	English
Publishing date	2024-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	411646-x
ISSN	1537-1948 ; 0025-7079
ISSN (online)	1537-1948
ISSN	0025-7079
DOI	10.1097/MLR.0000000000001994
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Article ; Online: Use of Tramadol vs Traditional Opioids and Adverse Outcomes in Patients with Inflammatory Bowel Disease: A Danish Nationwide Cohort Study.

Dalal, Rahul S / Lund, Ken / Zegers, Floor D / Friedman, Sonia / Allegretti, Jessica R / Nørgård, Bente Mertz

Inflammatory bowel diseases

2023

Abstract: Background: Use of traditional opioids (TOs) for pain management has been associated with adverse outcomes among patients with inflammatory bowel diseases (IBDs). It is unknown if similar associations exist for tramadol, a partial opioid agonist and ... ...

Abstract	Background: Use of traditional opioids (TOs) for pain management has been associated with adverse outcomes among patients with inflammatory bowel diseases (IBDs). It is unknown if similar associations exist for tramadol, a partial opioid agonist and serotonin and norephinephrine reuptake inhibitor. We sought to compare adverse outcomes associated with tramadol vs TOs in an IBD population. Methods: This nationwide cohort study included adults with IBD diagnosed from 1995 to 2021 in Denmark with subsequent prescriptions for tramadol or TOs. For each analgesic, 2 populations were assessed: initial users (first prescription) and persistent users (first 3 consecutive prescriptions within 365 days). Outcomes included infection, bowel obstruction/ileus, IBD surgery, and mortality within 90 days after the initial use index date (date of first prescription) and within 365 days after the persistent use index date (date of third prescription). Odds ratios adjusted for demographics, comorbidities, and IBD severity were calculated using multivariable logistic regression. Results: We identified 37 377 initial users and 15 237 persistent users of tramadol or TOs. Initial users of tramadol had lower adjusted odds of infection (adjusted odds ratio [OR], 0.80; 95% confidence interval [CI], 0.65-0.99), bowel obstruction/ileus (aOR, 0.74; 95% CI, 0.53-1.03), and mortality (aOR, 0.43; 95% CI, 0.35-0.55), and a higher adjusted odds of IBD-related surgery (aOR, 1.27; 95% CI, 1.02-1.60) vs initial users of TOs. Similar results were found for persistent users. Conclusions: Tramadol was associated with lower odds of infection, bowel obstruction/ileus, and mortality vs TOs among patients with IBD. These associations may be impacted by residual confounding.
Language	English
Publishing date	2023-07-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1093/ibd/izad156
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Article ; Online: Type 2-polarized memory B cells hold allergen-specific IgE memory.

Koenig, Joshua F E / Knudsen, Niels Peter H / Phelps, Allyssa / Bruton, Kelly / Hoof, Ilka / Lund, Gitte / Libera, Danielle Della / Lund, Anders / Christensen, Lars Harder / Glass, David R / Walker, Tina D / Fang, Allison / Waserman, Susan / Jordana, Manel / Andersen, Peter S

Science translational medicine

2024 Volume 16, Issue 733, Page(s) eadi0944

Abstract: Allergen-specific immunoglobulin E (IgE) antibodies mediate pathology in diseases such as allergic rhinitis and food allergy. Memory B cells (MBCs) contribute to circulating IgE by regenerating IgE-producing plasma cells upon allergen encounter. Here, we ...

Abstract	Allergen-specific immunoglobulin E (IgE) antibodies mediate pathology in diseases such as allergic rhinitis and food allergy. Memory B cells (MBCs) contribute to circulating IgE by regenerating IgE-producing plasma cells upon allergen encounter. Here, we report a population of type 2-polarized MBCs defined as CD23
MeSH term(s)	Humans ; Rhinitis, Allergic, Seasonal/metabolism ; Memory B Cells ; Allergens ; Immunoglobulin E ; Rhinitis, Allergic ; Immunoglobulin G ; Food Hypersensitivity
Chemical Substances	Allergens ; Immunoglobulin E (37341-29-0) ; Immunoglobulin G
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.adi0944
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Article ; Online: Evaluation of CBCT based dose calculation in the thorax and pelvis using two generic algorithms.

Thing, R S / Nilsson, R / Andersson, S / Berg, M / Lund, M D

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

2022 Volume 103, Page(s) 157–165

Abstract: ... as possible. Recalculated doses were compared using gamma analysis, as well as by comparing D: Results ...

Abstract	Purpose: This work examines the dosimetric performance of two algorithms creating a corrected CBCT (corrCBCT) and a virtual CT (vCT) implemented in a commercial treatment planning system. Methods: 60 patients distributed across all patient groups treated with curative intent at Vejle Hospital (breast, lung, prostate and anal/rectal cancer) were selected for the present study. Clinical treatment plans were recalculated on corrCBCT and vCT, as well as a reference CT (refCT) acquired as close in time to the CBCT image as possible. Recalculated doses were compared using gamma analysis, as well as by comparing D Results: High dosimetric accuracy is demonstrated on both the corrCBCT and vCT. Gamma 2%/2mm pass rates >98% were found for all patients except two outliers still having >93% pass rates. Equivalence of all evaluated dose metrics within ±1Gy was observed for all patient groups, while the pelvic patients additionally showed equivalence for all metrics within ±1% of the refCT dose. For the thoracic patients, equivalence within ±2.5% was established for all metrics except median dose to the ipsilateral lung, calculated on corrCBCT for the breast patient group. Conclusion: The corrCBCT and vCT images are shown in excellent dosimetric agreement with refCT images, and show high potential for future use for streamlined adaptive radiotherapy workflows.
MeSH term(s)	Male ; Humans ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy Dosage ; Cone-Beam Computed Tomography/methods ; Spiral Cone-Beam Computed Tomography ; Algorithms ; Pelvis/diagnostic imaging ; Thorax/diagnostic imaging ; Image Processing, Computer-Assisted/methods
Language	English
Publishing date	2022-10-31
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1122650-x
ISSN	1724-191X ; 1120-1797
ISSN (online)	1724-191X
ISSN	1120-1797
DOI	10.1016/j.ejmp.2022.10.012
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Article: Comparative dose effectiveness of intravenous and intrathecal AAV9.CB7.hIDS, RGX-121, in mucopolysaccharidosis type II mice.

Smith, Miles C / Belur, Lalitha R / Karlen, Andrea D / Erlanson, Olivia / Furcich, Justin / Lund, Troy C / Seelig, Davis / Kitto, Kelley F / Fairbanks, Carolyn A / Kim, Kwi Hye / Buss, Nick / McIvor, R Scott

Molecular therapy. Methods & clinical development

2024 Volume 32, Issue 1, Page(s) 101201

Abstract: Mucopolysaccharidosis type II (MPS II) is an X-linked recessive lysosomal disease caused by iduronate-2-sulfatase (IDS) deficiency, leading to accumulation of glycosaminoglycans (GAGs) and the emergence of progressive disease. Enzyme replacement therapy ... ...

Abstract	Mucopolysaccharidosis type II (MPS II) is an X-linked recessive lysosomal disease caused by iduronate-2-sulfatase (IDS) deficiency, leading to accumulation of glycosaminoglycans (GAGs) and the emergence of progressive disease. Enzyme replacement therapy is the only currently approved treatment, but it leaves neurological disease unaddressed. Cerebrospinal fluid (CSF)-directed administration of AAV9.CB7.hIDS (RGX-121) is an alternative treatment strategy, but it is unknown if this approach will affect both neurologic and systemic manifestations. We compared the effectiveness of intrathecal (i.t.) and intravenous (i.v.) routes of administration (ROAs) at a range of vector doses in a mouse model of MPS II. While lower doses were completely ineffective, a total dose of 1 × 10
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2872938-9
ISSN	2329-0501 ; 2329-0501
ISSN (online)	2329-0501
ISSN	2329-0501
DOI	10.1016/j.omtm.2024.101201
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Article: Effect of dietary protein level on nitrogen excretion in dry cows

Madsen, P. A. / Lund, R. / Brask-Pedersen, D. N. / Johansen, M.

Livestock science

2022 Volume 262, Issue -, Page(s) 104972

Language	English
Document type	Article
ZDB-ID	2226176-X
ISSN	1871-1413
Database	Current Contents Nutrition, Environment, Agriculture

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